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1.发明申请公开(公告)号：US20130150895A1
公开(公告)日：2013-06-13
申请号：US13617728
申请日：2012-09-14
IPC分类号： A61B17/76
CPC分类号： A61B17/7085 , A61B17/0218 , A61B17/3423 , A61B17/7011 , A61B17/7032 , A61B17/7037 , A61B17/7043 , A61B17/7049 , A61B17/705 , A61B17/7052 , A61B17/7055 , A61B17/708 , A61B17/7091 , A61B17/88
摘要： Apparatus and instruments for percutaneously extending an existing spinal construct ipsilaterally with an additional spinal construct in a patient are disclosed. The additional spinal construct comprises a rod connector that includes an elongate additional rod integrally attached thereto. The additional rod is placed through an access port in a first orientation generally parallel to the longitudinal axis of the access port and rotated to a different second orientation generally transverse to the longitudinal axis of the access port. During such rotation the additional rod is moved subcutaneously beneath the skin of the patient from the existing spinal rod to an additional bone engaging implant. In another arrangement, the extension of an existing spinal construct in a minimally invasive procedure comprises a rod connector having an offset support for receiving an additional spinal rod that may be placed laterally interiorly or exteriorly of the existing spinal construct.
摘要翻译： 公开了用于经皮扩张现有脊柱构造物的装置和仪器，其在患者体内用另外的脊柱构造物向内侧延伸。 附加的脊柱构造物包括杆连接器，其包括与其一体地附接的细长附加杆。 附加的杆以大致平行于进入口的纵向轴线的第一取向放置在进入端口中，并且旋转到大致横向于进入端口的纵向轴线的不同的第二取向。 在这种旋转期间，附加的杆从患者的皮肤皮下移动到现有的脊柱杆到另外的骨接合植入物。 在另一种布置中，现有脊柱构造物在微创手术中的延伸包括具有偏移支撑件的杆连接器，该偏移支撑件用于接纳另外的脊柱杆，其可以横向放置在现有脊柱构造物的内部或外部。
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2.发明申请公开(公告)号：US20110313477A1
公开(公告)日：2011-12-22
申请号：US12819007
申请日：2010-06-18
申请人： Scott McLean , David Boisvert
发明人： Scott McLean , David Boisvert
IPC分类号： A61B17/56
CPC分类号： A61B17/7083 , A61B17/7002 , A61B17/7004 , A61B17/7011 , A61B17/7032 , A61B17/7034 , A61B17/7035 , A61B17/7037 , A61B17/7076 , A61B17/7079 , A61B17/7082 , A61B17/7085 , A61B17/7086 , A61B17/8875
摘要： A surgical instrument for the distraction or compression of bones or bone portions comprises a pair of elongate cross members pivotally coupled for relative movement having at one end a respective pair of handles and at the other end a respective pair of jaws. The jaws are generally parallel to each other and define a first plane within which the jaws are relatively movable, the space on both sides of the plane defining a work space between the jaws. The instrument further comprises a fulcrum supported by at least one of the cross members projecting into the work space and having an axis spaced from the jaws.
摘要翻译： 用于分离或压缩骨骼或骨部分的外科器械包括一对可枢转地联接以用于相对运动的细长横梁，其一端具有相应的一对把手，另一端具有相应的一对夹爪。 钳口通常彼此平行并且限定第一平面，钳口在该第一平面内可相对移动，平面两侧的空间限定了钳口之间的工作空间。 仪器还包括支撑件，该支点由突出到工作空间中并且具有与夹爪间隔开的轴线的至少一个横向构件支撑。
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3.发明授权公开(公告)号：US08206395B2
公开(公告)日：2012-06-26
申请号：US12819007
申请日：2010-06-18
申请人： Scott McLean , David Boisvert
发明人： Scott McLean , David Boisvert
IPC分类号： A61B17/70
CPC分类号： A61B17/7083 , A61B17/7002 , A61B17/7004 , A61B17/7011 , A61B17/7032 , A61B17/7034 , A61B17/7035 , A61B17/7037 , A61B17/7076 , A61B17/7079 , A61B17/7082 , A61B17/7085 , A61B17/7086 , A61B17/8875
摘要： A surgical instrument for the distraction or compression of bones or bone portions comprises a pair of elongate cross members pivotally coupled for relative movement having at one end a respective pair of handles and at the other end a respective pair of jaws. The jaws are generally parallel to each other and define a first plane within which the jaws are relatively movable, the space on both sides of the plane defining a work space between the jaws. The instrument further comprises a fulcrum supported by at least one of the cross members projecting into the work space and having an axis spaced from the jaws.
