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    Defining virtual patient populations
    5.
    发明申请
    Defining virtual patient populations 审中-公开
    定义虚拟患者人群

    公开(公告)号：US20070026365A1

    公开(公告)日：2007-02-01

    申请号：US11346990

    申请日：2006-02-03

    申请人： Christina Friedrich ,  Anuraag Kansal ,  David Klinke ,  Seth Michelson ,  Thomas Paterson ,  David Polidori ,  Jeff Trimmer ,  Leif Wennerberg

    发明人： Christina Friedrich ,  Anuraag Kansal ,  David Klinke ,  Seth Michelson ,  Thomas Paterson ,  David Polidori ,  Jeff Trimmer ,  Leif Wennerberg

    IPC分类号： G09B19/00

    CPC分类号： G06Q50/22 ,  G06F19/324 ,  G16B5/00 ,  G16H10/20

    摘要： The invention encompasses methods, including computer-implemented methods, of defining a virtual patient population and mapping the virtual patient population to a population of real patients. The invention utilizes virtual measures from one or more virtual patients, and data representative of multiple real subjects in a sample population, such as data collected from patients in a clinical trial or epidemiological study of a real population. The invention includes evaluating the similarity between the virtual patients and the real subjects, and assigning prevalences to the virtual patients based on the evaluation. The similarity can be assessed using some or all of the virtual measures of the virtual patients and some or all of the data obtained for the real subjects. Any of various goodness-of-fit measures can be used to evaluate the similarity or to help identify prevalences. The virtual patient population is defined as the virtual patients according to their respective prevalences.

    摘要翻译： 本发明涵盖包括计算机实现的方法，定义虚拟患者人群并将虚拟患者人群映射到真实病人群体的方法。 本发明利用来自一个或多个虚拟患者的虚拟测量，以及代表样本群体中的多个实际受试者的数据，例如在临床试验或对真实人群的流行病学研究中从患者收集的数据。 本发明包括评估虚拟患者与实际受试者之间的相似性，并根据评估将流行率分配给虚拟患者。 可以使用虚拟患者的一些或全部虚拟测量以及为真实对象获得的部分或全部数据来评估相似性。 可以使用任何适合度的措施来评估相似性或帮助确定流行率。 虚拟患者群体根据各自的流行率定义为虚拟患者。

    Treatment of rheumatoid arthritis with hypoxia inducible factor-1alpha antagonists
    9.
    发明申请
    Treatment of rheumatoid arthritis with hypoxia inducible factor-1alpha antagonists 审中-公开
    用缺氧诱导因子-1α拮抗剂治疗类风湿性关节炎

    公开(公告)号：US20050148496A1

    公开(公告)日：2005-07-07

    申请号：US10997764

    申请日：2004-11-24

    申请人： Nadine Defranoux ,  Vincent Hurez ,  Seth Michelson ,  Lisl Shoda ,  Leif Wennerberg

    发明人： Nadine Defranoux ,  Vincent Hurez ,  Seth Michelson ,  Lisl Shoda ,  Leif Wennerberg

    IPC分类号： A61K38/17 ,  A61K45/00 ,  A61K45/06 ,  A61K48/00

    CPC分类号： A61K45/06

    摘要： The invention encompasses a novel method of treating inflammatory disease, such as rheumatoid arthritis, and novel methods of identifying and screening for drugs useful in the treatment of inflammatory diseases and their clinical symptoms. The inventors have made the discovery that the activity of HIF-1α, a transcription regulator known to have an effect on some cancers, has a significant impact on the pathophysiology of rheumatoid arthritis. The symptoms of an inflammatory disease, such as rheumatoid arthritis, may be alleviated by administering a compound that inhibits the activity of HIF-1α.

    摘要翻译： 本发明包括治疗炎性疾病如类风湿性关节炎的新方法，以及鉴定和筛选可用于治疗炎性疾病及其临床症状的药物的新方法。 本发明人已经发现，已知对某些癌症有影响的转录调节因子HIF-1α的活性对类风湿性关节炎的病理生理学具有显着的影响。 可以通过施用抑制HIF-1α活性的化合物来缓解炎性疾病如类风湿性关节炎的症状。