利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

11 条记录 (耗时 0.032 秒)

    CYCLIC DEPSIPEPTIDE COMPOUND AND USE THEREOF
    9.
    发明申请
    CYCLIC DEPSIPEPTIDE COMPOUND AND USE THEREOF 审中-公开
    环糊精化合物及其用途

    公开(公告)号：US20110207655A1

    公开(公告)日：2011-08-25

    申请号：US13126363

    申请日：2009-10-23

    申请人： Susumu Tsujimoto ,  Masatoshi Taniguchi ,  Yoshitaka Hirayama ,  Jun Takasaki ,  Tomihisa Kawasaki ,  Kazutoshi Sakamoto ,  Shinya Nishiwaki ,  Yukihiro Kitanaga

    发明人： Susumu Tsujimoto ,  Masatoshi Taniguchi ,  Yoshitaka Hirayama ,  Jun Takasaki ,  Tomihisa Kawasaki ,  Kazutoshi Sakamoto ,  Shinya Nishiwaki ,  Yukihiro Kitanaga

    IPC分类号： A61K38/15 ,  C07K11/02 ,  A61P11/00 ,  A61P11/06

    CPC分类号： A61K38/12 ,  A61K38/15 ,  C07K11/00

    摘要： [Problem]A compound useful for the prevention and/or treatment of chronic obstructive pulmonary disease (COPD) or asthma, and a pharmaceutical composition containing the compound as an active ingredient are provided.[Means for Solution]The present inventors have made extensive studies on the pharmacological actions of naturally fermented materials, and as a result, they have found that a cyclic depsipeptide compound derived from a soil bacterium belonging to the genus Chromobacterium which is collected in Okutama-machi, Tokyo has both an inhibitory action on airway contraction and an inhibitory action on airway inflammation, and thus, is useful as an agent for preventing or treating COPD or asthma, thereby completing the present invention. That is, the present invention relates to a pharmaceutical composition for preventing and/or treating chronic obstructive pulmonary disease (COPD) or asthma, which contains a cyclic depsipeptide compound or a salt thereof as an active ingredient and is intended to be administered by intratracheal administration, nasal drop administration, or inhalation administration.

    摘要翻译： [问题]提供了用于预防和/或治疗慢性阻塞性肺疾病（COPD）或哮喘的化合物和含有该化合物作为活性成分的药物组合物。 [解决方案]本发明人对天然发酵材料的药理作用进行了广泛的研究，结果发现，源自属于Chromobacterium属的土壤细菌的环状缩肽化合物是在Okutama- 东京都有对气道收缩的抑制作用和对气道炎症的抑制作用，因此可用作预防或治疗COPD或哮喘的药剂，从而完成了本发明。 也就是说，本发明涉及用于预防和/或治疗慢性阻塞性肺疾病（COPD）或哮喘的药物组合物，其包含环状缩肽化合物或其盐作为活性成分，并且旨在通过气管内给药 ，滴鼻给药或吸入给药。