公开(公告)号：US07303890B2

公开(公告)日：2007-12-04

申请号：US10381710

申请日：2001-09-27

申请人： Shiken Sha ,  Hidehito Mukai ,  Yoshiko Aoki ,  Yoshisuke Nishi

发明人： Shiken Sha ,  Hidehito Mukai ,  Yoshiko Aoki ,  Yoshisuke Nishi

IPC分类号： G01N33/567

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K48/00 ,  C07K14/535 ,  C07K16/18 ,  C07K16/243 ,  C07K2317/34

摘要： The present invention provides, as a gene encoding an antigen recognized by a G-CSF inducing antibody, a gene encoding any one of the following proteins: (a) a protein having an amino acid sequence shown in SEQ ID NO; 2; (b) a protein having an amino acid sequence comprising a deletion, substitution, addition or insertion of one or several amino acids with respect to the amino acid sequence shown in SEQ ID NO: 2, and having a binding ability for an antibody which induces and secretes a granulocyte colony-stimulating factor or a fragment thereof: or (c) a protein having at least 50% or more homology with the amino acid sequence shown in SEQ ID NO: 2, and having a binding ability for an antibody capable of inducing and secreting a granulocyte colony-stimulating factor or a fragment thereof.

摘要翻译： 作为编码由G-CSF诱导型抗体识别的抗原的基因，本发明提供编码以下蛋白质之一的基因：（a）具有SEQ ID NO所示的氨基酸序列的蛋白质， 2; （b）具有氨基酸序列的氨基酸序列的蛋白质，所述氨基酸序列包含相对于SEQ ID NO：2所示的氨基酸序列的一个或多个氨基酸的缺失，取代，添加或插入，并具有诱导的抗体的结合能力 并分泌粒细胞集落刺激因子或其片段;或（c）与SEQ ID NO：2所示的氨基酸序列具有至少50％以上同源性的蛋白质，并且具有与能够 诱导和分泌粒细胞集落刺激因子或其片段。

公开(公告)号：US07285618B1

公开(公告)日：2007-10-23

申请号：US10220849

申请日：2001-03-06

申请人： Hidehito Mukai ,  Yoshisuke Nishi ,  Eisuke Munekata

发明人： Hidehito Mukai ,  Yoshisuke Nishi ,  Eisuke Munekata

IPC分类号： C07K4/12 ,  A61K38/00

CPC分类号： C07K14/47

摘要： Neutrophil attracting and activating factors that may already exist in normal cells are located.Polypeptides having neutrophil stimulating activity were isolated from an extract originating from a normal porcine heart, whereby the invention was completed. The invention provides (a) a polypeptide consisting of the amino acid sequence of SEQ ID NO:1; (b) a polypeptide consisting of an amino acid sequence derived from the amino acid sequence of SEQ ID NO:3 by deletion, substitution, insertion or addition of one or more amino acids and having neutrophil stimulating activity; or (c) a polypeptide consisting of an amino acid sequence biologically equivalent to the amino acid sequence of said polypeptide (a) or (b).

摘要翻译： 位于正常细胞中可能存在的嗜中性粒细胞吸附和激活因子。 从源自正常猪心脏的提取物中分离出具有嗜中性粒细胞刺激活性的多肽，从而完成了本发明。 本发明提供（a）由SEQ ID NO：1的氨基酸序列组成的多肽; （b）通过缺失，取代，插入或添加一个或多个氨基酸并具有嗜中性粒细胞刺激活性的由SEQ ID NO：3的氨基酸序列衍生的氨基酸序列组成的多肽; 或（c）由与所述多肽（a）或（b）的氨基酸序列生物等同的氨基酸序列组成的多肽。

