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33 条记录 (耗时 0.068 秒)

    PACAP receptor protein, method for preparing said protein, and use thereof
    1.
    发明授权
    PACAP receptor protein, method for preparing said protein, and use thereof 失效
    PACAP受体蛋白质，所述蛋白质的制备方法及其用途

    公开(公告)号：US06399316B1

    公开(公告)日：2002-06-04

    申请号：US09201474

    申请日：1998-11-30

    申请人： Haruo Onda ,  Tetsuya Ohtaki ,  Yasushi Masuda ,  Chieko Kitada ,  Yoshihiro Ishibashi ,  Masaki Hosoya ,  Kazuhiro Ogi ,  Yasunori Miyamoto ,  Yugo Habata ,  Norio Shimamoto

    发明人： Haruo Onda ,  Tetsuya Ohtaki ,  Yasushi Masuda ,  Chieko Kitada ,  Yoshihiro Ishibashi ,  Masaki Hosoya ,  Kazuhiro Ogi ,  Yasunori Miyamoto ,  Yugo Habata ,  Norio Shimamoto

    IPC分类号： G01N3353

    CPC分类号： C07K14/72 ,  A61K38/00 ,  A61K48/00

    摘要： This invention discloses a PACAP receptor protein or a salt thereof, a DNA comprising a DNA fragment coding for the protein, a method for preparing the protein, antibody against the protein, and use of the protein, DNA, and antibodies. A PACAP receptor protein was purified from the bovine cerebrum. DNAs coding for PACAP receptor proteins were isolated from bovine, rat and human cDNA libraries, and their nucleotide sequences were determined. Further, amino acid sequences deduced from the nucleotide sequences were determined. The PACAP receptor proteins and the DNAs coding for the proteins of the present invention can be used for (1) acquisition of antibodies and antisera, (2) construction of expression systems of recombinant receptor proteins, (3) development of receptor binding assay systems using said expression systems and screening of potential compounds for drugs, (4) execution of drug design based on the comparison of ligands and receptors which are structurally similar to each other, (5) preparation of probes and PCR primers in gene diagnosis, and the like.

    摘要翻译： 本发明公开了一种PACAP受体蛋白或其盐，包含编码该蛋白质的DNA片段的DNA，该蛋白质的制备方法，针对该蛋白质的抗体以及该蛋白质，DNA及抗体的用途。 从牛大脑中纯化PACAP受体蛋白。 从牛，大鼠和人类cDNA文库中分离编码PACAP受体蛋白的DNA，测定其核苷酸序列。 此外，确定从核苷酸序列推导的氨基酸序列。 PACAP受体蛋白和编码本发明蛋白的DNA可用于（1）获得抗体和抗血清，（2）构建重组受体蛋白质的表达系统，（3）开发受体结合测定系统，使用 表达系统和药物潜在化合物的筛选，（4）基于结构相似的配体和受体的比较来执行药物设计，（5）基因诊断中探针和PCR引物的制备等 。

    Physiologically active peptide and its use
    4.
    发明授权
    Physiologically active peptide and its use 失效
    生理活性肽及其用途

    公开(公告)号：US07064181B1

    公开(公告)日：2006-06-20

    申请号：US09646078

    申请日：1999-03-24

    申请人： Tetsuya Ohtaki ,  Hideki Matsui ,  Yoshihiro Ishibashi ,  Kazuhiro Ogi ,  Chieko Kitada

    发明人： Tetsuya Ohtaki ,  Hideki Matsui ,  Yoshihiro Ishibashi ,  Kazuhiro Ogi ,  Chieko Kitada

    IPC分类号： C07K14/00

    CPC分类号： C07K16/18 ,  A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/72

    摘要： The present invention relates to a peptide comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 35 and having an ability of binding to a receptor protein comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3, or a precursor thereof, its amide or ester, or a salt thereof.An inventive peptide-encoding DNA or equivalent can be employed in (1) a development of a receptor binding assay system using an expression system of a recombinant receptor protein and a screening for a pharmaceutical candidate compound, and (2) a development of a pharmaceutical having a reduced side effect such as a memory function improving agent, a appetite improving agent, an uterine, renal, prostatic, testicular or skeletal muscle function regulating agent.

    摘要翻译： 本发明涉及一种肽，其包含与SEQ ID NO：35所示的氨基酸序列相同或基本相同的氨基酸序列，并且具有与受体蛋白结合的能力，所述受体蛋白包含与 由SEQ ID NO：1，SEQ ID NO：2或SEQ ID NO：3表示的氨基酸序列，或其前体，其酰胺或酯或其盐。 本发明的编码编码DNA的DNA或等同物可以用于（1）使用重组受体蛋白质的表达系统和药物候选化合物的筛选的受体结合测定系统的开发，和（2）药物 具有减少的副作用，例如记忆功能改善剂，食欲改善剂，子宫，肾，前列腺，睾丸或骨骼肌功能调节剂。

    Novel physiologically active peptide and its use
    5.
    发明申请
    Novel physiologically active peptide and its use 失效
    新型生理活性肽及其用途

    公开(公告)号：US20060155109A1

    公开(公告)日：2006-07-13

    申请号：US11376694

    申请日：2006-03-15

    申请人： Tetsuya Ohtaki ,  Hideki Matsui ,  Yoshihiro Ishibashi ,  Kazuhiro Ogi ,  Chieko Kitada

