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公开(公告)号：US20100261245A1
公开(公告)日：2010-10-14
申请号：US12422950
申请日：2009-04-13
申请人： Sei-Kwang HAHN , Hyun-Gu Kang , Sung-Ho Ryu , Jung-Kyu Park , Eun-Ju Oh
发明人： Sei-Kwang HAHN , Hyun-Gu Kang , Sung-Ho Ryu , Jung-Kyu Park , Eun-Ju Oh
IPC分类号： C12N9/00 , C07D207/40 , C07K14/00 , C07H21/00 , C07H1/00
CPC分类号： C08G65/329 , A61K47/60 , C08G65/33337 , C08G65/33396 , C08L2203/02
摘要： The invention relates to a long-acting formulation of biopharmaceutical, more specifically an aptamer therapeutics. A branched PEGylated aptamer or a hyaluronic acid (HA) derivative of which degradation in vivo is regulated is linked by the bioconjugation with biopharmaceutical to produce the long-action formulation.
摘要翻译： 本发明涉及生物药剂的长效制剂，更具体地涉及适体治疗剂。 通过与生物药物的生物缀合来连接体内降解调节的支化聚乙二醇化适体或透明质酸（HA）衍生物，以产生长效制剂。
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公开(公告)号：US08247493B2
公开(公告)日：2012-08-21
申请号：US12422950
申请日：2009-04-13
申请人： Sei-Kwang Hahn , Hyun-Gu Kang , Sung-Ho Ryu , Jung-Kyu Park , Eun-Ju Oh
发明人： Sei-Kwang Hahn , Hyun-Gu Kang , Sung-Ho Ryu , Jung-Kyu Park , Eun-Ju Oh
IPC分类号： A61K47/48
CPC分类号： C08G65/329 , A61K47/60 , C08G65/33337 , C08G65/33396 , C08L2203/02
摘要： The invention relates to a long-acting formulation of biopharmaceutical, more specifically an aptamer therapeutics. A branched PEGylated aptamer or a hyaluronic acid (HA) derivative of which degradation in vivo is regulated is linked by the bioconjugation with biopharmaceutical to produce the long-action formulation.
摘要翻译： 本发明涉及生物药剂的长效制剂，更具体地涉及适体治疗剂。 通过与生物药物的生物缀合来连接体内降解调节的支化聚乙二醇化适体或透明质酸（HA）衍生物，以产生长效制剂。
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公开(公告)号：US20110111477A9
公开(公告)日：2011-05-12
申请号：US12422950
申请日：2009-04-13
申请人： Sei-Kwang HAHN , Hyun-Gu Kang , Sung-Ho Ryu , Jung-Kyu Park , Eun-Ju Oh
发明人： Sei-Kwang HAHN , Hyun-Gu Kang , Sung-Ho Ryu , Jung-Kyu Park , Eun-Ju Oh
IPC分类号： C12N9/00 , C07D207/40 , C07K14/00 , C07H21/00 , C07H1/00
CPC分类号： C08G65/329 , A61K47/60 , C08G65/33337 , C08G65/33396 , C08L2203/02
摘要： The invention relates to a long-acting formulation of biopharmaceutical, more specifically an aptamer therapeutics. A branched PEGylated aptamer or a hyaluronic acid (HA) derivative of which degradation in vivo is regulated is linked by the bioconjugation with biopharmaceutical to produce the long-action formulation.
摘要翻译： 本发明涉及生物药剂的长效制剂，更具体地涉及适体治疗剂。 通过与生物药物的生物缀合来连接体内降解调节的支化聚乙二醇化适体或透明质酸（HA）衍生物，以产生长效制剂。
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公开(公告)号：US20100210509A1
公开(公告)日：2010-08-19
申请号：US12680955
申请日：2008-10-09
申请人： Eun-Ju Oh , Jung-Wook Kim , Sung-Ho Ryu , Sei-Kwang Hahn
发明人： Eun-Ju Oh , Jung-Wook Kim , Sung-Ho Ryu , Sei-Kwang Hahn
摘要： The invention relates to a novel bioconjugation protocol for peptide suitable for in vivo applications. Bioconjugation of the peptide to HA derivative increases its half life in circulation contributing for a high efficacy. More over, conjugate of HA derivative and peptide which is treated with hyaluronidase shows increased bioactivity. And also, in contrast to PEGylation, HA derivative can be conjugated with many numbers of peptide molecules per single HA derivative chain, which enables multiple action of peptide drugs.