公开(公告)号：US07893199B2

公开(公告)日：2011-02-22

申请号：US12443404

申请日：2007-09-28

申请人： Hidehito Mukai ,  Kaori Wakamatsu

发明人： Hidehito Mukai ,  Kaori Wakamatsu

IPC分类号： A61K38/00 ,  A61K38/04 ,  A61K38/16 ,  A61K39/00

CPC分类号： C07K14/4705

摘要： A peptide having a sequence which satisfies all of the following requirements (I) to (V) and has an activity of stimulating an immune cell: (I) the number of constituent amino acid residues is 12 to 36; (II) the sequence is amphipathic; (III) the charge of the whole molecule is +2 or more; (IV) when constituent amino acid residues are arranged so as to form an a-helical structure, a side chain of any aromatic amino acid residue is not located between side chains of at least two positively charged amino acid residues on a side where hydrophilic amino acid residues are located; and (V) the sequence contains an amino acid residue which serves as a cleavage point for a mitochondrial processing enzyme.

摘要翻译： 具有满足以下所有要求（I）〜（V）的序列并具有刺激免疫细胞活性的肽的肽：（I）构成氨基酸残基的数目为12〜36; （II）序列是两亲性的; （III）整个分子的电荷为+2以上; （IV）当组成氨基酸残基被排列以形成α-螺旋结构时，任何芳香族氨基酸残基的侧链不位于亲水性氨基酸一侧的至少两个带正电荷的氨基酸残基的侧链之间 酸残基位于; 和（V）序列包含用作线粒体加工酶的切割点的氨基酸残基。

公开(公告)号：US5276281A

公开(公告)日：1994-01-04

申请号：US935664

申请日：1992-08-24

申请人： Kenichi Sato ,  Hidehito Mukai ,  Nobuhiro Shibuta

发明人： Kenichi Sato ,  Hidehito Mukai ,  Nobuhiro Shibuta

IPC分类号： H01B12/06 ,  H01B12/16 ,  H01L39/14 ,  H01B12/00

CPC分类号： H01L39/143 ,  H01B12/06 ,  H01B12/16 ,  Y02E40/642 ,  Y02E40/647 ,  Y10S505/886 ,  Y10S505/887

摘要： A superconducting conductor, having an excellent repeated temperature property with no reduction of critical current density against a temperature cycle, comprises an oxide superconductor and an fiber reinforced plastic ("FRP"), serving as a support member, which is composed with the oxide superconductor for integrally moving with the oxide superconductor in thermal expansion and thermal shrinkage. The oxide superconductor is bonded to the FRP with an adhesive agent, or wound on and fixed to the same with a Teflon tape or the like.

摘要翻译： 具有优异的重复温度特性且在温度循环下没有临界电流密度降低的超导导体包括氧化物超导体和作为支撑构件的纤维增强塑料（“FRP”），其由氧化物超导体 用于与氧化物超导体在热膨胀和热收缩中整体移动。 氧化物超导体用粘合剂粘合到FRP上，或者用特氟隆胶带等缠绕并固定在其上。

公开(公告)号：US06276048B1

公开(公告)日：2001-08-21

申请号：US08747133

申请日：1996-11-12

申请人： Takeshi Hikata ,  Ken-ichi Sato ,  Hidehito Mukai ,  Nobuhiro Shibuta ,  Kazuya Ohmatsu ,  Masayuki Nagata ,  Satoshi Takano ,  Yoshikado Hosoda ,  Hajime Hitotsuyanagi ,  Maumi Kawashima

发明人： Takeshi Hikata ,  Ken-ichi Sato ,  Hidehito Mukai ,  Nobuhiro Shibuta ,  Kazuya Ohmatsu ,  Masayuki Nagata ,  Satoshi Takano ,  Yoshikado Hosoda ,  Hajime Hitotsuyanagi ,  Maumi Kawashima

IPC分类号： H01L3924

CPC分类号： C04B35/4525 ,  C04B35/64 ,  H01L39/126 ,  H01L39/248 ,  Y10S505/74 ,  Y10S505/742 ,  Y10S505/782 ,  Y10T29/49014

摘要： A method of producing a Bi—Pb—Sr—Ca—Cu oxide superconductor by thermally treating raw material comprises steps of performing first plastic deformation on the raw material, performing first heat treatment on the material being subjected to the first plastic deformation, performing second plastic deformation on the material being subjected to the first heat treatment, and performing second heat treatment on the material being subjected to the second plastic deformation.

