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公开(公告)号：US20160257668A1
公开(公告)日：2016-09-08
申请号：US15027086
申请日：2014-10-06
申请人： Ning SHAO , Scott D. EDMONDSON , Santhosh NEELAMKAVIL , Zhuyan GUO , Eric MERTZ , Yi ZANG , Jiafang HE
发明人： Ning Shao , Scott D. Edmondson , Santhosh Neelamkavil , Zhuyan Guo , Eric Mertz , Yi Zang , Jiafang He
IPC分类号： C07D401/14 , C07C269/06 , C07D401/10
CPC分类号： C07D401/14 , C07C269/06 , C07D401/04 , C07D401/10 , C07D413/14
摘要： The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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公开(公告)号：US20160229839A1
公开(公告)日：2016-08-11
申请号：US15023833
申请日：2014-09-23
申请人： Eric Mertz , Scott D. Edmondson , Ning Shao , Santhosh Neelamkavil , Corey Poker , Zahid Hussain , Zhuyan Guo , Nancy Jo Kevin , Yi Zang , Jiafang He
发明人： Eric Mertz , Scott D. Edmondson , Ning Shao , Santhosh Neelamkavil , Corey Poker , Zahid Hussain , Zhuyan Guo , Nancy Jo Kevin , Yi Zang , Jiafang He
IPC分类号： C07D401/14 , A01N1/02 , C07D401/06 , C07D401/10 , C07D211/60
CPC分类号： C07D401/14 , A01N1/0226 , C07D211/60 , C07D401/06 , C07D401/10 , C12N9/6443 , C12Y304/21027
摘要： The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
摘要翻译： 本发明提供式（I）的化合物和包含一种或多种所述化合物的药物组合物，以及使用所述化合物治疗或预防血栓形成，栓塞，高凝状态或纤维变化的方法。 该化合物是选择性因子XIa抑制剂或因子XIa和血浆激肽释放酶的双重抑制剂。
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公开(公告)号：US20140057836A1
公开(公告)日：2014-02-27
申请号：US13960343
申请日：2013-08-06
申请人： Thomas BARA , Sathesh Bhat , Dipshika Biswas , Linda Brockunier , Duane Burnette , Samuel Chackalamannil , Mariappan Vasu Cheliah , Austin Chen , Martin Clasby , Vince J. Colandrea , Zhuyan Guo , Yongxin Han , Charles Jayne , Hubert Josien , Karen Marcantonio , Shouwu Miao , Santhosh Neelamkavil , Patrick Pinto , Murali Rajogopalan , Unmesh Shah , Francisco Velazquez , Srikanth Venkatraman , Yan Xia
发明人： Thomas BARA , Sathesh Bhat , Dipshika Biswas , Linda Brockunier , Duane Burnette , Samuel Chackalamannil , Mariappan Vasu Cheliah , Austin Chen , Martin Clasby , Vince J. Colandrea , Zhuyan Guo , Yongxin Han , Charles Jayne , Hubert Josien , Karen Marcantonio , Shouwu Miao , Santhosh Neelamkavil , Patrick Pinto , Murali Rajogopalan , Unmesh Shah , Francisco Velazquez , Srikanth Venkatraman , Yan Xia
CPC分类号： C07K5/08 , A61K38/06 , A61K45/06 , C07D419/00 , C07D491/22
摘要： The present invention relates to hepatitis C virus (HCV) NS3 protease inhibitors containing a spirocyclic moeity, uses of such compounds, and synthesis of such compounds.
摘要翻译： 本发明涉及含有螺环状的丙型肝炎病毒（HCV）NS3蛋白酶抑制剂，这些化合物的用途，以及这些化合物的合成。
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公开(公告)号：US20160046581A1
公开(公告)日：2016-02-18
申请号：US14778765
申请日：2014-03-21
申请人： Anthony OGAWA , Scott EDMONDSON , Mark ERION , Santosh NEELAMKAVIL , Zhuyan GUO , Rudrajit MAL , Jiafang HE , Weiguo LIU , Ellen K. VAN BUNTE , MERCK SHARP & DOHME CORP.
发明人： Anthony Ogawa , Scott Edmondson , Mark Erion , Santhosh Neelamkavil , Zhuyan Guo , Rudrajit Mal , Jiafang He , Weiguo Liu , Ellen K. Vande Bunte
IPC分类号： C07D213/64 , C07D401/14 , C07F9/6558 , C07D487/04 , C07D413/06 , C07D491/052 , C07D401/12 , C07D401/10 , C07D413/14
CPC分类号： C07D213/64 , A61K31/551 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/044 , C07D491/052 , C07F9/65583
摘要： The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes.
