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公开(公告)号：US08318727B2
公开(公告)日：2012-11-27
申请号：US12962557
申请日：2010-12-07
申请人： Sheldon X Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Yan Liu , Chrisopher McBride , Srinivasa Ready Natala , Zhe Nie , Jeffrey A. Stafford , Betty Lam
发明人： Sheldon X Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Yan Liu , Chrisopher McBride , Srinivasa Ready Natala , Zhe Nie , Jeffrey A. Stafford , Betty Lam
IPC分类号： C07D487/04 , A61K31/55
CPC分类号： C07D487/04 , C07D487/14 , C07D519/00
摘要： Compounds of the following formula are provided for use with kinases: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译： 提供下式的化合物用于激酶：其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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公开(公告)号：US20090291938A1
公开(公告)日：2009-11-26
申请号：US12274213
申请日：2008-11-19
申请人： Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
发明人： Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
IPC分类号： A61K31/551 , C07D487/04
CPC分类号： C07D487/04
摘要： Compounds of the following formula are provided for use with kinases: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译： 提供下式的化合物用于激酶：其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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公开(公告)号：US20110201818A1
公开(公告)日：2011-08-18
申请号：US12680183
申请日：2008-09-24
申请人： Takashi Ichikawa , Benjamin Jones , Andre A. Kiryanov , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Sheldon X. Cao , Betty Lam , Victoria Feher , Stephen W. Kaldor , Yan Liu , Jeffrey A Stafford
发明人： Takashi Ichikawa , Benjamin Jones , Andre A. Kiryanov , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Sheldon X. Cao , Betty Lam , Victoria Feher , Stephen W. Kaldor , Yan Liu , Jeffrey A Stafford
IPC分类号： C07D211/72
CPC分类号： C07D487/04 , C07D487/14 , C07D519/00
摘要： Compounds of the following formula are provided for use with kinases: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译： 提供下式的化合物用于激酶：其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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公开(公告)号：US20110082111A1
公开(公告)日：2011-04-07
申请号：US12962557
申请日：2010-12-07
申请人： Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. KALDOR , Andre A. KIRYANOV , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
发明人： Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. KALDOR , Andre A. KIRYANOV , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
IPC分类号： A61K31/675 , C07D487/04 , A61K31/551 , A61K31/397 , C07F9/165 , C07D487/14 , C07C229/34 , C07C229/22 , C07C69/74 , C07C69/75 , A61P35/00
CPC分类号： C07D487/04 , C07D487/14 , C07D519/00
摘要： Compounds of the following formula are provided for use with kinases: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
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公开(公告)号：US20090281092A1
公开(公告)日：2009-11-12
申请号：US12237306
申请日：2008-09-24
申请人： Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
发明人： Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
IPC分类号： A61K31/5513 , C07D487/04 , A61P35/00 , A61P29/00 , A61P37/00 , A61P9/00 , A61P25/00 , A61P19/00
CPC分类号： C07D487/04 , C07D487/14 , C07D519/00
摘要： Compounds of the following formula are provided for use with kinases: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
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公开(公告)号：US07759339B2
公开(公告)日：2010-07-20
申请号：US11392297
申请日：2006-03-28
申请人： Kathleen Aertgeerts , Nancy K. Brennan , Sheldon X. Cao , Edcon Chang , Andre A. Kiryanov , Yan Liu
发明人： Kathleen Aertgeerts , Nancy K. Brennan , Sheldon X. Cao , Edcon Chang , Andre A. Kiryanov , Yan Liu
IPC分类号： C07D241/04 , C07D295/00 , C07D413/12 , A61K31/496 , A61K31/445
CPC分类号： C07D241/38 , C07D207/48 , C07D209/08 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/54 , C07D211/58 , C07D211/62 , C07D211/76 , C07D211/96 , C07D213/70 , C07D213/74 , C07D215/04 , C07D215/42 , C07D215/58 , C07D217/02 , C07D217/06 , C07D217/08 , C07D217/22 , C07D217/24 , C07D231/18 , C07D231/56 , C07D233/42 , C07D235/26 , C07D239/14 , C07D241/08 , C07D241/50 , C07D261/10 , C07D265/36 , C07D271/12 , C07D277/56 , C07D277/58 , C07D277/62 , C07D279/16 , C07D285/14 , C07D285/16 , C07D295/26 , C07D307/68 , C07D307/79 , C07D333/62 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D413/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D491/10 , C07D513/04
摘要： Compounds, pharmaceutical compositions, kits and methods are provided for use with hydroxysteroid dehydrogenases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.