摘要翻译： 通过对原料进行热处理来制造Bi-Pb-Sr-Ca-Cu氧化物超导体的方法包括以下步骤：在原料上进行第一塑性变形，对经受第一塑性变形的材料进行第一热处理，进行第二次 在对第一次热处理的材料上产生塑性变形，并且对经受第二塑性变形的材料进行第二次热处理。

公开(公告)号：US06194226B1

公开(公告)日：2001-02-27

申请号：US09112970

申请日：1998-07-09

申请人： Kenichi Sato ,  Takeshi Kato ,  Nobuhiro Shibuta ,  Hidehito Mukai

发明人： Kenichi Sato ,  Takeshi Kato ,  Nobuhiro Shibuta ,  Hidehito Mukai

IPC分类号： H01L2100

CPC分类号： C04B37/001 ,  C04B35/645 ,  C04B2235/6567 ,  C04B2237/34 ,  C04B2237/408 ,  C04B2237/66 ,  C04B2237/704 ,  C04B2237/76 ,  C04B2237/80 ,  C04B2237/82 ,  H01L39/02 ,  H01R4/68 ,  Y10S505/704

摘要： According to one aspect, provided is a junction between tape-type superconductors, which are formed of metal-coated oxide superconductors. The superconductors of the superconducting wires, which are oppositely joined to each other, are overlapped with each other. According to another aspect, provided is a method of joining tape-type superconducting wires formed of metal-coated oxide superconductors, which comprises a step of preparing tape-type superconducting wires having portions to be joined, a step of separating metal coatings from first sides of the superconductors in the portions to be joined for exposing the superconductors, a step of overlapping the exposed superconductors with each other, and a step of joining the overlapped superconductors to each other. In the junction obtained according to these aspects, it is possible to stably carry a uniform superconducting current.

摘要翻译： 根据一个方面，提供了由金属覆盖的氧化物超导体形成的带状超导体之间的连接点。 超导线彼此相对接合的超导体彼此重叠。 根据另一方面，提供一种连接由金属涂覆的氧化物超导体形成的带状超导线的方法，其包括制备具有待接合部分的带状超导线的步骤，将金属涂层从第一侧分离的步骤 在要连接的用于暴露超导体的部分中的超导体，将暴露的超导体彼此重叠的步骤以及将重叠的超导体彼此连接的步骤。 在根据这些方面获得的结中，可以稳定地承载均匀的超导电流。

公开(公告)号：US5512867A

公开(公告)日：1996-04-30

申请号：US385571

申请日：1995-02-08

申请人： Nobuhiro Shibuta ,  Kenichi Sato ,  Hidehito Mukai ,  Takato Masuda

发明人： Nobuhiro Shibuta ,  Kenichi Sato ,  Hidehito Mukai ,  Takato Masuda

IPC分类号： H01F6/06

CPC分类号： H01F6/06 ,  Y10S336/01 ,  Y10S505/705 ,  Y10S505/879 ,  Y10S505/88

摘要： A high temperature superconducting coil includes an oxide superconducting wire 2 wound in a coil, a container 3 for accommodating the superconducting wire 2, and a filling resin portion 4 for fixing the superconducting wire 2 in the container 3 by being injected into the container 3 and then cured.