摘要翻译： 用于分离或压缩骨骼或骨部分的外科器械包括一对可枢转地联接以用于相对运动的细长横梁，其一端具有相应的一对把手，另一端具有相应的一对夹爪。 钳口通常彼此平行并且限定第一平面，钳口在该第一平面内可相对移动，平面两侧的空间限定了钳口之间的工作空间。 仪器还包括支撑件，该支点由突出到工作空间中并且具有与夹爪间隔开的轴线的至少一个横向构件支撑。
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4.发明授权Apparatus and instruments for percutaneously extending an existing spinal construct 有权用于经皮延伸现有脊柱结构的装置和仪器公开(公告)号：US08663281B2
公开(公告)日：2014-03-04
申请号：US13617728
申请日：2012-09-14
CPC分类号： A61B17/7085 , A61B17/0218 , A61B17/3423 , A61B17/7011 , A61B17/7032 , A61B17/7037 , A61B17/7043 , A61B17/7049 , A61B17/705 , A61B17/7052 , A61B17/7055 , A61B17/708 , A61B17/7091 , A61B17/88
摘要： Apparatus and instruments for percutaneously extending an existing spinal construct ipsilaterally with an additional spinal construct in a patient are disclosed. The additional spinal construct comprises a rod connector that includes an elongate additional rod integrally attached thereto. The additional rod is placed through an access port in a first orientation generally parallel to the longitudinal axis of the access port and rotated to a different second orientation generally transverse to the longitudinal axis of the access port. During such rotation the additional rod is moved subcutaneously beneath the skin of the patient from the existing spinal rod to an additional bone engaging implant. In another arrangement, the extension of an existing spinal construct in a minimally invasive procedure comprises a rod connector having an offset support for receiving an additional spinal rod that may be placed laterally interiorly or exteriorly of the existing spinal construct.
摘要翻译： 公开了用于经皮扩张现有脊柱构造物的装置和仪器，其在患者体内用另外的脊柱构造物向内侧延伸。 附加的脊柱构造物包括杆连接器，其包括与其一体地附接的细长附加杆。 附加的杆以大致平行于进入口的纵向轴线的第一取向放置在进入端口中，并且旋转到大致横向于进入端口的纵向轴线的不同的第二取向。 在这种旋转期间，附加的杆从患者的皮肤皮下移动到现有的脊柱杆到另外的骨接合植入物。 在另一种布置中，现有脊柱构造物在微创手术中的延伸包括具有偏移支撑件的杆连接器，该偏移支撑件用于接纳另外的脊柱杆，其可以横向放置在现有脊柱构造物的内部或外部。
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公开(公告)号：US20110183920A1
公开(公告)日：2011-07-28
申请号：US12868621
申请日：2010-08-25
申请人： Clark Pan , Steve Roczniak , Jeffrey Michael Greve , Stephanie L. Yung , Malinda Longphre , Teresa Mo-Fun Wong , Adrian Tomkinson , David Boisvert , Elise Burmeister-Getz , Kathy Delaria
发明人： Clark Pan , Steve Roczniak , Jeffrey Michael Greve , Stephanie L. Yung , Malinda Longphre , Teresa Mo-Fun Wong , Adrian Tomkinson , David Boisvert , Elise Burmeister-Getz , Kathy Delaria
CPC分类号： C07K14/5406 , A61K38/00 , C07K14/7155
摘要： This invention relates to modified IL-4 mutein receptor antagonists comprising an IL-4 mutein receptor antagonist coupled to polyethylene glycol. Related formulations and dosages and methods of administration thereof for therapeutic purposes are also provided. These modified IL-4 mutein receptor antagonists, compositions and methods provide a treatment option for those individuals afflicted with a respiratory disorder such as asthma by inhibiting IL-4 and IL-13-mediated airway hyperresponsiveness and eosinophilia. More particularly, these antagonists have an increased duration of effect versus unmodified IL-4RA by virtue of a greater plasma half-life.
摘要翻译： 本发明涉及包含与聚乙二醇偶联的IL-4突变蛋白受体拮抗剂的经修饰的IL-4突变蛋白受体拮抗剂。 还提供了用于治疗目的的相关制剂和剂量及其施用方法。 这些修饰的IL-4突变蛋白受体拮抗剂，组合物和方法通过抑制IL-4和IL-13介导的气道高反应性和嗜酸性粒细胞增多为患有呼吸系统疾病如哮喘的个体提供治疗选择。 更具体地，这些拮抗剂由于更大的血浆半衰期而对未改性的IL-4RA具有增加的作用持续时间。
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公开(公告)号：US20110034678A1
公开(公告)日：2011-02-10
申请号：US12723517
申请日：2010-03-12
申请人： Wayne Froland , Katherine Delaria , David Boisvert , Robert Kuhn
发明人： Wayne Froland , Katherine Delaria , David Boisvert , Robert Kuhn
CPC分类号： C07K1/1136
摘要： The present invention provides large-scale methods for renaturation of proteins comprising adding a solution of denatured, chemically modified or reduced proteins to a refolding buffer containing sulfate derived from H2SO4 and/or MgSO4 in the presence of guanidine. The present invention further provides methods of isolating a refolded protein at a concentration of about 0.4 to 3.0 gm/L by using a hydrophobic interaction chromatography (HIC) column.
