公开(公告)号：US20130116256A1

公开(公告)日：2013-05-09

申请号：US13696697

申请日：2011-05-16

申请人： Song Li ,  Wu Zhong ,  Juan Liu ,  Lili Wang ,  Kunlun He ,  Long Long ,  Junhai Xiao ,  Zhibing Zheng ,  Wei Li ,  Xin Li ,  Guoliang Hu

发明人： Song Li ,  Wu Zhong ,  Juan Liu ,  Lili Wang ,  Kunlun He ,  Long Long ,  Junhai Xiao ,  Zhibing Zheng ,  Wei Li ,  Xin Li ,  Guoliang Hu

IPC分类号： C07D295/215

CPC分类号： C07D295/215 ,  C07D295/194

摘要： The present invention relates to a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof; to a composition comprising a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluent; and also to use of a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof for combating apoptosis, or preventing or treating a disease or disorder associated with apoptosis; and especially use for protecting cardiomyocyte, or preventing or treating a disease or disorder associated with cardiomyocyte apoptosis.

摘要翻译： 本发明涉及式I化合物或其异构体，药学上可接受的盐和溶剂化物; 涉及包含式I化合物或其异构体，药学上可接受的盐和溶剂化物以及药学上可接受的载体，赋形剂或稀释剂的组合物; 并且还使用式I化合物或其异构体，药学上可接受的盐和溶剂化物来防治凋亡，或预防或治疗与细胞凋亡相关的疾病或病症; 特别是用于保护心肌细胞，或预防或治疗与心肌细胞凋亡相关的疾病或病症。

公开(公告)号：US20130158022A1

公开(公告)日：2013-06-20

申请号：US13697810

申请日：2010-05-14

申请人： Kunlun He ,  Song Li ,  Wu Zhong ,  Juan Liu ,  Lili Wang ,  Xin Li ,  Guoliang Hu ,  Jie Wang ,  Long Long ,  Junhai Xiao ,  Zhibing Zheng ,  Wei Li ,  Ruijun Li ,  Chunlei Liu ,  Jie Tang

发明人： Kunlun He ,  Song Li ,  Wu Zhong ,  Juan Liu ,  Lili Wang ,  Xin Li ,  Guoliang Hu ,  Jie Wang ,  Long Long ,  Junhai Xiao ,  Zhibing Zheng ,  Wei Li ,  Ruijun Li ,  Chunlei Liu ,  Jie Tang

IPC分类号： C07D409/12 ,  C07D295/194 ,  C07C335/12 ,  C07D333/24

CPC分类号： A61K31/18 ,  A61K31/17 ,  A61K31/381 ,  A61K31/435 ,  A61K31/4453 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5375 ,  A61K31/5377 ,  C07C335/12 ,  C07D295/194 ,  C07D295/21 ,  C07D333/24 ,  C07D409/12

摘要： The present invention relates to a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate of the compound, and to a composition comprising the compound of Formula I, or the isomer, pharmaceutically acceptable salt and solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluents. The present invention also relates to use of the compound of Formula I, or the isomer, pharmaceutically acceptable salt and solvate thereof for combating apoptosis, preventing or treating a disease or disorder associated with apoptosis; and especially use for protecting cardiomyocyte, and for preventing or treating a disease or disorder associated with cardiomyocyte apoptosis.

摘要翻译： 本发明涉及式I化合物或其化合物的异构体，药学上可接受的盐和溶剂合物，以及包含式I化合物或其异构体，药学上可接受的盐和溶剂化物的组合物和药学上可接受的 载体，赋形剂或稀释剂。 本发明还涉及式I化合物或其异构体，药学上可接受的盐和溶剂合物用于防治凋亡，预防或治疗与凋亡相关的疾病或病症的用途; 特别是用于保护心肌细胞，并用于预防或治疗与心肌细胞凋亡相关的疾病或病症。

公开(公告)号：US09260384B2

公开(公告)日：2016-02-16

申请号：US13697888

申请日：2010-05-14

申请人： Kunlun He ,  Song Li ,  Wu Zhong ,  Juan Liu ,  Lili Wang ,  Xin Li ,  Guoliang Hu ,  Long Long ,  Junhai Xiao ,  Zhibing Zheng ,  Wei Li ,  Ruijun Li ,  Chunlei Liu ,  Jie Bai

发明人： Kunlun He ,  Song Li ,  Wu Zhong ,  Juan Liu ,  Lili Wang ,  Xin Li ,  Guoliang Hu ,  Long Long ,  Junhai Xiao ,  Zhibing Zheng ,  Wei Li ,  Ruijun Li ,  Chunlei Liu ,  Jie Bai

