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公开(公告)号：US20100240638A1
公开(公告)日：2010-09-23
申请号：US12527787
申请日：2008-02-19
申请人： Shawn D. Britt , Jiping Fu , David Thomas Parker , Michiael Patane , Parkash Raman , Branko Radetich , Mohindra Seepersaud , Aregahegn Yifru , Rui Zheng , Trixi Brand , Sylvain Cottens , Claus Ehrhardt , Stefan Andreas Randl , Pascal Rigollier , Nikolaus Schiering , Oliver Simic
发明人： Shawn D. Britt , Jiping Fu , David Thomas Parker , Michiael Patane , Parkash Raman , Branko Radetich , Mohindra Seepersaud , Aregahegn Yifru , Rui Zheng , Trixi Brand , Sylvain Cottens , Claus Ehrhardt , Stefan Andreas Randl , Pascal Rigollier , Nikolaus Schiering , Oliver Simic
IPC分类号： C07D285/00 , A61K38/13 , A61K31/33 , A61K31/00 , A61K31/551 , A61K31/5025 , A61K31/5377 , A61K31/50 , A61K31/496 , A61K31/497 , A61K31/519 , A61K31/4375 , A61K31/437 , A61K31/47 , A61K31/4523 , A61K31/4427 , A61K31/403 , A61P31/12 , A61P35/04 , A61P1/16 , A61P37/00
CPC分类号： C07D513/04 , C07D257/02 , C07D285/00 , C07D487/04 , C07D487/08 , C07D498/04 , C07D515/04 , C07D519/00 , C07K5/0202 , C07K5/0207 , C07K5/0804 , C07K5/0827 , C07K5/1008 , C07K5/1024
摘要： The present application describes macrocyclic compounds of formula (I) with NS3 protease inhibitory activity for treating hepatitis C virus infection.
摘要翻译： 本申请描述了式（I）的大环化合物与用于治疗丙型肝炎病毒感染的NS3蛋白酶抑制活性。
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公开(公告)号：US20100204159A1
公开(公告)日：2010-08-12
申请号：US12440139
申请日：2007-09-11
申请人： Trixl Brandl , Sylvain Cottens , Claus Ehrhardt , Jiping Fu , Subramanian Karur , David Thomas Parker , Michael A. Patane , Prakash Raman , Stefan Andreas Randl , Pascal Rigollier , Mohindra Seepersaud , Oliver Simic
发明人： Trixl Brandl , Sylvain Cottens , Claus Ehrhardt , Jiping Fu , Subramanian Karur , David Thomas Parker , Michael A. Patane , Prakash Raman , Stefan Andreas Randl , Pascal Rigollier , Mohindra Seepersaud , Oliver Simic
IPC分类号： A61K38/06 , C07D417/14 , A61P31/14 , A61K38/05 , C07K5/083
CPC分类号： C07D417/14 , C07D401/12 , C07D419/14 , C07K5/06078 , C07K5/0808 , C07K5/0823 , C12N2770/24211
摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
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公开(公告)号：US08309596B2
公开(公告)日：2012-11-13
申请号：US12665892
申请日：2008-06-26
申请人： Stefanie Flohr , Stefan Andreas Randl , Nils Ostermann , Ulrich Hassiepen , Frederic Berst , Ursula Bodendorf , Bernd Gerhartz , Andreas Marzinzik , Claus Ehrhardt , Josef Gottfried Meingassner
发明人： Stefanie Flohr , Stefan Andreas Randl , Nils Ostermann , Ulrich Hassiepen , Frederic Berst , Ursula Bodendorf , Bernd Gerhartz , Andreas Marzinzik , Claus Ehrhardt , Josef Gottfried Meingassner
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/437 , A61K31/4375 , A61K31/404 , A61K31/4035 , A61K31/403 , A61K31/4025 , A61K31/40 , C07D413/12 , C07D409/12 , C07D405/12 , C07D401/12 , C07D403/12 , C07D217/26 , C07D211/60 , C07D209/42 , C07D209/44 , C07D209/52 , C07D207/16
CPC分类号： A61K31/401 , A61K31/4025 , A61K31/403 , A61K31/4035 , A61K31/404 , A61K31/4439 , A61K31/4545 , A61K31/496 , C07D207/16 , C07D209/42 , C07D209/52 , C07D211/60 , C07D401/12 , C07D405/12 , C07K2299/00 , C12N9/6445 , C12Y304/21034
摘要： The present invention relates to the crystal structure of the serine protease kallikrein 7 and to the use of this crystal structure in drug discovery. The present invention also relates to compounds binding specifically to this active site of kallikrein 7.