摘要翻译： 本发明涉及适用于体内应用的肽的新型生物缀合方案。 肽与HA衍生物的生物共轭增加其循环的半衰期有助于高效力。 更具体地，HA衍生物和用透明质酸酶处理的肽的缀合物显示增加的生物活性。 而且，与聚乙二醇化相反，HA衍生物可以与单个HA衍生物链中的许多肽分子缀合，这使得肽药物能够多次作用。
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公开(公告)号：US08569252B2
公开(公告)日：2013-10-29
申请号：US12759813
申请日：2010-04-14
申请人： Jung-Hwan Lee , Soon-Hag Kim , Mi-Jin Kwon , Hyun-Gu Kang , Sung-Ho Ryu , Jong-In Kim , Youn-Dong Kim , Young-Chan Chae , Sung-Key Jang , Jong-Hun Im , Sun-Hak Lee , Hye-Jung Lee , Eun-Jung Jang , Ki-Seok Kim
发明人： Jung-Hwan Lee , Soon-Hag Kim , Mi-Jin Kwon , Hyun-Gu Kang , Sung-Ho Ryu , Jong-In Kim , Youn-Dong Kim , Young-Chan Chae , Sung-Key Jang , Jong-Hun Im , Sun-Hak Lee , Hye-Jung Lee , Eun-Jung Jang , Ki-Seok Kim
IPC分类号： C12N15/11
CPC分类号： G01N33/57496 , C12N15/115 , C12N2310/16 , C12N2310/335
摘要： Improved G-rich oligonucleotide (GRO) aptamers specific to nucleolin, a method of preparing the aptamers, and a use of the aptamers for diagnosing and/or treating a nucleolin-associated disease, are provided.
摘要翻译： 提供了改进的对核仁林特异性的富G寡核苷酸（GRO）适配体，制备适体的方法，以及适配体用于诊断和/或治疗核仁素相关疾病的用途。
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6.发明授权Method of preparing 5′-amino-linker oligonucleotides derivatives and analogous 5′-labeled-linker oligonucleotides therefrom 有权从其中制备5'-氨基 - 连接寡核苷酸衍生物和类似的5'-标记 - 接头寡核苷酸的方法公开(公告)号：US08124756B2
公开(公告)日：2012-02-28
申请号：US12559666
申请日：2009-09-15
申请人： Jung-Hwan Lee , Hyun-Gu Kang , Sung-Ho Ryu , Jong-In Kim , Sun-Hak Lee , Hye-Jung Lee , Eun-Jung Jang
发明人： Jung-Hwan Lee , Hyun-Gu Kang , Sung-Ho Ryu , Jong-In Kim , Sun-Hak Lee , Hye-Jung Lee , Eun-Jung Jang
IPC分类号： C07H21/00
摘要： A method for preparing amino linker oligonucleotides is provided. More specifically, a method of preparing 5′-amino-linker oligonucleotides comprising the steps of: introducing an amino linker having a protecting group into the 5′ terminus of an oligonucleotide; and removing the protecting group from the amino linker oligonucleotide by contacting with acetic acid and 2,2,2-trifluoroethanol is provided. The amino protecting group is efficiently removed from the amino linker oligonucleotides, and thereby achieving a high yield of the amino linker oligonucleotides.
摘要翻译： 提供了制备氨基接头寡核苷酸的方法。 更具体地说，制备5'-氨基连接寡核苷酸的方法包括以下步骤：将具有保护基的氨基接头引入寡核苷酸的5'末端; 并通过与乙酸和2,2,2-三氟乙醇接触，从氨基接头寡核苷酸中除去保护基。 从氨基接头寡核苷酸有效地除去氨基保护基，从而达到高产量的氨基接头寡核苷酸。
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7.发明申请REPARATION METHOD OF AN AMINO LINKER OLIGONUCLEOTIDES AND LABELED-LINKER OLIGONUCLEOTIDE THEREFROM 有权氨基连接子寡核苷酸和标记的寡核苷酸寡核苷酸的重复方法公开(公告)号：US20100093994A1
公开(公告)日：2010-04-15
申请号：US12559666
申请日：2009-09-15
申请人： Jung-Hwan LEE , Hyun-Gu Kang , Sung-Ho Ryu , Jong-In Kim , Sun-Hak Lee , Hye-Jung Lee , Eun-Jung Jang
发明人： Jung-Hwan LEE , Hyun-Gu Kang , Sung-Ho Ryu , Jong-In Kim , Sun-Hak Lee , Hye-Jung Lee , Eun-Jung Jang
IPC分类号： C08B37/00
摘要： A method for preparing amino linker oligonucleotides is provided, wherein an amino protecting group is efficiently removed from the amino linker oligonucleotides protected by the protecting group, and thereby achieving a high yield of the amino linker oligonucleotides.