摘要翻译： 本发明提供式（I）的化合物和包含一种或多种所述化合物的药物组合物，以及使用所述化合物治疗或预防血栓形成，栓塞，高凝状态或纤维变化的方法。
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公开(公告)号：US20160347757A1
公开(公告)日：2016-12-01
申请号：US15116659
申请日：2015-02-06
申请人： Santhosh F. NEELAMKAVIL , Scott D. EDMONDSON , Zhuyan GUO , Alan W. HRUZA , Zahid HUSSAIN , Charles A. LESBURG , Remond MONINGKA , Anthony K. OGAWA , Rudrajit MAL , MERCK SHARP & DOHME CORP
发明人： Santhosh F. Neelamkavil , Scott D. Edmondson , Zhuyan Guo , Alan W. Hruza , Zahid Hussain , Charles A. Lesburg , Remond Moningka , Anthony K. Ogawa , Rudrajit Mal
IPC分类号： C07D487/08 , C07D471/08
CPC分类号： C07D487/08 , C07D471/08
摘要： The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
摘要翻译： 本发明提供式（I）的化合物和包含一种或多种所述化合物的药物组合物，以及使用所述化合物治疗或预防血栓形成，栓塞，高凝状态或纤维变化的方法。 该化合物是选择性因子XIa抑制剂或因子XIa和血浆激肽释放酶的双重抑制剂。
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公开(公告)号：US20170044183A1
公开(公告)日：2017-02-16
申请号：US15305421
申请日：2015-04-21
申请人： Yeon-Hee Lim , Zhuyan Guo , Amjad Ali , Scott D. Edmondson , Weiguo Liu , Giocanda V. Gallo-Etienne , Heping Wu , Ying-Duo Gao , Andrew W. Stamford , Younong Yu , Nancy J. Kevin , Rajan Anand , Deyou Sha , Santhosh F. Neelamkavil , Zahid Hussain , Puneet Kumar , Remond Moningka , Joseph L. Duffy , Jiayi Xu , Yu Jiang , Anjan Chakrabarti , Hiroki Sone
发明人： Yeon-Hee Lim , Zhuyan Guo , Amjad Ali , Scott D. Edmondson , Weiguo Liu , Giocanda V. Gallo-Etienne , Heping Wu , Ying-Duo Gao , Andrew W. Stamford , Younong Yu , Nancy J. Kevin , Rajan Anand , Deyou Sha , Santhosh F. Neelamkavil , Zahid Hussain , Puneet Kumar , Remond Moningka , Joseph L. Duffy , Jiayi Xu , Yu Jiang , Anjan Chakrabarti , Hiroki Sone
IPC分类号： C07D498/20 , C07F9/6561 , C07D487/10 , C07D498/10 , C07D471/10
CPC分类号： C07D498/20 , C07D471/10 , C07D487/10 , C07D498/10 , C07F9/6561
摘要： The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
摘要翻译： 本发明提供式（I）的化合物和包含一种或多种所述化合物的药物组合物，以及使用所述化合物治疗或预防血栓形成，栓塞，高凝状态或纤维变化的方法。 该化合物是选择性因子XIa抑制剂或因子XIa和血浆激肽释放酶的双重抑制剂。
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公开(公告)号：US20090170875A1
公开(公告)日：2009-07-02
申请号：US12338425
申请日：2008-12-18
申请人： Wensheng Yu , Ling Tong , Lei Chen , Joseph A. Kozlowski , Brian J. Lavey , Neng-Yang Shih , Vincent S. Madison , Guowei Zhou , Peter Orth , Zhuyan Guo , Michael K.C. Wong , De-Yi Yang , Seong Heon Kim , Bandarpalle B. Shankar , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Umar Faruk Mansoor , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li
发明人： Wensheng Yu , Ling Tong , Lei Chen , Joseph A. Kozlowski , Brian J. Lavey , Neng-Yang Shih , Vincent S. Madison , Guowei Zhou , Peter Orth , Zhuyan Guo , Michael K.C. Wong , De-Yi Yang , Seong Heon Kim , Bandarpalle B. Shankar , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Umar Faruk Mansoor , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li
IPC分类号： A61K31/497 , C07D403/06 , A61K31/4166 , A61K31/4709 , C07D403/14 , C07D401/14 , C07D417/14 , A61K31/427
CPC分类号： C07D403/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00 , C07D473/34 , C07D487/04 , C07D491/04 , C07D495/04
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.
