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1.发明授权Copolymer containing 3-hydroxyalkanoate unit and lactate unit, and its manufacturing method 有权含有3-羟基链烷酸酯单元和乳酸单体的共聚物及其制备方法公开(公告)号：US08765402B2
公开(公告)日：2014-07-01
申请号：US12312636
申请日：2007-11-21
申请人： Si-Jae Park , Taek-Ho Yang , Hye-Ok Kang , Sang-Hyun Lee , Eun-Jeong Lee , Tae-Wan Kim , Sang-Yup Lee
发明人： Si-Jae Park , Taek-Ho Yang , Hye-Ok Kang , Sang-Hyun Lee , Eun-Jeong Lee , Tae-Wan Kim , Sang-Yup Lee
IPC分类号： C12P1/04
摘要： The present invention relates to a copolymer comprising 3-hydroxyalkanoate monomer unit and lactate monomer unit, or their preparing method. More specifically, the present invention relates to a method for preparing a copolymer comprising lactate monomer and 3-hydroxyalkanoate monomer, wherein the method comprises culturing a cell or plant comprising the gene of enzyme converting lactate and 3-hydroxyalkanoate into lactyl-CoA and 3-hydroxyalkanoyl-CoA, respectively, and polyhydroxyalkanoate synthase gene together, and the copolymer made by the method. The copolymer of the present invention is a biodegradable polymer being able to be usefully used instead of conventional synthetic plastic, and the copolymer can be used also for medical use.
摘要翻译： 本发明涉及包含3-羟基链烷酸酯单体单元和乳酸单体单元的共聚物或其制备方法。 更具体地说，本发明涉及一种制备包含乳酸单体和3-羟基链烷酸酯单体的共聚物的方法，其中所述方法包括将包含转化乳酸酯和3-羟基链烷酸酯的酶的基因的细胞或植物培养成乳酰CoA和3- 羟基烷酰基-CoA和聚羟基链烷酸酯合酶基因，以及通过该方法制备的共聚物。 本发明的共聚物是可以有效地代替常规合成塑料的可生物降解的聚合物，并且共聚物也可以用于医疗用途。
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2.发明授权Mutants of PHA synthase from Pseudomonas sp. 6-19 and method for preparing lactate homopolymer or copolymer using the same 有权来自假单胞菌属的PHA合酶突变体 6-19和使用该乳酸酯均聚物或共聚物的方法公开(公告)号：US08541652B2
公开(公告)日：2013-09-24
申请号：US12312676
申请日：2007-11-21
申请人： Taek-Ho Yang , Hye-Ok Kang , Si-Jae Park , Sang-Hyun Lee , Eun-Jeong Lee , Tae-wan Kim , Sang-Yup Lee
发明人： Taek-Ho Yang , Hye-Ok Kang , Si-Jae Park , Sang-Hyun Lee , Eun-Jeong Lee , Tae-wan Kim , Sang-Yup Lee
CPC分类号： C12N9/1025 , C12N15/8243 , C12P7/625
摘要： The present invention relates to polyhydroxyalkanoate synthase (PHA synthase) mutant originated from Pseudomonas sp. 6-19 (KCTC 11027BP) which can prepare lactate polymer and/or copolymer by using lactyl-CoA as a substrate. The present invention relates to a method for preparing lactate polymer and/or copolymer with the synthase mutant. The polyhydroxyalkanoate synthase mutants of the present invention originated from Pseudomonas sp. 6-19 can efficiently prepare lactate polymer and/or copolymer by using as a substrate lactyl-CoA which is difficult to be used as a substrate by conventional polyhydroxyalkanoate synthase.