摘要翻译： 提供了制备氨基接头寡核苷酸的方法，其中氨基保护基被有效地从保护基保护的氨基接头寡核苷酸中除去，从而达到高产量的氨基接头寡核苷酸。
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公开(公告)号：US08785132B2
公开(公告)日：2014-07-22
申请号：US13092209
申请日：2011-04-22
申请人： Young-Chan Chae , Youn-Dong Kim , Jung-Hwan Lee , Ki-Seok Kim , Dong-II Han , Bum-Su Park , Seung-Jin Lee , Jong-Hun Im , Jong-In Kim , Sung-Ho Ryu , Sung-Key Jang
发明人： Young-Chan Chae , Youn-Dong Kim , Jung-Hwan Lee , Ki-Seok Kim , Dong-II Han , Bum-Su Park , Seung-Jin Lee , Jong-Hun Im , Jong-In Kim , Sung-Ho Ryu , Sung-Key Jang
CPC分类号： G01N33/5308
摘要： The present invention provides methods for identifying the plurality of aptamers that bind to different sites of a target molecule and methods for using the same, for example, in sandwich assays. In particular, the plurality of aptamers binding to different sites of the target molecules is identified from a library of aptamers identified from the same SELEX process.
摘要翻译： 本发明提供用于鉴定结合靶分子的不同位点的多个适体的方法以及使用其的方法，例如在夹心测定中。 特别地，从相同SELEX过程鉴定的适配体文库中鉴定结合靶分子不同位点的多个适体。
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9.发明申请公开(公告)号：US20110171968A1
公开(公告)日：2011-07-14
申请号：US12917266
申请日：2010-11-01
申请人： Dong-Joon Hyun , Sung-Ho Ryu , Seok-Hyun Yoon , Hee-Seon Park , Min-Hyok Bang , Dong-Hun Park
发明人： Dong-Joon Hyun , Sung-Ho Ryu , Seok-Hyun Yoon , Hee-Seon Park , Min-Hyok Bang , Dong-Hun Park
IPC分类号： H04W24/00
CPC分类号： G06Q10/107 , G06Q30/0255 , G06Q30/0261 , G06Q30/0267 , H04W4/025 , H04W4/12 , H04W4/185 , H04W64/003
摘要： A method and apparatus for locating a mobile terminal by use of messages received to the mobile terminal are provided. The mobile terminal locating method may include creating at least one location related candidate for the mobile terminal by use of a message that is received to the mobile terminal, and determining a location of the mobile terminal by matching the created location related candidate to stored place information. The current location of the mobile terminal may be recognized by simply analyzing the received messages without the need for installation of additional device on the mobile terminal.
摘要翻译： 提供了一种通过使用接收到移动终端的消息来定位移动终端的方法和装置。 移动终端定位方法可以包括通过使用接收到移动终端的消息来创建移动终端的至少一个位置相关的候选，并且通过将所创建的位置相关候选者与存储的地点信息相匹配来确定移动终端的位置 。 可以通过简单地分析所接收的消息来识别移动终端的当前位置，而不需要在移动终端上安装附加设备。
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公开(公告)号：US07074891B2
公开(公告)日：2006-07-11
申请号：US10774147
申请日：2004-02-05
申请人： Sung-Ho Ryu , Yoe-Sik Bae , Eun-Young Park , Pann-Ghill Suh
发明人： Sung-Ho Ryu , Yoe-Sik Bae , Eun-Young Park , Pann-Ghill Suh
摘要： The present application describes peptides that stimulate arachidonic acid release in target cells. The application also discloses peptides that cause intracellular calcium release.
摘要翻译： 本申请描述了刺激靶细胞中花生四烯酸释放的肽。 本申请还公开了引起细胞内钙释放的肽。
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