IPC分类号： A61K31/47 ,  C07C275/28 ,  C07D215/40

CPC分类号： C07C275/28 ,  C07D215/40

摘要： A compound of Formula I, or an isomer, pharmaceutically acceptable salt or solvate thereof, is provided. Also, a composition containing a compound of Formula I, or an isomer, pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluents, is provided. Further, use of a compound of Formula I, or an isomer, pharmaceutically acceptable salt or solvate thereof for anti-apoptosis is provided, preventing or treating a disease or disorder associated with apoptosis; especially for protecting cardiomyocyte, preventing or treating a disease or disorder associated with cardiomyocyte apoptosis.

摘要翻译： 提供式I化合物或其异构体，药学上可接受的盐或溶剂合物。 此外，还提供含有式I化合物或其异构体，药学上可接受的盐或溶剂合物，以及药学上可接受的载体，赋形剂或稀释剂的组合物。 此外，提供了式I化合物或其异构体，其药学上可接受的盐或溶剂合物用于抗凋亡的用途，用于预防或治疗与凋亡相关的疾病或病症; 特别是用于保护心肌细胞，预防或治疗与心肌细胞凋亡相关的疾病或病症。

公开(公告)号：US08884007B2

公开(公告)日：2014-11-11

申请号：US13696697

申请日：2011-05-16

申请人： Song Li ,  Wu Zhong ,  Juan Liu ,  Lili Wang ,  Kunlun He ,  Long Long ,  Junhai Xiao ,  Zhibing Zheng ,  Wei Li ,  Xin Li ,  Guoliang Hu

发明人： Song Li ,  Wu Zhong ,  Juan Liu ,  Lili Wang ,  Kunlun He ,  Long Long ,  Junhai Xiao ,  Zhibing Zheng ,  Wei Li ,  Xin Li ,  Guoliang Hu

IPC分类号： C07D295/215 ,  C07D295/194

CPC分类号： C07D295/215 ,  C07D295/194

摘要： The present invention relates to a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof; to a composition comprising a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluent; and also to use of a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof for combating apoptosis, or preventing or treating a disease or disorder associated with apoptosis; and especially use for protecting cardiomyocyte, or preventing or treating a disease or disorder associated with cardiomyocyte apoptosis.

摘要翻译： 本发明涉及式I化合物或其异构体，药学上可接受的盐和溶剂化物; 涉及包含式I化合物或其异构体，药学上可接受的盐和溶剂化物以及药学上可接受的载体，赋形剂或稀释剂的组合物; 并且还使用式I化合物或其异构体，药学上可接受的盐和溶剂化物来防治凋亡，或预防或治疗与细胞凋亡相关的疾病或病症; 特别是用于保护心肌细胞，或预防或治疗与心肌细胞凋亡相关的疾病或病症。

公开(公告)号：US20130123300A1

公开(公告)日：2013-05-16

申请号：US13697888

申请日：2010-05-14

申请人： Kunlun He ,  Song Li ,  Wu Zhong ,  Juan Liu ,  Lili Wang ,  Xin Li ,  Guoliang Hu ,  Long Long ,  Junhai Xiao ,  Zhibing Zheng ,  Wei Li ,  Ruijun Li ,  Chunlei Liu ,  Jie Bai

发明人： Kunlun He ,  Song Li ,  Wu Zhong ,  Juan Liu ,  Lili Wang ,  Xin Li ,  Guoliang Hu ,  Long Long ,  Junhai Xiao ,  Zhibing Zheng ,  Wei Li ,  Ruijun Li ,  Chunlei Liu ,  Jie Bai

IPC分类号： C07C275/28 ,  C07D215/40

CPC分类号： C07C275/28 ,  C07D215/40

摘要： A compound of Formula I, or an isomer, pharmaceutically acceptable salt or solvate thereof, is provided. Also, a composition containing a compound of Formula I, or an isomer, pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluents, is provided. Further, use of a compound of Formula I, or an isomer, pharmaceutically acceptable salt or solvate thereof for anti-apoptosis is provided, preventing or treating a disease or disorder associated with apoptosis; especially for protecting cardiomyocyte, preventing or treating a disease or disorder associated with cardiomyocyte apoptosis.