摘要翻译： 高温超导线圈包括缠绕在线圈中的氧化物超导线2，用于容纳超导线2的容器3和用于通过注入容器3而将超导线2固定在容器3中的填充树脂部分4，以及 然后治愈。

公开(公告)号：US06536097B1

公开(公告)日：2003-03-25

申请号：US09723170

申请日：2000-11-27

申请人： Kenichi Sato ,  Hidehito Mukai ,  Nobuhiro Shibuta

发明人： Kenichi Sato ,  Hidehito Mukai ,  Nobuhiro Shibuta

IPC分类号： H01L3924

CPC分类号： H01L39/248 ,  H01L39/143 ,  Y10S505/704 ,  Y10S505/884 ,  Y10T29/49014

摘要： In order to obtain a superconducting wire containing an oxide superconductor, whose critical current density is not much reduced upon application of bending, a plurality of strands 3, comprising oxide superconductors 1 covered with first metal sheaths 2, are filled into a second metal sheath 4, and deformation processing is performed to sectionally apply a compressive load to the second metal sheath, so that the thickness of the oxide superconductor 1 contained in each strand 3 is not more than 5% of the overall thickness of the superconducting wire 6.

摘要翻译： 为了获得含有氧化物超导体的超导线材，其临界电流密度在施加弯曲时其临界电流密度不会降低，包括用第一金属护套2覆盖的包含氧化物超导体1的多个线束3被填充到第二金属护套4中 并且进行变形处理以向第二金属护套分层施加压缩载荷，使得包含在每个绞线3中的氧化物超导体1的厚度不超过超导线6的总厚度的5％。

公开(公告)号：US06357105B1

公开(公告)日：2002-03-19

申请号：US08999675

申请日：1997-10-14

申请人： Takeshi Hikata ,  Hidehito Mukai ,  Kenichi Sato

发明人： Takeshi Hikata ,  Hidehito Mukai ,  Kenichi Sato

IPC分类号： H01L3924

CPC分类号： C04B35/45 ,  H01L39/143 ,  H01L39/248 ,  Y10T29/49014

摘要： An oxide superconducting wire of an anisotropic oxide superconductor comprises a core part of the wire and a superconducting layer enclosing the core part so that specific crystal axes of the oxide superconductor are oriented toward the core part. A method of producing a wire of an anisotropic oxide superconductor comprises the steps of arranging a metal sheath around a metal rod for forming a core part of the wire and charging powder of the oxide superconductor in a clearance between the metal sheath and the metal rod for preparing a composite material, and plastically working the composite material so that the metal sheath is larger in reduction of area than the metal rod.

摘要翻译： 各向异性氧化物超导体的氧化物超导线包括导线的芯部和包围芯部的超导层，使得氧化物超导体的特定晶轴朝向芯部。 制造各向异性氧化物超导体的线的方法包括以下步骤：在金属棒周围配置金属护套，以形成电线的芯部，并且在金属护套和金属棒之间的间隙中加入氧化物超导体的粉末， 制备复合材料，并且对复合材料进行塑性加工，使得金属护套的面积减小比金属棒大。

公开(公告)号：US06311384B1

公开(公告)日：2001-11-06

申请号：US08955323

申请日：1997-10-20

申请人： Hidehito Mukai

发明人： Hidehito Mukai

IPC分类号： H01L3924

CPC分类号： H01L39/248 ,  Y10S505/739 ,  Y10S505/74

摘要： An oxide superconducting wire is obtained by performing plastic working and heat treatment of a metal pipe which is filled up with raw material powder of an oxide superconductor. In the plastic working step, the metal pipe is subjected to flat working so that the raw material powder flows in the longitudinal direction as well as the cross direction in the metal pipe. In this case, a draft of at least 80% and not more than 98% is selected in the flat working step, to further promote the cross-directional flow of the raw material powder, thereby further improving density of the raw material powder. Thus, the as-formed oxide superconducting wire exhibits higher critical current density.

摘要翻译： 通过对填充有氧化物超导体的原料粉末的金属管进行塑性加工和热处理，获得氧化物超导线。 在塑性加工工序中，对金属管进行平面加工，原料粉末沿金属管的长度方向以及横方向流动。 在这种情况下，在平面加工工序中选择至少80％以上且98％以下的进料，以进一步促进原料粉末的横向流动，从而进一步提高原料粉末的密度。 因此，形成的氧化物超导线材具有更高的临界电流密度。