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    Piperazine derivatives, of aromatic acids
    1.
    发明授权
    Piperazine derivatives, of aromatic acids 失效
    哌嗪衍生物，芳香酸

    公开(公告)号：US4443603A

    公开(公告)日：1984-04-17

    申请号：US381443

    申请日：1982-05-24

    申请人： Setsuro Fujii ,  Eizou Hattori ,  Mitsuteru Hirata ,  Koichiro Watanabe ,  Hiroshi Ishihama

    发明人： Setsuro Fujii ,  Eizou Hattori ,  Mitsuteru Hirata ,  Koichiro Watanabe ,  Hiroshi Ishihama

    IPC分类号： C07D295/18 ,  A61K31/495 ,  A61P43/00 ,  C07D207/24 ,  C07D209/18 ,  C07D295/088 ,  C07D295/13 ,  C07D295/15 ,  C07D295/185 ,  C07D403/12 ,  C07D241/04

    CPC分类号： C07D295/185 ,  C07D207/24 ,  C07D209/18 ,  C07D295/088 ,  C07D295/13 ,  C07D295/15

    摘要： A piperazine derivartive represented by the following formula: ##STR1## wherein R.sub.1 : an indolyl group which may optionally be substituted by one or more lower alkyl and/or lower alkoxy groups, naphthyl group which may optionally be saturated partially with 2 or 4 hydrogen atoms, or phenyl or cyclohexyl group which may optionally be substituted by one or more lower alkyl groups;A: a single bond or alkylene group;P: a single bond or vinylene group;Q: an -O-alkylene group or -NH-alkylene group when P is a single bond, or a single bond when P is a vinylene group; andR.sub.2 : a lower alkyl, morpholino-lower alkyl, morpholino-carbonyl lower alkyl, piperidinocarbonyl lower alkyl, piperazinocarbonyl lower alkyl or lower alkylaminocarbonyl lower alkyl group, or an acid addition salt thereof is a proteolytic enzyme inhibitor.

    摘要翻译： 由下式表示的哌嗪衍生物：其中R 1：可任选被一个或多个低级烷基和/或低级烷氧基取代的吲哚基，可任选地被2或4个氢原子部分饱和的萘基 ，或可任意被一个或多个低级烷基取代的苯基或环己基; A：单键或亚烷基; P：单键或亚乙烯基; Q：当P为单键时为-O-亚烷基或-NH-亚烷基，或当P为亚乙烯基时为单键; R2为低级烷基，吗啉代低级烷基，吗啉代羰基低级烷基，哌啶子基羰基低级烷基，哌嗪基羰基低级烷基或低级烷基氨基羰基低级烷基，或其酸加成盐为蛋白水解酶抑制剂。

    Phenyl guanidinobenzoate derivatives which have protease inhibitory activity
    4.
    发明授权
    Phenyl guanidinobenzoate derivatives which have protease inhibitory activity 失效
    具有蛋白酶抑制活性的苯胍基苯甲酸酯衍生物

    公开(公告)号：US4746737A

    公开(公告)日：1988-05-24

    申请号：US886046

    申请日：1986-07-16

    申请人： Setsuro Fujii ,  Eizou Hattori ,  Mitsuteru Hirata ,  Koichiro Watanabe ,  Tomio Ohta ,  Nobuo Yokoo ,  Masahiko Nagakura

    发明人： Setsuro Fujii ,  Eizou Hattori ,  Mitsuteru Hirata ,  Koichiro Watanabe ,  Tomio Ohta ,  Nobuo Yokoo ,  Masahiko Nagakura

    IPC分类号： C07C279/18 ,  C07D207/16 ,  C07D207/26 ,  C07D207/27 ,  C07D243/08 ,  C07D295/185 ,  C07D265/30

    CPC分类号： C07D207/27 ,  C07C279/18 ,  C07D207/16 ,  C07D243/08 ,  C07D295/185

    摘要： Novel benzoyl esters of the following formula (I), and acid addition salts thereof, ##STR1## in which R.sub.1 and R.sub.2 are the same or different and represent a hydrogen atom or a lower alkoxy group, A represents a single bond, a linear or branched lower alkylene group, a lower alkenylene group, R.sub.3 and R.sub.4 are the same or different and represent a hydrogen atom or a lower alkyl group, or R.sub.3 and R.sub.4 join together to form a lower alkylene group, R.sub.5 represents a group of the formula, --X--(CO).sub.n --Y in which X represents a single bond, a linear or branched lower alkylene group or an alkenylene group, n is 0 or 1, Y represents a hydrogen atom, a cycloalkyl group, an aryl group, a hydroxyl group, a lower alkoxy group and the like are prepared by reacting para-nitrobenzoic acid or its derivative with a compound of the general formula (III) or its derivative ##STR2## to obtain a compound of the general formula (IV) ##STR3## followed by reducing the compound of the formula (IX) ##STR4## and subjecting the compound (IX) to guanidylation reaction, or by reaction para-guanidinobenzoic derivative with compound (III) or its derivative.The benzoyl esters have strong anti-trypsin activity, anti-thrombin activity and anticoagulant activity with low toxicity and are useful as a medicine for treatment of pancreatitis and disseminated intravascular coagulation (DIC).