摘要翻译： 提供式I化合物或其异构体，药学上可接受的盐或溶剂合物。 此外，还提供含有式I化合物或其异构体，药学上可接受的盐或溶剂合物，以及药学上可接受的载体，赋形剂或稀释剂的组合物。 此外，提供了式I化合物或其异构体，其药学上可接受的盐或溶剂合物用于抗凋亡的用途，用于预防或治疗与凋亡相关的疾病或病症; 特别是用于保护心肌细胞，预防或治疗与心肌细胞凋亡相关的疾病或病症。

公开(公告)号：US09199978B2

公开(公告)日：2015-12-01

申请号：US13697810

申请日：2010-05-14

申请人： Kunluu He ,  Song Li ,  Wu Zhong ,  Juan Liu ,  Lili Wang ,  Xin Li ,  Guoliang Hu ,  Jie Wang ,  Long Long ,  Junhai Xiao ,  Zhibing Zheng ,  Wei Li ,  Ruijun Li ,  Chunlei Liu ,  Jie Tang

发明人： Kunluu He ,  Song Li ,  Wu Zhong ,  Juan Liu ,  Lili Wang ,  Xin Li ,  Guoliang Hu ,  Jie Wang ,  Long Long ,  Junhai Xiao ,  Zhibing Zheng ,  Wei Li ,  Ruijun Li ,  Chunlei Liu ,  Jie Tang

IPC分类号： A61K31/5377 ,  C07D295/194 ,  C07D295/21 ,  C07D409/12 ,  A61K31/17 ,  A61K31/381 ,  A61K31/435 ,  A61K31/4709 ,  A61K31/496 ,  C07C335/12 ,  C07D333/24

CPC分类号： A61K31/18 ,  A61K31/17 ,  A61K31/381 ,  A61K31/435 ,  A61K31/4453 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5375 ,  A61K31/5377 ,  C07C335/12 ,  C07D295/194 ,  C07D295/21 ,  C07D333/24 ,  C07D409/12

摘要： The present invention relates to a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate of the compound, and to a composition comprising the compound of Formula I, or the isomer, pharmaceutically acceptable salt and solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluents. The present invention also relates to use of the compound of Formula I, or the isomer, pharmaceutically acceptable salt and solvate thereof for combating apoptosis, preventing or treating a disease or disorder associated with apoptosis; and especially use for protecting cardiomyocyte, and for preventing or treating a disease or disorder associated with cardiomyocyte apoptosis.

摘要翻译： 本发明涉及式I化合物或其化合物的异构体，药学上可接受的盐和溶剂合物，以及包含式I化合物或其异构体，药学上可接受的盐和溶剂化物的组合物和药学上可接受的 载体，赋形剂或稀释剂。 本发明还涉及式I化合物或其异构体，药学上可接受的盐和溶剂合物用于防治凋亡，预防或治疗与凋亡相关的疾病或病症的用途; 特别是用于保护心肌细胞，并用于预防或治疗与心肌细胞凋亡相关的疾病或病症。

公开(公告)号：US08859587B2

公开(公告)日：2014-10-14

申请号：US13697808

申请日：2010-05-14

申请人： Kunlun He ,  Song Li ,  Lili Wang ,  Xin Li ,  Wu Zhong ,  Guoliang Hu ,  Jie Wang ,  Ruijin Li ,  Chunlei Liu ,  Junhai Xiao ,  Long Long ,  Wei Li ,  Hua Chen

发明人： Kunlun He ,  Song Li ,  Lili Wang ,  Xin Li ,  Wu Zhong ,  Guoliang Hu ,  Jie Wang ,  Ruijin Li ,  Chunlei Liu ,  Junhai Xiao ,  Long Long ,  Wei Li ,  Hua Chen

IPC分类号： A61K31/04 ,  C07D215/40 ,  A61K31/47

CPC分类号： C07D215/40 ,  A61K31/47

摘要： The present invention relates to an acrylamide compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof, to a composition comprising the compound or an isomer, pharmaceutically acceptable salt and solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluent, and to a use of the compound or the composition for prophylaxis and/or treatment of a disease or disorder associated with cardiomyocyte apoptosis.

