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公开(公告)号：US20080051656A1
公开(公告)日：2008-02-28
申请号：US11928667
申请日：2007-10-30
申请人： Shahram Vaezy , Arthur Chan , Victor Fujimoto , Donald Moore , Roy Martin
发明人： Shahram Vaezy , Arthur Chan , Victor Fujimoto , Donald Moore , Roy Martin
IPC分类号： A61N7/00
CPC分类号： A61N7/00 , A61B8/08 , A61B8/0833 , A61B8/0841 , A61B8/12 , A61B8/4209 , A61B8/4218 , A61B8/462 , A61B2017/2253 , A61B2017/4216 , A61B2090/378 , A61N7/02
摘要： A plurality of concepts related to HIFU therapy are disclosed, including a technique to spatially track and display the relative positions of a HIFU focal point and an imaging plane from an ultrasound imager, so that a clinician can ensure that the HIFU focus remains in the image plane during HIFU therapy, thereby facilitating image guided HIFU therapy. Also disclosed are a plurality of transvaginal probes that include a HIFU transducer optimized for the treatment of uterine fibroids. In one embodiment, the probe includes a piezoceramic crystal bonded to an aluminum lens, to achieve a HIFU transducer having a focal length of about 4 cm. In another embodiment, the probe includes a generally spoon-shaped transducer including a plurality of individual emitter elements. Still another concept disclosed herein is a method for evaluating a quality of a coupling between a liquid-filled volume encompassing a HIFU transducer and a tissue interface.
摘要翻译： 公开了与HIFU治疗相关的多个概念，包括从超声成像器空间跟踪和显示HIFU焦点和成像平面的相对位置的技术，使得临床医生可以确保HIFU焦点保留在图像中 在HIFU治疗期间平面，从而促进图像引导的HIFU治疗。 还公开了多个经阴道探针，其包括优化用于治疗子宫肌瘤的HIFU换能器。 在一个实施例中，探针包括结合到铝透镜的压电陶瓷晶体，以实现焦距为约4cm的HIFU换能器。 在另一个实施例中，探针包括一般包括多个单个发射器元件的匙形换能器。 本文公开的另一概念是用于评估包含HIFU换能器的液体填充体与组织界面之间的耦合质量的方法。
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2.发明申请公开(公告)号：US20050203399A1
公开(公告)日：2005-09-15
申请号：US10977339
申请日：2004-10-29
申请人： Shahram Vaezy , Arthur Chan , Victor Fujimoto , Donald Moore , Roy Martin
发明人： Shahram Vaezy , Arthur Chan , Victor Fujimoto , Donald Moore , Roy Martin
CPC分类号： A61N7/00 , A61B8/08 , A61B8/0833 , A61B8/0841 , A61B8/12 , A61B8/4209 , A61B8/4218 , A61B8/462 , A61B2017/2253 , A61B2017/4216 , A61B2090/378 , A61N7/02
摘要： A frame ensures that the alignment between a high intensity focused ultrasound (HIFU) transducer designed for vaginal use and a commercially available ultrasound image probe is maintained, so that the HIFU focus remains in the image plane during HIFU therapy. A water-filled membrane placed between the HIFU transducer and the treatment site provides acoustic coupling. The coupling is evaluated to determine whether any air bubbles exist at the coupling interface, which might degrade the therapy provided by the HIFU transducer. HIFU lesions on tissue appear as hyperechoic spots on the ultrasound image in real time during application of HIFU therapy. Ergonomic testing in humans has demonstrated clear visualization of the HIFU transducer relative to the uterus and showed the potential for the HIFU transducer to treat fibroids from the cervix to the fundus through the width of the uterus.
