-
公开(公告)号：US07645789B2
公开(公告)日：2010-01-12
申请号：US11975297
申请日：2007-10-18
申请人： Sara S. Hadida Ruah , Peter D. J. Grootenhuis , Fredrick Van Goor , Jinglan Zhou , Brian Bear , Mark T. Miller , Jason McCartney , Mehdi Michel Djamel Numa
发明人： Sara S. Hadida Ruah , Peter D. J. Grootenhuis , Fredrick Van Goor , Jinglan Zhou , Brian Bear , Mark T. Miller , Jason McCartney , Mehdi Michel Djamel Numa
IPC分类号： A61K31/36 , C07D405/12
CPC分类号： A61K31/47 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/407 , A61K31/41 , A61K31/4184 , A61K31/4192 , A61K31/454 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D233/64 , C07D403/12 , C07D405/12 , C07D405/14 , C07D471/04 , C07D487/04 , G01N33/5035 , G01N2333/705 , G01N2500/10
摘要： Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
摘要翻译： 本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。 本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。
-
公开(公告)号：US08415387B2
公开(公告)日：2013-04-09
申请号：US12619412
申请日：2009-11-16
申请人： Sara S. Hadida Ruah , Peter D. J. Grootenhuis , Mark T Miller , Jason McCartney , Fredrick van Goor , Mehdi Michel Djamel Numa , Jinglan Zhou , Brian Bear
发明人： Sara S. Hadida Ruah , Peter D. J. Grootenhuis , Mark T Miller , Jason McCartney , Fredrick van Goor , Mehdi Michel Djamel Numa , Jinglan Zhou , Brian Bear
IPC分类号： A61K31/36 , C07D405/12
CPC分类号： A61K31/47 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/407 , A61K31/41 , A61K31/4184 , A61K31/4192 , A61K31/454 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D233/64 , C07D403/12 , C07D405/12 , C07D405/14 , C07D471/04 , C07D487/04 , G01N33/5035 , G01N2333/705 , G01N2500/10
摘要： Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
摘要翻译： 本发明化合物及其药学上可接受的组合物可用作ATP结合盒（ABC）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（CFTR）。 本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。
-
公开(公告)号：US20110060024A1
公开(公告)日：2011-03-10
申请号：US12767472
申请日：2010-04-26
申请人： Sara S. Hadida Ruah , Peter D.J. Grootenhuis , Fredrick Van Goor , Jinglan Zhou , Brian Bear , Mark T. Miller , Jason McCartney , Mehdi Michel Djamel Numa
发明人： Sara S. Hadida Ruah , Peter D.J. Grootenhuis , Fredrick Van Goor , Jinglan Zhou , Brian Bear , Mark T. Miller , Jason McCartney , Mehdi Michel Djamel Numa
IPC分类号： A61K31/407 , C07D209/20 , C07D405/12 , C07D487/04 , A61K31/404 , C12N5/071 , C12Q1/02 , A61P11/12 , A61P11/08 , A61P31/00 , A61P29/00 , A61P43/00 , A61P25/28 , A61P7/12 , A61P27/04 , A61P25/16 , A61P3/10 , A61P35/00
CPC分类号： A61K31/47 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/407 , A61K31/41 , A61K31/4184 , A61K31/4192 , A61K31/454 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D233/64 , C07D403/12 , C07D405/12 , C07D405/14 , C07D471/04 , C07D487/04 , G01N33/5035 , G01N2333/705 , G01N2500/10
摘要： Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
-
公开(公告)号：US20100113555A1
公开(公告)日：2010-05-06
申请号：US12619412
申请日：2009-11-16
申请人： Sara S. Hadida Ruah , Peter D.J. Grootenhuis , Fredrick Van Goor , Jinglan Zhou , Brian Bear , Mark T. Miller , Jason McCartney , Mehdi Michel Djamel Numa
发明人： Sara S. Hadida Ruah , Peter D.J. Grootenhuis , Fredrick Van Goor , Jinglan Zhou , Brian Bear , Mark T. Miller , Jason McCartney , Mehdi Michel Djamel Numa
IPC分类号： A61K31/404 , A61P25/00
CPC分类号： A61K31/47 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/407 , A61K31/41 , A61K31/4184 , A61K31/4192 , A61K31/454 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D233/64 , C07D403/12 , C07D405/12 , C07D405/14 , C07D471/04 , C07D487/04 , G01N33/5035 , G01N2333/705 , G01N2500/10
摘要： Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
摘要翻译： 本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。 本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。
-
公开(公告)号：US20110071206A1
公开(公告)日：2011-03-24
申请号：US12948162
申请日：2010-11-17
申请人： Sara S. Hadida Ruah , Peter D.J. Grootenhuis , Fredrick Van Goor , Jinglan Zhou , Brian Bear , Mark T. Miller , Jason McCartney , Mehdi Michel Djamel Numa , Xiaoqing Yang
发明人： Sara S. Hadida Ruah , Peter D.J. Grootenhuis , Fredrick Van Goor , Jinglan Zhou , Brian Bear , Mark T. Miller , Jason McCartney , Mehdi Michel Djamel Numa , Xiaoqing Yang
IPC分类号： A61K31/403 , C07D405/12 , A61P11/00 , A61P25/28
CPC分类号： A61K31/47 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/407 , A61K31/41 , A61K31/4184 , A61K31/4192 , A61K31/454 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D233/64 , C07D403/12 , C07D405/12 , C07D405/14 , C07D471/04 , C07D487/04 , G01N33/5035 , G01N2333/705 , G01N2500/10
