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公开(公告)号:US08318727B2
公开(公告)日:2012-11-27
申请号:US12962557
申请日:2010-12-07
申请人: Sheldon X Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Yan Liu , Chrisopher McBride , Srinivasa Ready Natala , Zhe Nie , Jeffrey A. Stafford , Betty Lam
发明人: Sheldon X Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Yan Liu , Chrisopher McBride , Srinivasa Ready Natala , Zhe Nie , Jeffrey A. Stafford , Betty Lam
IPC分类号: C07D487/04 , A61K31/55
CPC分类号: C07D487/04 , C07D487/14 , C07D519/00
摘要: Compounds of the following formula are provided for use with kinases: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译: 提供下式的化合物用于激酶:其中变量如本文所定义。 还提供了包含这些化合物的药物组合物,试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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公开(公告)号:US20090291938A1
公开(公告)日:2009-11-26
申请号:US12274213
申请日:2008-11-19
申请人: Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
发明人: Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
IPC分类号: A61K31/551 , C07D487/04
CPC分类号: C07D487/04
摘要: Compounds of the following formula are provided for use with kinases: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译: 提供下式的化合物用于激酶:其中变量如本文所定义。 还提供了包含这些化合物的药物组合物,试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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公开(公告)号:US20110201818A1
公开(公告)日:2011-08-18
申请号:US12680183
申请日:2008-09-24
申请人: Takashi Ichikawa , Benjamin Jones , Andre A. Kiryanov , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Sheldon X. Cao , Betty Lam , Victoria Feher , Stephen W. Kaldor , Yan Liu , Jeffrey A Stafford
发明人: Takashi Ichikawa , Benjamin Jones , Andre A. Kiryanov , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Sheldon X. Cao , Betty Lam , Victoria Feher , Stephen W. Kaldor , Yan Liu , Jeffrey A Stafford
IPC分类号: C07D211/72
CPC分类号: C07D487/04 , C07D487/14 , C07D519/00
摘要: Compounds of the following formula are provided for use with kinases: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译: 提供下式的化合物用于激酶:其中变量如本文所定义。 还提供了包含这些化合物的药物组合物,试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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公开(公告)号:US20090281092A1
公开(公告)日:2009-11-12
申请号:US12237306
申请日:2008-09-24
申请人: Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
发明人: Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
IPC分类号: A61K31/5513 , C07D487/04 , A61P35/00 , A61P29/00 , A61P37/00 , A61P9/00 , A61P25/00 , A61P19/00
CPC分类号: C07D487/04 , C07D487/14 , C07D519/00
摘要: Compounds of the following formula are provided for use with kinases: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
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公开(公告)号:US20100075973A1
公开(公告)日:2010-03-25
申请号:US12544419
申请日:2009-08-20
申请人: Sheldon X. Cao , Takashi Ichikawa , Andre A. Kiryanov , Christopher McBride , Srinivasa Reddy Natala , Stephen W. Kaldor , Jeffrey A. Stafford
发明人: Sheldon X. Cao , Takashi Ichikawa , Andre A. Kiryanov , Christopher McBride , Srinivasa Reddy Natala , Stephen W. Kaldor , Jeffrey A. Stafford
IPC分类号: A61K31/5025 , C07D471/14 , A61P35/00
CPC分类号: C07D487/14
摘要: The present invention provides PLK inhibitors of the formula wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using the compounds.
摘要翻译: 本发明提供下式的PLK抑制剂,其中变量如本文所定义。 还提供了包含这些化合物的药物组合物,试剂盒和制品; 用于制备化合物的方法和中间体; 和使用该化合物的方法。
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公开(公告)号:US08138168B1
公开(公告)日:2012-03-20
申请号:US12239538
申请日:2008-09-26
申请人: Benjamin Jones , Stephen W. Kaldor , Walter Keung , Andre A. Kiryanov , Zhe Li , Jeffrey A. Stafford , John Tyhonas , Craig Behnke
发明人: Benjamin Jones , Stephen W. Kaldor , Walter Keung , Andre A. Kiryanov , Zhe Li , Jeffrey A. Stafford , John Tyhonas , Craig Behnke
IPC分类号: A61K31/407 , A61K31/4745 , A61K31/4178 , C07D453/02
CPC分类号: C07D235/14 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D417/12
摘要: The invention relates to compounds having the formulae: wherein the variables are as defined herein. The invention further relates to methods of making and using these compounds, and pharmaceutical compositions, kits and articles of manufacture comprise the compounds.