摘要翻译： 本发明涉及式I的丙烯酰胺化合物或其异构体，药学上可接受的盐和溶剂化物，其涉及包含所述化合物或其异构体，药学上可接受的盐和溶剂合物，以及药学上可接受的载体，赋形剂或稀释剂， 以及该化合物或组合物用于预防和/或治疗与心肌细胞凋亡相关的疾病或病症的用途。

公开(公告)号：US20130143917A1

公开(公告)日：2013-06-06

申请号：US13697808

申请日：2010-05-14

申请人： Kunlun He ,  Song Li ,  Lili Wang ,  Xin Li ,  Wu Zhong ,  Guoliang Hu ,  Jie Wang ,  Ruijun Li ,  Chunlei Liu ,  Junhai Xiao ,  Long Long ,  Wei Li ,  Hua Chen

发明人： Kunlun He ,  Song Li ,  Lili Wang ,  Xin Li ,  Wu Zhong ,  Guoliang Hu ,  Jie Wang ,  Ruijun Li ,  Chunlei Liu ,  Junhai Xiao ,  Long Long ,  Wei Li ,  Hua Chen

IPC分类号： A61K31/47 ,  C07D215/40

CPC分类号： C07D215/40 ,  A61K31/47

摘要： The present invention relates to an acrylamide compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof, to a composition comprising the compound or an isomer, pharmaceutically acceptable salt and solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluent, and to a use of the compound or the composition for prophylaxis and/or treatment of a disease or disorder associated with cardiomyocyte apoptosis

摘要翻译： 本发明涉及式I的丙烯酰胺化合物或其异构体，药学上可接受的盐和溶剂化物，其涉及包含所述化合物或其异构体，药学上可接受的盐和溶剂合物，以及药学上可接受的载体，赋形剂或稀释剂， 以及该化合物或组合物用于预防和/或治疗与心肌细胞凋亡相关的疾病或病症的用途

公开(公告)号：US20140057804A1

公开(公告)日：2014-02-27

申请号：US14008093

申请日：2012-03-14

申请人： Lili Wang ,  Shengqian Yang ,  Long Long ,  Junhai Xiao ,  Song Li

发明人： Lili Wang ,  Shengqian Yang ,  Long Long ,  Junhai Xiao ,  Song Li

IPC分类号： G01N33/50

CPC分类号： G01N33/5035 ,  C07K14/4705 ,  C07K14/7153 ,  C12Q1/485 ,  C12Y207/01112 ,  G01N2500/10

摘要： The present invention provides a cell model and a method for screening c-Fms tyrosine kinase inhibitors. Specifically, the present invention provides a cell that expresses macrophage colony stimulating factor receptor and STAT1 protein simultaneously. The present invention further provides a method for screening c-Fms tyrosine kinase inhibitors, a method for evaluating the inhibiting activity of a compound or a composition against c-Fms tyrosine kinase, and use of the cell in screening c-Fms tyrosine kinase inhibitors. The cell model established in the present invention is sensitive, highly effective and reliable, and can be used in high-throughput screening and/or high-content screening of c-Fms tyrosine kinase inhibitors.

摘要翻译： 本发明提供了一种细胞模型和筛选c-Fms酪氨酸激酶抑制剂的方法。 具体地，本发明提供同时表达巨噬细胞集落刺激因子受体和STAT1蛋白的细胞。 本发明进一步提供了筛选c-Fms酪氨酸激酶抑制剂的方法，用于评估化合物或组合物对c-Fms酪氨酸激酶的抑制活性的方法，以及该筛选c-Fms酪氨酸激酶抑制剂中该细胞的用途。 本发明建立的细胞模型是敏感，高效和可靠的，可用于c-Fms酪氨酸激酶抑制剂的高通量筛选和/或高含量筛选。

公开(公告)号：US09683988B2

公开(公告)日：2017-06-20

申请号：US14008093

申请日：2012-03-14

申请人： Lili Wang ,  Shengqian Yang ,  Long Long ,  Junhai Xiao ,  Song Li

发明人： Lili Wang ,  Shengqian Yang ,  Long Long ,  Junhai Xiao ,  Song Li

IPC分类号： C12N5/02 ,  G01N33/50 ,  C12Q1/48 ,  C07K14/715 ,  C07K14/47

CPC分类号： G01N33/5035 ,  C07K14/4705 ,  C07K14/7153 ,  C12Q1/485 ,  C12Y207/01112 ,  G01N2500/10

摘要： The present invention provides a cell model and a method for screening c-Fms tyrosine kinase inhibitors. Specifically, the present invention provides a cell that expresses macrophage colony stimulating factor receptor and STAT1 protein simultaneously. The present invention further provides a method for screening c-Fms tyrosine kinase inhibitors, a method for evaluating the inhibiting activity of a compound or a composition against c-Fms tyrosine kinase, and use of the cell in screening c-Fms tyrosine kinase inhibitors. The cell model established in the present invention is sensitive, highly effective and reliable, and can be used in high-throughput screening and/or high-content screening of c-Fms tyrosine kinase inhibitors.