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公开(公告)号：US20050282864A1
公开(公告)日：2005-12-22
申请号：US11157093
申请日：2005-06-20
申请人： Silvia McArthur , Cornelia Hertel , Matthias Nettekoven , Susanne Raab , Olivier Roche , Rosa Rodriguez-Sarmiento , Franz Schuler , Jean Marc Plancher
发明人： Silvia McArthur , Cornelia Hertel , Matthias Nettekoven , Susanne Raab , Olivier Roche , Rosa Rodriguez-Sarmiento , Franz Schuler , Jean Marc Plancher
IPC分类号： C07D209/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , A61K31/454 , C07D43/02
CPC分类号： C07D405/14 , C07D209/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
摘要： The present invention relates to compounds of formula I: wherein X, R1, R2, R3, R4 and R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物：其中X，R 1，R 2，R 3，R 4， SUP和R 5如在说明书和权利要求书及其药学上可接受的盐中所定义，用于制备这些化合物和含有它们的药物组合物。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US20070265254A1
公开(公告)日：2007-11-15
申请号：US11821263
申请日：2007-06-22
申请人： Silvia McArthur , Cornelia Hertel , Matthias Nettekoven , Jean-Marc Plancher , Susanne Raab , Olivier Roche , Rosa Rodriguez-Sarmiento , Franz Schuler
发明人： Silvia McArthur , Cornelia Hertel , Matthias Nettekoven , Jean-Marc Plancher , Susanne Raab , Olivier Roche , Rosa Rodriguez-Sarmiento , Franz Schuler
IPC分类号： A61K31/40 , A61K31/445 , A61K31/47 , A61K31/497 , A61K31/535 , A61K31/54 , A61P25/00 , C07D207/12 , C07D211/06 , C07D217/22 , C07D401/02 , C07D403/02 , C07D413/02 , C07D417/02
CPC分类号： C07D401/10 , C07D205/04 , C07D207/06 , C07D207/12 , C07D207/14 , C07D209/44 , C07D211/22 , C07D211/38 , C07D211/42 , C07D211/46 , C07D217/06 , C07D295/088 , C07D295/192
摘要： The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
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公开(公告)号：US20060009449A1
公开(公告)日：2006-01-12
申请号：US11142738
申请日：2005-06-01
申请人： Silvia McArthur , Cornelia Hertel , Matthias Nettekoven , Jean-Marc Plancher , Sussanne Raab , Olivier Roche , Rosa Rodriguez-Sarmiento , Franz Schuler
发明人： Silvia McArthur , Cornelia Hertel , Matthias Nettekoven , Jean-Marc Plancher , Sussanne Raab , Olivier Roche , Rosa Rodriguez-Sarmiento , Franz Schuler
IPC分类号： A61K31/541 , A61K31/496 , A61K31/454 , C07D417/14 , C07D43/14
CPC分类号： C07D401/10 , C07D205/04 , C07D207/06 , C07D207/12 , C07D207/14 , C07D209/44 , C07D211/22 , C07D211/38 , C07D211/42 , C07D211/46 , C07D217/06 , C07D295/088 , C07D295/192
摘要： The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
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公开(公告)号：US20060084679A1
公开(公告)日：2006-04-20
申请号：US11251509
申请日：2005-10-14
申请人： Silvia McArthur , Cornelia Hertel , Matthias Nettekoven , Susanne Raab , Hans Richter , Olivier Roche , Rosa Rodriguez-Sarmiento , Franz Schuler
发明人： Silvia McArthur , Cornelia Hertel , Matthias Nettekoven , Susanne Raab , Hans Richter , Olivier Roche , Rosa Rodriguez-Sarmiento , Franz Schuler
IPC分类号： A61K31/4709 , A61K31/47 , C07D401/02 , C07D215/38
CPC分类号： C07D401/14 , C07D215/48 , C07D401/12 , C07D405/14 , C07D417/12
摘要： The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof as well as to pharmaceutical compositions comprising these compounds and to methods for their preparation. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
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公开(公告)号：US07259158B2
公开(公告)日：2007-08-21
申请号：US11142738
申请日：2005-06-01
申请人： Silvia Gatti McArthur , Cornelia Hertel , Matthias Heinrich Nettekoven , Jean-Marc Plancher , Susanne Raab , Olivier Roche , Rosa Maria Rodriguez-Sarmiento , Franz Schuler
发明人： Silvia Gatti McArthur , Cornelia Hertel , Matthias Heinrich Nettekoven , Jean-Marc Plancher , Susanne Raab , Olivier Roche , Rosa Maria Rodriguez-Sarmiento , Franz Schuler
IPC分类号： C07D211/14 , C07D213/02 , C07D403/10 , C07D211/20 , C07D417/10 , C07D413/10 , C07D401/10
CPC分类号： C07D401/10 , C07D205/04 , C07D207/06 , C07D207/12 , C07D207/14 , C07D209/44 , C07D211/22 , C07D211/38 , C07D211/42 , C07D211/46 , C07D217/06 , C07D295/088 , C07D295/192