摘要翻译： 本发明涉及源于假单胞菌属的聚羟基链烷酸酯合成酶（PHA合酶）突变体。 6-19（KCTC 11027BP），其可以通过使用乳酰辅酶A作为底物制备乳酸聚合物和/或共聚物。 本发明涉及一种用合成酶突变体制备乳酸聚合物和/或共聚物的方法。 本发明的聚羟基链烷酸酯合酶突变体起源于假单胞菌属 6-19可以通过使用难以用作常规聚羟基链烷酸酯合成酶的底物的底物乳酰基辅酶A来有效地制备乳酸聚合物和/或共聚物。
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3.发明申请MUTANTS OF PHA SYNTHASE FROM PSEUDOMONAS SP. 6-19 AND METHOD FOR PREPARING LACTATE HOMOPOLYMER OR COPOLYMER USING THE SAME 有权来自PSEUDOMONAS SP的PHA合成酶的突变体 6-19及其制备使用其的乳化剂共聚物或共聚物的方法公开(公告)号：US20100050298A1
公开(公告)日：2010-02-25
申请号：US12312676
申请日：2007-11-21
申请人： Si-Jae Park , Taek-Ho Yang , Hye-Ok Kang , Sang-Hyun Lee , Eun-Jeong Lee , Tae-Wan Kim , Sang-Yup Lee
发明人： Si-Jae Park , Taek-Ho Yang , Hye-Ok Kang , Sang-Hyun Lee , Eun-Jeong Lee , Tae-Wan Kim , Sang-Yup Lee
CPC分类号： C12N9/1025 , C12N15/8243 , C12P7/625
摘要： The present invention relates to polyhydroxyalkanoate synthase (PHA synthase) mutant originated from Pseudomonas sp. 6-19 (KCTC 11027BP) which can prepare lactate polymer and/or copolymer by using lactyl-CoA as a substrate. The present invention relates to a method for preparing lactate polymer and/or copolymer with the synthase mutant. The polyhydroxyalkanoate synthase mutants of the present invention originated from Pseudomonas sp. 6-19 can efficiently prepare lactate polymer and/or copolymer by using as a substrate lactyl-CoA which is difficult to be used as a substrate by conventional polyhydroxyalkanoate synthase.
摘要翻译： 本发明涉及源于假单胞菌属的聚羟基链烷酸酯合成酶（PHA合酶）突变体。 6-19（KCTC 11027BP），其可以通过使用乳酰辅酶A作为底物制备乳酸聚合物和/或共聚物。 本发明涉及一种用合成酶突变体制备乳酸聚合物和/或共聚物的方法。 本发明的聚羟基链烷酸酯合酶突变体起源于假单胞菌属 6-19可以通过使用难以用作常规聚羟基链烷酸酯合成酶的底物的底物乳酰基辅酶A来有效地制备乳酸聚合物和/或共聚物。
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4.发明申请COPOLYMER CONTAINING 3-HYDROXYALKANOATE UNIT AND LACTATE UNIT, AND ITS MANUFACTURING METHOD 有权含有三羟基烷酸酯单体和乳酸单体的共聚物及其制造方法公开(公告)号：US20110046339A1
公开(公告)日：2011-02-24
申请号：US12312636
申请日：2007-11-21
申请人： Si-Jae Park , Taek-Ho Yang , Hye-ok Kang , Sang-Hyun Lee , Eun-Jeong Lee , Tae-Wan Kim , Sang-Yup Lee
发明人： Si-Jae Park , Taek-Ho Yang , Hye-ok Kang , Sang-Hyun Lee , Eun-Jeong Lee , Tae-Wan Kim , Sang-Yup Lee
摘要： The present invention relates to a copolymer comprising 3-hydroxyalkanoate monomer unit and lactate monomer unit, or their preparing method. More specifically, the present invention relates to a method for preparing a copolymer comprising lactate monomer and 3-hydroxyalkanoate monomer, wherein the method comprises culturing a cell or plant comprising the gene of enzyme converting lactate and 3-hydroxyalkanoate into lactyl-CoA and 3-hydroxyalkanoyl-CoA, respectively, and polyhydroxyalkanoate synthase gene together, and the copolymer made by the method. The copolymer of the present invention is a biodegradable polymer being able to be usefully used instead of conventional synthetic plastic, and the copolymer can be used also for medical use.
