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公开(公告)号：US11738191B2
公开(公告)日：2023-08-29
申请号：US16189177
申请日：2018-11-13
发明人： Hyungwoo Lee , Duk Lyul Na , Dae Won Seo , Young Min Shon , Jin San Lee , Woo Ram Jung , Sang Joon Kim , Joonseong Kang , Wonseok Lee
IPC分类号： A61N1/05 , G06F3/01 , A61B5/00 , A61N1/36 , A61N1/378 , H02J50/10 , A61N1/372 , A61B5/053 , A61B5/01 , A61B5/30 , A61B5/291 , A61B5/316 , A61B5/375
CPC分类号： A61N1/0529 , A61B5/0031 , A61B5/4064 , A61B5/4836 , A61N1/36135 , G06F3/015 , A61B5/0006 , A61B5/0008 , A61B5/01 , A61B5/053 , A61B5/291 , A61B5/30 , A61B5/316 , A61B5/375 , A61B2560/0219 , A61N1/36064 , A61N1/36103 , A61N1/3787 , A61N1/37247 , A61N1/37264 , H02J50/10
摘要： Disclosed are a medical device apparatus, system, and method. A method includes receiving biometric information, by an external device external to a body of a user, of the user from an internal device within the body of the user, and wirelessly transmitting stimulus information configured to specify a stimulus based on the biometric information, and power to the internal device configured to drive the internal device and to apply the stimulus in response to the transmitted stimulus information. A method also includes wirelessly transmitting, from an internal device in a body of a user, biometric information of the user to an external device located outside the body of the user, and wirelessly receiving from the external device stimulus information configured to specify a stimulus, and power configured to drive the internal device and to apply the stimulus to the user in response to the received stimulus information.
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公开(公告)号：US20210369979A1
公开(公告)日：2021-12-02
申请号：US16760351
申请日：2018-10-31
发明人： Duk Lyul Na , Jeongmin Lee , Wooram Jung , Jung-ll Lee
IPC分类号： A61M5/32
摘要： The present disclosure provides an apparatus for intracranial drug injection including a body unit having a through-hole extending between a first opening in a topmost surface and a second opening in a bottommost surface, a cap unit having a shape corresponding to at least a part of an inner surface of the through-hole and being inserted into the first opening to cover the first opening, and a tube unit having one end coupled to the second opening and another end extending toward an affected brain lesion.
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公开(公告)号：US11317849B2
公开(公告)日：2022-05-03
申请号：US16131269
申请日：2018-09-14
发明人： Duk Lyul Na , Ko Woon Kim , Jong Doo Choi , Ju Hee Chin , Byung Hwa Lee , Jee Hyun Choi , Hye Joo Lee , Hyo Been Han
摘要： Disclosed is a VR (Virtual Reality) device for diagnosis of nerve disorder, system and method thereof, wherein the device comprises: a display part providing a user with a VR environment in response to an image; and a user response receiver receiving a user response relative to the image, and wherein the image includes an introduction video included with two or more characters, and a question video image provided subsequent to the introduction video to include an inquiry related to the characters, whereby a user's linguistic competence, visual ability and associative ability can be comprehensively evaluated, and more accurately grasp a degree of user's nerve disorder can be accurately grasped without being influenced by a user's academic background and age.
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公开(公告)号：US11946070B2
公开(公告)日：2024-04-02
申请号：US17054939
申请日：2020-07-15
发明人： Duk Lyul Na , Jong Wook Chang , Hyo Jin Son
IPC分类号： C12N5/0735 , A61K35/51 , A61K35/545 , A61P25/28 , A61P29/00 , C12N5/0775
CPC分类号： C12N5/0606 , A61K35/51 , A61K35/545 , A61P25/28 , A61P29/00 , C12N5/0665 , C12N2501/999
摘要： The present invention relates to a medium composition for reinforcing the efficacy of stem cells, including ethionamide, a method of reinforcing the efficacy of stem cells, including culturing stem cells in the medium composition, a method of preparing stem cells with reinforced efficacy, stem cells prepared by the above-mentioned method, and a use thereof. According to the present invention, the anti-inflammatory effect of mesenchymal stem cells and expression levels of paracrine factors may be effectively improved by a simple method of treating mesenchymal stem cells with ethionamide, and the stem cells obtained by the above method may be effectively used for preventing or treating an inflammatory disease or a degenerative brain disease.