摘要翻译： 框架确保维持设计用于阴道使用的高强度聚焦超声（HIFU）换能器和商业上可获得的超声图像探针之间的对准，使得HIFU治疗期间HIFU焦点保留在图像平面中。 放置在HIFU换能器和处理部位之间的充水膜提供声耦合。 评估耦合以确定耦合界面是否存在任何气泡，这可能降低由HIFU传感器提供的治疗。 HIFU治疗期间组织上的HIFU损伤实时显示为超声图像上的高回声点。 人体工程学测试已经证明了HIFU传感器相对于子宫的清晰可视化，并显示HIFU传感器通过子宫宽度将子宫肌瘤从子宫颈治疗到眼底的潜力。
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3.发明申请公开(公告)号：US20050038340A1
公开(公告)日：2005-02-17
申请号：US10770350
申请日：2004-02-02
申请人： Shahram Vaezy , Roy Martin , Stephen Carter , Lawrence Crum
发明人： Shahram Vaezy , Roy Martin , Stephen Carter , Lawrence Crum
CPC分类号： A61B8/12 , A61B8/06 , A61B8/0833 , A61B8/445 , A61B8/4483 , A61B8/481 , A61B8/483 , A61B2017/4216 , A61B2090/378 , A61N7/02
摘要： Ultrasound contrast agents are used to enhance imaging and facilitate HIFU therapy in four different ways. A contrast agent is used: (1) before therapy to locate specific vascular structures for treatment; (2) to determine the focal point of a HIFU therapy transducer while the HIFU therapy transducer is operated at a relatively low power level, so that non-target tissue is not damaged as the HIFU is transducer is properly focused at the target location; (3) to provide a positive feedback mechanism by causing cavitation that generates heat, reducing the level of HIFU energy administered for therapy compared to that required when a contrast agent is not used; and, (4) to shield non-target tissue from damage, by blocking the HIFU energy. Various combinations of these techniques can also be employed in a single therapeutic implementation.
摘要翻译： 超声造影剂用于增强成像，并以四种不同的方式促进HIFU治疗。 使用造影剂：（1）治疗前定位特异性血管结构进行治疗; （2）确定HIFU治疗传感器的焦点，而HIFU治疗传感器在相对较低的功率水平下运行，使得非目标组织不会因HIFU换能器被适当地聚焦在目标位置而被损坏; （3）通过引起产生热量的空化来提供正反馈机制，与不使用造影剂时所需的HIFU能量相比，降低施用的HIFU能量水平; 和（4）通过阻止HIFU能量来屏蔽非靶组织免受损伤。 这些技术的各种组合也可以在单一治疗实施中使用。
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公开(公告)号：US20060184074A1
公开(公告)日：2006-08-17
申请号：US11369281
申请日：2006-03-07
申请人： Shahram Vaezy , Adrian Prokop , Roy Martin , Peter Kaczkowski , Misty Noble
发明人： Shahram Vaezy , Adrian Prokop , Roy Martin , Peter Kaczkowski , Misty Noble
CPC分类号： A61K41/0028 , A61B8/4281 , A61B2017/2253 , A61K49/226 , A61N7/02
摘要： The present invention employs hydrogels as acoustic couplings for clinical applications of ultrasound imaging and therapy, but is particularly applicable to high intensity focused ultrasound (HIFU) based therapy. While other materials can be used, it has been determined that polyacrylamide is sufficiently robust and transmissive to withstand the high temperatures encountered in HIFU therapy. One embodiment of a hydrogel coupling is configured in shape and size (length) to ensure that a focal region of an ultrasound transducer is disposed proximate the target area when the distal tip of the transducer is in contact with tissue. These couplings can be shaped to correspond to the beam focus characteristics of specific transducers. Water can be applied to hydrate the tip of the hydrogel coupling during use, and medication absorbed into the hydrogel material can be applied to the tissue in contact with the distal surface of the hydrogel.