摘要翻译： 本发明涉及包含3-羟基链烷酸酯单体单元和乳酸单体单元的共聚物或其制备方法。 更具体地说，本发明涉及一种制备包含乳酸单体和3-羟基链烷酸酯单体的共聚物的方法，其中所述方法包括将包含转化乳酸酯和3-羟基链烷酸酯的酶的基因的细胞或植物培养成乳酰CoA和3- 羟基烷酰基-CoA和聚羟基链烷酸酯合酶基因，以及通过该方法制备的共聚物。 本发明的共聚物是可以有效地代替常规合成塑料的可生物降解的聚合物，并且共聚物也可以用于医疗用途。
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5.发明申请COPOLYMER COMPRISING 4-HYDROXYBUTYRATE UNIT AND LACTATE UNIT AND ITS MANUFACTURING METHOD 有权包含4-羟基丁酸酯单体和乳液单元的共聚物及其制造方法公开(公告)号：US20100222545A1
公开(公告)日：2010-09-02
申请号：US12312635
申请日：2007-11-21
申请人： Si-Jae Park , Taek-Ho Yang , Hye-Ok Kang , Sang-Hyun Lee , Eun-Jeong Lee , Tae-Wan Kim , Sang-Yup Lee
发明人： Si-Jae Park , Taek-Ho Yang , Hye-Ok Kang , Sang-Hyun Lee , Eun-Jeong Lee , Tae-Wan Kim , Sang-Yup Lee
CPC分类号： C08G63/06 , C12N9/1025 , C12N15/8243 , C12N15/8245 , C12P7/625
摘要： The present invention relates to a copolymer comprising 4-hydroxybutyrate monomer unit and lactate monomer unit, a copolymer 4-hydroxybutyrate monomer unit, lactate monomer unit and 3-hydroxyalkanoate, or their preparing method. More specifically, the present invention relates to a method for preparing a copolymer comprising lactate monomer; 4-hydroxybutyrate monomer; and optionally 3-hydroxyalkanoate, wherein the method comprises culturing a cell or plant comprising the gene of enzyme converting lactate and 3-hydroxyalkanoate into lactyl-CoA and 3-hydroxyalkanoyl-CoA, respectively, phosphotransbutylase gene, butyrate kinase gene and polyhydroxyalkanoate synthase gene together, and the copolymer made by the method. The copolymer of the present invention is a biodegradable polymer being able to be usefully used instead of conventional synthetic plastic, and the copolymer can be used for medical use.
摘要翻译： 本发明涉及包含4-羟基丁酸酯单体单元和乳酸酯单体单元，共聚物4-羟基丁酸酯单体单元，乳酸酯单体单元和3-羟基链烷酸酯的共聚物或其制备方法。 更具体地说，本发明涉及制备包含乳酸酯单体的共聚物的方法; 4-羟基丁酸酯单体; 和任选的3-羟基链烷酸酯，其中所述方法包括分别将含有转化乳酸盐和3-羟基链烷酸酯的酶的基因的细胞或植物分别培养成乳酰基-CoA和3-羟基烷酰基-CoA，磷酸转移酶基因，丁酸酯激酶基因和聚羟基链烷酸酯合酶基因 和通过该方法制备的共聚物。 本发明的共聚物是能够有效地代替常规合成塑料的可生物降解聚合物，该共聚物可用于医疗用途。
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6.发明授权Copolymer comprising 4-hydroxybutyrate unit and lactate unit and its manufacturing method 有权包含4-羟基丁酸酯单元和乳酸单元的共聚物及其制备方法公开(公告)号：US08383379B2
公开(公告)日：2013-02-26
申请号：US12312635
申请日：2007-11-21
申请人： Si-Jae Park , Taek-Ho Yang , Hye-Ok Kang , Sang-Hyun Lee , Eun-Jeong Lee , Tae-Wan Kim , Sang-Yup Lee
发明人： Si-Jae Park , Taek-Ho Yang , Hye-Ok Kang , Sang-Hyun Lee , Eun-Jeong Lee , Tae-Wan Kim , Sang-Yup Lee
CPC分类号： C08G63/06 , C12N9/1025 , C12N15/8243 , C12N15/8245 , C12P7/625
摘要： The present invention relates to a copolymer comprising 4-hydroxybutyrate monomer unit and lactate monomer unit, a copolymer 4-hydroxybutyrate monomer unit, lactate monomer unit and 3-hydroxyalkanoate, or their preparing method. More specifically, the present invention relates to a method for preparing a copolymer comprising lactate monomer; 4-hydroxybutyrate monomer; and optionally 3-hydroxyalkanoate, wherein the method comprises culturing a cell or plant comprising the gene of enzyme converting lactate and 3-hydroxyalkanoate into lactyl-CoA and 3-hydroxyalkanoyl-CoA, respectively, phosphotransbutylase gene, butyrate kinase gene and polyhydroxyalkanoate synthase gene together, and the copolymer made by the method. The copolymer of the present invention is a biodegradable polymer being able to be usefully used instead of conventional synthetic plastic, and the copolymer can be used for medical use.
