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1.发明授权Medical device and delivery system for modification of left atrial appendage and methods thereof 有权用于修改左心耳的医疗装置和输送系统及其方法公开(公告)号：US09351716B2
公开(公告)日：2016-05-31
申请号：US13450755
申请日：2012-04-19
CPC分类号： A61B17/12122 , A61B17/00234 , A61B17/0057 , A61B17/12022 , A61B17/12172 , A61B17/12177 , A61B2017/00243 , A61B2017/00309 , A61B2017/00327 , A61B2017/0053 , A61B2017/00575 , A61B2017/0069 , A61B2017/12054
摘要： Devices, methods and systems are provided for occluding an opening within the tissue of a body, such as a left atrial appendage. In one embodiment, a delivery system for use in occluding an opening in the tissue of a body includes an actuation assembly operatively coupled to a medical device including an anchor portion and an occluder portion. The actuation assembly is configured to move the anchor portion between a deployed state and retracted state while the occluder portion maintains a deployed state. With this arrangement, the deployed occluder portion can be visualized via imaging at a preferred position prior to deploying the anchor portion of the medical device.
摘要翻译： 提供装置，方法和系统用于阻塞身体的组织内的开口，例如左心耳。 在一个实施例中，用于阻塞身体组织中的开口的输送系统包括可操作地联接到包括锚固部分和封堵器部分的医疗装置的致动组件。 致动组件构造成在封堵器部分保持展开状态的同时在展开状态和缩回状态之间移动锚定部分。 通过这种布置，在部署医疗装置的锚定部分之前，可以在优选位置处经由成像来可视化部署的封堵器部分。
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公开(公告)号：US08979941B2
公开(公告)日：2015-03-17
申请号：US11836037
申请日：2007-08-08
CPC分类号： A61B17/0057 , A61B17/0487 , A61B17/083 , A61B17/12122 , A61B17/12168 , A61B17/12172 , A61B2017/00084 , A61B2017/00407 , A61B2017/00575 , A61B2017/00579 , A61B2017/00588 , A61B2017/00592 , A61B2017/00597 , A61B2017/00601 , A61B2017/00606 , A61B2017/0061 , A61B2017/00619 , A61B2017/00623 , A61B2017/00654 , A61B2017/00858 , A61B2017/00862 , A61B2017/00867 , A61B2017/00884 , A61B2017/0488 , A61B2017/0496 , A61B2017/12054
摘要： A medical system for treating an internal tissue opening can include a closure device and associated delivery device. The closure device can include a body portion operatively associated with a first anchor and a second anchor. The body portion can include a plurality of segments defining a multi-cellular structure. The closure device can be configured to apply lateral force to tissue of the internal tissue opening to bring tissue together. The closure device can have a substantially flat aspect, and can include a member adapted to induce tissue growth. The anchors can extend from the body portion and return back to the body portion to define a closed periphery. The anchors can include undulations and can include multiple segments. A method of forming a closure device can include positioning a material on a working surface and cutting a closure device from the material.
摘要翻译： 用于治疗内部组织开口的医疗系统可以包括闭合装置和相关联的递送装置。 闭合装置可以包括与第一锚固件和第二锚固件可操作地相关联的主体部分。 身体部分可以包括限定多细胞结构的多个片段。 闭合装置可以构造成向内部组织开口的组织施加横向力以将组织带到一起。 闭合装置可以具有基本平坦的方面，并且可以包括适于诱导组织生长的构件。 锚固件可以从主体部分延伸并返回到主体部分以限定封闭的外围。 锚点可以包括起伏并且可以包括多个段。 形成闭合装置的方法可以包括将材料定位在工作表面上并从材料切割闭合装置。
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3.发明授权公开(公告)号：US08864809B2
公开(公告)日：2014-10-21
申请号：US11836013
申请日：2007-08-08
CPC分类号： A61B17/0057 , A61B17/12122 , A61B17/12168 , A61B17/12172 , A61B2017/00084 , A61B2017/00407 , A61B2017/00575 , A61B2017/00579 , A61B2017/00588 , A61B2017/00592 , A61B2017/00597 , A61B2017/00601 , A61B2017/00606 , A61B2017/0061 , A61B2017/00619 , A61B2017/00623 , A61B2017/00654 , A61B2017/00858 , A61B2017/00862 , A61B2017/00867 , A61B2017/00884 , A61B2017/12054
摘要： A medical system for treating an internal tissue opening can include a closure device and associated delivery device. The closure device can include a multi-cellular body portion operatively associated with a first anchor and a second anchor. The closure device can be configured to apply lateral force to tissue of the internal tissue opening for tissue approximation. The closure device can also include an ingrowth material. The delivery device can include an actuating assembly configured to partially deploy the closure device by a first movement, and deploy a second portion of the closure device by a second movement. The delivery device can also include a release assembly to selectively release or disconnect the closure device from the delivery device.