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5.发明申请Treatment of unwanted tissue by the selective destruction of vasculature providing nutrients to the tissue 有权通过选择性破坏脉管系统来为组织提供营养物来治疗不想要的组织公开(公告)号：US20060052701A1
公开(公告)日：2006-03-09
申请号：US11207554
申请日：2005-08-18
申请人： Stephen Carter , Shahram Vaezy , Roy Martin , George Keilman , Lawrence Crum
发明人： Stephen Carter , Shahram Vaezy , Roy Martin , George Keilman , Lawrence Crum
CPC分类号： A61N7/02 , A61B8/08 , A61B8/4209 , A61B8/4254 , A61B8/4281 , A61B34/20 , A61B2034/2051 , A61B2090/378 , A61H23/0245
摘要： A noninvasive technique that can be used to deny blood flow to a particular region of tissue, without the inherent risks associated with invasive procedures such as surgery and minimally-invasive procedures such as embolization. Blood flow in selected portions of the vasculature can be occluded by selectively treating specific portions of the vasculature with high intensity focused ultrasound (HIFU). The occlusion denies undesired tissue the nutrients and oxygen provided by blood flow, causing necrosis in the undesired tissue. An imaging technology (such as magnetic resonance imaging, magnetic resonance angiography, ultrasound imaging, Doppler based ultrasound imaging, or computed tomographic angiography) is used to identify the undesired tissue, and the vascular structures associated with the undesired tissue. A portion of the vasculature providing blood flow to the undesired tissue is selected, and HIFU is administered to the selected portion of the vasculature to occlude blood flow through that portion of the vasculature.
摘要翻译： 一种非侵入性技术，可用于阻止血液流向组织的特定区域，而不会与诸如手术和诸如栓塞的微创手术等侵入性手术相关的固有风险。 通过用高强度聚焦超声（HIFU）选择性处理脉管系统的特定部分，可以阻断脉管系统选定部分的血流。 闭塞阻止不需要的组织由血液流动提供的营养物质和氧气，从而引起不想要的组织中的坏死。 使用成像技术（例如磁共振成像，磁共振血管造影术，超声成像，基于多普勒超声成像或计算机断层造影血管造影术）来鉴别不需要的组织以及与不想要的组织相关的血管结构。 选择向不想要的组织提供血液流动的脉管系统的一部分，并且将HIFU施用于脉管系统的选定部分以阻塞通过脉管系统的那部分的血流。
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6.发明授权Methods for using high intensity focused ultrasound and associated systems and devices 有权使用高强度聚焦超声及相关系统和装置的方法公开(公告)号：US08337434B2
公开(公告)日：2012-12-25
申请号：US12946727
申请日：2010-11-15
IPC分类号： A61H1/00
CPC分类号： A61N7/00 , A61B8/08 , A61B8/0833 , A61B8/0841 , A61B8/12 , A61B8/4209 , A61B8/4218 , A61B8/462 , A61B2017/2253 , A61B2017/4216 , A61B2090/378 , A61N7/02
摘要： A plurality of concepts related to HIFU therapy are disclosed, including a technique to spatially track and display the relative positions of a HIFU focal point and an imaging plane from an ultrasound imager, so that a clinician can ensure that the HIFU focus remains in the image plane during HIFU therapy, thereby facilitating image guided HIFU therapy. Also disclosed are a plurality of transvaginal probes that include a HIFU transducer optimized for the treatment of uterine fibroids. In one embodiment, the probe includes a piezoceramic crystal bonded to an aluminum lens, to achieve a HIFU transducer having a focal length of about 4 cm. In another embodiment, the probe includes a generally spoon-shaped transducer including a plurality of individual emitter elements. Still another concept disclosed herein is a method for evaluating a quality of a coupling between a liquid-filled volume encompassing a HIFU transducer and a tissue interface.
