Thermosensitive nanostructure for hyperthermia treatment
    6.
    发明授权
    Thermosensitive nanostructure for hyperthermia treatment 有权
    热敏纳米结构热疗治疗

    公开(公告)号:US08586095B2

    公开(公告)日:2013-11-19

    申请号:US11511464

    申请日:2006-08-29

    IPC分类号: A61K9/16

    摘要: A thermosensitive nanostructure for hyperthermia treatment. Magnetic nanoparticles are encapsulated in a thermosensitive polymer nanostructure having a lower critical solution temperature (LCST) of about 40-45° C. The thermosensitive polymer nanostructure may carry a drug. When the magnetic nanoparticles are heated to 40-45° C. by application of an alternating magnetic field in hyperthermia treatment, the thermosensitive polymer nanostructure collapses to release the drug, thus providing concurrent drug treatment.

    摘要翻译: 用于热疗治疗的热敏纳米结构。 磁性纳米颗粒被封装在具有约40-45℃的较低临界溶解温度(LCST)的热敏聚合物纳米结构中。热敏聚合物纳米结构可携带药物。 当通过在热疗处理中施加交变磁场将磁性纳米颗粒加热至40-45℃时,热敏聚合物纳米结构崩溃以释放药物,从而提供同时进行的药物治疗。

    Group IV elements-bridged metallocene catalyst for preparing bimodal olefin polymers
    7.
    发明授权
    Group IV elements-bridged metallocene catalyst for preparing bimodal olefin polymers 失效
    用于制备双峰烯烃聚合物的IV族元素桥连茂金属催化剂

    公开(公告)号:US06297392B1

    公开(公告)日:2001-10-02

    申请号:US08881897

    申请日:1997-06-23

    IPC分类号: C07F1700

    摘要: A novel Group IV elements-bridged metallocene complex is disclosed which is represented by the following formula (I): wherein R and R1 are different and are independently selected from the group consisting of &eegr;5-cyclopentadienyl group, substituted &eegr;5-cyclopentadienyl group, indenyl group, and fluorenyl group; R2 is selected from the group consisting of —N(CH3)2, —N(C2H5)2, halogen, alkoxy, —(C═O)NH2, and C6-12 hydrocarbyl group; M is a Group IVA element; and M1 is a Group IVB metal. When employing the metallocene complex to prepare olefin polymers, since it is bridged by a Group IV element, there are two catalytic sites in the single metallocene complex catalyst. Therefore, the olefin monomers can be polymerized to a bimodal olefin polymer by a single catalyst in a single reactor, resulting in lowered capital costs.

    摘要翻译: 公开了由下式(I)表示的新型IV族元素桥连茂金属络合物:其中R和R 1不同,并且独立地选自η5-环戊二烯基,取代的η5-环戊二烯基,茚基 ,和芴基; R 2选自-N(CH 3)2,-N(C 2 H 5)2,卤素,烷氧基, - (C = O)NH 2和C 6-12烃基; M是IVA族元素; M1是ⅣB族金属。 当使用茂金属络合物来制备烯烃聚合物时,由于它被IV族元素桥接,所以在单一茂金属络合物催化剂中有两个催化位点。 因此,烯烃单体可以通过单个催化剂在单个反应器中聚合成双峰烯烃聚合物,从而降低资本成本。

    Nuclear molecular imaging contrast agent
    10.
    发明申请
    Nuclear molecular imaging contrast agent 审中-公开
    核分子成像对比剂

    公开(公告)号:US20070154390A1

    公开(公告)日:2007-07-05

    申请号:US11449764

    申请日:2006-06-09

    CPC分类号: A61K51/065

    摘要: A nuclear molecular imaging contrast agent. The nuclear imaging contrast agent comprises a polymer according to the structure of wherein, P is and 1 is not less than 1; D is a C3-30 dendritic moiety having a plurality of oxygen residue; Z is a C3-20 moiety having a plurality of functional groups, wherein the functional groups comprise carbonyl, carboxyl, amine, ester, amide, or chelate group; L is a radioisotope or analyte-specific moiety ; m is not less than two ; and at least one X is an analyte-specific moiety; the other X can be hydrogen atom.

    摘要翻译: 核分子成像造影剂。 核成像造影剂包含根据其结构的聚合物,其中P为1且不小于1; D是具有多个氧残基的C3-30树枝状部分; Z是具有多个官能团的C3-20部分,其中官能团包括羰基,羧基,胺,酯,酰胺或螯合基团; L是放射性同位素或分析物特异性部分; m不小于2; 并且至少一个X是分析物特异性部分; 另外X可以是氢原子。