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公开(公告)号:US4948808A
公开(公告)日:1990-08-14
申请号:US225278
申请日:1988-07-28
申请人: Shigeru Souda , Naoyuki Shimomura , Norihiro Ueda , Shuhei Miyazawa , Takashi Yamanaka , Kaname Miyamoto , Ieharu Hishinuma , Junichi Nagakawa , Naoko Nagaoka , Hidetoshi Kawashima , Tsutomu Kawata , Junsaku Nagaoka , Tsuneo Wakabayashi
发明人: Shigeru Souda , Naoyuki Shimomura , Norihiro Ueda , Shuhei Miyazawa , Takashi Yamanaka , Kaname Miyamoto , Ieharu Hishinuma , Junichi Nagakawa , Naoko Nagaoka , Hidetoshi Kawashima , Tsutomu Kawata , Junsaku Nagaoka , Tsuneo Wakabayashi
IPC分类号: A61K31/235 , A61K31/245 , A61K31/40 , A61K31/4015 , A61K31/403 , A61K31/4035 , A61K31/42 , A61K31/421 , A61K31/445 , A61P1/00 , A61P7/02 , A61P7/04 , A61P43/00 , C07C67/00 , C07C313/00 , C07C319/20 , C07C323/20 , C07D207/40 , C07D207/404 , C07D207/408 , C07D209/48 , C07D209/76 , C07D211/76 , C07D211/88 , C07D263/44
CPC分类号: C07D207/404 , C07C323/20 , C07D209/48 , C07D263/44
摘要: A guanidinobenzoic ester derivative having the formula is novel and effective to inhibit enzymes such as trypsin, plasmin and thrombin, being useful for treatment of the pancreatitis and hemorrhagic disease and thrombosis. ##STR1## wherein X represents a group of the formula: ##STR2## in which Y is a group of the formula: --(CH.sub.2).sub.m--, m being an integer of 2 or 3, ##STR3## or a group of the formula:--ORin which R is a hydrogen atom or a lower alkyl group, and n represents an integer of 1 to 5.
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公开(公告)号:US5075335A
公开(公告)日:1991-12-24
申请号:US495444
申请日:1990-03-16
申请人: Shigeru Souda , Naoyuki Shimomura , Norihiro Ueda , Shuhei Miyazawa , Takashi Yamanaka , Kaname Miyamoto , Ieharu Hishinuma , Junichi Nagakawa , Naoko Nagaoka , Hidetoshi Kawashima , Tsutomu Kawata , Junsaku Nagaoka , Tsuneo Wakabayashi
发明人: Shigeru Souda , Naoyuki Shimomura , Norihiro Ueda , Shuhei Miyazawa , Takashi Yamanaka , Kaname Miyamoto , Ieharu Hishinuma , Junichi Nagakawa , Naoko Nagaoka , Hidetoshi Kawashima , Tsutomu Kawata , Junsaku Nagaoka , Tsuneo Wakabayashi
IPC分类号: A61K31/235 , A61K31/245 , A61K31/40 , A61K31/4015 , A61K31/403 , A61K31/4035 , A61K31/42 , A61K31/421 , A61K31/445 , A61P1/00 , A61P7/02 , A61P7/04 , A61P43/00 , C07C67/00 , C07C313/00 , C07C319/20 , C07C323/20 , C07D207/40 , C07D207/404 , C07D207/408 , C07D209/48 , C07D209/76 , C07D211/76 , C07D211/88 , C07D263/44
CPC分类号: C07D207/404 , C07C323/20 , C07D209/48 , C07D263/44
摘要: A guanidinobenzoic ester derivative having the formula is novel and effective to inhibit enzymes such as trypsin, plasmin and thrombin, being useful for treatment of the pancreatitis and hemorrhagic disease and thrombosis. ##STR1## wherein X represents a group of the formula: ##STR2## in which Y is a group of the formula: --(CH.sub.2).sub.m --, m being an integer of 2 or 3, ##STR3## or a group of the formula:--ORin which R is a hydrogen atom or a lower alkyl group, and n represents an integer of 1 to 5.
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公开(公告)号:US4801603A
公开(公告)日:1989-01-31
申请号:US946458
申请日:1986-12-24
申请人: Shigeru Souda , Naoyuki Shimomura , Norihiro Ueda , Shuhei Miyazawa , Takashi Yamanaka , Kaname Miyamoto , Ieharu Hishinuma , Junichi Nagakawa , Naoko Nagaoka , Hidetoshi Kawashima , Tsutomu Kawata , Junsaku Nagaoka , Tsuneo Wakabayashi
发明人: Shigeru Souda , Naoyuki Shimomura , Norihiro Ueda , Shuhei Miyazawa , Takashi Yamanaka , Kaname Miyamoto , Ieharu Hishinuma , Junichi Nagakawa , Naoko Nagaoka , Hidetoshi Kawashima , Tsutomu Kawata , Junsaku Nagaoka , Tsuneo Wakabayashi
IPC分类号: A61K31/235 , A61K31/245 , A61K31/40 , A61K31/4015 , A61K31/403 , A61K31/4035 , A61K31/42 , A61K31/421 , A61K31/445 , A61P1/00 , A61P7/02 , A61P7/04 , A61P43/00 , C07C67/00 , C07C313/00 , C07C319/20 , C07C323/20 , C07D207/40 , C07D207/404 , C07D207/408 , C07D209/48 , C07D209/76 , C07D211/76 , C07D211/88 , C07D263/44
CPC分类号: C07D207/404 , C07C323/20 , C07D209/48 , C07D263/44
摘要: A guanidinobenzoic ester derivative having the formula is novel and effective to inhibit enzymes such as trypsin, plasmin and thrombin, being useful for treatment of the pancreatitis and hemorrhagic disease and thrombosis. ##STR1## wherein X represents a group of the formula: ##STR2## in which Y is a group of the formula: --(CH.sub.2).sub.m --, m being an integer of 2 or 3, ##STR3## or a group of the formula:--ORin which R is a hydrogen atom or a lower alkyl group, and n represents an integer of 1 to 5.