摘要翻译: 本发明涉及具有下式的化合物:其中变量如本文所定义。 本发明还涉及制备和使用这些化合物的方法,药物组合物,试剂盒和制品包含这些化合物。
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公开(公告)号:US07790734B2
公开(公告)日:2010-09-07
申请号:US10934326
申请日:2004-09-02
申请人: Sheldon X. Cao , Jun Feng , Stephen L. Gwaltney , Stephen W. Kaldor , Jeffrey A. Stafford , Michael B. Wallace , Xiao-Yi Xiao , Zhiyuan Zhang
发明人: Sheldon X. Cao , Jun Feng , Stephen L. Gwaltney , Stephen W. Kaldor , Jeffrey A. Stafford , Michael B. Wallace , Xiao-Yi Xiao , Zhiyuan Zhang
IPC分类号: C07D239/47 , C07D239/48 , C07D403/12 , A61K31/505
CPC分类号: C07D401/04
摘要: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein.
摘要翻译: 提供化合物,药物,试剂盒和方法用于包含式I的DPP-IV抑制剂:其中取代基如本文所述。
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公开(公告)号:US20100210635A1
公开(公告)日:2010-08-19
申请号:US12294906
申请日:2007-03-23
IPC分类号: A61K31/538 , C07D241/04 , A61K31/495 , C12N9/99 , C07D403/06 , A61K31/496 , C07D405/06 , C07D401/10 , C07D265/36 , C07D413/02 , C07D403/02 , A61K31/5377 , A61P9/00 , A61P9/12 , A61P29/00 , A61P35/00 , A61P25/00 , A61P13/12
CPC分类号: C07D241/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D413/06
摘要: Compounds, pharmaceutical compositions, kits and methods are provided for use with Renin that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.
摘要翻译: 提供化合物,药物组合物,试剂盒和方法用于含有选自以下的化合物的Renin:其中变量如本文所定义。
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公开(公告)号:US20100204471A1
公开(公告)日:2010-08-12
申请号:US12446974
申请日:2007-10-22
申请人: Qing Dong , Victoria Feher , Stephen W. Kaldor , Naoki Tomita
发明人: Qing Dong , Victoria Feher , Stephen W. Kaldor , Naoki Tomita
IPC分类号: C07D413/02 , C07D239/10 , C07D405/02
CPC分类号: C07D239/545 , C07D239/557 , C07D401/12 , C07D403/06 , C07D405/12 , C07D413/06
摘要: Compounds, pharmaceutical compositions, kits and methods are provided for use with MEK that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.
摘要翻译: 提供化合物,药物组合物,试剂盒和方法用于包含选自以下的化合物的MEK:其中变量如本文所定义。
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公开(公告)号:US20080125437A1
公开(公告)日:2008-05-29
申请号:US11876635
申请日:2007-10-22
申请人: Qing DONG , Victoria Feher , Stephen W. Kaldor , Naoki Tomita
发明人: Qing DONG , Victoria Feher , Stephen W. Kaldor , Naoki Tomita
IPC分类号: A61K31/495 , A61K31/496 , A61K31/4965 , C07D403/02
CPC分类号: C07D239/545 , C07D239/557 , C07D401/12 , C07D403/06 , C07D405/12 , C07D413/06
摘要: Compounds, pharmaceutical compositions, kits and methods are provided for use with MEK that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.
摘要翻译: 提供化合物,药物组合物,试剂盒和方法用于包含选自以下的化合物的MEK:其中变量如本文所定义。
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