公开(公告)号：US20130203723A1

公开(公告)日：2013-08-08

申请号：US13825552

申请日：2011-09-29

申请人： Satoshi Sakuma ,  Hiroshi Ueda ,  Akira Mashimo ,  Hiroshi Murazato

发明人： Satoshi Sakuma ,  Hiroshi Ueda ,  Akira Mashimo ,  Hiroshi Murazato

IPC分类号： A61K9/00

CPC分类号： A61K9/0053 ,  A61K9/1611 ,  A61K9/1617 ,  A61K9/1623 ,  A61K9/1652 ,  A61K9/2054 ,  A61K9/2077 ,  A61K31/405 ,  A61K31/426

摘要： The present invention relates to solubility improving preparation for enhancing the oral absorption of a poorly soluble drug, which is comprising (A) and (B); (A) a granulated substance which comprises (i) a poorly soluble drug having an acidic group in the molecule, (ii) an alkaline agent, (iii) a surfactant, and this granulated substance dose not substantially contain a disintegrator, (B) a disintegrator existing only in the external of the granulated substance.

摘要翻译： 本发明涉及用于增强难溶性药物的口服吸收的溶解度提高制剂，其包含（A）和（B）; （A）粒状物质，其包含（i）分子中具有酸性基团的难溶性药物，（ii）碱性试剂，（iii）表面活性剂，该粒状物质基本不含崩解剂，（B） 仅在颗粒物外部存在的分解剂。

公开(公告)号：US09427402B2

公开(公告)日：2016-08-30

申请号：US13825552

申请日：2011-09-29

申请人： Satoshi Sakuma ,  Hiroshi Ueda ,  Akira Mashimo ,  Hiroshi Murazato

发明人： Satoshi Sakuma ,  Hiroshi Ueda ,  Akira Mashimo ,  Hiroshi Murazato

IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K9/16 ,  A61K31/405 ,  A61K31/426

CPC分类号： A61K9/0053 ,  A61K9/1611 ,  A61K9/1617 ,  A61K9/1623 ,  A61K9/1652 ,  A61K9/2054 ,  A61K9/2077 ,  A61K31/405 ,  A61K31/426

摘要： The present invention relates to solubility improving preparation for enhancing the oral absorption of a poorly soluble drug, which is comprising (A) and (B); (A) a granulated substance which comprises (i) a poorly soluble drug having an acidic group in the molecule, (ii) an alkaline agent, (iii) a surfactant, and this granulated substance dose not substantially contain a disintegrator, (B) a disintegrator existing only in the external of the granulated substance.

摘要翻译： 本发明涉及用于增强难溶性药物的口服吸收的溶解度提高制剂，其包含（A）和（B）; （A）粒状物质，其包含（i）分子中具有酸性基团的难溶性药物，（ii）碱性试剂，（iii）表面活性剂，该粒状物质基本不含崩解剂，（B） 仅在颗粒物外部存在的分解剂。

公开(公告)号：US09023835B2

公开(公告)日：2015-05-05

申请号：US13390058

申请日：2010-08-09

申请人： Hiroshi Ueda

发明人： Hiroshi Ueda

IPC分类号： A61K38/22 ,  A61K45/06

CPC分类号： A61K38/2292 ,  A61K45/06 ,  A61K2300/00

摘要： The invention provides a method of ameliorating a blood-brain barrier disorder, as well as a method of treating a disease accompanied by a blood-brain barrier disorder and a method of treating a cerebral ischemic disease, by administering a prothymosin α, or a protein or polypeptide possessing the same function as the prothymosin α. The invention also provides polypeptides useful in the context of the aforesaid methods.

摘要翻译： 本发明提供一种改善血脑屏障障碍的方法，以及治疗伴有血脑屏障障碍的疾病的方法和治疗脑缺血疾病的方法，通过施用孕激素α或蛋白质 或具有与胸腺素α相同功能的多肽。 本发明还提供了在上述方法的上下文中有用的多肽。

公开(公告)号：US20130203738A1

公开(公告)日：2013-08-08

申请号：US13578230

申请日：2011-02-09

申请人： Yoshifumi Nishimura ,  Aritaka Nagadoi ,  Yuuka Hirao ,  Yoshio Goshima ,  Naoya Yamashita ,  Naoki Miyata ,  Takayoshi Suzuki ,  Ryuta Hiraishi ,  Hiroshi Ueda

发明人： Yoshifumi Nishimura ,  Aritaka Nagadoi ,  Yuuka Hirao ,  Yoshio Goshima ,  Naoya Yamashita ,  Naoki Miyata ,  Takayoshi Suzuki ,  Ryuta Hiraishi ,  Hiroshi Ueda

