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1.发明申请METHOD FOR PREPARING BUTANOL THROUGH BUTYRYL-COA AS AN INTERMEDIATE USING YEAST 审中-公开通过使用YEAST的中间体通过丁基丙烯制备丁醇的方法公开(公告)号：US20100143985A1
公开(公告)日：2010-06-10
申请号：US12525403
申请日：2008-02-11
摘要： Disclosed herein are a method for producing butanol in yeast having the ability to biosynthesize butanol using butyryl-CoA as an intermediate, the method comprises producing butyryl-CoA in yeast having a CoAT (acetyl-CoA:butyryl-CoA CoA-transferase)-encoding gene introduced thereinto, through various pathways, and then converting the produced butyryl-CoA to butanol.
摘要翻译： 本发明公开了一种使用丁酰辅酶A作为中间体生产丁醇生物合成能力的酵母中的丁醇生产方法，该方法包括在具有CoAT（乙酰辅酶A：丁酰辅酶A CoA转移酶）编码的酵母中制备丁酰辅酶A 基因通过各种途径导入其中，然后将生成的丁酰辅酶A转化为丁醇。
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2.发明申请RECOMBINANT MICROORGANISMS HAVING INCREASED ABILITY TO PRODUCE BUTANOL AND METHOD OF PRODUCING BUTANOL USING THE SAME 有权具有生产丁醇的能力提高的重组微生物和使用其的丁醇的生产方法公开(公告)号：US20130017588A1
公开(公告)日：2013-01-17
申请号：US13497743
申请日：2010-09-21
申请人： Sang Yup Lee , Yu-Sin Jang , Jin Young Lee , Joung Min Lee , Jin Hwan Park
发明人： Sang Yup Lee , Yu-Sin Jang , Jin Young Lee , Joung Min Lee , Jin Hwan Park
CPC分类号： C12P7/16 , C12N9/0006 , C12N9/1029 , C12Y101/01001 , C12Y203/01008 , C12Y203/01019 , Y02E50/10
摘要： The present invention relates to recombinant microorganisms having an increased ability to produce butanol, and a method of producing butanol using the same. More specifically, the invention relates to recombinant microorganisms whose ability to produce butanol was increased by manipulation of their metabolic networks, and a method of producing butanol using the same. The recombinant microorganisms having an increased ability to produce butanol comprise a deletion of a gene, which encodes an enzyme that converts acetyl CoA to acetate, in host microorganisms having genes that encode enzymes involved in acetyl CoA and butyryl CoA biosynthetic pathway. The recombinant microorganisms obtained by manipulating the metabolic flux of microorganisms are able to selectively produce butanol with high efficiency, and thus are useful as microorganisms for producing industrial solvents and transportation fuels.
摘要翻译： 本发明涉及生产丁醇的能力提高的重组微生物，以及使用其制备丁醇的方法。 更具体地，本发明涉及通过操作其代谢网络来增加生产丁醇的能力的重组微生物，以及使用其生产丁醇的方法。 在具有编码参与乙酰辅酶A和丁酰辅酶A生物合成途径的酶的基因的宿主微生物中，具有增加的产生丁醇能力的重组微生物包括编码转化乙酰CoA至乙酸的酶的基因的缺失。 通过操作微生物的代谢通过获得的重组微生物能够高效地选择性地生产丁醇，因此可用作生产工业溶剂和运输燃料的微生物。
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3.发明申请RECOMBINANT MUTANT MICROORGANISMS HAVING INCREASED ABILITY TO PRODUCE ALCOHOLS AND METHOD OF PRODUCING ALCOHOLS USING THE SAME 有权具有增加生产酒精的能力的重组突变体微生物和使用该醇的生产醇的方法公开(公告)号：US20120301936A1
公开(公告)日：2012-11-29
申请号：US13497736
申请日：2010-09-21
申请人： Sang Yup Lee , Yu-Sin Jang , Joung Min Lee , Jung Ae Im , Hyohak Song
发明人： Sang Yup Lee , Yu-Sin Jang , Joung Min Lee , Jung Ae Im , Hyohak Song
CPC分类号： C12N9/13 , C12N9/0006 , C12N9/88 , C12N15/74 , C12P3/00 , C12P7/04 , C12P7/06 , C12P7/16 , C12P7/26 , C12P7/28 , C12P7/52 , C12P7/54 , C12P7/56 , Y02E50/10 , Y02E50/17
摘要： The present invention relates to recombinant mutant microorganisms having an increased ability to produce alcohol and a method of producing alcohol using the same, and more particularly to recombinant mutant microorganisms which have an increased ability to produce butanol, ethanol, isopropanol or mixed alcohols, which can be used as fuel, while producing little or no producing acetone as a byproduct, and to a method of producing butanol, ethanol, isopropanol or mixed alcohols using the same. The inventive recombinant mutant microorganisms having an increased ability to produce butanol or mixed alcohols and to remove acetone are those in which genes that encode enzymes involved in producing butanol from butyryl-CoA or butylaldehyde and in producing isopropanol from acetone were amplified or introduced in host microorganisms. The recombinant mutant microorganisms produce little or no byproducts such as acetone and can have an increased ability to produce alcohols, as a result of manipulating metabolic pathways. Thus, the recombinant mutant microorganisms are useful for industrial production of butanol or mixed alcohols comprising butanol and isopropanol.