    发明人： Tetsuya Ohtaki ,  Hideki Matsui ,  Yoshihiro Ishibashi ,  Kazuhiro Ogi ,  Chieko Kitada

    IPC分类号： A61K38/22 ,  C07K14/575

    CPC分类号： C07K16/18 ,  A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/72

    摘要： The present invention relates to a peptide comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 35 and having an ability of binding to a receptor protein comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3, or a precursor thereof, its amide or ester, or a salt thereof. An inventive peptide-encoding DNA or equivalent can be employed in (1) a development of a receptor binding assay system using an expression system of a recombinant receptor protein and a screening for a pharmaceutical candidate compound, and (2) a development of a pharmaceutical having a reduced side effect such as a memory function improving agent, an appetite improving agent, an uterine, renal, prostatic, testicular or skeletal muscle function regulating agent.

    摘要翻译： 本发明涉及一种肽，其包含与SEQ ID NO：35所示的氨基酸序列相同或基本相同的氨基酸序列，并且具有与受体蛋白结合的能力，所述受体蛋白包含与 由SEQ ID NO：1，SEQ ID NO：2或SEQ ID NO：3表示的氨基酸序列，或其前体，其酰胺或酯或其盐。 本发明的编码编码DNA的DNA或等同物可以用于（1）使用重组受体蛋白质的表达系统和药物候选化合物的筛选的受体结合测定系统的开发，和（2）药物 具有减少的副作用，例如记忆功能改善剂，食欲改善剂，子宫，肾，前列腺，睾丸或骨骼肌功能调节剂。

    DNA encoding galanin receptor activating peptide
    6.
    发明授权
    DNA encoding galanin receptor activating peptide 失效
    编码甘丙肽受体激活肽的DNA

    公开(公告)号：US07374910B2

    公开(公告)日：2008-05-20

    申请号：US11376694

    申请日：2006-03-15

    申请人： Tetsuya Ohtaki ,  Hideki Matsui ,  Yoshihiro Ishibashi ,  Kazuhiro Ogi ,  Chieko Kitada

    发明人： Tetsuya Ohtaki ,  Hideki Matsui ,  Yoshihiro Ishibashi ,  Kazuhiro Ogi ,  Chieko Kitada

    IPC分类号： C01N15/11 ,  C01N15/63 ,  C01N5/10

    CPC分类号： C07K16/18 ,  A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/72

    摘要： The present invention relates to a peptide comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 35 and having an ability of binding to a receptor protein comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3, or a precursor thereof, its amide or ester, or a salt thereof.An inventive peptide-encoding DNA or equivalent can be employed in (1) a development of a receptor binding assay system using an expression system of a recombinant receptor protein and a screening for a pharmaceutical candidate compound, and (2) a development of a pharmaceutical having a reduced side effect such as a memory function improving agent, an appetite improving agent, an uterine, renal, prostatic, testicular or skeletal muscle function regulating agent.

    摘要翻译： 本发明涉及一种肽，其包含与SEQ ID NO：35所示的氨基酸序列相同或基本相同的氨基酸序列，并且具有与受体蛋白结合的能力，所述受体蛋白包含与 由SEQ ID NO：1，SEQ ID NO：2或SEQ ID NO：3表示的氨基酸序列，或其前体，其酰胺或酯或其盐。 本发明的编码编码DNA的DNA或等同物可以用于（1）使用重组受体蛋白质的表达系统和药物候选化合物的筛选的受体结合测定系统的开发，和（2）药物 具有减少的副作用，例如记忆功能改善剂，食欲改善剂，子宫，肾，前列腺，睾丸或骨骼肌功能调节剂。

    Gonadal function improving agents
    9.
    发明申请
    Gonadal function improving agents 有权
    性腺功能改善剂

    公开(公告)号：US20060287227A1

    公开(公告)日：2006-12-21

    申请号：US10547974

    申请日：2004-03-11

    申请人： Tetsuya Ohtaki ,  Hisanori Matsui ,  Hirokazu Matsumoto ,  Chieko Kitada

    发明人： Tetsuya Ohtaki ,  Hisanori Matsui ,  Hirokazu Matsumoto ,  Chieko Kitada

    IPC分类号： A61K48/00 ,  A61K38/24

    CPC分类号： G01N33/689 ,  A61K31/00 ,  A61K31/7088 ,  A61K38/1709

    摘要： Metastin, compounds that promote the activity of metastin or its receptors and the like are excellent gonadal function improving agents, ovulation inducers or promoters, gonadotropic hormone secretion promoters, gonadotropic hormone secretion inhibitors, sex hormone secretion promoters, sex hormone secretion inhibitors, etc., and can be used as agents for preventing/treating sterility, hormone-sensitive cancers, endometriosis, etc. Metastin and its receptors are useful for screening for these pharmaceuticals.

    摘要翻译： 促甲状腺激素分泌抑制剂，雌激素分泌促进剂，性激素分泌抑制剂等的促性腺激素分泌抑制剂，促性腺激素分泌促进剂，性激素分泌抑制剂等的优良性腺功能改善剂，排卵诱导剂或促进剂，促性腺激素分泌促进剂， 并且可以用作预防/治疗无菌，激素敏感性癌症，子宫内膜异位症等的药剂.MCastin及其受体可用于筛选这些药物。