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    GUIDE ASSEMBLY FOR INTRAMEDULLARY FIXATION AND METHOD OF USING THE SAME
    1.
    发明申请
    GUIDE ASSEMBLY FOR INTRAMEDULLARY FIXATION AND METHOD OF USING THE SAME 有权
    用于内插式固定的指导装置及其使用方法

    公开(公告)号：US20090157077A1

    公开(公告)日：2009-06-18

    申请号：US11957742

    申请日：2007-12-17

    申请人： Scott Larsen ,  Varik Tan ,  Mark J. Warburton

    发明人： Scott Larsen ,  Varik Tan ,  Mark J. Warburton

    IPC分类号： A61B17/58 ,  A61B17/56

    CPC分类号： A61B17/72 ,  A61B17/164 ,  A61B17/1686 ,  A61B17/1725 ,  A61B17/1735 ,  A61B17/1782 ,  A61B17/921 ,  A61B2017/00915 ,  A61B2017/90 ,  A61B2090/034 ,  A61B2090/062

    摘要： A guide assembly for facilitating placement of a fixation member within a medullary canal of a radius is provided. According to one embodiment, a guide assembly includes a guide fastener configured to attach to a fixation member and a guide member configured to receive the guide fastener such that the guide member is secured to the fixation member. The guide assembly also includes an interchangeable distal guide member configured to engage and be disengaged from the guide member. The distal guide member defines a plurality of fastener guide openings for guiding respective fasteners through a plurality of fastener openings defined in the fixation member.

    摘要翻译： 提供了一种用于促进将固定构件放置在半径的髓质管内的引导组件。 根据一个实施例，引导组件包括构造成附接到固定构件的引导紧固件和构造成接收引导紧固件的引导构件，使得引导构件固定到固定构件。 引导组件还包括可互换的远侧引导构件，其构造成与引导构件接合并脱离。 远侧引导构件限定多个紧固件引导开口，用于通过限定在固定构件中的多个紧固件开口引导相应的紧固件。

    Guide assembly for intramedullary fixation and method of using the same
    2.
    发明授权
    Guide assembly for intramedullary fixation and method of using the same 有权
    髓内固定导引装置及其使用方法

    公开(公告)号：US08771283B2

    公开(公告)日：2014-07-08

    申请号：US11957742

    申请日：2007-12-17

    申请人： Scott Larsen ,  Virak Tan ,  Mark J. Warburton

    发明人： Scott Larsen ,  Virak Tan ,  Mark J. Warburton

    IPC分类号： A61B17/58 ,  A61B17/60 ,  A61F2/00

    CPC分类号： A61B17/72 ,  A61B17/164 ,  A61B17/1686 ,  A61B17/1725 ,  A61B17/1735 ,  A61B17/1782 ,  A61B17/921 ,  A61B2017/00915 ,  A61B2017/90 ,  A61B2090/034 ,  A61B2090/062

    摘要： A guide assembly for facilitating placement of a fixation member within a medullary canal of a radius is provided. According to one embodiment, a guide assembly includes a guide fastener configured to attach to a fixation member and a guide member configured to receive the guide fastener such that the guide member is secured to the fixation member. The guide assembly also includes an interchangeable distal guide member configured to engage and be disengaged from the guide member. The distal guide member defines a plurality of fastener guide openings for guiding respective fasteners through a plurality of fastener openings defined in the fixation member.

    摘要翻译： 提供了一种用于促进将固定构件放置在半径的髓质管内的引导组件。 根据一个实施例，引导组件包括构造成附接到固定构件的引导紧固件和构造成接收引导紧固件的引导构件，使得引导构件固定到固定构件。 引导组件还包括可互换的远侧引导构件，其构造成与引导构件接合并脱离。 远侧引导构件限定多个紧固件引导开口，用于通过限定在固定构件中的多个紧固件开口引导相应的紧固件。

    INTRAMEDULLARY FIXATION ASSEMBLY AND DEVICES AND METHODS FOR INSTALLING THE SAME
    5.
    发明申请
    INTRAMEDULLARY FIXATION ASSEMBLY AND DEVICES AND METHODS FOR INSTALLING THE SAME 有权
    内置式固定装置及其装置及其安装方法

    公开(公告)号：US20090157079A1

    公开(公告)日：2009-06-18

    申请号：US12389137

    申请日：2009-02-19

    申请人： Mark J. Warburton ,  Robert M. Fencl ,  John T. Capo ,  Virak Tan ,  Aaron C. Smith

    发明人： Mark J. Warburton ,  Robert M. Fencl ,  John T. Capo ,  Virak Tan ,  Aaron C. Smith

    IPC分类号： A61B17/58

    CPC分类号： A61B17/1725 ,  A61B17/1659 ,  A61B17/1668 ,  A61B17/1684 ,  A61B17/72 ,  A61B17/848 ,  A61B17/861 ,  A61B17/8875 ,  A61B2017/0046 ,  A61B2017/922 ,  A61B2090/062

    摘要： An intramedullary fixation assembly usable with different long bone types and a guide assembly for guiding deployment of the intramedullary fixation assembly. The intramedullary fixation assembly includes a fixation member that has ends and a curved body extending between the ends. The curved body of the fixation member has a radius of curvature configured to extend through the medullary canal regardless of the long bone anatomy. Fasteners fix the fixation member to the bone fragments and are guided by a guide assembly. The guide assembly includes a guide body defining openings configured to guide the fasteners through openings defined in the fixation member and into the bone fragments. A fixation end of the guide body includes a pair of opposing, converging surfaces that are configured to engage in a positive fit with an exposed end of the fixation member accessible through the side aperture in the first fragment.