IPC分类号： C07D211/16 ,  C07D211/10 ,  C07D265/30 ,  C07D207/06 ,  C07D223/04 ,  C07D225/02 ,  C07D211/14 ,  C07C233/65

CPC分类号： C07D211/16 ,  A61K31/445 ,  C07C233/65 ,  C07C233/66 ,  C07C2601/14 ,  C07D207/06 ,  C07D211/10 ,  C07D211/14 ,  C07D211/96 ,  C07D223/04 ,  C07D225/02 ,  C07D265/30 ,  C07D295/192

摘要： The present invention identifies a compound which binds to the PAH1 domain of mSin3B that specifically binds to neural restrictive silencer factor NRSF, and uses the compound as a prophylactic and/or a therapeutic for diseases associated with abnormal expression of neural restrictive silencer factor NRSF/REST or abnormal expression of genes targeted by NRSF/REST, such as Huntington's disease, medulloblastoma and neuropathic pain.The present invention provides a pharmaceutical composition comprising a substance capable of binding to the PAH1 domain of mSin3B, e.g., a compound represented by the following formula (I), a pharmacologically acceptable salt thereof, or a pharmacologically acceptable ester thereof: wherein n represents 0 or 1; R1, R2, R3, R4 and R5 each independently represent a hydrogen atom, a hydrocarbon group or a functional group; Y represents a single bond, a carbonyl group, —CONH—, —NHCO— or a sulfonyl group; and Z represents a nitrogen-containing heterocyclic group which may have a substituent, an amino group which may have a hydrocarbon group or an aromatic hydrocarbon group, or a nitrogen and oxygen-containing heterocyclic group which may have a substituent.

摘要翻译： 本发明鉴定了与特异性结合神经限制性沉默因子NRSF的mSin3B的PAH1结构域结合的化合物，并且将该化合物用作与神经限制性消音因子NRSF / REST的异常表达相关的疾病的预防和/或治疗 或NRSF / REST靶向的基因异常表达，如亨廷顿氏病，成神经管细胞瘤和神经性疼痛。 本发明提供一种药物组合物，其包含能够结合mSin3B的PAH1结构域的物质，例如下式（I）表示的化合物，其药理学上可接受的盐或其药理学上可接受的酯：其中n表示0 或1; R1，R2，R3，R4和R5各自独立地表示氢原子，烃基或官能团; Y表示单键，羰基，-CONH-，-NHCO-或磺酰基; Z表示可以具有取代基的含氮杂环基，可以具有烃基或芳香族烃基的氨基或可以具有取代基的含氮和含氧杂环基。

公开(公告)号：US08411196B2

公开(公告)日：2013-04-02

申请号：US12095818

申请日：2006-11-30

申请人： Hiroshi Ueda ,  Kenichi Honjo ,  Naoto Yumiki ,  Toshio Makabe ,  Kenji Maeda ,  Kaoru Mokunaka ,  Kazuhiko Ishimaru

发明人： Hiroshi Ueda ,  Kenichi Honjo ,  Naoto Yumiki ,  Toshio Makabe ,  Kenji Maeda ,  Kaoru Mokunaka ,  Kazuhiko Ishimaru

IPC分类号： H04N5/232

CPC分类号： H04N5/23203 ,  G03B19/00 ,  G03B19/12 ,  H04N5/2254 ,  H04N5/23212 ,  H04N5/23245 ,  H04N5/23293 ,  H04N5/238

摘要： A digital camera of the present invention includes a microcomputer 110 having a live view mode controlling so that image data generated by a CMOS sensor 130 or image data obtained by subjecting the image data generated by the CMOS sensor 130 to predetermined processing is displayed on a liquid crystal monitor 150 as a moving image in real time, wherein when a release button 141 receives an instruction regarding start of an autofocus operation in a live view mode, the microcomputer 110 controls a movable mirror to enter an optical path to measure by an AF sensor 132, and thereafter, allow the movable mirror to retract from the optical path to return the digital camera to the live view mode. Due to this configuration, in a digital camera that includes a movable mirror and is capable of displaying a subject image in a live view through an electronic viewfinder, the operability thereof can be enhanced.