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公开(公告)号：US11913020B2
公开(公告)日：2024-02-27
申请号：US16760004
申请日：2018-10-08
发明人： Duk Lyul Na , Jong Wook Chang , Hyo Jin Son
IPC分类号： C12N5/0735 , A61K35/51 , C12N5/0775
CPC分类号： C12N5/0606 , A61K35/51 , C12N5/0663 , C12N5/0665 , C12N5/0668 , C12N2501/999
摘要： The present invention relates to a medium composition for improving stem cell migration, which includes ethionamide, and a use thereof. According to the present invention, the migration of stem cells may be effectively improved by the adjustment of a culture environment, which is a simple and safe method, without using gene manipulation or a viral vector, and the stem cells improved in migration by the method may be effectively used as a stem cell therapeutic agent that is able to function by rapidly migrating to the damaged region after transplantation.
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公开(公告)号：US11724043B2
公开(公告)日：2023-08-15
申请号：US16760351
申请日：2018-10-31
发明人： Duk Lyul Na , Jeongmin Lee , Wooram Jung , Jung-Il Lee
IPC分类号： A61M5/32
CPC分类号： A61M5/3287 , A61M5/32 , A61M2210/0693
摘要： The present disclosure provides an apparatus for intracranial drug injection including a body unit having a through-hole extending between a first opening in a topmost surface and a second opening in a bottommost surface, a cap unit having a shape corresponding to at least a part of an inner surface of the through-hole and being inserted into the first opening to cover the first opening, and a tube unit having one end coupled to the second opening and another end extending toward an affected brain lesion.
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公开(公告)号：US11826160B2
公开(公告)日：2023-11-28
申请号：US16496100
申请日：2018-03-20
发明人： Duk Lyul Na , Ko Woon Kim , Ju Hee Chin , Byung Hwa Lee , Jong Doo Choi , Jee Hyun Choi , Hio Been Han
CPC分类号： A61B5/4088 , G06F3/013 , G16H50/20
摘要： The purpose of the present invention is to diagnose a neurological disease such as dementia by using virtual reality, and the present invention receives a neurological disease-diagnosing problem from an external device, displays a virtual reality image through a display on the basis of the received neurological disease-diagnosing problem, and performs an examination using the virtual reality image according to user actions detected through various sensors. This process can be performed when linked with an external device such as a PC or a smart phone. Particularly, with respect to the neurological disease-diagnosing problem, the present invention includes: a first screen for introducing at least one object in a virtual reality space and hiding the same; and a second screen having a question on the hidden object. According to the present invention, neurological disease such as dementia can be conveniently examined without inconveniencing or burdening a patient.
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公开(公告)号：US11730419B2
公开(公告)日：2023-08-22
申请号：US16496100
申请日：2018-03-20
发明人： Duk Lyul Na , Ko Woon Kim , Ju Hee Chin , Byung Hwa Lee , Jong Doo Choi , Jee Hyun Choi , Hio Been Han
CPC分类号： A61B5/4088 , G06F3/013 , G16H50/20
摘要： The purpose of the present invention is to diagnose a neurological disease such as dementia by using virtual reality, and the present invention receives a neurological disease-diagnosing problem from an external device, displays a virtual reality image through a display on the basis of the received neurological disease-diagnosing problem, and performs an examination using the virtual reality image according to user actions detected through various sensors. This process can be performed when linked with an external device such as a PC or a smart phone. Particularly, with respect to the neurological disease-diagnosing problem, the present invention includes: a first screen for introducing at least one object in a virtual reality space and hiding the same; and a second screen having a question on the hidden object. According to the present invention, neurological disease such as dementia can be conveniently examined without inconveniencing or burdening a patient.
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