Thermosensitive nanostructure for hyperthermia treatment
    1.
    发明授权
    Thermosensitive nanostructure for hyperthermia treatment 有权
    热敏纳米结构热疗治疗

    公开(公告)号:US08586095B2

    公开(公告)日:2013-11-19

    申请号:US11511464

    申请日:2006-08-29

    IPC分类号: A61K9/16

    摘要: A thermosensitive nanostructure for hyperthermia treatment. Magnetic nanoparticles are encapsulated in a thermosensitive polymer nanostructure having a lower critical solution temperature (LCST) of about 40-45° C. The thermosensitive polymer nanostructure may carry a drug. When the magnetic nanoparticles are heated to 40-45° C. by application of an alternating magnetic field in hyperthermia treatment, the thermosensitive polymer nanostructure collapses to release the drug, thus providing concurrent drug treatment.

    摘要翻译: 用于热疗治疗的热敏纳米结构。 磁性纳米颗粒被封装在具有约40-45℃的较低临界溶解温度(LCST)的热敏聚合物纳米结构中。热敏聚合物纳米结构可携带药物。 当通过在热疗处理中施加交变磁场将磁性纳米颗粒加热至40-45℃时,热敏聚合物纳米结构崩溃以释放药物,从而提供同时进行的药物治疗。

    Thermosensitive nanostructure for hyperthermia treatment
    2.
    发明申请
    Thermosensitive nanostructure for hyperthermia treatment 有权
    热敏纳米结构热疗治疗

    公开(公告)号:US20070154397A1

    公开(公告)日:2007-07-05

    申请号:US11511464

    申请日:2006-08-29

    IPC分类号: A61K49/10

    摘要: A thermosensitive nanostructure for hyperthermia treatment. Magnetic nanoparticles are encapsulated in a thermosensitive polymer nanostructure having a lower critical solution temperature (LCST) of about 40-45° C. The thermosensitive polymer nanostructure may carry a drug. When the magnetic nanoparticles are heated to 40-45° C. by application of an alternating magnetic field in hyperthermia treatment, the thermosensitive polymer nanostructure collapses to release the drug, thus providing concurrent drug treatment.

    摘要翻译: 用于热疗治疗的热敏纳米结构。 磁性纳米颗粒被封装在具有约40-45℃的较低临界溶解温度(LCST)的热敏聚合物纳米结构中。热敏聚合物纳米结构可携带药物。 当通过在热疗处理中施加交变磁场将磁性纳米颗粒加热至40-45℃时,热敏聚合物纳米结构崩溃以释放药物,从而提供同时进行的药物治疗。

    DENDRITIC POLYMERS AND MAGNETIC RESONANCE IMAGING CONTRAST AGENT EMPLOYING THE SAME
    7.
    发明申请
    DENDRITIC POLYMERS AND MAGNETIC RESONANCE IMAGING CONTRAST AGENT EMPLOYING THE SAME 有权
    透明聚合物和磁共振成像对比剂使用它

    公开(公告)号:US20090169481A1

    公开(公告)日:2009-07-02

    申请号:US12174439

    申请日:2008-07-16

    IPC分类号: A61K49/12 C08G77/00

    CPC分类号: C08G83/003 A61K49/124

    摘要: A dendritic polymer and a magnetic resonance imaging contrast agent employing the same. The magnetic resonance contrast agent includes the dendritic polymer according to the structure of SP-DZ-L)i)j or SP-DX-Z-L)i)j, wherein, S is cyclosilane moiety with j silicon oxygen residual groups, and j is not less than 2; P is and 1 is not less than 1; D is a C3-30 dendritic moiety having n oxygen residue, and n is not less than 3; X is C3-30 moiety having bi-functional groups; Z is a C3-20 moiety having a plurality of functional group; and L is a metal cation.

    摘要翻译: 树突状聚合物和使用其的磁共振成像造影剂。 磁共振造影剂包括根据S
    结构的结构的树枝状聚合物)i)j或S分子量XZL)i)j,其中S是具有j个硅氧残基的环硅烷部分,j是 不低于2; P为1,不小于1; D是具有n个氧残基的C3-30树枝状部分,n不小于3; X是具有双官能团的C3-30部分; Z是具有多个官能团的C3-20部分; L是金属阳离子。

    Nuclear molecular imaging contrast agent
    9.
    发明申请
    Nuclear molecular imaging contrast agent 审中-公开
    核分子成像对比剂

    公开(公告)号:US20070154390A1

    公开(公告)日:2007-07-05

    申请号:US11449764

    申请日:2006-06-09

    CPC分类号: A61K51/065

    摘要: A nuclear molecular imaging contrast agent. The nuclear imaging contrast agent comprises a polymer according to the structure of wherein, P is and 1 is not less than 1; D is a C3-30 dendritic moiety having a plurality of oxygen residue; Z is a C3-20 moiety having a plurality of functional groups, wherein the functional groups comprise carbonyl, carboxyl, amine, ester, amide, or chelate group; L is a radioisotope or analyte-specific moiety ; m is not less than two ; and at least one X is an analyte-specific moiety; the other X can be hydrogen atom.

    摘要翻译: 核分子成像造影剂。 核成像造影剂包含根据其结构的聚合物,其中P为1且不小于1; D是具有多个氧残基的C3-30树枝状部分; Z是具有多个官能团的C3-20部分,其中官能团包括羰基,羧基,胺,酯,酰胺或螯合基团; L是放射性同位素或分析物特异性部分; m不小于2; 并且至少一个X是分析物特异性部分; 另外X可以是氢原子。

    Dendritic polymers and magnetic resonance imaging contrast agent employing the same
    10.
    发明授权
    Dendritic polymers and magnetic resonance imaging contrast agent employing the same 有权
    树突状聚合物和使用其的磁共振成像造影剂

    公开(公告)号:US08303937B2

    公开(公告)日:2012-11-06

    申请号:US12174439

    申请日:2008-07-16

    IPC分类号: C08L73/00 A61K9/00 C07D407/00

    CPC分类号: C08G83/003 A61K49/124

    摘要: A dendritic polymer and a magnetic resonance imaging contrast agent employing the same. The magnetic resonance contrast agent includes the dendritic polymer according to the structure of SP-DZ-L)i)j or SP-DX-Z-L)i)j, wherein, S is cyclosilane moiety with j silicon oxygen residual groups, and j is not less than 2; P is and l is not less than 1; D is a C3-30 dendritic moiety having n oxygen residue, and n is not less than 3; X is C3-30 moiety having bi-functional groups; Z is a C3-20 moiety having a plurality of functional group; and L is a metal cation.

    摘要翻译: 树突状聚合物和使用其的磁共振成像造影剂。 磁共振造影剂包括根据SP-DZ-L)i)j或SP-DX-ZL)i)j的结构的树枝状聚合物,其中S是具有j个硅氧残基的环硅烷部分,j是 不低于2; P和l不小于1; D是具有n个氧残基的C3-30树枝状部分,n不小于3; X是具有双官能团的C3-30部分; Z是具有多个官能团的C3-20部分; L是金属阳离子。