摘要翻译： 本发明涉及具有增加的产生醇的能力的重组突变微生物和使用其的醇的制备方法，更具体地说涉及生产丁醇，乙醇，异丙醇或混合醇的能力增加的重组突变微生物，其可以 作为燃料使用，同时产生很少或不产生丙酮作为副产物，以及使用其制备丁醇，乙醇，异丙醇或混合醇的方法。 生产丁醇或混合醇并除去丙酮的能力增强的本发明的重组突变微生物是那些编码参与从丁酰辅酶A或丁醛生产丁醇和从丙酮生产异丙醇的酶的基因被扩增或引入宿主微生物 。 由于操纵代谢途径，重组突变体微生物产生很少或没有副产物如丙酮，并且可以具有增加的产生醇的能力。 因此，重组突变微生物可用于工业生产丁醇或包含丁醇和异丙醇的混合醇。
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4.发明授权Recombinant mutant microorganisms having increased ability to produce alcohols and method of producing alcohols using the same 有权具有增加生产醇的能力的重组突变体微生物和使用其制备醇的方法公开(公告)号：US08765446B2
公开(公告)日：2014-07-01
申请号：US13497736
申请日：2010-09-21
申请人： Sang Yup Lee , Yu-Sin Jang , Joung Min Lee , Jung Ae Im , Hyohak Song
发明人： Sang Yup Lee , Yu-Sin Jang , Joung Min Lee , Jung Ae Im , Hyohak Song
CPC分类号： C12N9/13 , C12N9/0006 , C12N9/88 , C12N15/74 , C12P3/00 , C12P7/04 , C12P7/06 , C12P7/16 , C12P7/26 , C12P7/28 , C12P7/52 , C12P7/54 , C12P7/56 , Y02E50/10 , Y02E50/17
摘要： The present invention relates to recombinant mutant microorganisms having an increased ability to produce alcohol and a method of producing alcohol using the same, and more particularly to recombinant mutant microorganisms which have an increased ability to produce butanol, ethanol, isopropanol or mixed alcohols, which can be used as fuel, while producing little or no producing acetone as a byproduct, and to a method of producing butanol, ethanol, isopropanol or mixed alcohols using the same. The inventive recombinant mutant microorganisms having an increased ability to produce butanol or mixed alcohols and to remove acetone are those in which genes that encode enzymes involved in producing butanol from butyryl-CoA or butylaldehyde and in producing isopropanol from acetone were amplified or introduced in host microorganisms. The recombinant mutant microorganisms produce little or no byproducts such as acetone and can have an increased ability to produce alcohols, as a result of manipulating metabolic pathways. Thus, the recombinant mutant microorganisms are useful for industrial production of butanol or mixed alcohols comprising butanol and isopropanol.