    摘要翻译： 可用于不同长骨类型的髓内固定组件和用于引导髓内固定组件的部署的引导组件。 髓内固定组件包括具有端部的固定构件和在端部之间延伸的弯曲体。 固定构件的弯曲体具有构造成延伸穿过髓管的曲率半径，而不管长骨解剖结构如何。 紧固件将固定构件固定在骨碎片上并由导向组件引导。 引导组件包括引导体，该引导体限定了被构造成引导紧固件通过限定在固定构件中的开口并进入骨碎片的开口。 引导体的固定端包括一对相对的会聚表面，其被配置成与通过第一片段中的侧孔可接近的固定构件的暴露端以正配合接合。

    APPARATUS AND METHODS FOR AOL AND DRL RECONSTRUCTION OF CMC JOINTS
    7.
    发明申请
    APPARATUS AND METHODS FOR AOL AND DRL RECONSTRUCTION OF CMC JOINTS 审中-公开
    装置和方法，用于AOL和DRL重建CMC接头

    公开(公告)号：US20140277450A1

    公开(公告)日：2014-09-18

    申请号：US14213348

    申请日：2014-03-14

    申请人： Mark J. Warburton

    发明人： Mark J. Warburton

    IPC分类号： A61B17/17 ,  A61F2/08

    CPC分类号： A61B17/1782 ,  A61B17/68 ,  A61F2/0811

    摘要： A surgical pin guide for reconstruction of a carpo-metacarpal (CMC) joint of a hand includes: a guide body having first and second opposed second end portions; a first pin receiving member connected to the first end portion of the guide body, the first pin receiving member having an elongated channel extending therethrough; and a second pin receiving member connected to the second end portion of the guide body, the second pin receiving member having an elongated channel extending therethrough. The first pin receiving member channel is sized and configured to receive a proximal end portion of a first pin that has a distal end portion residing in a trapezium of a hand. The second pin receiving member channel is sized and configured to receive and align a second pin for insertion into a first metacarpal of the hand.

    摘要翻译： 用于重建手掌的掌骨（CMC）接头的手术针引导件包括：具有第一和第二相对的第二端部的引导体; 连接到所述引导体的所述第一端部的第一销接收构件，所述第一销接收构件具有延伸穿过其中的细长通道; 以及连接到所述引导体的第二端部的第二销接收构件，所述第二销接收构件具有延伸穿过其中的细长通道。 第一销接收构件通道的尺寸和构造适于容纳具有驻留在手的梯形中的远端部分的第一销的近端部分。 第二销接收构件通道的尺寸和构造用于接收和对准第二销以插入到手的第一掌骨中。

    Methods of treating microbial infections
    9.
    发明授权
    Methods of treating microbial infections 失效
    治疗微生物感染的方法

    公开(公告)号：US07875620B2

    公开(公告)日：2011-01-25

    申请号：US11420826

    申请日：2006-05-30

    申请人： Mark J. Warburton

    发明人： Mark J. Warburton

    IPC分类号： A01N43/90 ,  A61K31/522 ,  C07D473/00

    CPC分类号： A61K31/522 ,  A61K9/12 ,  A61K31/555 ,  A61K31/695 ,  Y02A50/475

    摘要： The present invention provides methods of treating microbacterial infections comprising administering to a subject in need thereof, a composition comprising a compound of formula I: wherein: X1, X2 and X3 are selected from the group consisting of oxygen, sulfur, aminoalkyl, alkoxy, aryl, and heteroaryl, unsubstituted or substituted; and R1, R2, R3 and R4 are selected from the group consisting of hydrogen, actinium, silicon, germanium, cyano, alkyl, alkoxy, allyl, alkenyl, alkynyl, alkylaryl, arylalkyl, aminoalkyl, alkylamino, alkene, alkyne, aryl, halide, alkylhalide, alkyloxyalkyl, thioalkyl, alkylthioalkyl, alkylamino, cycloalkyl, heterocyclyl, unsubstituted or substituted; or a pharmaceutically acceptable salt thereof. The present invention further provides methods of treating bacterial infections comprising administering to a subject in need thereof, an effective amount of a pharmaceutical composition comprising uric acid, urate, derivatives thereof, salts and hydrates thereof and prodrugs thereof and a pharmaceutically acceptable carrier.

    摘要翻译： 本发明提供了治疗微细菌感染的方法，其包括向有需要的受试者施用包含式I化合物的组合物：其中：X 1，X 2和X 3选自氧，硫，氨基烷基，烷氧基，芳基 和杂芳基，未取代或取代的; R 1，R 2，R 3和R 4选自氢，锕，硅，锗，氰基，烷基，烷氧基，烯丙基，烯基，炔基，烷基芳基，芳基烷基，氨基烷基，烷基氨基，烯烃，炔，芳基，卤化物 ，烷基卤，烷氧基烷基，硫代烷基，烷基硫代烷基，烷基氨基，环烷基，杂环基，未取代或取代的; 或其药学上可接受的盐。 本发明进一步提供治疗细菌感染的方法，包括向有需要的受试者施用有效量的包含尿酸，尿酸盐，其衍生物，其盐和水合物及其前药和药学上可接受的载体的药物组合物。