摘要： The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐，用于制备这些化合物和含有它们的药物组合物。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US07608617B2
公开(公告)日：2009-10-27
申请号：US11821263
申请日：2007-06-22
申请人： Silvia Gatti McArthur , Cornelia Hertel , Matthias Heinrich Nettekoven , Jean-Marc Plancher , Susanne Raab , Olivier Roche , Rosa Maria Rodriguez-Sarmiento , Franz Schuler
发明人： Silvia Gatti McArthur , Cornelia Hertel , Matthias Heinrich Nettekoven , Jean-Marc Plancher , Susanne Raab , Olivier Roche , Rosa Maria Rodriguez-Sarmiento , Franz Schuler
IPC分类号： A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D401/10 , C07D217/06 , C07D417/10 , C07D211/06 , C07D413/10
CPC分类号： C07D401/10 , C07D205/04 , C07D207/06 , C07D207/12 , C07D207/14 , C07D209/44 , C07D211/22 , C07D211/38 , C07D211/42 , C07D211/46 , C07D217/06 , C07D295/088 , C07D295/192
摘要： The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐，用于制备这些化合物和含有它们的药物组合物。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US07361682B2
公开(公告)日：2008-04-22
申请号：US11157093
申请日：2005-06-20
申请人： Silvia Gatti McArthur , Cornelia Hertel , Matthias Heinrich Nettekoven , Susanne Raab , Olivier Roche , Rosa Maria Rodriguez-Sarmiento , Franz Schuler , Jean-Marc Plancher
发明人： Silvia Gatti McArthur , Cornelia Hertel , Matthias Heinrich Nettekoven , Susanne Raab , Olivier Roche , Rosa Maria Rodriguez-Sarmiento , Franz Schuler , Jean-Marc Plancher
IPC分类号： A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/454 , A61K31/4545 , A61K31/4045 , C07D209/42 , C07D401/02 , C07D413/02 , C07D417/02
CPC分类号： C07D405/14 , C07D209/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
摘要： The present invention relates to compounds of formula I: wherein X, R1, R2, R3, R4 and R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物：其中X，R 1，R 2，R 3，R 4， SUP和R 5如在说明书和权利要求书及其药学上可接受的盐中所定义，用于制备这些化合物和含有它们的药物组合物。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US07534891B2
公开(公告)日：2009-05-19
申请号：US11251509
申请日：2005-10-14
申请人： Silvia Gatti McArthur , Cornelia Hertel , Matthias Heinrich Nettekoven , Susanne Raab , Hans Richter , Olivier Roche , Rosa Maria Rodriguez-Sarmiento , Franz Schuler
发明人： Silvia Gatti McArthur , Cornelia Hertel , Matthias Heinrich Nettekoven , Susanne Raab , Hans Richter , Olivier Roche , Rosa Maria Rodriguez-Sarmiento , Franz Schuler
IPC分类号： C07D215/38
CPC分类号： C07D401/14 , C07D215/48 , C07D401/12 , C07D405/14 , C07D417/12
摘要： The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof as well as to pharmaceutical compositions comprising these compounds and to methods for their preparation. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐以及包含这些化合物的药物组合物及其制备方法。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US20060204436A1
公开(公告)日：2006-09-14
申请号：US10561654
申请日：2004-06-18
IPC分类号： A61K51/00 , C07D487/10
CPC分类号： A61K51/0455
摘要： The present invention relates to a tritiated growth hormone secretagogue which can be used for the identification of compounds capable of binding to growth hormone secretagogue receptors, or of compounds having activity as growth hormone secretagogues.
摘要翻译： 本发明涉及可用于鉴定能够结合生长激素促分泌素受体的化合物或具有活性作为生长激素促分泌素的化合物的氚生长激素促分泌素。
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公开(公告)号：US08592426B2
公开(公告)日：2013-11-26
申请号：US13351253
申请日：2012-01-17
申请人： Johannes Aebi , Alfred Binggeli , Cornelia Hertel , Anish Ashok Konkar , Holger Kuehne , Bernd Kuhn , Hans P. Maerki , Haiyan Wang
发明人： Johannes Aebi , Alfred Binggeli , Cornelia Hertel , Anish Ashok Konkar , Holger Kuehne , Bernd Kuhn , Hans P. Maerki , Haiyan Wang
IPC分类号： A61K31/24 , A61K31/42 , C07D271/06
CPC分类号： C07C237/24 , C07C2602/02 , C07C2602/08 , C07C2602/10 , C07D257/04 , C07D271/06 , C07D271/10 , C07D305/08 , C07D401/10 , C07D401/14 , C07D405/10 , C07D405/12 , C07D409/10 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, A1, A2 and n are as described herein, compositions including the compounds and methods of using the compounds.
摘要翻译： 本发明提供具有通式（I）的新化合物，其中R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，R11，R12，A1，A2和n如本文所述， 化合物和使用该化合物的方法。
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