摘要翻译： 本发明涉及具有增加的产生醇的能力的重组突变微生物和使用其的醇的制备方法，更具体地说涉及生产丁醇，乙醇，异丙醇或混合醇的能力增加的重组突变微生物，其可以 作为燃料使用，同时产生很少或不产生丙酮作为副产物，以及使用其制备丁醇，乙醇，异丙醇或混合醇的方法。 生产丁醇或混合醇并除去丙酮的能力增强的本发明的重组突变微生物是那些编码参与从丁酰辅酶A或丁醛生产丁醇和从丙酮生产异丙醇的酶的基因被扩增或引入宿主微生物 。 由于操纵代谢途径，重组突变体微生物产生很少或没有副产物如丙酮，并且可以具有增加的产生醇的能力。 因此，重组突变微生物可用于工业生产丁醇或包含丁醇和异丙醇的混合醇。
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5.发明授权Recombinant microorganisms having increased ability to produce butanol and method of producing butanol using the same 有权具有提高丁醇生产能力的重组微生物和使用其生产丁醇的方法公开(公告)号：US09096872B2
公开(公告)日：2015-08-04
申请号：US13497743
申请日：2010-09-21
申请人： Sang Yup Lee , Yu-Sin Jang , Jin Young Lee , Joung Min Lee , Jin Hwan Park
发明人： Sang Yup Lee , Yu-Sin Jang , Jin Young Lee , Joung Min Lee , Jin Hwan Park
CPC分类号： C12P7/16 , C12N9/0006 , C12N9/1029 , C12Y101/01001 , C12Y203/01008 , C12Y203/01019 , Y02E50/10
摘要： The present invention relates to recombinant microorganisms having an increased ability to produce butanol, and a method of producing butanol using the same. More specifically, the invention relates to recombinant microorganisms whose ability to produce butanol was increased by manipulation of their metabolic networks, and a method of producing butanol using the same. The recombinant microorganisms having an increased ability to produce butanol comprise a deletion of a gene, which encodes an enzyme that converts acetyl CoA to acetate, in host microorganisms having genes that encode enzymes involved in acetyl CoA and butyryl CoA biosynthetic pathway. The recombinant microorganisms obtained by manipulating the metabolic flux of microorganisms are able to selectively produce butanol with high efficiency, and thus are useful as microorganisms for producing industrial solvents and transportation fuels.
摘要翻译： 本发明涉及生产丁醇的能力提高的重组微生物，以及使用其制备丁醇的方法。 更具体地，本发明涉及通过操作其代谢网络来增加生产丁醇的能力的重组微生物，以及使用其生产丁醇的方法。 在具有编码参与乙酰辅酶A和丁酰辅酶A生物合成途径的酶的基因的宿主微生物中，具有增加的产生丁醇能力的重组微生物包括编码转化乙酰CoA至乙酸的酶的基因的缺失。 通过操作微生物的代谢通过获得的重组微生物能够以高效率选择性地生产丁醇，因此可用作生产工业溶剂和运输燃料的微生物。
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6.发明申请ENHANCED ETHANOL AND BUTANOL PRODUCING MICROORGANISMS AND METHOD FOR PREPARING ETHANOL AND BUTANOL USING THE SAME 审中-公开生产微生物的增强的乙醇和丁醇和使用它们制备乙醇和丁醇的方法公开(公告)号：US20110027845A1
公开(公告)日：2011-02-03
申请号：US12809323
申请日：2008-12-22
申请人： Sang Yup Lee , Yu-Sin Jang , Jin Young Lee , Kwang Seop Jung , Jae Hyun Kim
发明人： Sang Yup Lee , Yu-Sin Jang , Jin Young Lee , Kwang Seop Jung , Jae Hyun Kim
摘要： The present invention relates to a recombinant microorganism having an enhanced ability to produce ethanol and butanol and a method for preparing ethanol and butanol using the same, and more particularly to a recombinant microorganism having an enhanced ability to produce ethanol and butanol, into which a gene encoding CoA transferase and a gene encoding alcohol/aldehyde dehydrogenase are introduced, and to a method for preparing ethanol and butanol using the same. The recombinant microorganism according to the present invention, obtained by manipulating metabolic pathways of microorganisms, is capable of producing butanol and ethanol exclusively without producing any byproduct, and thus is useful as a microorganism producing industrial solvents and transportation fuel.
摘要翻译： 本发明涉及具有提高乙醇和丁醇生产能力的重组微生物，以及使用该重组微生物制备乙醇和丁醇的方法，更具体地说，涉及生产乙醇和丁醇的能力增强的重组微生物，其中基因 引入编码CoA转移酶和编码醇/醛脱氢酶的基因，以及使用其制备乙醇和丁醇的方法。 根据本发明的通过操纵微生物代谢途径获得的重组微生物能够仅生产丁醇和乙醇而不产生任何副产物，因此可用作产生工业溶剂和运输燃料的微生物。
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