摘要翻译: 具有下式的胍基苯甲酸酯衍生物是新颖有效的抑制酶如胰蛋白酶,纤溶酶和凝血酶,可用于治疗胰腺炎和出血性疾病和血栓形成。 其中X表示下式的基团:其中Y是下式的基团: - (CH 2)m - ,m是2或3的整数,
或基团 其中R是氢原子或低级烷基,n表示1〜5的整数。 -
公开(公告)号:US5476863A
公开(公告)日:1995-12-19
申请号:US129301
申请日:1993-09-30
申请人: Kazuo Okano , Osamu Asano , Naoyuki Shimomura , Tetsuya Kawahara , Shinya Abe , Shuhei Miyazawa , Mitsuaki Miyamoto , Hiroyuki Yoshimura , Koukichi Harada , Junsaku Nagaoka , Tsutomu Kawata , Tsutomu Yoshimura , Hiromasa Suzuki , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
发明人: Kazuo Okano , Osamu Asano , Naoyuki Shimomura , Tetsuya Kawahara , Shinya Abe , Shuhei Miyazawa , Mitsuaki Miyamoto , Hiroyuki Yoshimura , Koukichi Harada , Junsaku Nagaoka , Tsutomu Kawata , Tsutomu Yoshimura , Hiromasa Suzuki , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
IPC分类号: C07D213/40 , C07D401/06 , C07D401/12 , C07D405/12 , A61K31/44 , A61K31/495 , C07D213/72
CPC分类号: C07D213/40 , C07D401/06 , C07D401/12 , C07D405/12
摘要: A glycerin derivative having the following formula (I) or (I') and a pharmacologically acceptable salt thereof are useful to treat diseases caused by the platelet activating factor. ##STR1##
摘要翻译: 具有下式(I)或(I')的甘油衍生物及其药理学上可接受的盐可用于治疗血小板活化因子引起的疾病。 (I)
(I) -
公开(公告)号:US5273985A
公开(公告)日:1993-12-28
申请号:US710089
申请日:1991-06-04
申请人: Kazuo Okano , Osamu Asano , Naoyuki Shimomura , Tetsuya Kawahara , Shinya Abe , Shuhei Miyazawa , Mitsuaki Miyamoto , Hiroyuki Yoshimura , Koukichi Harada , Junsaku Nagaoka , Tsutomu Kawata , Tsutomu Yoshimura , Hiromasa Suzuki , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
发明人: Kazuo Okano , Osamu Asano , Naoyuki Shimomura , Tetsuya Kawahara , Shinya Abe , Shuhei Miyazawa , Mitsuaki Miyamoto , Hiroyuki Yoshimura , Koukichi Harada , Junsaku Nagaoka , Tsutomu Kawata , Tsutomu Yoshimura , Hiromasa Suzuki , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
IPC分类号: C07D213/40 , C07D401/06 , C07D401/12 , C07D405/12 , A61K31/44 , C07D213/72
CPC分类号: C07D213/40 , C07D401/06 , C07D401/12 , C07D405/12
摘要: A glycerin derivative having the following formula (I) or (I') and a pharmacologically acceptable salt thereof are useful to treat diseases caused by the platelet activating factor. ##STR1##
摘要翻译: 具有下式(I)或(I')的甘油衍生物及其药理学上可接受的盐可用于治疗血小板活化因子引起的疾病。 (I)
(I) -
公开(公告)号:US5476864A
公开(公告)日:1995-12-19
申请号:US129302
申请日:1993-11-10
申请人: Kazuo Okano , Osamu Asano , Naoyuki Shimomura , Tetsuya Kawahara , Shinya Abe , Shuhei Miyazawa , Mitsuaki Miyamoto , Hiroyuki Yoshimura , Koukichi Harada , Junsaku Nagaoka , Tsutomu Kawata , Tsutomu Yoshimura , Hiromasa Suzuki , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
发明人: Kazuo Okano , Osamu Asano , Naoyuki Shimomura , Tetsuya Kawahara , Shinya Abe , Shuhei Miyazawa , Mitsuaki Miyamoto , Hiroyuki Yoshimura , Koukichi Harada , Junsaku Nagaoka , Tsutomu Kawata , Tsutomu Yoshimura , Hiromasa Suzuki , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
IPC分类号: C07D213/40 , C07D401/06 , C07D401/12 , C07D405/12 , A61K31/44 , C07D213/02
CPC分类号: C07D213/40 , C07D401/06 , C07D401/12 , C07D405/12
摘要: A glycerin derivative having the following formula (I) or (I') and a pharmacologically acceptable salt thereof are useful to treat diseases caused by the platelet activating factor. ##STR1##
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公开(公告)号:US5037827A
公开(公告)日:1991-08-06
申请号:US373350
申请日:1989-06-29
申请人: Kazuo Okano , Osamu Asano , Naoyuki Shimomura , Tetsuya Kawahara , Shinya Abe , Shuhei Miyazawa , Mitsuaki Miyamoto , Hiroyuki Yoshimura , Koukichi Harada , Junsaku Nagaoka , Tsutomu Kawata , Tsutomu Yoshimura , Hiromasa Suzuki , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
发明人: Kazuo Okano , Osamu Asano , Naoyuki Shimomura , Tetsuya Kawahara , Shinya Abe , Shuhei Miyazawa , Mitsuaki Miyamoto , Hiroyuki Yoshimura , Koukichi Harada , Junsaku Nagaoka , Tsutomu Kawata , Tsutomu Yoshimura , Hiromasa Suzuki , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
