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    CRYSTALS OF L-ORNITHINE AND PROCESS FOR PRODUCING THE SAME
    6.
    发明申请
    CRYSTALS OF L-ORNITHINE AND PROCESS FOR PRODUCING THE SAME 失效
    L-ORNITHINE的晶体及其生产方法

    公开(公告)号：US20090082594A1

    公开(公告)日：2009-03-26

    申请号：US11719122

    申请日：2005-11-14

    申请人： Hideki Murata ,  Ikuhiro Nakatani ,  Mariko Shitashige ,  Kenji Tajima

    发明人： Hideki Murata ,  Ikuhiro Nakatani ,  Mariko Shitashige ,  Kenji Tajima

    IPC分类号： C07C229/26

    CPC分类号： C07C227/42 ,  C07C229/26

    摘要： The present invention provides crystals of L-ornithine and a process for producing the crystals of L-ornithine including the steps of (i) exposing L-ornithine or a salt thereof, a composition comprising L-ornithine or a salt thereof, or a solution containing L-ornithine, a salt thereof, or the composition to a cation exchange resin to adsorb L-ornithine onto the cation exchange resin; (ii) eluting L-ornithine from the cation exchange resin on which L-ornithine is adsorbed with an aqueous alkaline solution, and removing an alkaline component from the resulting eluate to prepare an aqueous L-ornithine solution; and (iii) mixing the aqueous L-ornithine solution with a hydrophilic organic solvent, and crystallizing L-ornithine from the resulting mixed solution.

    摘要翻译： 本发明提供L-鸟氨酸的晶体和L-鸟氨酸晶体的制造方法，其特征在于，包括以下步骤：（i）使L-鸟氨酸或其盐，包含L-鸟氨酸或其盐的组合物或溶液 将含有L-鸟氨酸的盐或其组合物或阳离子交换树脂，将L-鸟氨酸吸附到阳离子交换树脂上; （ii）从碱性水溶液中吸附L-鸟氨酸的阳离子交换树脂中洗脱L-鸟氨酸，从得到的洗脱液中除去碱性成分，制备L-鸟氨酸水溶液; 和（iii）将L-鸟氨酸水溶液与亲水性有机溶剂混合，并从所得混合溶液中结晶L-鸟氨酸。

    Method for purifying histidine from a cell culture
    9.
    发明授权
    Method for purifying histidine from a cell culture 有权
    从细胞培养物中纯化组氨酸的方法

    公开(公告)号：US08119373B2

    公开(公告)日：2012-02-21

    申请号：US12282815

    申请日：2007-03-15

    申请人： Hideki Murata ,  Noboru Fujii ,  Kenji Tajima

    发明人： Hideki Murata ,  Noboru Fujii ,  Kenji Tajima

    IPC分类号： C12P13/24

    CPC分类号： C12P13/24 ,  B01J39/05

    摘要： In the method for separating and purifying histidine from a culture containing the amino acid, the culture containing histidine and microbial cells is charged onto the top of a column filled with a carrier particle whose particle size is 420 μm or more and which has an ability to adsorb histidine and then an eluent is passed through the column whereby accomplishing the separation and purification of histidine, and preferably in the step mentioned above, a strong acid cation exchange resin is employed as a carrier particle whereby accomplishing the separation and purification of histidine.

    摘要翻译： 在从含有氨基酸的培养物中分离和纯化组氨酸的方法中，将含有组氨酸和微生物细胞的培养物装入填充有粒径为420μm以上的载体颗粒的柱的顶部，并且具有 吸附组氨酸，然后使洗脱液通过柱，从而完成组氨酸的分离和纯化，优选在上述步骤中，使用强酸阳离子交换树脂作为载体颗粒，从而完成组氨酸的分离和纯化。

    Process for producing solution containing ubiquinone-10
    10.
    发明申请
    Process for producing solution containing ubiquinone-10 审中-公开
    生产含有泛醌-10的溶液的方法

    公开(公告)号：US20050153406A1

    公开(公告)日：2005-07-14

    申请号：US10522658

    申请日：2003-07-25

    申请人： Hideki Murata ,  Hiroyuki Yonemitsu

    发明人： Hideki Murata ,  Hiroyuki Yonemitsu

    IPC分类号： C12P7/66 ,  C12N1/21

    CPC分类号： C12P7/66

    摘要： In accordance with the present invention, a process for producing a ubiquinone-10-containing solution is provided, which comprises the following steps: [1] adding a methanol solution to a culture obtained by culturing a microorganism having an ability to produce ubiquinone-10 in a medium, a processed product of the culture, or a partially purified product of ubiquinone-10, to a final concentration of 50 to 100 v/v % and then retaining the resulting mixture at a temperature of 0° C. or above to 30° C. or below; [2] separating and recovering an insoluble matter from the solution obtained at the step [1]; [3] adding a methanol solution of a concentration of 85 to 100 v/v % to the insoluble matter obtained in the step [2] and retaining the resulting mixture at a temperature of more than 30° C. and 80° C. or below; and [4] removing an insoluble matter from the solution obtained in the step [3].

    摘要翻译： 根据本发明，提供了含有泛醌-10的溶液的制备方法，其包括以下步骤：[1]向通过培养具有生产泛醌-10的能力的微生物获得的培养液中加入甲醇溶液 在培养基中，培养物的加工产物或泛醌-10的部分纯化产物至终浓度为50至100v / v％，然后将所得混合物保持在0℃或更高的温度至 30℃以下; [2]从在步骤[1]获得的溶液中分离和回收不溶物; [3]将浓度为85〜100v / v％的甲醇溶液加入到步骤[2]中得到的不溶性物质中，并将所得混合物保持在大于30℃和80℃的温度，或 下面; 和[4]从步骤[3]中得到的溶液中除去不溶物。