    摘要翻译： 下式（I）的新型苯甲酰基酯及其酸加成盐，其中R 1和R 2相同或不同，表示氢原子或低级烷氧基，A表示单键， 直链或支链低级亚烷基，低级亚烯基，R3和R4相同或不同，表示氢原子或低级烷基，或R3和R4连接在一起形成低级亚烷基，R5表示 其中X表示单键的-X-（CO）nY，直链或支链低级亚烷基或亚烯基，n为0或1，Y表示氢原子，环烷基，芳基， 通过使对硝基苯甲酸或其衍生物与通式（III）的化合物或其衍生物（IMAGE）（III）反应来制备羟基，低级烷氧基等，以获得通式（III）的化合物 （Ⅳ），然后还原式（Ⅸ）化合物（IX）和 使化合物（IX）进行胍基化反应，或通过反应对 - 胍基苯甲酸衍生物与化合物（III）或其衍生物反应。 苯甲酰酯具有很强的抗胰蛋白酶活性，抗凝血酶活性和抗凝血活性，毒性低，可用作治疗胰腺炎和弥散性血管内凝血（DIC）的药物。

    Non-aqueous electrolyte secondary battery, negative electrode material, and making method
    6.
    发明授权
    Non-aqueous electrolyte secondary battery, negative electrode material, and making method 有权
    非水电解质二次电池，负极材料及制造方法

    公开(公告)号：US08105718B2

    公开(公告)日：2012-01-31

    申请号：US12404710

    申请日：2009-03-16

    申请人： Tetsuo Nakanishi ,  Koichiro Watanabe ,  Hirofumi Fukuoka

    发明人： Tetsuo Nakanishi ,  Koichiro Watanabe ,  Hirofumi Fukuoka

    IPC分类号： H01M4/13 ,  B05D5/12

    CPC分类号： H01M10/0525 ,  H01M4/0428 ,  H01M4/134 ,  H01M4/1395 ,  H01M4/364 ,  H01M4/366 ,  H01M4/386 ,  H01M4/483 ,  H01M4/622 ,  H01M4/625

    摘要： A negative electrode material comprising an active material and 1-20 wt % of a polyimide resin binder is suitable for use in non-aqueous electrolyte secondary batteries. The active material comprises silicon oxide particles and 1-50 wt % of silicon particles. The negative electrode exhibits improved cycle performance while maintaining the high battery capacity and low volume expansion of silicon oxide. The non-aqueous electrolyte secondary battery has a high initial efficiency and maintains improved performance and efficiency over repeated charge/discharge cycles by virtue of mitigated volumetric changes during charge/discharge cycles.

    摘要翻译： 包含活性物质的负极材料和1-20重量％的聚酰亚胺树脂粘合剂适用于非水电解质二次电池。 活性材料包括氧化硅颗粒和1-50重量％的硅颗粒。 负极具有改善的循环性能，同时保持高的电池容量和低的氧化硅体积膨胀。 非水电解质二次电池具有高的初始效率，并且通过在充电/放电循环期间减轻的体积变化，在重复的充电/放电循环中保持改进的性能和效率。

    SEPARATOR FOR LITHIUM SECONDARY BATTERY AND LITHIUM SECONDARY BATTERY USING THE SAME
    7.
    发明申请
    SEPARATOR FOR LITHIUM SECONDARY BATTERY AND LITHIUM SECONDARY BATTERY USING THE SAME 审中-公开
    锂二次电池和锂二次电池的分离器

    公开(公告)号：US20110159347A1

    公开(公告)日：2011-06-30

    申请号：US13062151

    申请日：2010-04-06

    申请人： Yasuyuki Shibano ,  Norihiro Yamamoto ,  Yasuo Shinohara ,  Koichiro Watanabe

    发明人： Yasuyuki Shibano ,  Norihiro Yamamoto ,  Yasuo Shinohara ,  Koichiro Watanabe

    IPC分类号： H01M2/16

    CPC分类号： H01M10/052 ,  H01M2/1646 ,  H01M2/1653 ,  H01M2/1686

    摘要： A separator 4 for a lithium secondary battery includes a porous film 12 including a polyolefin layer 16 and a lubricant layer 14 disposed on a surface of the porous film 12. The lubricant layer 14 includes a particulate substance 22 and has a three-dimensional surface roughness of 0.15 to 1.45 μm. The particulate substance 22 can adhere to the surface of the porous film 12 by electrostatic attraction. The porous film 12 can further include a heat-resistant porous layer 18 between the polyolefin layer 16 and the lubricant layer 14. The separator 4 allows a winding core for the lithium secondary battery to be pulled out smoothly.

    摘要翻译： 用于锂二次电池的隔板4包括多孔膜12，其包括聚烯烃层16和设置在多孔膜12的表面上的润滑剂层14.润滑剂层14包括颗粒物质22，并且具有三维表面粗糙度 为0.15〜1.45μm。 颗粒物质22可通过静电吸附附着在多孔膜12的表面上。 多孔膜12还可以包括在聚烯烃层16和润滑剂层14之间的耐热多孔层18.隔膜4使得用于锂二次电池的卷芯被平滑地拉出。