摘要翻译： 公开了与HIFU治疗相关的多个概念，包括从超声成像器空间跟踪和显示HIFU焦点和成像平面的相对位置的技术，使得临床医生可以确保HIFU焦点保留在图像中 在HIFU治疗期间平面，从而促进图像引导的HIFU治疗。 还公开了多个经阴道探针，其包括优化用于治疗子宫肌瘤的HIFU换能器。 在一个实施例中，探针包括结合到铝透镜的压电陶瓷晶体，以实现焦距为约4cm的HIFU换能器。 在另一个实施例中，探针包括一般包括多个单个发射器元件的匙形换能器。 本文公开的另一概念是用于评估包含HIFU换能器的液体填充体与组织界面之间的耦合质量的方法。
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公开(公告)号：US20120316426A1
公开(公告)日：2012-12-13
申请号：US13590146
申请日：2012-08-20
申请人： Jessica L. Foley , Shahram Vaezy , James W. Little
发明人： Jessica L. Foley , Shahram Vaezy , James W. Little
CPC分类号： A61B8/13 , A61B5/0035 , A61B8/0808 , A61B8/4209 , A61B8/4254 , A61B8/4272 , A61B8/4281 , A61B2017/320069 , A61B2090/378 , A61N7/02
摘要： A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic effect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversibly block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures.
摘要翻译： 一种使用高强度聚焦超声（HIFU）治疗神经结构以达到理想治疗效果的方法。 根据施用的HIFU的剂量，它可以对神经结构具有可逆或不可逆的作用。 例如，相对高剂量的HIFU可用于永久性阻断神经功能，提供切断神经以治疗严重痉挛状态的非侵入性替代方案。 相对较低剂量的HIFU可用于可逆地阻断神经功能，减轻疼痛，达到麻醉效果，或达到美容效果。 如果感觉神经对于自愿功能不是必需的，而是涉及与肿瘤或骨癌相关的疼痛，HIFU可用于非侵入性地破坏这种感觉神经以缓解没有药物的疼痛。 优选地，与HIFU治疗同步的超声成像被用于提供神经结构的实时超声图像引导的HIFU治疗。
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公开(公告)号：US20050240126A1
公开(公告)日：2005-10-27
申请号：US11016701
申请日：2004-12-16
申请人： Jessica Foley , Shahram Vaezy , James Little
发明人： Jessica Foley , Shahram Vaezy , James Little
CPC分类号： A61B8/06 , A61B8/0816 , A61B8/0833 , A61B8/12 , A61B8/4209 , A61B8/4254 , A61B8/4281 , A61B8/4444 , A61B8/481 , A61B8/483 , A61B2017/4216 , A61B2018/00434 , A61B2090/378 , A61N7/02
摘要： A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic affect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversible a block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures.
摘要翻译： 一种使用高强度聚焦超声（HIFU）治疗神经结构以达到理想的治疗效果的方法。 根据施用的HIFU的剂量，它可以对神经结构具有可逆或不可逆的作用。 例如，相对高剂量的HIFU可用于永久性阻断神经功能，提供切断神经以治疗严重痉挛状态的非侵入性替代方案。 相对较低剂量的HIFU可用于逆转阻断神经功能，减轻疼痛，达到麻醉效果，或达到美容效果。 如果感觉神经对于自愿功能不是必需的，而是涉及与肿瘤或骨癌相关的疼痛，HIFU可用于非侵入性地破坏这种感觉神经以缓解没有药物的疼痛。 优选地，与HIFU治疗同步的超声成像被用于提供神经结构的实时超声图像引导的HIFU治疗。
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9.发明授权公开(公告)号：US06716184B2
公开(公告)日：2004-04-06
申请号：US10166795
申请日：2002-06-07
申请人： Shahram Vaezy , Roy W. Martin , Stephen J. Carter , George W. Keilman , Victor Y. Fujimoto , Lawrence A. Crum
发明人： Shahram Vaezy , Roy W. Martin , Stephen J. Carter , George W. Keilman , Victor Y. Fujimoto , Lawrence A. Crum
IPC分类号： A61N700
CPC分类号： A61B8/4488 , A61B8/06 , A61B8/0833 , A61B8/12 , A61B8/4209 , A61B8/4254 , A61B8/445 , A61B8/4483 , A61B8/481 , A61B8/483 , A61B2017/4216 , A61B2090/378 , A61N7/02