摘要翻译： 用于治疗内部组织开口的医疗系统可以包括闭合装置和相关联的递送装置。 闭合装置可以包括与第一锚固件和第二锚固件可操作地相关联的多细胞主体部分。 闭合装置可以被配置为向内部组织开口的组织施加横向力用于组织近似。 闭合装置还可以包括向内生长材料。 输送装置可以包括构造成通过第一运动部分展开闭合装置的致动组件，并且通过第二运动来展开闭合装置的第二部分。 递送装置还可以包括释放组件，用于选择性地将封闭装置从输送装置释放或断开。
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4.发明授权公开(公告)号：US08840655B2
公开(公告)日：2014-09-23
申请号：US11836051
申请日：2007-08-08
CPC分类号： A61B17/0057 , A61B17/12122 , A61B17/12168 , A61B17/12172 , A61B2017/00084 , A61B2017/00407 , A61B2017/00575 , A61B2017/00579 , A61B2017/00588 , A61B2017/00592 , A61B2017/00597 , A61B2017/00601 , A61B2017/00606 , A61B2017/0061 , A61B2017/00619 , A61B2017/00623 , A61B2017/00654 , A61B2017/00858 , A61B2017/00862 , A61B2017/00867 , A61B2017/00884 , A61B2017/12054
摘要： A medical system for treating an internal tissue opening can include a closure device and associated delivery device. The delivery device can include an actuating assembly configured to partially deploy the closure device by a first movement, and deploy a second portion of the closure device by a second movement. The delivery device can also include a release assembly to selectively release or disconnect the closure device from the delivery device. The delivery device can include a tip member coupled to the distal end of a catheter. The tip member can include a first passageway and a second passageway being in a spaced apart arrangement. A guidewire can be received into the first passageway to facilitate positioning of the delivery device. The second passageway can house and facilitate delivery of the closure device.
摘要翻译： 用于治疗内部组织开口的医疗系统可以包括闭合装置和相关联的递送装置。 输送装置可以包括构造成通过第一运动部分展开闭合装置的致动组件，并且通过第二运动来展开闭合装置的第二部分。 递送装置还可以包括释放组件，用于选择性地将封闭装置从输送装置释放或断开。 输送装置可以包括联接到导管的远端的尖端构件。 尖端构件可以包括第一通道和间隔开的布置的第二通道。 导丝可以被接收到第一通道中以便于输送装置的定位。 第二通道可容纳和便于封闭装置的输送。
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公开(公告)号：US08235988B2
公开(公告)日：2012-08-07
申请号：US12359223
申请日：2009-01-23
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B5/042 , A61B18/082 , A61B18/18 , A61B2017/00367 , A61B2017/0046 , A61B2017/00575 , A61B2017/00867 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00351 , A61B2018/00375 , A61B2018/00577 , A61B2018/00839 , A61B2018/1435 , A61M2025/0183 , A61M2025/1047 , A61M2025/1052
摘要： Embodiments of the present invention are directed to ablation catheter systems configured, for example, to ablate tissue adjacent an ostium of the pulmonary vein in a left atria of a heart. In one embodiment, an ablation catheter system includes a handle including an actuator and a catheter coupled to the handle defining a lumen extending through a length of the catheter, the catheter including a tip portion at a distal end thereof. The ablation catheter system may also include an electrode coupled to the handle with lines extending through the lumen of the catheter, the electrode being configured to be constrained within the tip portion of the catheter and configured to be deployed from the tip portion and self expand to an expanded configuration. With this arrangement, the electrode is configured to self expand to a conical configuration with a tip portion configured to be disposed within the pulmonary vein.