摘要： Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
摘要翻译： 本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。 本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。
-
公开(公告)号：US20090131492A1
公开(公告)日：2009-05-21
申请号：US11975297
申请日：2007-10-18
申请人： Sara S. Hadida Ruah , Peter D.J. Grootenhuis , Fredrick Van Goor , Jinglan Zhou , Brian Bear , Mark T. Miller , Jason McCartney , Mehdi Michel Djamel Numa
发明人： Sara S. Hadida Ruah , Peter D.J. Grootenhuis , Fredrick Van Goor , Jinglan Zhou , Brian Bear , Mark T. Miller , Jason McCartney , Mehdi Michel Djamel Numa
IPC分类号： A61K31/404 , C07D405/12 , A61K31/41 , A61P7/00 , A61P3/00 , A61P25/00 , A61P11/00 , C07D405/14
CPC分类号： A61K31/47 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/407 , A61K31/41 , A61K31/4184 , A61K31/4192 , A61K31/454 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D233/64 , C07D403/12 , C07D405/12 , C07D405/14 , C07D471/04 , C07D487/04 , G01N33/5035 , G01N2333/705 , G01N2500/10
摘要： Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
摘要翻译： 本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。 本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。
-
公开(公告)号：US08623905B2
公开(公告)日：2014-01-07
申请号：US12767472
申请日：2010-04-26
申请人： Sara S. Hadida Ruah , Peter D. J. Grootenhuis , Fredrick F. van Goor , Jinglan Zhou , Brian Bear , Mark T. Miller , Jason McCartney , Mehdi Michel Djamel Numa
发明人： Sara S. Hadida Ruah , Peter D. J. Grootenhuis , Fredrick F. van Goor , Jinglan Zhou , Brian Bear , Mark T. Miller , Jason McCartney , Mehdi Michel Djamel Numa
IPC分类号： A61K31/404 , C07D209/40
CPC分类号： A61K31/47 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/407 , A61K31/41 , A61K31/4184 , A61K31/4192 , A61K31/454 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D233/64 , C07D403/12 , C07D405/12 , C07D405/14 , C07D471/04 , C07D487/04 , G01N33/5035 , G01N2333/705 , G01N2500/10
摘要： Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFFR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
摘要翻译： 本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFFR”）。 本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。
-
公开(公告)号：US08598205B2
公开(公告)日：2013-12-03
申请号：US13439379
申请日：2012-04-04
申请人： Hayley Binch , Lev T. D. Fanning , Dennis Hurley , Urvi Sheth , Alina Silina , Xiaoqing Yang , Martyn Botfield , Peter D. J. Grootenhuis , Fredrick Van Goor , Mehdi Michel Djamel Numa
发明人： Hayley Binch , Lev T. D. Fanning , Dennis Hurley , Urvi Sheth , Alina Silina , Xiaoqing Yang , Martyn Botfield , Peter D. J. Grootenhuis , Fredrick Van Goor , Mehdi Michel Djamel Numa
IPC分类号： C07D215/38 , A61K31/04
CPC分类号： A61K31/4709 , A61K45/06 , C07D215/56 , C07D221/22 , C07D451/02 , C07D471/06 , C07D471/08 , C07D487/04 , C07D487/08 , C07F7/1804 , G01N33/5041 , G01N33/6872 , G01N2800/382
摘要： The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR.
-
公开(公告)号：US08513282B2
公开(公告)日：2013-08-20
申请号：US12605053
申请日：2009-10-23
申请人： Hayley Binch , Lev T. D. Fanning , Dennis Hurley , Urvi Sheth , Alina Silina , Xiaoqing Yang , Martyn Botfield , Peter D. J. Grootenhuis , Fredrick Van Goor , Mehdi Michel Djamel Numa
发明人： Hayley Binch , Lev T. D. Fanning , Dennis Hurley , Urvi Sheth , Alina Silina , Xiaoqing Yang , Martyn Botfield , Peter D. J. Grootenhuis , Fredrick Van Goor , Mehdi Michel Djamel Numa
IPC分类号： A61K31/04
CPC分类号： A61K31/4709 , A61K45/06 , C07D215/56 , C07D221/22 , C07D451/02 , C07D471/06 , C07D471/08 , C07D487/04 , C07D487/08 , C07F7/1804 , G01N33/5041 , G01N33/6872 , G01N2800/382
摘要： The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR.
摘要翻译： 本发明涉及囊性纤维化跨膜传导调节剂（“CFTR”）的调节剂，其组合物及其方法。 本发明还涉及使用CFTR的调节剂治疗疾病的方法。
-
公开(公告)号：US20100113508A1
公开(公告)日：2010-05-06
申请号：US12605053
申请日：2009-10-23
申请人： Hayley Binch , Lev T.D. Fanning , Dennis Hurley , Urvi Sheth , Alina Silina , Xiaoqing Yang , Martyn Botfield , Peter D.J. Grootenhuis , Fredrick Van Goor , Mehdi Michel Djamel Numa
发明人： Hayley Binch , Lev T.D. Fanning , Dennis Hurley , Urvi Sheth , Alina Silina , Xiaoqing Yang , Martyn Botfield , Peter D.J. Grootenhuis , Fredrick Van Goor , Mehdi Michel Djamel Numa
IPC分类号： A61K31/439 , C07D453/04 , C12Q1/02
CPC分类号： A61K31/4709 , A61K45/06 , C07D215/56 , C07D221/22 , C07D451/02 , C07D471/06 , C07D471/08 , C07D487/04 , C07D487/08 , C07F7/1804 , G01N33/5041 , G01N33/6872 , G01N2800/382
摘要： The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR.
摘要翻译： 本发明涉及囊性纤维化跨膜传导调节剂（“CFTR”）的调节剂，其组合物及其方法。 本发明还涉及使用CFTR的调节剂治疗疾病的方法。
-
-
-
-
-
-
-
-
-
搜索结果
21 条记录 (耗时 0.057 秒)
