摘要:
The invention relates to a novel bioconjugation protocol for peptide suitable for in vivo applications. Bioconjugation of the peptide to HA derivative increases its half life in circulation contributing for a high efficacy. More over, conjugate of HA derivative and peptide which is treated with hyaluronidase shows increased bioactivity. And also, in contrast to PEGylation, HA derivative can be conjugated with many numbers of peptide molecules per single HA derivative chain, which enables multiple action of peptide drugs.
摘要:
In a stacked semiconductor device and method of manufacturing the same, an insulation multilayer pattern is formed on a substrate. The insulation multilayer pattern includes a first insulating interlayer pattern, a second insulating interlayer pattern and an opening exposing a surface of the substrate. A first channel pattern may be interposed between the first insulating interlayer pattern and the second insulating interlayer pattern, with a sidewall of the channel pattern being exposed through the opening. A barrier metal layer including a first continuous sub-layer is provided along a sidewall and bottom surface of the opening. The first sub-layer may have a substantially uniform thickness around the first channel pattern.
摘要:
In a capacitor having a high dielectric constant, the capacitor includes a cylindrical lower electrode, a dielectric layer and an upper electrode. A metal oxide layer is formed on inner, top and outer surfaces of the lower electrode as the dielectric layer. A first sub-electrode is formed on a surface of the dielectric layer along the profile of the lower electrode and a second sub-electrode is continuously formed on the first sub-electrode corresponding to the top surface of the lower electrode, so an opening portion of the lower electrode is covered with the second sub-electrode. The first and second sub-electrodes include first and second metal nitride layers in which first and second stresses are applied, respectively. Directions of the first and second stresses are opposite to each other. Accordingly, cracking is minimized in the upper electrode with the high dielectric constant, thereby reducing current leakage.
摘要:
In an embodiment, a method of forming a lower electrode of a capacitor in a semiconductor memory device includes etching a mold oxide layer to have at a cylindrical structure, resulting in an electrode with increased surface area. The cylindrical structure may have more than one radius. This increased surface area results in an increased capacitance. An excessive etch phenomenon, which occurs because a sacrificial oxide layer is etched at a higher rate than the mold oxide layer, is avoided.
摘要:
In a capacitor having a high dielectric constant, the capacitor includes a cylindrical lower electrode, a dielectric layer and an upper electrode. A metal oxide layer is formed on inner, top and outer surfaces of the lower electrode as the dielectric layer. A first sub-electrode is formed on a surface of the dielectric layer along the profile of the lower electrode and a second sub-electrode is continuously formed on the first sub-electrode corresponding to the top surface of the lower electrode, so an opening portion of the lower electrode is covered with the second sub-electrode. The first and second sub-electrodes include first and second metal nitride layers in which first and second stresses are applied, respectively. Directions of the first and second stresses are opposite to each other. Accordingly, cracking is minimized in the upper electrode with the high dielectric constant, thereby reducing current leakage.
摘要:
In an embodiment, a method of forming a lower electrode of a capacitor in a semiconductor memory device includes etching a mold oxide layer to have at a cylindrical structure, resulting in an electrode with increased surface area. The cylindrical structure may have more than one radius. This increased surface area results in an increased capacitance. An excessive etch phenomenon, which occurs because a sacrificial oxide layer is etched at a higher rate than the mold oxide layer, is avoided.
摘要:
A semiconductor device, and a method of fabricating the same, includes cobalt as a capping layer. An interconnection structure of the semiconductor device has an improved via resistance. In the semiconductor device, a single cobalt layer or a composite film including a cobalt layer and a titanium nitride layer is used as the capping layer of a metal layer.
摘要:
A semiconductor device, and a method of fabricating the same, includes cobalt as a capping layer. An interconnection structure of the semiconductor device has an improved via resistance. In the semiconductor device, a single cobalt layer or a composite film including a cobalt layer and a titanium nitride layer is used as the capping layer of a metal layer.
摘要:
The nozzle error correction method is provided for adjusting information of an output image to correct an error nozzle. A position of an error nozzle firing an ink amount different from a reference value is detected from a plurality of nozzles. A determination is made from an input image as to whether a current pixel for output is an error pixel of the detected error nozzle. A channel value of the error nozzle is set to a certain value if the current pixel is the error pixel. However, if the current pixel is not the error pixel, a determination is made as to whether an error pixel exists in a certain area around the current pixel. A value of the current pixel is then adjusted based on error information. Image-processing is performed in order for the current pixel to be outputted, if the error pixel exists in the certain area. Accordingly, degradation of a print speed and a shortened life span of the head are prevented.
摘要:
The image encoder includes a block arrangement unit configured to chromatically subsample an externally input image signal and to arrange the image signal in units of a plurality of blocks, a plurality of Discrete Cosine Transform (DCT) units configured to perform DCT with respect to the image signal divided into the plurality of blocks, a plurality of quantization units configured to quantize the outputs of the plurality of DCT units, a delta modulation unit configured to perform Differential Pulse Code Modulation (DPCM) with respect to the outputs of the plurality of quantization units, a plurality of Huffman encoding units configured to encode the outputs of the delta modulation units using a Huffman encoding method, and a code connection unit configured to reconstruct the signals output from the plurality of Huffman encoding units in constant bit units and to output a compressed image signal. Since the image is encoded in parallel, it is possible to increase encoding speed.