摘要翻译： 本发明的实施例涉及消融导管系统，其被配置为例如在心脏的左心房内消融邻近肺静脉的口的组织。 在一个实施例中，消融导管系统包括手柄，其包括致动器和联接到手柄的导管，其限定延伸穿过导管的一段长度的内腔，所述导管在其远端处包括尖端部分。 消融导管系统还可以包括连接到手柄的电极，线路延伸穿过导管的内腔，电极被配置为被限制在导管的尖端部分内并且被构造成从尖端部分展开并自我扩张到 扩展配置。 通过这种布置，电极被配置成自膨胀成圆锥形构造，其中末端部分构造成设置在肺静脉内。
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6.发明授权Methods, systems and devices for reducing the size of an internal tissue opening 有权用于减小内部组织开口尺寸的方法，系统和装置公开(公告)号：US08167894B2
公开(公告)日：2012-05-01
申请号：US11836123
申请日：2007-08-08
IPC分类号： A61B17/03
CPC分类号： A61B17/0057 , A61B17/12122 , A61B17/12168 , A61B17/12172 , A61B2017/00084 , A61B2017/00407 , A61B2017/00575 , A61B2017/00579 , A61B2017/00588 , A61B2017/00592 , A61B2017/00597 , A61B2017/00601 , A61B2017/00606 , A61B2017/0061 , A61B2017/00619 , A61B2017/00623 , A61B2017/00654 , A61B2017/00858 , A61B2017/00862 , A61B2017/00867 , A61B2017/00884 , A61B2017/12054
摘要： A medical system for treating an internal tissue opening can include a closure device and associated delivery device. The closure device can include a multi-cellular body portion operatively associated with a first anchor and a second anchor. The closure device can be configured to apply lateral force to tissue of the internal tissue opening for tissue approximation. The closure device can have a substantially flat aspect, and have a depth that is substantially greater than the thickness of a majority of the members forming the closure device. The closure device can also include an in-growth material. The delivery device can include an actuating assembly configured to partially deploy the closure device by a first movement, and deploy a second portion of the closure device by a second movement. The delivery device can also include a release assembly to selectively release or disconnect the closure device from the delivery device.
摘要翻译： 用于治疗内部组织开口的医疗系统可以包括闭合装置和相关联的递送装置。 闭合装置可以包括与第一锚固件和第二锚固件可操作地相关联的多细胞主体部分。 闭合装置可以被配置为向内部组织开口的组织施加横向力用于组织近似。 闭合装置可以具有基本平坦的方面，并且具有基本上大于形成闭合装置的构件的大部分的厚度的深度。 闭合装置还可以包括生长内材料。 输送装置可以包括构造成通过第一运动部分展开闭合装置的致动组件，并且通过第二运动来展开闭合装置的第二部分。 递送装置还可以包括释放组件，用于选择性地将封闭装置从输送装置释放或断开。
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公开(公告)号：US20100324585A1
公开(公告)日：2010-12-23
申请号：US12818041
申请日：2010-06-17
IPC分类号： A61M29/00
CPC分类号： A61B17/12122 , A61B17/0057 , A61B17/12022 , A61B17/12172 , A61B17/12177 , A61B2017/00309 , A61B2017/00327 , A61B2017/00575 , A61B2017/0069 , A61B2017/12054
摘要： Devices, methods and systems are provided for occluding an opening within the tissue of a body, such as a left atrial appendage. In one embodiment, a system for use in occluding an opening in the tissue of a body includes a handle, a catheter coupled with the handle and a medical device disposed within a lumen of the catheter. The medical device includes an anchor system having a plurality of anchor segments coupled with an anchor hub. The medical device further includes an occluder system having a plurality of occluder segments coupled with an occluder hub. A first actuator is configured to displace the occluder hub independent of, and relative to, the anchor hub to deploy the occluder system from a refracted state to an expanded state while the anchor system remains in a retracted state.
