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公开(公告)号：US20070106259A1
公开(公告)日：2007-05-10
申请号：US11636638
申请日：2006-12-11
申请人： Samuel Epstein , Wendy Naimark , Tim Mickley
发明人： Samuel Epstein , Wendy Naimark , Tim Mickley
CPC分类号： A61B17/3478 , A61B2017/00247 , A61B2017/3419 , A61B2017/3488 , A61B2018/00392 , A61M2025/0089
摘要： The present invention relates to the direct delivery of therapeutic to a target tissue. In one embodiment a method for direct injection of plug forming material into a body tissue is provided. The method may comprise providing a catheter including a injection tube having a first channel, a second channel and a piercing tip. The first and second channels can be in fluid communication with a pressure source and a plug forming material. The injection tube may be slidably positioned in a pressure apron and moved from a first position to a second position so that the piercing tip extends beyond the tissue-mating surface in the second position to deliver the plug forming material.
摘要翻译： 本发明涉及将治疗剂直接递送到靶组织。 在一个实施例中，提供了一种用于将栓塞形成材料直接注射到身体组织中的方法。 该方法可以包括提供包括具有第一通道，第二通道和穿刺尖端的注射管的导管。 第一和第二通道可以与压力源和塞子形成材料流体连通。 注射管可以可滑动地定位在压力皮圈中并从第一位置移动到第二位置，使得穿刺尖端在第二位置延伸超过组织配合表面以递送栓塞形成材料。
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公开(公告)号：US20070055352A1
公开(公告)日：2007-03-08
申请号：US11221647
申请日：2005-09-07
申请人： Wendy Naimark , Peter Shank , Maria Palasis , Toby Freyman , Anastasia Panos , Samuel Epstein , Alexandra Rousseau
发明人： Wendy Naimark , Peter Shank , Maria Palasis , Toby Freyman , Anastasia Panos , Samuel Epstein , Alexandra Rousseau
IPC分类号： A61F2/90
CPC分类号： A61L31/16 , A61F2/91 , A61F2/915 , A61F2002/075 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2210/0076 , A61F2220/0008 , A61F2230/0013 , A61F2250/0068 , A61L2300/606
摘要： A medical device for: delivering a therapeutic agent to a body lumen is described. The device may generally be a stent with an inner sidewall surface and an outer sidewall surface, with a plurality of struts having a plurality of openings therein. An inner and outer layer may be applied to the stent, forming pockets within at least a portion of the openings. The pockets may be filled with at least one therapeutic agent. The pockets may take a variety of shapes and sizes, and may be designed for release or rupture in variety of ways.
摘要翻译： 描述了用于将治疗剂递送到体腔的医疗装置。 该装置通常可以是具有内侧壁表面和外侧壁表面的支架，多个支柱在其中具有多个开口。 内层和外层可以施加到支架上，在开口的至少一部分内形成袋。 口袋可以填充有至少一种治疗剂。 口袋可以采取各种形状和尺寸，并且可以设计为以各种方式释放或破裂。
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3.发明授权公开(公告)号：US07892205B2
公开(公告)日：2011-02-22
申请号：US10455298
申请日：2003-06-06
申请人： Maria Palasis , Wendy Naimark , Toby Freyman , Samuel Epstein
发明人： Maria Palasis , Wendy Naimark , Toby Freyman , Samuel Epstein
IPC分类号： A61M37/00
CPC分类号： A61M11/06 , A61M25/0054 , A61M2025/0057
摘要： The present invention provides a catheter and catheter assembly for delivering micronized therapeutic agents to a target site in the body and, in particular, to a target site in the heart. The micronized therapeutic agents are delivered in aerosol form or dry powder form. The present invention also provides a method of delivering micronized therapeutic agents to a target site in the body by placing the therapeutic agents in a catheter, positioning the catheter in the target site, and exposing the therapeutic agents to an energizing mechanism sufficient to create supersonic flow to carry the therapeutic agents from a stationary state in the catheter to a mobile state towards the target site.
摘要翻译： 本发明提供一种导管和导管组件，用于将微粉化的治疗剂递送到身体中的靶部位，特别是向心脏中的靶位点递送。 微粉化治疗剂以气溶胶形式或干粉形式递送。 本发明还提供了一种通过将治疗剂放置在导管中将微粉化治疗剂递送到体内的靶位点的方法，将导管定位在靶位点，并将治疗剂暴露于足以产生超音速流动的激励机制 将治疗剂从导管中的静止状态运送到朝向目标部位的移动状态。
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公开(公告)号：US20060286071A1
公开(公告)日：2006-12-21
申请号：US11158452
申请日：2005-06-21
申请人： Samuel Epstein , Wendy Naimark
发明人： Samuel Epstein , Wendy Naimark
IPC分类号： A61K48/00
CPC分类号： A61K9/06 , A61K9/0024 , A61K31/711 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/258 , A61L2300/606 , C08L53/02
摘要： This invention provides a high-solids therapeutic composition for coating a medical device comprising: (a) a first material which is a hydrophilic therapeutic agent; and (b) a second material which includes a hydrophobic polymer and an emulsifying surfactant, wherein the composition is in a singular stable phase. Also provided is a mold-cast medical device, said medical device comprising a cured mixture of: (a) a first material which is a hydrophilic therapeutic agent; and (b) a second material which includes a hydrophobic polymer and an emulsifying surfactant, wherein the mixture forms a high-solids device. Further provided is an injectable polymer comprising: (a) a first material which is a hydrophilic therapeutic agent; and (b) a second material which includes a hydrophobic polymer and an emulsifying surfactant, wherein the polymer is in a singular stable phase.