摘要翻译： 本发明提供用于复性蛋白质的大规模方法，其包括在胍存在下，将含有来自H 2 SO 4和/或MgSO 4的硫酸盐的重折叠缓冲液加入变性，化学修饰或还原的蛋白质溶液中。 本发明还提供了通过使用疏水相互作用色谱（HIC）柱分离浓度为约0.4至3.0gm / L的重折叠蛋白质的方法。
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公开(公告)号：US20070000829A1
公开(公告)日：2007-01-04
申请号：US11137170
申请日：2005-05-25
申请人： David Boisvert
发明人： David Boisvert
CPC分类号： B01D29/96 , B01D35/147 , B01D35/30 , B01D2201/302 , B01D2201/4015
摘要： A filter housing having radial sealing means is disclosed herein. Upper bosses and lower bosses can be used to attach the head to the sump for easy opening and closing the filter housing when replacing the filter cartridge. The filter housing of the present invention provides simplified filter cartridge changes to minimize process downtime and without recourse to tools. The filter housing contains fluid flow directing mean to facilitate filter cartridge replacement and safety means to prevent removal of the sump when fluid is passing through the sump.
摘要翻译： 本文公开了一种具有径向密封装置的过滤器壳体。 当更换过滤器滤芯时，可以使用上部凸台和下部凸台将头部附接到油底壳，以便于打开和关闭过滤器外壳。 本发明的过滤器壳体提供了简化的过滤器盒改变，以最小化过程停机时间并且不追求工具。 过滤器壳体包含流体导向装置，以便于更换滤芯和安全装置，以防止当流体通过贮槽时去除贮槽。
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公开(公告)号：US07889251B1
公开(公告)日：2011-02-15
申请号：US11149128
申请日：2005-06-08
申请人： Chung Wai Ng , David Boisvert , Kunhong Qu , Mehmet Aslan
发明人： Chung Wai Ng , David Boisvert , Kunhong Qu , Mehmet Aslan
IPC分类号： H04N5/16
CPC分类号： H04N5/16 , H04N17/002
摘要： Calibrating a white level in an image scanning device. A target white level is accessed. A high white level is determined for pixel data output by an amplifier. A gain adjustment to the amplifier is determined to correct a portion of an error between the target white level and the high white level. The gain adjustment is applied to the amplifier.
摘要翻译： 校准图像扫描设备中的白平衡。 访问目标白色级别。 确定由放大器输出的像素数据的高白电平。 确定对放大器的增益调整以校正目标白电平和高白电平之间的误差的一部分。 增益调整应用于放大器。
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公开(公告)号：US20060063236A1
公开(公告)日：2006-03-23
申请号：US11026396
申请日：2004-12-29
申请人： David Boisvert , Malinda Longphre , Teresa Wong , Sydney Zaremba
发明人： David Boisvert , Malinda Longphre , Teresa Wong , Sydney Zaremba
CPC分类号： C07K14/54
摘要： Chimeric polypeptide antagonists that include an interleukin-4 (IL-4) mutein linked to an interleukin-9 (IL-9) mutein are provided, as are polynucleotides encoding the IL-4 and IL-9 chimeric mutein antagonists. Also provided are methods of using the chimeric mutein antagonists and encoding polypeptides to reduce or inhibit the responsiveness of a cell to a cytokine such as IL-4, IL-9 and/or interleukin-13. Methods using the compositions to treat disorders such as pulmonary disorders (e.g., asthma) also are provided.
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公开(公告)号：US20050050254A1
公开(公告)日：2005-03-03
申请号：US10619133
申请日：2003-07-13
申请人： David Boisvert
发明人： David Boisvert
IPC分类号： E05B45/06 , E05B65/00 , E05B73/00 , E05G1/00 , G06F1/16 , G06F21/00 , G07C9/00 , G08B13/06 , G08B13/14 , G06F12/00
CPC分类号： E05G1/00 , E05B45/06 , E05B65/0075 , E05B73/0082 , G06F21/86 , G06F21/88 , G07C9/0069 , G08B13/06 , G08B13/1436
摘要： An apparatus for preventing the theft of laptop computers. with a self contained secure enclosure for a laptop computer, a way to mount the enclosure in a vertical orientation, a keyless mechanism to access enclosure, a way to better prevent access to the security enclosure, a way to notify the owner of unauthorized access to the enclosure, a way to notify the owner of unauthorized attempts to access the enclosure, a way to limit access to enclosure to authorized personnel, a way to determine which authorized personnel have accessed the secure enclosure, a way to provide authorized emergency access to the enclosure, a way to enhance backup electrical power for the enclosure, and a way to notify the owner of reduced available electrical power.
摘要翻译： 一种用于防止膝上型计算机被盗的装置。 具有用于膝上型计算机的独立的安全外壳，以垂直方向安装外壳的方式，用于访问外壳的无钥匙机构，更好地防止访问安全外壳的方式，通知所有者未经授权的访问 该机箱是通知所有者未经授权的访问机箱的尝试的方法，一种限制对授权人员访问机箱的方法，一种确定哪些授权人员访问了安全机箱的方法，一种向 外壳，一种增强外壳备用电源的方法，以及通知所有者降低可用电力的方式。
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