摘要翻译： 本发明涉及丝氨酸蛋白酶激肽释放酶7的晶体结构以及这种晶体结构在药物发现中的应用。 本发明还涉及特异性结合激素释放酶7的该活性位点的化合物。
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公开(公告)号：US20100256144A1
公开(公告)日：2010-10-07
申请号：US12665892
申请日：2008-06-26
申请人： Stefanie Flohr , Stefan Andreas Randl , Nils Ostermann , Ulrich Hassiepen , Frederic Berst , Ursula Bodendorf , Bernd Gerhartz , Adreas Marzinzik , Claus Ehrhardt , Josef Gottfried Meingassner
发明人： Stefanie Flohr , Stefan Andreas Randl , Nils Ostermann , Ulrich Hassiepen , Frederic Berst , Ursula Bodendorf , Bernd Gerhartz , Adreas Marzinzik , Claus Ehrhardt , Josef Gottfried Meingassner
IPC分类号： A61K31/4439 , C07D401/12 , C07D207/16 , A61K31/40 , A61K31/454 , C07D403/12 , A61K31/496 , C07D413/12 , A61K31/5377 , A61K31/4545 , C07D217/26 , A61K31/472 , C07D211/60 , A61K31/445 , C07D409/12 , A61K31/4025 , A61P17/10 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/04 , A61P35/00 , A61P29/00 , C12N9/48 , G01N33/573
CPC分类号： A61K31/401 , A61K31/4025 , A61K31/403 , A61K31/4035 , A61K31/404 , A61K31/4439 , A61K31/4545 , A61K31/496 , C07D207/16 , C07D209/42 , C07D209/52 , C07D211/60 , C07D401/12 , C07D405/12 , C07K2299/00 , C12N9/6445 , C12Y304/21034
摘要： The present invention relates to the crystal structure of the serine protease kallikrein 7 and to the use of this crystal structure in drug discovery. The present invention also relates to compounds binding specifically to this active site of kallikrein 7.
摘要翻译： 本发明涉及丝氨酸蛋白酶激肽释放酶7的晶体结构以及这种晶体结构在药物发现中的应用。 本发明还涉及特异性结合激素释放酶7的该活性位点的化合物。
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公开(公告)号：US09085555B2
公开(公告)日：2015-07-21
申请号：US13342161
申请日：2012-01-02
申请人： Eva Altmann , Ulrich Hommel , Edwige Liliane Jeanne Lorthiois , Juergen Klaus Maibaum , Nils Ostermann , Jean Quancard , Stefan Andreas Randl , Oliver Simic , Anna Vulpetti , Véronique Stark-Rogel
发明人： Eva Altmann , Ulrich Hommel , Edwige Liliane Jeanne Lorthiois , Juergen Klaus Maibaum , Nils Ostermann , Jean Quancard , Stefan Andreas Randl , Olivier Rogel , Oliver Simic , Anna Vulpetti
IPC分类号： C07D471/04 , C07D487/04 , A61K31/437 , A61K31/404 , C07D403/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14
CPC分类号： C07D403/12 , A61K31/404 , A61K31/437 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention provides a compound of formula I: a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供式I化合物：制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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公开(公告)号：US20150148349A1
公开(公告)日：2015-05-28
申请号：US14409911
申请日：2013-06-27
申请人： Eva Altmann , Ulrich Hommel , Edwige Liliane Jeanne Lorthiois , Jeurgen Klaus Maibaum , Nils Ostermann , Jean Quancard , Stefan Andreas Randl , Olivier Rogel , Anna Vulpetti
发明人： Eva Altmann , Ulrich Hommel , Edwige Liliane Jeanne Lorthiois , Jeurgen Klaus Maibaum , Nils Ostermann , Jean Quancard , Stefan Andreas Randl , Olivier Rogel , Anna Vulpetti
IPC分类号： C07D209/52 , C07D487/04 , C07D403/06 , C07D403/14 , C07D471/04 , C07D401/14
CPC分类号： C07D209/52 , A61K45/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D471/04 , C07D487/04
摘要： The present invention provides a compound of formula (I): a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供式（I）化合物：本发明化合物的制备方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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公开(公告)号：US20150141455A1
公开(公告)日：2015-05-21
申请号：US14409871
申请日：2013-06-27
申请人： Eva Altmann , Ulrich Hommel , Edwige Liliane Jeanne Lorthiois , Jeurgen Klaus Maibaum , Nils Ostermann , Jean Quancard , Stefan Andreas Randl , Olivier Rogel , Anna Vulpetti
发明人： Eva Altmann , Ulrich Hommel , Edwige Liliane Jeanne Lorthiois , Jeurgen Klaus Maibaum , Nils Ostermann , Jean Quancard , Stefan Andreas Randl , Olivier Rogel , Anna Vulpetti
IPC分类号： C07D403/06 , C07D491/056 , C07D471/04
CPC分类号： C07D403/06 , A61K31/416 , A61K31/4162 , A61K45/06 , C07D471/04 , C07D491/056 , A61K2300/00
摘要： The present invention provides a compound of formula I: (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供式I化合物：（I）制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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公开(公告)号：US09452990B2
公开(公告)日：2016-09-27
申请号：US14408216
申请日：2013-06-19
申请人： Michael Dechantsreiter , Jonathan E. Grob , Aengus Macsweeney , Wolfgang Miltz , Stefan Andreas Randl , Richard Sedrani , Holger Sellner , Finton Sirockin , Eric Valeur
发明人： Michael Dechantsreiter , Jonathan E. Grob , Aengus Macsweeney , Wolfgang Miltz , Stefan Andreas Randl , Richard Sedrani , Holger Sellner , Finton Sirockin , Eric Valeur
IPC分类号： C07D239/95 , C07D403/12 , C07D401/14 , C07D413/14 , C07D401/12 , C07D403/04 , C07D403/14 , C07D405/12 , C07D409/12 , A61K31/517 , A61K31/5377
CPC分类号： C07D239/95 , A61K31/517 , A61K31/5377 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D413/14
摘要： The present invention provides a compound of formula I a method for manufacturing the compounds of the invention, and its therapeutic uses as inhibitor of the complement alternative pathway and particularly as inhibitor of Factor B for the treatment of e.g. age-related macular degeneration and diabetic retinopathy. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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