摘要:
The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
摘要:
The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
摘要:
The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.
摘要:
The invention is directed to compounds and methods to inhibit p38 kinase wherein the compounds are a pyrimidine or pyridine coupled to two mandatory substituents.
摘要:
Disclosed are a wearable mobile phone capable of detecting EMG changed by hand motion of a user and a control method of an input unit of the wearable mobile phone. The wearable mobile phone includes an EMG measuring unit 10 having a plurality of EMG measuring sensors 11 for detecting the EMG changed by hand motion of a user, and made in a ring shape to be worn on a wrist of the user, an EMG transferring unit 20 connected to the EMG measuring unit 10 for transferring the EMG measured by the EMG measuring unit, an EMG determining unit 30 mounted to one side of the EMG transferring unit 20 for receiving EMG from the EMG transferring unit to determine the hand motion and extract an input signal for the mobile phone corresponding to the hand motion, and a mobile phone functioning unit 40 receiving the input signal from the EMG determining unit for functioning the mobile function and having an antenna and a sound transferring device. The wearable mobile phone allows the user to input wanted information related to operation of the mobile phone, without using input keys, which can miniaturize the mobile phone and easily carry the mobile phone.
摘要:
The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.
摘要:
The present invention relates to pyrazolopyridines and imidazopyridines which are inhibitors of the kinase PDK1 and are thus useful for the treatment of myeloproliferative disorders or cancer. The compounds are also useful as inhibitors of other kinases such as FGFR3, NTRK3, RP-S6K and WEE1. Furthermore, the present compounds also selectively inhibit microtubule affinity regulating kinase (MARK) and are therefore useful for the treatment or prevention of Alzheimer's disease.
摘要:
The present invention relates to pyrazine substituted pyrrolopyridines which are inhibitors of JAK kinases (JAK1, JAK2, JAK3 and/or TYK2) and/or PDK1 and are thus useful for the treatment of myeloproliferative disorders or cancer.
摘要:
An integrated suspension system includes a cylinder that hermetically contains gas therein and is fixed to a vehicle body; a piston that has a motor at an upper portion thereof, is configured to support a road wheel and is guided within the cylinder to move vertically; a disk unit including a second disk that has a plurality of passage holes formed there through and a bottom surface coupled to a driving shaft of the motor to rotate while moving vertically integrally along with the piston, and a first disk that has a plurality of passage holes and is stacked on and connected via a hinge to the center of a top surface of the second disk to move vertically within the cylinder integrally along with the second disk without any rotation; and a control unit that controls an opening degree established through overlap of the passage holes formed in the first and second disks by changing power supplied to the motor to control a rotational angle of the second disk.
摘要:
The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.