公开(公告)号：US08877454B2

公开(公告)日：2014-11-04

申请号：US12681573

申请日：2008-10-03

申请人： Shinichiro Nishimura ,  Yasuro Shinohara ,  Yoshiaki Miura ,  Hiroshi Yamazaki ,  Michio Horiuchi ,  Hiroaki Motoki ,  Toshiharu Kuroda ,  Yoko Kita ,  Mika Nakano

发明人： Shinichiro Nishimura ,  Yasuro Shinohara ,  Yoshiaki Miura ,  Hiroshi Yamazaki ,  Michio Horiuchi ,  Hiroaki Motoki ,  Toshiharu Kuroda ,  Yoko Kita ,  Mika Nakano

IPC分类号： C12Q1/37 ,  G01N33/68 ,  G01N30/72 ,  H01J49/00

CPC分类号： G01N33/6848 ,  G01N30/7233 ,  G01N2400/00 ,  H01J49/00

摘要： To provide an autoanalyzer for analyzing a sugar chain contained in a biological sample, in particular, serum. Namely, it is intended to provide a method of analyzing a sugar chain in a sample, which comprises the following steps: A) the sugar chain-releasing step of releasing the sugar chain in the sample; B) the detection sample-preparing step of preparing the released sugar chain for detection; and, in the case of conducting mass spectrometry using a plate, C) the step of forming a plate for the mass spectrometry having the captured sugar chain dotted thereon which comprises the step of providing the tagged sugar chain sample solution obtained in the step B) on a collection plate; and, if required, the step of conducting an operation in a solid phase support-enclosed plate to form the plate for mass spectrometry; and D) the step of analyzing the sugar chain to be assayed.

摘要翻译： 提供一种用于分析生物样品，特别是血清中所含的糖链的自动分析仪。 即，提供一种分析样品中的糖链的方法，其包括以下步骤：A）释放样品中的糖链的糖链释放步骤; B）制备释放的糖链进行检测的检测样品制备步骤; 并且在使用板进行质谱分析的情况下，C）形成具有点状捕获的糖链的用于质谱的板的步骤，其包括提供步骤B）中获得的标记的糖链样品溶液的步骤， 在收集板上; 如果需要，在固相支持封闭板中进行操作以形成质谱板的步骤; 和D）分析要测定的糖链的步骤。

公开(公告)号：US20110111443A1

公开(公告)日：2011-05-12

申请号：US12681573

申请日：2008-10-03

申请人： Shinichiro Nishimura ,  Yasuro Shinohara ,  Yoshiaki Miura ,  Hiroshi Yamazaki ,  Michio Horiuchi ,  Hiroaki Motoki ,  Toshiharu Kuroda ,  Yoko Kita ,  Mika Nakano

发明人： Shinichiro Nishimura ,  Yasuro Shinohara ,  Yoshiaki Miura ,  Hiroshi Yamazaki ,  Michio Horiuchi ,  Hiroaki Motoki ,  Toshiharu Kuroda ,  Yoko Kita ,  Mika Nakano

IPC分类号： C12Q1/37 ,  C12M1/34 ,  C12P19/00 ,  C40B60/14

CPC分类号： G01N33/6848 ,  G01N30/7233 ,  G01N2400/00 ,  H01J49/00

摘要： To provide an autoanalyzer for analyzing a sugar chain contained in a biological sample, in particular, serum. Namely, it is intended to provide a method of analyzing a sugar chain in a sample, which comprises the following steps: A) the sugar chain-releasing step of releasing the sugar chain in the sample; B) the detection sample-preparing step of preparing the released sugar chain for detection; and, in the case of conducting mass spectrometry using a plate, C) the step of forming a plate for the mass spectrometry having the captured sugar chain dotted thereon which comprises the step of providing the tagged sugar chain sample solution obtained in the step B) on a collection plate; and, if required, the step of conducting an operation in a solid phase support-enclosed plate to form the plate for mass spectrometry; and D) the step of analyzing the sugar chain to be assayed.