摘要翻译： 本发明涉及包含4-羟基丁酸酯单体单元和乳酸酯单体单元，共聚物4-羟基丁酸酯单体单元，乳酸酯单体单元和3-羟基链烷酸酯的共聚物或其制备方法。 更具体地说，本发明涉及制备包含乳酸酯单体的共聚物的方法; 4-羟基丁酸酯单体; 和任选的3-羟基链烷酸酯，其中所述方法包括分别将含有转化乳酸盐和3-羟基链烷酸酯的酶的基因的细胞或植物分别培养成乳酰基-CoA和3-羟基烷酰基-CoA，磷酸转移酶基因，丁酸酯激酶基因和聚羟基链烷酸酯合酶基因 和通过该方法制备的共聚物。 本发明的共聚物是能够有效地代替常规合成塑料的可生物降解聚合物，该共聚物可用于医疗用途。
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7.发明授权Mutants having capability to produce 1, 4-butanediol and method for preparing 1, 4-butanediol using the same 有权具有生产1,4-丁二醇能力的突变体和使用其制备1,4-丁二醇的方法公开(公告)号：US09096860B2
公开(公告)日：2015-08-04
申请号：US12676840
申请日：2008-08-13
申请人： Si-Jae Park , Sang-Hyun Lee , Sang-Yup Lee , Eun-Jeong Lee
发明人： Si-Jae Park , Sang-Hyun Lee , Sang-Yup Lee , Eun-Jeong Lee
CPC分类号： C12N15/77 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/13 , C12P7/18 , C12Y101/01061 , C12Y102/01024 , C12Y103/99002
摘要： A mutant capable of producing 1,4-butanediol and a method of preparing 1,4-butanediol using the same are provided. The mutant microorganism is prepared by introducing and amplifying genes encoding enzymes converting succinate into 4-hydroxybutyrate and 4-hydroxybutyrate into 1,4-butanediol in a microorganism capable of producing succinate. The method includes culturing the mutant in a medium containing carbohydrate and obtaining 1,4-butanediol from the culture. Thus, 1,4-butanediol, which is essential in chemical industry, can be prepared in a biological process.
摘要翻译： 提供能够生产1,4-丁二醇的突变体和使用其制备1,4-丁二醇的方法。 通过在能够产生琥珀酸的微生物中引入和扩增编码将琥珀酸酯转化成4-羟基丁酸酯和4-羟基丁酸酯的基因转化成1,4-丁二醇来制备突变体微生物。 该方法包括在含有碳水化合物的培养基中培养该突变体并从培养物中获得1,4-丁二醇。 因此，在化学工业中必不可少的1,4-丁二醇可以在生物过程中制备。
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8.发明申请Adhesive Bead For Immobilization of Biomolecules and Method For Fabricating a Biochip Using the Same 审中-公开用于固定生物分子的粘合珠和使用其制造生物芯片的方法公开(公告)号：US20080248962A1
公开(公告)日：2008-10-09
申请号：US11547362
申请日：2006-04-24
申请人： Jae-Kwon Kim , Eun-Jeong Lee , Dong Jo Ryu , Jae-Young Jang
发明人： Jae-Kwon Kim , Eun-Jeong Lee , Dong Jo Ryu , Jae-Young Jang
CPC分类号： C12Q1/706 , C09J133/08
摘要： The present invention relates to an adhesive bead for immobilizing biomolecules and a method for fabricating a biochip using the same, and more particularly, relates to an adhesive bead functioning both as a solid support immobilizing biomolecules and an adhesive to the surface of a biochip substrate, and a method for fabricating a biochip, the method comprising the steps of immobilizing biomolecules to the adhesive bead to prepare an aqueous suspension of beads on which biomolecules are fixed and fixing the aqueous suspension on a substrate. The adhesive beads of the present invention can be directely immobilized on a biochip without additional equipment and treatment process due to the dual functions of a solid support immobilizing biomolecules and an adhesive to the surface of a substrate.
摘要翻译： 本发明涉及用于固定生物分子的粘合剂珠粒和使用其的生物芯片的制造方法，更具体地说，涉及一种用作将固体生物分子固定的固体载体和粘附剂固定在生物芯片基材表面上的粘合剂珠粒， 和一种制造生物芯片的方法，该方法包括以下步骤：将生物分子固定在粘合剂珠粒上，以制备其上固定有生物分子的珠的水悬浮液，并将该悬浮液固定在基材上。 由于固体支持物固定生物分子和粘合剂到基底表面的双重功能，本发明的粘合剂珠粒可以直接固定在生物芯片上，无需额外的设备和处理工艺。
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