摘要翻译： 本发明提供了用于涂覆医疗装置的高固体治疗组合物，其包括：（a）作为亲水治疗剂的第一材料; 和（b）包含疏水性聚合物和乳化表面活性剂的第二种材料，其中所述组合物处于单一的稳定相。 还提供了一种模铸医疗装置，所述医疗装置包括：（a）作为亲水治疗剂的第一材料的固化混合物; 和（b）包含疏水性聚合物和乳化表面活性剂的第二种材料，其中混合物形成高固体装置。 还提供了一种可注射聚合物，其包含：（a）作为亲水性治疗剂的第一材料; 和（b）包含疏水性聚合物和乳化表面活性剂的第二种材料，其中所述聚合物处于单一的稳定相。
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公开(公告)号：US20060029720A1
公开(公告)日：2006-02-09
申请号：US10909408
申请日：2004-08-03
申请人： Anastasia Panos , Wendy Naimark , Maria Palasis , Toby Freyman , Samuel Epstein
发明人： Anastasia Panos , Wendy Naimark , Maria Palasis , Toby Freyman , Samuel Epstein
CPC分类号： B05C5/0208 , A61F2/86 , A61F2002/072 , A61L31/08 , A61L31/10 , A61L2420/02 , B05C13/025 , B05D1/002 , B05D1/26 , B05D1/30
摘要： Methods and apparatus for coating at least a portion of the surface of medical devices using an injection coating device are disclosed. In one embodiment, the invention includes a coating method wherein an orifice of the injection coating device is placed adjacent a vertically positioned medical device, coating material is ejected from the orifice onto the medical device, and the coating material gravitationally flows downward coating the medical device. In another embodiment, an orifice of an injection coating device is positioned adjacent a horizontally positioned medical device to gravitationally flow and deposit coating material onto the medical device. These methods may be used to apply one or more coating materials, simultaneously or in sequence. In another embodiment, multiple injection coating devices may be utilized. In certain embodiments of the invention, the coating materials include therapeutic or biologically active agents.
摘要翻译： 公开了使用注射涂覆装置涂覆医疗装置的表面的至少一部分的方法和装置。 在一个实施方案中，本发明包括一种涂覆方法，其中注射涂覆装置的孔口邻近垂直定位的医疗装置放置，涂层材料从孔口喷射到医疗装置上，并且涂覆材料重力地向下流动涂覆医疗装置 。 在另一个实施例中，注射涂覆装置的孔口邻近水平定位的医疗装置定位以重力地流动并将涂层材料沉积到医疗装置上。 这些方法可以同时或按顺序施用一种或多种涂料。 在另一个实施例中，可以使用多个注射涂覆装置。 在本发明的某些实施方案中，涂层材料包括治疗或生物活性剂。
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6.发明申请公开(公告)号：US20110130715A1
公开(公告)日：2011-06-02
申请号：US13022217
申请日：2011-02-07
申请人： Maria Palasis , Wendy Naimark , Toby Freyman , Samuel Epstein
发明人： Maria Palasis , Wendy Naimark , Toby Freyman , Samuel Epstein
IPC分类号： A61M5/00
CPC分类号： A61M11/06 , A61M25/0054 , A61M2025/0057
摘要： The present invention provides a catheter and catheter assembly for delivering micronized therapeutic agents to a target site in the body and, in particular, to a target site in the heart. The micronized therapeutic agents are delivered in aerosol form or dry powder form. The present invention also provides a method of delivering micronized therapeutic agents to a target site in the body by placing the therapeutic agents in a catheter, positioning the catheter in the target site, and exposing the therapeutic agents to an energizing mechanism sufficient to create supersonic flow to carry the therapeutic agents from a stationary state in the catheter to a mobile state towards the target site.