摘要： Method and apparatus for the simultaneous use of ultrasound on a probe for imaging and therapeutic purposes. The probe limits the effects of undesirable interference noise in a display by synchronizing high intensity focused ultrasound (HIFU) waves with an imaging transducer to cause the noise to be displayed in an area of the image that does not overlap the treatment site. In one embodiment, the HIFU is first energized at a low power level that does not cause tissue damage, so that the focal point of the HIFU can be identified by a change in the echogenicity of the tissue caused by the HIFU. Once the focal point is properly targeted on a desired treatment site, the power level is increased to a therapeutic level. The location of each treatment site is stored and displayed to the user to enable a plurality of spaced-apart treatment sites to be achieved. As the treatment progresses, any changes in the treatment site can be seen in the real time, noise-free image. A preferred application of the HIFU waves is to cause lesions in blood vessels, so that the supply of nutrients and oxygen to a region, such as a tumor, is interrupted. The tumor will thus eventually be destroyed. In a preferred embodiment, the HIFU is used to treat disorders of the female reproductive system, such as uterine fibroids. The HIFU treatment can be repeated at spaced-apart intervals, until any remaining fibroid tissue is destroyed.
摘要翻译： 用于在探针上同时使用超声波用于成像和治疗目的的方法和装置。 该探针通过将高强度聚焦超声波（HIFU）波与成像换能器同步来将显示中的不期望的干扰噪声的影响限制在使得噪声显示在不与治疗部位重叠的图像区域中。 在一个实施例中，HIFU首先在不会导致组织损伤的低功率水平下通电，使得可以通过由HIFU引起的组织的回波反射性的变化来识别HIFU的焦点。 一旦焦点适当地对准所需的治疗部位，功率水平就提高到治疗水平。 每个治疗部位的位置被存储并显示给使用者，以实现多个间隔开的治疗部位。 随着治疗的进行，治疗部位的任何变化都可以在实时，无噪音的图像中看到。 HIFU波的优选应用是引起血管中的损伤，使得诸如肿瘤等区域的营养物和氧气供应被中断。 因此肿瘤最终将被破坏。 在优选的实施方案中，HIFU用于治疗女性生殖系统的疾病，例如子宫肌瘤。 可以间隔间隔重复HIFU治疗，直到残留的纤维组织被破坏为止。
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公开(公告)号：US07510536B2
公开(公告)日：2009-03-31
申请号：US11016701
申请日：2004-12-16
申请人： Jessica L. Foley , Shahram Vaezy , James W. Little
发明人： Jessica L. Foley , Shahram Vaezy , James W. Little
CPC分类号： A61B8/06 , A61B8/0816 , A61B8/0833 , A61B8/12 , A61B8/4209 , A61B8/4254 , A61B8/4281 , A61B8/4444 , A61B8/481 , A61B8/483 , A61B2017/4216 , A61B2018/00434 , A61B2090/378 , A61N7/02
摘要： A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic affect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversible a block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures.
摘要翻译： 一种使用高强度聚焦超声（HIFU）治疗神经结构以达到理想的治疗效果的方法。 根据施用的HIFU的剂量，它可以对神经结构具有可逆或不可逆的作用。 例如，相对高剂量的HIFU可用于永久性阻断神经功能，提供切断神经以治疗严重痉挛状态的非侵入性替代方案。 相对较低剂量的HIFU可用于逆转阻断神经功能，减轻疼痛，达到麻醉效果，或达到美容效果。 如果感觉神经对于自愿功能不是必需的，而是涉及与肿瘤或骨癌相关的疼痛，HIFU可用于非侵入性地破坏这种感觉神经以缓解没有药物的疼痛。 优选地，同步到HIFU治疗超声成像用于提供神经结构的实时超声图像引导HIFU疗法。
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