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    Marker of wound infection
    4.
    发明授权
    Marker of wound infection 失效
    伤口感染的标记

    公开(公告)号：US08491852B2

    公开(公告)日：2013-07-23

    申请号：US11914884

    申请日：2006-04-24

    申请人： Breda Mary Cullen ,  Rachael Clark ,  Philip Stephens ,  Ryan Moseley

    发明人： Breda Mary Cullen ,  Rachael Clark ,  Philip Stephens ,  Ryan Moseley

    IPC分类号： G01N33/52

    CPC分类号： G01N33/528 ,  C12Q1/26 ,  G01N33/523 ,  G01N33/6893

    摘要： An indicator device adapted give a detectable signal when the antioxidant capacity of a sample of a mammalian wound fluid exceeds a predetermined minimum level which is characteristic of an infected wound. Also provided system for use in the diagnosis and treatment of wounds comprising the inventive diagnostic device and a wound dressing comprising at least one antimicrobial agent for selective application to infected wounds. Also provided are methods of diagnosis and treatment by means of the inventive device and system.

    摘要翻译： 当哺乳动物伤口流体的样品的抗氧化能力超过感染伤口特征的预定最小水平时，指示装置适于产生可检测信号。 还提供了用于诊断和治疗伤口的系统，包括本发明的诊断装置和包含至少一种用于选择性应用于感染伤口的抗微生物剂的伤口敷料。 还提供了通过本发明的装置和系统进行诊断和治疗的方法。

    MARKER OF WOUND INFECTION
    5.
    发明申请
    MARKER OF WOUND INFECTION 失效
    创伤感染标志

    公开(公告)号：US20090299161A1

    公开(公告)日：2009-12-03

    申请号：US11914884

    申请日：2006-04-24

    申请人： Breda Mary Cullen ,  Rachael Clark ,  Philip Stephens ,  Ryan Moseley

    发明人： Breda Mary Cullen ,  Rachael Clark ,  Philip Stephens ,  Ryan Moseley

    IPC分类号： A61B5/1468 ,  A61F13/00 ,  A61M35/00

    CPC分类号： G01N33/528 ,  C12Q1/26 ,  G01N33/523 ,  G01N33/6893

    摘要： An indicator device adapted give a detectable signal when the antioxidant capacity of a sample of a mammalian wound fluid exceeds a predetermined minimum level which is characteristic of an infected wound. Also provided system for use in the diagnosis and treatment of wounds comprising the inventive diagnostic device and a wound dressing comprising at least one antimicrobial agent for selective application to infected wounds. Also provided are methods of diagnosis and treatment by means of the inventive device and system.

    摘要翻译： 当哺乳动物伤口流体的样品的抗氧化能力超过感染伤口特征的预定最小水平时，指示装置适于产生可检测信号。 还提供了用于诊断和治疗伤口的系统，包括本发明的诊断装置和包含至少一种用于选择性应用于感染伤口的抗微生物剂的伤口敷料。 还提供了通过本发明的装置和系统进行诊断和治疗的方法。

    MEDICAL ADHESIVE COMPOSITIONS
    9.
    发明申请
    MEDICAL ADHESIVE COMPOSITIONS 审中-公开
    医用粘合剂组合物

    公开(公告)号：US20110230561A1

    公开(公告)日：2011-09-22

    申请号：US13130591

    申请日：2009-11-17

    申请人： Hongbo Liu ,  Sandra Gonzalez ,  Breda Mary Cullen ,  Derek Walter Silcock

    发明人： Hongbo Liu ,  Sandra Gonzalez ,  Breda Mary Cullen ,  Derek Walter Silcock

    IPC分类号： A61K47/16 ,  A61K31/192 ,  A61K31/16 ,  C08F120/44 ,  A61P29/00

    CPC分类号： A61L24/0015 ,  A61L24/06 ,  A61L2300/404 ,  A61L2300/41 ,  C08L35/04

    摘要： A medical adhesive composition comprising, based upon the total weight of the composition, from about 50 wt. % to about 99.9 wt. % of one or more α-cyanoacrylate monomers and from about 0.1 wt. % to about 5 wt. % of one or more non-steroidal anti-inflammatory drugs (NSAIDs). Suitable NSAIDs include ibuprofen and acetaminophen. The resulting compositions provide enhances fibroblast proliferation and reduced cytotoxicity compared to compositions that do not contain NSAID.

    摘要翻译： 一种医用粘合剂组合物，其包含基于所述组合物的总重量为约50wt。 ％至约99.9wt。 ％的一种或多种α-氰基丙烯酸酯单体和约0.1wt。 ％至约5wt。 ％的一种或多种非甾体抗炎药（NSAID）。 合适的NSAIDs包括布洛芬和对乙酰氨基酚。 与不含NSAID的组合物相比，所得组合物提供增强的成纤维细胞增殖和降低的细胞毒性。

    Diagnosis of clinical infection of a wound
    10.
    发明授权
    Diagnosis of clinical infection of a wound 有权
    伤口临床感染诊断

    公开(公告)号：US07794925B2

    公开(公告)日：2010-09-14

    申请号：US10494507

    申请日：2002-11-05

    申请人： Breda Mary Cullen

    发明人： Breda Mary Cullen

    IPC分类号： C12Q1/00

    CPC分类号： C12Q1/37 ,  G01N33/573 ,  G01N33/6893 ,  G01N2333/78

    摘要： A method of predicting or diagnosing clinical infection of a wound comprising measuring the concentration of a marker associated with an inflammatory response in wound fluid, wherein the marker is a fibronectin fragment, a neutrophil protease or a macrophage protease. Also provided is a use of a wound dressing or biosensor comprising components of an assay system for measuring the concentration of a marker associated with an inflammatory response, wherein the marker is a fibronectin fragment, a neutrophil protease or a macrophage protease, for use in the manufacture of a medicament for predicting the likelihood of clinical infection of the wound or for diagnosing clinical infection of a wound.

    摘要翻译： 一种预测或诊断伤口的临床感染的方法，包括测量与伤口液中的炎症反应相关的标志物的浓度，其中所述标记是纤连蛋白片段，嗜中性粒细胞蛋白酶或巨噬细胞蛋白酶。 还提供伤口敷料或生物传感器的用途，所述创伤敷料或生物传感器包括用于测量与炎症反应相关的标志物的浓度的测定系统的组分，其中所述标记是纤连蛋白片段，嗜中性粒细胞蛋白酶或巨噬细胞蛋白酶，用于 制造用于预测伤口的临床感染的可能性或用于诊断伤口的临床感染的药物。