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    Use of carotenoids and/or carotenoid derivatives/analogs for reduction/inhibition of certain negative effects of COX inhibitors
    4.
    发明申请
    Use of carotenoids and/or carotenoid derivatives/analogs for reduction/inhibition of certain negative effects of COX inhibitors 审中-公开
    使用类胡萝卜素和/或类胡萝卜素衍生物/类似物来减少/抑制COX抑制剂的某些负面影响

    公开(公告)号：US20080293679A1

    公开(公告)日：2008-11-27

    申请号：US11417307

    申请日：2006-05-02

    申请人： Samuel F. Lockwood ,  R. Preston Mason

    发明人： Samuel F. Lockwood ,  R. Preston Mason

    IPC分类号： A61K31/6615 ,  A61K31/122 ,  A61K31/015 ,  A61K31/047 ,  A61K31/01

    CPC分类号： A61K31/01 ,  A61K31/015 ,  A61K31/047 ,  A61K31/122 ,  A61K31/6615

    摘要： Administering carotenoids, and in particular xanthophyll carotenoids, or analogs or derivatives of astaxanthin, lutein, zeaxanthin, lycoxanthin, lycophyll, or lycopene to a subject undergoing treatment with COX-2 inhibitor drugs may reduce at least a portion of the adverse side effects associated with administration of COX-2 selective inhibitor drugs. The carotenoids, or analogs or derivatives thereof may be administered to a subject prior to, at the same time as, or after the commencement of COX-2 selective inhibitor drug therapy. The carotenoids, or analogs or derivatives thereof may be administered to a subject concurrently with COX-2 selective inhibitor drugs therapy. The carotenoids, or analogs or derivatives thereof may be incorporated into pharmaceutical preparation in combination with the COX-2 selective inhibitor drug or may be administered separately. Administration of the analogs or derivatives described herein may reduce peroxidation of LDL and other lipids in the serum and plasma cell membranes of subjects undergoing COX-2 selective inhibitor drug therapy. Administration of the analogs or derivatives described herein may reduce the incidence of deleterious clinical cardiovascular events undergoing COX-2 selective inhibitor drug therapy.

    摘要翻译： 将类胡萝卜素，特别是叶黄素类胡萝卜素或虾青素，叶黄素，玉米黄质，lycoxanthin，番茄红素或番茄红素的类似物或衍生物施用于用COX-2抑制剂药物治疗的受试者可以减少至少一部分与 给予COX-2选择性抑制药物。 类胡萝卜素或其类似物或衍生物可以在COX-2选择性抑制剂药物治疗开始之前，同时或之后施用于受试者。 类胡萝卜素或其类似物或衍生物可以与COX-2选择性抑制剂药物治疗同时给予受试者。 类胡萝卜素或其类似物或衍生物可以与COX-2选择性抑制剂药物组合引入药物制剂中，或者可以分开施用。 本文所述的类似物或衍生物的施用可以减少经历COX-2选择性抑制剂药物治疗的受试者的血清和浆细胞膜中LDL和其它脂质的过氧化。 本文所述的类似物或衍生物的给药可以降低经历COX-2选择性抑制剂药物治疗的有害临床心血管事件的发生率。

    Carotenoid analogs and derivatives for the prevention of platelet aggregation
    5.
    发明授权
    Carotenoid analogs and derivatives for the prevention of platelet aggregation 有权
    类胡萝卜素类似物和衍生物用于预防血小板聚集

    公开(公告)号：US08063101B2

    公开(公告)日：2011-11-22

    申请号：US12079253

    申请日：2008-03-24

    申请人： Samuel F. Lockwood ,  R. Preston Mason

    发明人： Samuel F. Lockwood ,  R. Preston Mason

    IPC分类号： A61K31/335 ,  C07C403/24

    CPC分类号： A61K31/01

    摘要： The presently described embodiments are directed to compositions that include one or more carotenoid analogs or derivatives for use in the treatment of a disorder associated with platelet aggregation. Certain embodiments provide for the use of said carotenoid analogs or derivatives in preparing compositions suitable for use in such treatments. Further embodiments provide for pharmaceutical compositions that include one or more carotenoid analogs or derivatives in combination with one or more additional compositions or medicaments suitable for the treatment of a disorder associated with platelet aggregation. Yet further embodiments provide for methods of treating a disorder associated with platelet aggregation that include administering to a subject who would benefit from such treatment pharmaceutical compositions suitable for inhibiting platelet aggregation in a subject undergoing said treatments, and that include carotenoid analogs or derivatives, optionally in combination with one or more additional antiplatelet agents.

    摘要翻译： 目前描述的实施方案涉及包含用于治疗与血小板聚集相关的病症的一种或多种类胡萝卜素类似物或衍生物的组合物。 某些实施方案提供了使用所述类胡萝卜素类似物或衍生物制备适用于这种治疗的组合物。 另外的实施方案提供包含一种或多种类胡萝卜素类似物或衍生物与一种或多种适用于治疗与血小板聚集有关的病症的其它组合物或药物组合的药物组合物。 另外的实施方案提供了治疗与血小板聚集相关的病症的方法，其包括向受试者受益，所述受试者适合于在经历所述治疗的受试者中抑制血小板聚集的药物组合物，并且包括类胡萝卜素类似物或衍生物，任选地 与一种或多种另外的抗血小板药物组合。

    Carotenoid analogs and derivatives for the prevention of platelet aggregation
    6.
    发明申请
    Carotenoid analogs and derivatives for the prevention of platelet aggregation 有权
    类胡萝卜素类似物和衍生物用于预防血小板聚集

    公开(公告)号：US20090124574A1

    公开(公告)日：2009-05-14

    申请号：US12079253

    申请日：2008-03-24

    申请人： Samuel F. Lockwood ,  R. Preston Mason

    发明人： Samuel F. Lockwood ,  R. Preston Mason

    IPC分类号： A61K31/225 ,  A61P7/02 ,  A61K31/27 ,  A61K31/365 ,  A61K31/661 ,  A61K31/60 ,  A61K31/727 ,  A61K31/366 ,  A61K31/4365

    CPC分类号： A61K31/01

    摘要： The presently described embodiments are directed to compositions that include one or more carotenoid analogs or derivatives for use in the treatment of a disorder associated with platelet aggregation. Certain embodiments provide for the use of said carotenoid analogs or derivatives in preparing compositions suitable for use in such treatments. Further embodiments provide for pharmaceutical compositions that include one or more carotenoid analogs or derivatives in combination with one or more additional compositions or medicaments suitable for the treatment of a disorder associated with platelet aggregation. Yet farther embodiments provide for methods of treating a disorder associated with platelet aggregation that include administering to a subject who would benefit from such treatment pharmaceutical compositions suitable for inhibiting platelet aggregation in a subject undergoing said treatments, and that include carotenoid analogs or derivatives, optionally in combination with one or more additional antiplatelet agents.

    摘要翻译： 目前描述的实施方案涉及包含一种或多种类胡萝卜素类似物或衍生物用于治疗与血小板聚集相关的病症的组合物。 某些实施方案提供了使用所述类胡萝卜素类似物或衍生物制备适用于这种治疗的组合物。 另外的实施方案提供包含一种或多种类胡萝卜素类似物或衍生物与一种或多种适用于治疗与血小板聚集有关的病症的其它组合物或药物组合的药物组合物。 更进一步的实施方案提供了治疗与血小板聚集相关的病症的方法，其包括向受治疗受试者施用适合于在经历所述治疗的受试者中抑制血小板聚集的药物组合物，并且包括类胡萝卜素类似物或衍生物，任选地 与一种或多种另外的抗血小板药物组合。