摘要:
An adsorbent for .beta..sub.2 -microglobulin and immunoglobulin L-chain suitable for use in an extracorporeal circulation treatment, which comprises a porous water-insoluble carrier and a compound immobilized onto said carrier, said compound satisfying that the value of log P, in which P is a partition coefficient in an octanol-water system, is not less than 2.5. The adsorbent is inexpensive, and efficiently adsorb and remove .beta..sub.2 -microglobulin and immunoglobulin L-chain contained in a body fluid.
摘要:
The present invention provides an adsorbent, adsorption unit, and an adsorption method which make it possible to selectively adsorb an immunoglobulin and/or an immune complex present in a body fluid (for example, blood, plasma, etc.) efficiently without pretreating the body fluid. By immobilizing a compound having binding activity for an immunoglobulin and/or an immune complex on a water-insoluble carrier, an adsorbent having remarkably excellent adsorption capacity may be obtained.
摘要:
An adsorbent which comprises a water-insoluble carrier and a compound, which is immobilized on said carrier, having a binding affinity for an antibody against β1-adrenoceptor and/or an antibody against M2 muscarinic receptor exhibits a remarkably large adsorptive capacity.
摘要:
The present invention provides an adsorbent, adsorption unit, and an adsorption method which make it possible to selectively adsorb an immunoglobulin and/or an immune complex present in a body fluid (for example, blood, plasma, etc.) efficiently without pretreating the body fluid. By immobilizing a compound having binding activity for an immunoglobulin and/or an immune complex on a water-insoluble carrier, an adsorbent having remarkably excellent adsorption capacity may be obtained.
摘要:
The present invention provides an adsorbent, adsorption unit, and an adsorption method which make it possible to selectively adsorb an immunoglobulin and/or an immune complex present in a body fluid (for example, blood, plasma, etc.) efficiently without pretreating the body fluid. By immobilizing a compound having binding activity for an immunoglobulin and/or an immune complex on a water-insoluble carrier, an adsorbent having remarkably excellent adsorption capacity may be obtained.
摘要:
An adsorbent for toxic shock syndrome toxin-1 (TSST-1) comprising a compound which has a log P value of at least 2.50 wherein P is a partition coefficient in an octanol-water system and which is immobilized on a water-insoluble carrier; a method for removing TSST-1 body fluids by adsorption which comprises bringing a body fluid containing TSST-1 into contact with the adsorbent; an adsorber for TSST-1 comprising an adsorbent packed in a container having an inlet and an outlet for a body fluid and a means for preventing the adsorbent from flowing out of the container; and use of the adsorbent. TSST-1 in body fluids can be efficiently removed by the adsorbent.
摘要:
An adsorbent that exhibits a high specificity in adsorbing immunoglobulins and/or complexes thereof, is extremely reduced in the lowering of the adsorption characteristic during sterilization or storage, is highly stable and safe, and is prepared by immobilizing on a water-insoluble support either a peptide derivative which has undergone at least one of the deletion, substitution, insertion, or addition of amino acids in a peptide having a specified amino acid sequence or an amino acid sequence, or the above peptide derivative which has undergone the addition of Lyn or Cys at the amino and/or carboxyl terminal thereof; a device for adsorption and removal made by packing the adsorbent in a vessel equipped with effluent preventing means; and a method of adsorbing and removing immunoglobulins and/or complexes thereof contained in the blood, plasma or other body fluids with the adsorbent.
摘要:
An endotoxin adsorption system of the present invention comprises a combination of a cation exchange resin having sodium as a counter ion and a cation exchange resin having sodium and one or more metal ions other than sodium as a counter ion, and adsorbs an endotoxin without decreasing of the concentration of cations.
摘要:
An adsorbent for removing ketoamine-containing protein, which comprises carrying a compound having a terminal functional group of the formula: ##STR1## wherein each of R.sup.1 and R.sup.2 is an organic group and X is 0 or 1, on a porous water-insoluble carrier, a process for removing ketoamine-containing protein by employing the above adsorbent, a process for preventing or treating for diabetic complication by removing ketoamine-containing protein with the above adsorbent and an adsorber for removing ketoamine-containing protein.
摘要:
There is provided a method for immobilizing a ligand by reacting a solvent-insoluble carrier having aldehyde group with a compound shown by the general formula: ##STR1## wherein X is --S-- or --O--, R.sup.1, R.sup.2 and R.sup.6 are the same or different, each of which is hydrogen atom or an alkyl group having 1 to 4 carbon atoms, R.sup.3 is hydrogen atom or a substituent wherein an atom adjacent to nitrogen atom shown in the above-mentioned general formula has no unsaturated bond, R.sup.4, R.sup.5 and R.sup.7 are arbitrary substituents; provided that only one partial chemical structure of HX--C--C--NHR.sup.3 wherein X and R.sup.3 are the same as defined above or HX--C--C--C--NHR.sup.3 wherein X and R.sup.3 are the same as defined above is contained in one compound described above by which, a ligand or a compound to which a ligand is bonded can react specifically and effectively with aldehyde group in a solvent-insoluble carrier at a prescribed position to form a stable bond.