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    1-Phenyl-1H-pyrazolo [3,4-b]pyrazine derivatives and process for preparing same
    1.
    发明授权
    1-Phenyl-1H-pyrazolo [3,4-b]pyrazine derivatives and process for preparing same 失效
    1-苯基-1H-吡唑并[3,4-b]吡嗪衍生物及其制备方法

    公开(公告)号：US4460773A

    公开(公告)日：1984-07-17

    申请号：US428016

    申请日：1982-09-29

    申请人： Shinichi Suzuki ,  Kunitomo Suzuki ,  Hiromitsu Honda

    发明人： Shinichi Suzuki ,  Kunitomo Suzuki ,  Hiromitsu Honda

    IPC分类号： C07D407/04 ,  C07D487/04 ,  A61K31/495

    CPC分类号： C07D407/04

    摘要： Novel 1-phenyl-1H-pyrazolo[3,4-b]pyrazine derivatives are provided which are represented by the formula: ##STR1## wherein A is (i) ##STR2## in which R.sub.1 and R.sub.2 are hydrogen or an alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl or amino group, or a divalent radical forming a nitrogen-containing saturated heterocyclic ring together with the nitrogen atom, (ii) ##STR3## wherein R.sub.3 is a phenyl group which is unsubstituted or substituted by halogen or a lower alkyl, lower alokoxy, carboxyl or nitro group, and R.sub.4 is halogen or a methyl or ethyl group, (iii)--OR.sub.5 in which R.sub.5 is a phenyl group which is unsubstituted or substituted by halogen or a hydroxyl, lower alkyl, lower alkoxy, amino or lower alkylamide group, or (iv)--OR.sub.6 is an alkyl group which is unsubstituted or substituted by halogen or a phenyl, furanyl, tetrahydrofuranyl or alkylamino group. These derivatives have antitumor or antiviral activity.

    摘要翻译： 提供新的1-苯基-1H-吡唑并[3,4-b]吡嗪衍生物，其由下式表示：其中A是（i）其中R 1和R 2是氢或烷基，被取代的 烷基，环烷基，取代的环烷基或氨基，或与氮原子一起形成含氮饱和杂环的二价基团，（ii）其中R3是未被取代或被卤素或低级 烷基，低级甲氧基，羧基或硝基，R4为卤素或甲基或乙基，（ⅲ）-OR5，其中R5为未取代的或被卤素或羟基取代的苯基，低级烷基，低级烷氧基， 氨基或低级烷基酰胺基，或（iv）-OR 6是未被取代或被卤素或苯基，呋喃基，四氢呋喃基或烷基氨基取代的烷基。 这些衍生物具有抗肿瘤或抗病毒活性。

    Novel compounds spiro[5-isopropylbicyclo[3.1.0]hexane-2,2'-oxiranes], process for the production of the novel compounds, and process for the production of sabinene hydrates therefrom
    2.
    发明授权
    Novel compounds spiro[5-isopropylbicyclo[3.1.0]hexane-2,2'-oxiranes], process for the production of the novel compounds, and process for the production of sabinene hydrates therefrom 失效
    新颖的化合物螺（{8-5-异丙基双环{8 3.1.0 {9己烷-2,2 {40-环氧乙烷{9，生产新化合物的方法，以及由其制备桧烯水合物的方法

    公开(公告)号：US4162258A

    公开(公告)日：1979-07-24

    申请号：US890337

    申请日：1978-03-27

    申请人： Moriaki Higo ,  Haruhiko Toda ,  Kunitomo Suzuki ,  Yasukuni Nishida

    发明人： Moriaki Higo ,  Haruhiko Toda ,  Kunitomo Suzuki ,  Yasukuni Nishida

    IPC分类号： C07C29/132 ,  C07C35/27 ,  C07C381/00 ,  C07D303/04 ,  C11B9/00

    CPC分类号： C11B9/0088 ,  C07C29/132 ,  C07C35/27 ,  C07C381/00 ,  C07C45/69 ,  C07D303/04 ,  C07C2101/10 ,  C07C2102/14

    摘要： Novel compounds trans- and/or cis-spiro[5-isopropylbicyclo[3.1.0]hexane-2,2'-oxiranes], process for the production of the novel compounds comprising reacting 3-isopropyl-2-cyclopenten-1-one with sulfoxonium methylide to form the novel compounds, process for the production of novel compounds comprising reacting 5-isopropylbicyclo[3.1.0]hexan-2-one with sulfonium methylide or sulfoxonium methylide to form the novel compounds, and process for the production of novel compounds comprising the steps of reacting 3-isopropyl-2-cyclopenten-1-one with sulfoxonium methylide to form 5-isopropylbicyclo[3.1.0]hexan-2-one and then reacting the 5-isopropylbicyclo[3.1.0]hexan-2-one with sulfonium methylide or sulfoxonium methylide to form the novel compounds. Trans- and/or cis-sabinene hydrates can readily be prepared from the novel compounds trans- and/or cis-spiro[5-isopropylbicyclo[3.1.0]hexane-2,2'-oxiranes].

    摘要翻译： 新型化合物反式和/或顺式 - 螺[5-异丙基双环[3.1.0]己烷-2,2'-环氧乙烷]，制备新型化合物的方法，包括使3-异丙基-2-环戊烯-1-酮 与甲基化氧化锍形成新化合物，生产新化合物的方法包括使5-异丙基双环[3.1.0]己-2-酮与锍甲基化物或甲基锍甲肟反应形成新化合物，以及生产新型化合物的方法 包括以下步骤的方法：使3-异丙基-2-环戊烯-1-酮与环氧锍甲基化物反应形成5-异丙基双环[3.1.0]己-2-酮，然后使5-异丙基双环[3.1.0]己烷-2 - 用甲基化锍或甲基化氧化锍形成新化合物。 反式和/或顺式 - 亚乙烯基水合物可以容易地由新型化合物反式和/或顺式 - 螺[5-异丙基双环[3.1.0]己烷-2,2'-环氧乙烷]制备。