摘要翻译： 提供一种用于分析生物样品，特别是血清中所含的糖链的自动分析仪。 即，提供一种分析样品中的糖链的方法，其包括以下步骤：A）释放样品中的糖链的糖链释放步骤; B）制备释放的糖链进行检测的检测样品制备步骤; 并且在使用板进行质谱分析的情况下，C）形成具有点状捕获的糖链的用于质谱的板的步骤，其包括提供步骤B）中获得的标记的糖链样品溶液的步骤， 在收集板上; 如果需要，在固相支持封闭板中进行操作以形成质谱板的步骤; 和D）分析要测定的糖链的步骤。

公开(公告)号：US08642070B2

公开(公告)日：2014-02-04

申请号：US10588969

申请日：2005-04-27

申请人： Akira Okutani ,  Hiroaki Motoki ,  Eiji Tamura ,  Yumi Takashima ,  Shunsuke Sakai

发明人： Akira Okutani ,  Hiroaki Motoki ,  Eiji Tamura ,  Yumi Takashima ,  Shunsuke Sakai

IPC分类号： A23K1/17 ,  A23K1/165

CPC分类号： A61K31/198 ,  A23K20/105 ,  A23K20/158 ,  A23K40/35 ,  A23K50/10

摘要： The coating composition which coats the biologically active substance includes at least one protective material selected from the group consisting of a hardened animal fat, a hardened vegetable oil, a linear or branched, saturated or unsaturated aliphatic monocarboxylic acid having 12 to 22 carbon atoms, a fatty acid ester, and a wax group; lecithin; and at least one preservative selected from a propionic acid or its salt, a sorbic acid or its salt, a benzoic acid or its salt, a dehydroacetic acid or its salt, parahydroxybenzoic acid esters, an imazalil, a thiabendazole, an orthophenyl phenol, an orthophenyl phenol natrium, and a diphenyl.

摘要翻译： 涂覆生物活性物质的涂料组合物包括至少一种选自硬化动物脂肪，硬化植物油，具有12-22个碳原子的直链或支链，饱和或不饱和脂肪族单羧酸的保护材料， 脂肪酸酯和蜡基; 卵磷脂 和选自丙酸或其盐，山梨酸或其盐，苯甲酸或其盐的至少一种防腐剂，脱氢乙酸或其盐，对羟基苯甲酸酯，咪达唑仑，噻苯达唑，邻苯基苯酚， 邻苯基苯酚钠和二苯基。

公开(公告)号：US4269765A

公开(公告)日：1981-05-26

申请号：US891645

申请日：1978-03-30

申请人： Yoshiji Matsuda ,  Keiji Tamura ,  Hiroaki Motoki ,  Fumio Kitame ,  Nakao Ishida

发明人： Yoshiji Matsuda ,  Keiji Tamura ,  Hiroaki Motoki ,  Fumio Kitame ,  Nakao Ishida

IPC分类号： G01N33/574 ,  A61K39/395 ,  C07K14/435 ,  C07K16/00 ,  C07K16/06 ,  A61K39/00 ,  A61K39/44 ,  C07G7/00 ,  G01N33/54

CPC分类号： C07K16/06 ,  Y10S436/813 ,  Y10S530/806 ,  Y10S530/828 ,  Y10S530/851

摘要： The present invention provides a method for the preparation of a specific immune serum by immunizing IAP in animals other than humans and absorbing the thus obtained serum with normal human serum.

摘要翻译： 本发明提供了通过在除人以外的动物中免疫IAP而制备特异性免疫血清的方法，并用正常人血清吸收由此获得的血清。

公开(公告)号：US20070148212A1

公开(公告)日：2007-06-28

申请号：US10588969

申请日：2005-04-27

申请人： Akira Okutani ,  Hiroaki Motoki ,  Eiji Tamura ,  Yumi Takashima ,  Shunsuke Sakai

发明人： Akira Okutani ,  Hiroaki Motoki ,  Eiji Tamura ,  Yumi Takashima ,  Shunsuke Sakai

IPC分类号： A61K31/198 ,  A23K1/17

CPC分类号： A61K31/198 ,  A23K20/105 ,  A23K20/158 ,  A23K40/35 ,  A23K50/10

摘要： The coating composition which coats the biologically active substance includes at least one protective material selected from the group consisting of a hardened animal fat, a hardened vegetable oil, a linear or branched, saturated or unsaturated aliphatic monocarboxylic acid having 12 to 22 carbon atoms, a fatty acid ester, and a wax group; lecithin; and at least one preservative selected from a propionic acid or its salt, a sorbic acid or its salt, a benzoic acid or its salt, a dehydroacetic acid or its salt, parahydroxybenzoic acid esters, an imazalil, a thiabendazole, an orthophenyl phenol, an orthophenyl phenol natrium, and a diphenyl.

摘要翻译： 涂覆生物活性物质的涂料组合物包括至少一种选自硬化动物脂肪，硬化植物油，具有12-22个碳原子的直链或支链，饱和或不饱和脂肪族单羧酸的保护材料， 脂肪酸酯和蜡基; 卵磷脂 和选自丙酸或其盐，山梨酸或其盐，苯甲酸或其盐的至少一种防腐剂，脱氢乙酸或其盐，对羟基苯甲酸酯，咪达唑仑，噻苯达唑，邻苯基苯酚， 邻苯基苯酚钠和二苯基。