IPC分类号: C07D211/46 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61K31/4425 , A61K31/4427 , A61K31/443 , A61K31/445 , A61K31/495 , A61P7/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07D213/02 , C07D213/20 , C07D213/40 , C07D401/06 , C07D401/12 , C07D405/12
CPC分类号: C07D213/40 , C07D401/06 , C07D401/12 , C07D405/12 , Y10S514/921
摘要: A glycerin derivative having the following formula (I) or (I') and a pharmacologically acceptable salt thereof are useful to treat diseases caused by the platelet activating factor. ##STR1##
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8.
公开(公告)号:US5162317A
公开(公告)日:1992-11-10
申请号:US445664
申请日:1989-12-05
申请人: Shigeru Souda , Shuhei Miyazawa , Norihiro Ueda , Katsuya Tagami , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Masatoshi Fujimoto , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki , Hisashi Shibata , Tsuneo Wakabayashi
发明人: Shigeru Souda , Shuhei Miyazawa , Norihiro Ueda , Katsuya Tagami , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Masatoshi Fujimoto , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki , Hisashi Shibata , Tsuneo Wakabayashi
IPC分类号: C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D513/14
CPC分类号: C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D513/14
摘要: A pyridinium salt useful as an antiulcer agent, defined by formula (I) is disclosed. It includes a sulphenamide compound and a pyridinium compound. J is benzimidazole, K is --S-- or --SSR-- and Z is hydroxy or alkoxy. ##STR1##
摘要翻译: PCT No.PCT / JP89 / 00482 Sec。 371日期1989年12月5日第 102(e)日期1989年12月5日PCT提交1989年5月11日PCT公布。 出版物WO89 / 10927 日本公报(公开)公开了用作抗溃疡剂的吡啶鎓盐。 它包括苯丙胺化合物和吡啶鎓化合物。 J为苯并咪唑,K为-S-或-SSR-,Z为羟基或烷氧基。 (一)
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公开(公告)号:US5045552A
公开(公告)日:1991-09-03
申请号:US462328
申请日:1989-12-28
申请人: Shigeru Souda , Norihiro Ueda , Shuhei Miyazawa , Katsuya Tagami , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Masatoshi Fujimoto , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki , Hisashi Shibata , Tsuneo Wakabayashi
发明人: Shigeru Souda , Norihiro Ueda , Shuhei Miyazawa , Katsuya Tagami , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Masatoshi Fujimoto , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki , Hisashi Shibata , Tsuneo Wakabayashi
IPC分类号: A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/54 , A61P1/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
CPC分类号: C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要: Pyridine derivatives useful for preventing or treating peptic ulcers, pharmaceutical preparations and methods of treating peptic ulcers are described.
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公开(公告)号:US5840910A
公开(公告)日:1998-11-24
申请号:US354726
申请日:1994-12-06
申请人: Shigeru Souda , Norihiro Ueda , Shuhei Miyazawa , Katsuya Tagami , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Masatoshi Fujimoto , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki , Hisashi Shibata , Tsuneo Wakabayashi
发明人: Shigeru Souda , Norihiro Ueda , Shuhei Miyazawa , Katsuya Tagami , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Masatoshi Fujimoto , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki , Hisashi Shibata , Tsuneo Wakabayashi
IPC分类号: A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/54 , A61P1/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
CPC分类号: C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要: Pyridine derivatives useful for preventing or treating peptic ulcers, pharmaceutical preparations and methods of treating peptic ulcers are disclosed.
摘要翻译: 公开了用于预防或治疗消化性溃疡的吡啶衍生物,药物制剂和治疗消化性溃疡的方法。
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