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8.发明授权Medical device for modification of left atrial appendage and related systems and methods 有权用于修改左心耳和相关系统和方法的医疗装置公开(公告)号：US08795328B2
公开(公告)日：2014-08-05
申请号：US12684783
申请日：2010-01-08
CPC分类号： A61B17/1215 , A61B17/00234 , A61B17/0057 , A61B17/0401 , A61B17/0487 , A61B17/06166 , A61B17/12022 , A61B17/12031 , A61B17/1204 , A61B17/12122 , A61B17/12131 , A61B17/12159 , A61B17/12172 , A61B17/122 , A61B2017/00243 , A61B2017/00526 , A61B2017/00575 , A61B2017/00579 , A61B2017/00588 , A61B2017/00592 , A61B2017/00597 , A61B2017/00601 , A61B2017/0061 , A61B2017/00632 , A61B2017/00867 , A61B2017/00884 , A61B2017/0409 , A61B2017/0412 , A61B2017/0414 , A61B2017/0437 , A61B2017/0446 , A61B2017/0448 , A61B2017/0459 , A61B2017/0464 , A61B2017/1205 , Y10T29/49826
摘要： A medical device and system for modifying a left atrial appendage (“LAA”), as well as related methods, are provided. In accordance with one embodiment, a medical device includes a plurality of discrete frame segments coupled with at least one ring member to form a frame structure. Each discrete frame segment includes an expanding leg, a collapsing leg and a hub extension. A tissue growth member is coupled with the plurality of discrete frame segments to define a substantially convex surface and a substantially concave surface.
摘要翻译： 提供了一种用于修改左心耳（“LAA”）的医疗装置和系统以及相关方法。 根据一个实施例，医疗设备包括与至少一个环构件联接以形成框架结构的多个离散框架段。 每个离散的帧段包括扩展的腿，折叠腿和轮毂延伸。 组织生长构件与多个分立的框架段联接以限定基本上凸的表面和基本上凹的表面。
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公开(公告)号：US08529597B2
公开(公告)日：2013-09-10
申请号：US12783498
申请日：2010-05-19
申请人： Richard J. Linder , Clark C. Davis , Scott D. Miles , DeWayne C. Fox , Daryl R. Edmiston , David A. Ewell
发明人： Richard J. Linder , Clark C. Davis , Scott D. Miles , DeWayne C. Fox , Daryl R. Edmiston , David A. Ewell
IPC分类号： A61B17/84
CPC分类号： A61B17/0057 , A61B17/12122 , A61B17/12172 , A61B2017/00084 , A61B2017/00407 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00597 , A61B2017/00606 , A61B2017/0061 , A61B2017/00619 , A61B2017/00623 , A61B2017/00858 , A61B2017/00862 , A61B2017/00867
摘要： A medical system for treating an internal tissue opening can include a closure device and associated delivery device. The closure device can include a body portion operatively associated with a first anchor and a second anchor. The body portion can include a plurality of segments defining a multi-cellular structure. The closure device can be configured to apply lateral force to tissue of the internal tissue opening to bring tissue together. The closure device can have a substantially flat aspect, and have a depth thickness that is substantially greater than the thickness or width of a majority of the members forming the closure device to reduce out of plane bending. The closure device can also include a member adapted to induce tissue growth.
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公开(公告)号：US20100006105A1
公开(公告)日：2010-01-14
申请号：US12169506
申请日：2008-07-08
申请人： Phillip J. Carter , Richard J. Linder , Randall K. Jones , Scott D. Miles , Clark C. Davis , Daryl R. Edmiston , DeWayne C. Fox
发明人： Phillip J. Carter , Richard J. Linder , Randall K. Jones , Scott D. Miles , Clark C. Davis , Daryl R. Edmiston , DeWayne C. Fox
IPC分类号： A61F6/22 , A61B17/425
CPC分类号： A61F6/225
摘要： The present invention is directed to various embodiments of medical devices and methods for occluding a fallopian tube for contraception and permanent sterilization. In one embodiment, the medical device includes an outer member, an inner member and a tissue growth member. The outer member includes an outer surface and an inner surface, wherein the inner surface defines a bore in the outer member. The inner member is configured to be positioned within the bore of the outer member. The tissue growth member is attached to the outer surface of the outer member and is configured to induce tissue growth thereto. With this arrangement, the medical device can be implanted within the fallopian tube and serve as a permanent occluding device therein. If desired, the medical device can be partially removed from the fallopian tube to restore the ability for conception.
摘要翻译： 本发明涉及用于闭塞输卵管用于避孕和永久灭菌的医疗装置和方法的各种实施例。 在一个实施例中，医疗装置包括外部构件，内部构件和组织生长构件。 外部构件包括外表面和内表面，其中内表面在外构件中限定孔。 内部构件构造成定位在外部构件的孔内。 组织生长构件附接到外部构件的外表面并且构造成诱导组织生长。 利用这种布置，医疗装置可以植入输卵管内并用作其中的永久性闭塞装置。 如果需要，医疗设备可以部分地从输卵管中移除以恢复受孕的能力。
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