摘要翻译： 本发明提供一种导管和导管组件，用于将微粉化的治疗剂递送到身体中的靶部位，特别是向心脏中的靶位点递送。 微粉化治疗剂以气溶胶形式或干粉形式递送。 本发明还提供了一种通过将治疗剂放置在导管中将微粉化治疗剂递送到体内的靶位点的方法，将导管定位在靶位点，并将治疗剂暴露于足以产生超音速流动的激励机制 将治疗剂从导管中的静止状态运送到朝向目标部位的移动状态。
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7.发明授权公开(公告)号：US08235937B2
公开(公告)日：2012-08-07
申请号：US13022217
申请日：2011-02-07
申请人： Maria Palasis , Wendy Naimark , Toby Freyman , Samuel Epstein
发明人： Maria Palasis , Wendy Naimark , Toby Freyman , Samuel Epstein
IPC分类号： A61M31/00
CPC分类号： A61M11/06 , A61M25/0054 , A61M2025/0057
摘要： The present invention provides a catheter and catheter assembly for delivering micronized therapeutic agents to a target site in the body and, in particular, to a target site in the heart. The micronized therapeutic agents are delivered in aerosol form or dry powder form. The present invention also provides a method of delivering micronized therapeutic agents to a target site in the body by placing the therapeutic agents in a catheter, positioning the catheter in the target site, and exposing the therapeutic agents to an energizing mechanism sufficient to create supersonic flow to carry the therapeutic agents from a stationary state in the catheter to a mobile state towards the target site.
摘要翻译： 本发明提供一种导管和导管组件，用于将微粉化的治疗剂递送到身体中的靶部位，特别是向心脏中的靶位点递送。 微粉化治疗剂以气溶胶形式或干粉形式递送。 本发明还提供了一种通过将治疗剂放置在导管中将微粉化治疗剂递送到体内的靶位点的方法，将导管定位在靶位点，并将治疗剂暴露于足以产生超音速流动的激励机制 将治疗剂从导管中的静止状态运送到朝向目标部位的移动状态。
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公开(公告)号：US20060105018A1
公开(公告)日：2006-05-18
申请号：US10989519
申请日：2004-11-17
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L31/10 , A61L2300/258 , A61L2300/602 , A61L2430/02
摘要： The present invention regards the delivery of therapeutic at a target site. Systems that employ the present invention may employ a medical device sized to be inserted into a target site, a driving layer covering at least a portion of an accessible surface of the medical device, and a therapeutic interfaced with at least a portion of the driving layer. In this system, the driving layer may have a material characteristic that serves to release the therapeutic from the medical device when the medical device is at the target site. Other systems that employ the invention may also have properties that include having a driving layer with a higher solubility than the therapeutic at the target site, a medical device that is hydrophobic while the therapeutic is hydrophilic, and a coating covering at least a portion of the therapeutic.
摘要翻译： 本发明涉及在靶位点递送治疗剂。 采用本发明的系统可以采用尺寸设计成可插入到目标部位的医疗装置，覆盖医疗装置的可接近表面的至少一部分的驱动层，以及与驱动层的至少一部分接合的治疗 。 在该系统中，当医疗装置在目标位置时，驱动层可以具有用于从医疗装置释放治疗剂的材料特性。 使用本发明的其它系统还可具有包括具有比目标部位的治疗剂具有更高溶解度的驱动层的性质，在治疗剂是亲水性时是疏水性的医疗装置，以及覆盖至少一部分 治疗。
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公开(公告)号：US07951392B2
公开(公告)日：2011-05-31
申请号：US10219668
申请日：2002-08-16
IPC分类号： A61F2/00
CPC分类号： A61L31/10 , A61K9/0024 , A61L31/16 , A61L2300/602 , A61L2300/61 , A61L2420/08
摘要： The present invention relates to microarray polymeric barriers designed to control the release rate of therapeutic agents. By varying the thickness of the coating or affecting, physically and/or chemically, the constituents of the barrier composition, the release profile of the underlying therapeutic agent can be modified and controlled.
摘要翻译： 本发明涉及设计用于控制治疗剂释放速率的微阵列聚合物屏障。 通过改变涂层的厚度或物理和/或化学地影响阻挡组合物的成分，可以改变和控制下面的治疗剂的释放特性。
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10.发明申请公开(公告)号：US20060206056A1
公开(公告)日：2006-09-14
申请号：US11432398
申请日：2006-05-12
申请人： Toby Freyman , Wendy Naimark , Tim Mickley , Samuel Epstein
发明人： Toby Freyman , Wendy Naimark , Tim Mickley , Samuel Epstein
IPC分类号： A61M5/178
CPC分类号： A61M5/1582
摘要： Injection devices are provided, which reduce potential outflow of therapeutic agents from an injection site. Devices are provided having at least a first lumen containing one or more therapeutic agents and a second lumen containing a second material for injection into tissue. Other devices are provided having an inner lumen with an injection needle to inject a therapeutic agent and an outer lumen that provides a vacuum seal between the injection needle and the needle track. Further provided are methods of delivering a therapeutic agent to tissue.
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