摘要翻译： 本发明的数码相机包括具有实时取景模式控制的微型计算机110，使得由CMOS传感器130生成的图像数据或通过对由CMOS传感器130生成的图像数据进行预定处理而获得的图像数据显示在液体 晶体监视器150作为运动图像实时地实现，其中当释放按钮141接收到关于在实时取景模式中的自动对焦操作的开始的指令时，微型计算机110控制可移动反射镜进入光学路径以由AF传感器 132，然后允许可移动镜从光路缩回以将数字照相机返回到实时取景模式。 由于这种结构，在包括可移动镜并且能够通过电子取景器在实时取景中显示被摄体图像的数码相机中，可以提高其可操作性。

公开(公告)号：US20120270338A1

公开(公告)日：2012-10-25

申请号：US13510105

申请日：2010-11-19

申请人： Hiroshi Ueda ,  Ryoji Abe ,  Masaki Ihara ,  Hiroaki Takagi

发明人： Hiroshi Ueda ,  Ryoji Abe ,  Masaki Ihara ,  Hiroaki Takagi

IPC分类号： G01N21/76 ,  C07K17/02

CPC分类号： G01N33/582 ,  A61K49/0058 ,  C07K16/18 ,  C07K16/44 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/92 ,  G01N21/6428 ,  G01N33/6857 ,  G01N2021/6439

摘要： An object is to provide an immunoassay method requiring neither a solid-phase immobilization step nor a washing step, enabling quick and simple quantitative measurement of a target substance in a liquid phase and capable of visualizing an antigen. Such an object is attained by measuring the concentration of a target antigen present in a test substance by sequentially performing a step (a) of bringing an antibody light-chain variable region polypeptide and an antibody heavy-chain variable region polypeptide labeled with a fluorescent dye into contact with an antigen in a test substance in a liquid phase; or bringing an antibody heavy-chain variable region polypeptide and an antibody light-chain variable region polypeptide labeled with a fluorescent dye into contact with an antigen in a test substance in a liquid phase; a step (b) of measuring the fluorescence intensity of the fluorescent dye; and a step (c) of computationally obtaining the level of the antigen contained in the test substance with reference to a positive correlation between the concentration of the antigen in a liquid phase and the fluorescence intensity of the fluorescent dye.

摘要翻译： 本发明的目的是提供一种不需要固相固定步骤和洗涤步骤的免疫测定方法，能够快速和简单地定量测定液相中的目标物质并能够使抗原呈现。 通过依次进行使荧光染料标记的抗体轻链可变区多肽和抗体重链可变区多肽的步骤（a），测定待测物质中存在的靶抗原的浓度， 与液相中测试物质中的抗原接触; 或使用荧光染料标记的抗体重链可变区多肽和抗体轻链可变区多肽与液相中的测试物质中的抗原接触; 测量荧光染料的荧光强度的步骤（b）; 和（c）参考在液相中的抗原浓度与荧光染料的荧光强度之间的正相关性来计算获得测试物质中含有的抗原水平的步骤（c）。

公开(公告)号：US08223263B2

公开(公告)日：2012-07-17

申请号：US12831001

申请日：2010-07-06

申请人： Hiroshi Ueda ,  Kenichi Honjo ,  Naoto Yumiki ,  Toshio Makabe ,  Kenji Maeda ,  Kaoru Mokunaka ,  Kazuhiko Ishimaru

发明人： Hiroshi Ueda ,  Kenichi Honjo ,  Naoto Yumiki ,  Toshio Makabe ,  Kenji Maeda ,  Kaoru Mokunaka ,  Kazuhiko Ishimaru

IPC分类号： H04N5/225

CPC分类号： H04N5/23203 ,  G03B19/00 ,  G03B19/12 ,  H04N5/2254 ,  H04N5/23212 ,  H04N5/23245 ,  H04N5/23293 ,  H04N5/238

摘要： A digital camera of the present invention includes a microcomputer 110 having a live view mode controlling so that image data generated by a CMOS sensor 133 or image data obtained by subjecting the image data generated by the CMOS sensor 133 to predetermined processing is displayed on a liquid crystal monitor 150 as a moving image in real time, wherein the microcomputer 110 controls so that, when the live view mode is set, the digital camera comes out of the live view mode, and setting information on the digital camera is displayed on the liquid crystal monitor 150, in accordance with the manipulation of the manipulation portion 140. Due to this configuration, in a digital camera that includes a movable mirror and is capable of displaying a subject image in a live view through an electronic viewfinder, the operability thereof can be enhanced.