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公开(公告)号：US07504424B2
公开(公告)日：2009-03-17
申请号：US11333663
申请日：2006-01-17
申请人： Wensheng Yu , Ling Tong , Lei Chen , Joseph A. Kozlowski , Brian J. Lavey , Neng-Yang Shih , Vincent S. Madison , Guowei Zhou , Peter Orth , Zhuyan Guo , Michael K. C. Wong , De-Yi Yang , Seong Heon Kim , Bandarpalle B. Shankar , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Umar Faruk Mansoor , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li
发明人： Wensheng Yu , Ling Tong , Lei Chen , Joseph A. Kozlowski , Brian J. Lavey , Neng-Yang Shih , Vincent S. Madison , Guowei Zhou , Peter Orth , Zhuyan Guo , Michael K. C. Wong , De-Yi Yang , Seong Heon Kim , Bandarpalle B. Shankar , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Umar Faruk Mansoor , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li
IPC分类号： A61K31/416 , A61K31/428 , C07D209/04 , C07D231/08 , C07D275/04 , C07D417/14 , C07D513/12
CPC分类号： C07D403/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00 , C07D473/34 , C07D487/04 , C07D491/04 , C07D495/04
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂化物，酯或异构体，其可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖酶，TNF-或组合介导的疾病或病症 其中。
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9.发明申请公开(公告)号：US20080004287A1
公开(公告)日：2008-01-03
申请号：US11769030
申请日：2007-06-27
申请人： Yao Ma , Brian Lahue , Gerald Shipps , Yaolin Wang , Stephane Bogen , Matthew Voss , Latha Nair , Yuan Tian , Ronald Doll , Zhuyan Guo , Corey Strickland , Rumin Zhang , Mark McCoy , Weidong Pan , Elise Siegel , Craig Gibeau
发明人： Yao Ma , Brian Lahue , Gerald Shipps , Yaolin Wang , Stephane Bogen , Matthew Voss , Latha Nair , Yuan Tian , Ronald Doll , Zhuyan Guo , Corey Strickland , Rumin Zhang , Mark McCoy , Weidong Pan , Elise Siegel , Craig Gibeau
IPC分类号： A61K31/497 , A61P43/00 , C07D401/14
CPC分类号： C07D409/14 , C07D401/06 , C07D401/14
摘要： In its many embodiments, the present invention discloses novel compounds, as inhibitors of HDM2 protein, methods for preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of treatment, prevention, inhibition, of one or more diseases associated with the HDM2 protein or P53 using such compounds or pharmaceutical compositions.
摘要翻译： 在其许多实施方案中，本发明公开了作为HDM2蛋白的抑制剂的新化合物，制备这些化合物的方法，包含一种或多种这样的化合物的药物组合物，治疗，预防，抑制与HDM2相关的一种或多种疾病的方法 蛋白质或P53使用这些化合物或药物组合物。
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公开(公告)号：US20070219218A1
公开(公告)日：2007-09-20
申请号：US11653676
申请日：2007-01-16
申请人： Wensheng Yu , Ling Tong , Lei Chen , Joseph Kozlowski , Brian Lavey , Neng-Yang Shih , Vincent Madison , Guowei Zhou , Peter Orth , Zhuyan Guo , Michael Wong , De-Yi Yang , Seong Kim , Bandarpalle Shankar , M. Siddiqui , Kristin Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay Girijavallabhan , Dansu Li , Razia Rizvi , Aneta Micula , Robert Feltz
发明人： Wensheng Yu , Ling Tong , Lei Chen , Joseph Kozlowski , Brian Lavey , Neng-Yang Shih , Vincent Madison , Guowei Zhou , Peter Orth , Zhuyan Guo , Michael Wong , De-Yi Yang , Seong Kim , Bandarpalle Shankar , M. Siddiqui , Kristin Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay Girijavallabhan , Dansu Li , Razia Rizvi , Aneta Micula , Robert Feltz
IPC分类号： A61K31/497 , A61K31/506 , A61K31/4709 , A61K31/4741 , A61K31/4745 , A61K31/4178 , C07D403/14 , C07D491/02 , C07D471/02
CPC分类号： C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00 , C07D473/34 , C07D487/04 , C07D491/04 , C07D495/04
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂化物，酯或异构体，其可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖酶，TNF-或组合介导的疾病或病症 其中。
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