摘要翻译： 提供化合物，药物组合物，试剂盒和方法用于含有选自以下的化合物的羟基类固醇脱氢酶：其中变量如本文所定义。
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公开(公告)号：US08124617B2
公开(公告)日：2012-02-28
申请号：US12065607
申请日：2006-09-01
申请人： Hidehisa Iwata , Yasuhisa Kohara , Sheldon X. Cao , Prasuna Guntupalli , Stephen L. Gwaltney , David J. Hosfield , Yan Liu , Jeffrey A Stafford , Beverly Wolgast
发明人： Hidehisa Iwata , Yasuhisa Kohara , Sheldon X. Cao , Prasuna Guntupalli , Stephen L. Gwaltney , David J. Hosfield , Yan Liu , Jeffrey A Stafford , Beverly Wolgast
IPC分类号： A61K31/44 , C07D513/02 , C07D515/02
CPC分类号： A61K31/437 , A61K9/2018 , A61K9/4858 , C07D471/02 , C07D471/04 , C12N9/1205 , C12Y207/01001
摘要： Compounds, pharmaceutical compositions, kits and methods are provided for use with glucokinase that comprise a compound selected from the group consisting of formula (I) wherein the variables are as defined herein.
摘要翻译： 提供化合物，药物组合物，试剂盒和方法用于含有选自式（I）的化合物的葡糖激酶，其中变量如本文所定义。
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公开(公告)号：US20100069431A1
公开(公告)日：2010-03-18
申请号：US12065607
申请日：2006-09-01
申请人： Hidehisa Iwata , Yasuhisa Kohara , Sheldon X. Cao , Prasuna Guntupalli , Stephen L. Gwaltney , David J. Hosfield , Yan Liu , Jeffrey A. Stafford , Beverly Throop
发明人： Hidehisa Iwata , Yasuhisa Kohara , Sheldon X. Cao , Prasuna Guntupalli , Stephen L. Gwaltney , David J. Hosfield , Yan Liu , Jeffrey A. Stafford , Beverly Throop
IPC分类号： A61K31/437 , C07D471/02
CPC分类号： A61K31/437 , A61K9/2018 , A61K9/4858 , C07D471/02 , C07D471/04 , C12N9/1205 , C12Y207/01001
摘要： Compounds, pharmaceutical compositions, kits and methods are provided for use with glucokinase that comprise a compound selected from the group consisting of formula (I) wherein the variables are as defined herein.
摘要翻译： 提供化合物，药物组合物，试剂盒和方法用于含有选自式（I）的化合物的葡糖激酶，其中变量如本文所定义。
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公开(公告)号：US20100160633A1
公开(公告)日：2010-06-24
申请号：US12706837
申请日：2010-02-17
申请人： Jason W. Brown , Qing Dong , Bheema R. Paraselli , Jeffrey A. Stafford , Xianchang Gong , Yan Liu , Nicholas Scorah , Michael B. Wallace
发明人： Jason W. Brown , Qing Dong , Bheema R. Paraselli , Jeffrey A. Stafford , Xianchang Gong , Yan Liu , Nicholas Scorah , Michael B. Wallace
IPC分类号： C07F9/06
CPC分类号： C07F9/6561 , C07D471/04
摘要： Compounds are provided for use with kinases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译： 提供化合物用于与包含选自以下的化合物的激酶一起使用：其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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公开(公告)号：US20090156557A1
公开(公告)日：2009-06-18
申请号：US12103625
申请日：2008-04-15
申请人： Jason W. Brown , Qing Dong , Bheema R. Paraselli , Jeffrey A. Stafford , Xianchang Gong , Yan Liu , Nicholas Scorah , Michael B. Wallace
发明人： Jason W. Brown , Qing Dong , Bheema R. Paraselli , Jeffrey A. Stafford , Xianchang Gong , Yan Liu , Nicholas Scorah , Michael B. Wallace
IPC分类号： C07D487/04 , A61K31/437 , A61K31/496 , A61K31/5377 , A61K31/675 , C07F9/576 , C12N9/99 , A61P25/28 , A61P29/00 , A61P25/00 , A61P35/00
CPC分类号： C07F9/6561 , C07D471/04
摘要： Compounds are provided for use with kinases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
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