公开(公告)号：US08077560B2

公开(公告)日：2011-12-13

申请号：US12608173

申请日：2009-10-29

申请人： Hiroshi Ueda ,  Motoshi Ito

发明人： Hiroshi Ueda ,  Motoshi Ito

IPC分类号： G11B7/00

CPC分类号： G11B27/105 ,  G11B7/00736 ,  G11B20/1217 ,  G11B27/329 ,  G11B2220/218 ,  G11B2220/2562

摘要： An additionally recordable information recording medium has a complicated management structure for managing an unrecorded area. Therefore, there are problems that it takes a long time for a disk to startup and it is difficult to build a recording/reproducing system. The additionally recordable information recording medium according to the present invention includes a simple data structure for managing a location information for a recorded area located at the rearmost location in a user data area. An additionally recordable apparatus according to the present invention also includes means for updating the location information of the recorded area so that the recorded area located at the rearmost location in the user data area is always managed.

摘要翻译： 另外可记录的信息记录介质具有用于管理未记录区域的复杂管理结构。 因此，存在磁盘启动需要很长时间并且难以构建记录/再现系统的问题。 根据本发明的另外可记录的信息记录介质包括用于管理位于用户数据区域中最后位置的记录区域的位置信息的简单数据结构。 根据本发明的另外可记录的装置还包括用于更新记录区域的位置信息的装置，使得位于用户数据区域中的最后位置的记录区域总是被管理。

公开(公告)号：US08004945B2

公开(公告)日：2011-08-23

申请号：US12282439

申请日：2007-03-13

申请人： Harumitsu Miyashita ,  Kohei Nakata ,  Hiroshi Ueda ,  Youichi Ogura

发明人： Harumitsu Miyashita ,  Kohei Nakata ,  Hiroshi Ueda ,  Youichi Ogura

IPC分类号： G11B7/00

CPC分类号： G11B20/10009 ,  G11B7/0053 ,  G11B7/08523 ,  G11B2220/2537

摘要： An information reproduction device according to the present invention is a device for accessing a recording medium having first address information and second address information recorded thereon. The first address information is represented by a shape formed on the recording medium in advance; and the second address information is recorded on the recording medium together with data. The information reproduction device includes a head section for accessing the recording medium to generate a reproduction signal; a first detection section for detecting the first address information from the reproduction signal; a second detection section for detecting the second address information from the reproduction signal; and a control section for, based on a detection result of either the first detection section or the second detection section which detected the address information first, controlling an access after the detection to the recording medium.

摘要翻译： 根据本发明的信息再现装置是用于访问其上记录有第一地址信息和第二地址信息的记录介质的装置。 第一地址信息由形成在记录介质上的形状预先表示; 并且第二地址信息与数据一起被记录在记录介质上。 信息再现装置包括用于访问记录介质以产生再现信号的头部分; 第一检测部分，用于从再现信号中检测第一地址信息; 第二检测部分，用于从再现信号中检测第二地址信息; 以及控制部分，用于基于首先检测到地址信息的第一检测部分或第二检测部分的检测结果，控制检测到记录介质之后的访问。

公开(公告)号：USRE42585E1

公开(公告)日：2011-08-02

申请号：US12819785

申请日：2010-06-21

申请人： Yoshikazu Yamamoto ,  Motoshi Ito ,  Hiroshi Ueda

发明人： Yoshikazu Yamamoto ,  Motoshi Ito ,  Hiroshi Ueda

IPC分类号： G11B5/09

CPC分类号： G11B20/1217 ,  G11B20/1883 ,  G11B2020/1893 ,  G11B2220/20 ,  G11B2220/2537

摘要： Information recording media 101 and 102 usable for either a first recording density D1 or a second recording density D2 each include a user data area 106 in which user data is to be recorded, a first defect management information area 108 in which first defect management information for managing a defect area in the user data area is to be recorded, and a second defect management information area 109 in which second defect management information having an identical content to that of the first defect management information is to be recorded. The first and second defect management information areas 108 and 109 are located such that angles θ1 and θ2 made by start blocks thereof fulfill the relationships of 150°≦θ1≦210° and 150°≦θ2≦210° (θ1: in the case of the first recording density, and θ2: in the case of the second recording density).

摘要翻译： 可用于第一记录密度D1或第二记录密度D2的信息记录介质101和102分别包括要记录用户数据的用户数据区域106，第一缺陷管理信息区域108，其中第一缺陷管理信息用于 要记录用户数据区域中的缺陷区域的管理，以及要记录与第一缺陷管理信息的内容相同的第二缺陷管理信息的第二缺陷管理信息区域109。 第一和第二缺陷管理信息区域108和109被定位成使得由其起始块制成的角度和角度1和θ2与第一和第二缺陷管理信息区域108和109之间的关系满足150°＆nlE;＆amp; thetas; 1＆nlE; 210°和150°＆nlE;＆thetas; 2＆nlE ; 210°（＆amp; thetas; 1：在第一记录密度的情况下，和＆amp;; 2：在第二记录密度的情况下）。