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1.发明授权Biodegradable and thermosensitive poly(organophosphazene) hydrogel, preparation method thereof and use thereof 有权可生物降解和热敏聚（有机膦腈）水凝胶，其制备方法和用途公开(公告)号：US09526699B2
公开(公告)日：2016-12-27
申请号：US11568851
申请日：2006-11-03
Applicant: Soo-Chang Song , Sun-Mi Lee , Chang-Won Kim , Mi-Ran Park
Inventor： Soo-Chang Song , Sun-Mi Lee , Chang-Won Kim , Mi-Ran Park
IPC: A61K38/00 , C08G79/02 , A61K9/00 , A61K38/02 , A61K39/00 , A61K48/00 , A61K47/30 , A61K38/21 , A61K38/26 , A61K38/18 , A61K38/20 , A61K38/28 , A61K38/23 , A61K38/27 , A61K39/395 , A61K39/29 , A61K31/337 , A61K31/704 , A61K9/06 , A61K9/08 , A61K47/34 , A61K47/48
CPC classification number: A61K9/06 , A61K9/0024 , A61K9/08 , A61K47/34 , A61K47/6903 , C08G79/025
Abstract: The present invention relates to a biodegradable and thermosensitive poly(organophosphazene) with a functional group, a preparation method thereof, and a use thereof for delivery of bioactive substances. According to the present invention, poly(organophosphazene) is a phosphagen-based polymer showing biodegradability, thermosensitivity, and sol-gel phase transition depending on temperature change, whereby when administered into a living body with bioactive substances such as drugs, the poly(organophosphazene) forms a gel-phase at body temperature to be capable of controlled release of the bioactive substances. Further, the poly(organophosphazene) has functional groups to chemically bind with bioactive substances through an ionic bond, covalent bond, or coordinate covalent bond to be capable of a sustained release of the bioactive substances due to its good binding property. Therefore, the poly(organophosphazene) is useful as a delivery material for bioactive substances.
Abstract translation: 本发明涉及具有官能团的生物可降解和热敏聚（有机膦腈），其制备方法及其用于递送生物活性物质的用途。 根据本发明，聚（有机膦腈）是基于温度变化显示生物降解性，热敏性和溶胶 - 凝胶相变的基于磷酸酯的聚合物，其中当用生物活性物质如药物施用于生物体时，聚（有机膦腈 ）在体温下形成凝胶相以能够控制释放生物活性物质。 此外，聚（有机膦腈）具有通过离子键，共价键或配位共价键与生物活性物质化学结合的官能团，由于其良好的结合性能，能够持续释放生物活性物质。 因此，聚（有机膦腈）可用作生物活性物质的递送材料。
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2.发明申请Biodegradable and Thermosensitive Poly(Organophosphazene) Hydrogel, Preparation Method Thereof and Use Thereof 有权可生物降解和热敏聚（有机膦腈）水凝胶，其制备方法及用途公开(公告)号：US20090022683A1
公开(公告)日：2009-01-22
申请号：US11568851
申请日：2006-11-03
Applicant: Soo-Chang Song , Sun-Mi Lee , Chang-Won Kim , Mi-Ran Park
Inventor： Soo-Chang Song , Sun-Mi Lee , Chang-Won Kim , Mi-Ran Park
IPC: A61K38/00 , C08G79/02 , A61K9/00 , A61K38/02 , A61K39/00 , A61K48/00 , A61K47/30 , A61K38/21 , A61K38/26 , A61K38/18 , A61K38/20 , A61K38/28 , A61K38/22 , A61K38/23 , A61K38/27 , A61K39/395 , A61K39/29 , A61K31/337 , A61K31/704
CPC classification number: A61K9/06 , A61K9/0024 , A61K9/08 , A61K47/34 , A61K47/6903 , C08G79/025
Abstract: The present invention relates to a biodegradable and thermosensitive poly(organophosphazene) with a functional group, a preparation method thereof, and a use thereof for delivery of bioactive substances. According to the present invention, poly(organophosphazene) is a phosphagen-based polymer showing biodegradability, thermosensitivity, and sol-gel phase transition depending on temperature change, whereby when administered into a living body with bioactive substances such as drugs, the poly(organophosphazene) forms a gel-phase at body temperature to be capable of controlled release of the bioactive substances. Further, the poly(organophosphazene) has functional groups to chemically bind with bioactive substances through an ionic bond, covalent bond, or coordinate covalent bond to be capable of a sustained release of the bioactive substances due to its good binding property. Therefore, the poly(organophosphazene) is useful as a delivery material for bioactive substances.
Abstract translation: 本发明涉及具有官能团的生物可降解和热敏聚（有机膦腈），其制备方法及其用于递送生物活性物质的用途。 根据本发明，聚（有机膦腈）是基于温度变化显示生物降解性，热敏性和溶胶 - 凝胶相变的基于磷酸酯的聚合物，其中当用生物活性物质如药物施用于生物体时，聚（有机膦腈 ）在体温下形成凝胶相以能够控制释放生物活性物质。 此外，聚（有机膦腈）具有通过离子键，共价键或配位共价键与生物活性物质化学结合的官能团，由于其良好的结合性能，能够持续释放生物活性物质。 因此，聚（有机膦腈）可用作生物活性物质的递送材料。
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3.发明授权Poly(organophosphazene) hydrogels for drug delivery, preparation method thereof and use thereof 有权用于药物递送的聚（有机膦腈）水凝胶，其制备方法和用途公开(公告)号：US08075916B2
公开(公告)日：2011-12-13
申请号：US12122665
申请日：2008-05-17
Applicant: Soo-Chang Song , Mi-Ran Park , Sun-Mi Lee
Inventor： Soo-Chang Song , Mi-Ran Park , Sun-Mi Lee
CPC classification number: A61K31/56 , A61K9/06 , A61K31/7052 , A61K47/34 , C08G65/33306 , C08G79/025 , C08G2650/50 , C08L2203/02
Abstract: A biodegradable and thermosensitive poly(organophosphazene) with a functional group, a preparation method thereof, and a use thereof for delivery of bioactive substances are provided.
Abstract translation: 提供具有官能团的可生物降解和热敏聚（有机膦腈），其制备方法及其用于递送生物活性物质的用途。
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4.发明授权Thermosensitive polyphosphazene-bioactive molecule conjugates, preparation method thereof and use thereof 有权热敏聚磷腈 - 生物活性分子共轭物，其制备方法和用途公开(公告)号：US08287888B2
公开(公告)日：2012-10-16
申请号：US11568852
申请日：2006-11-03
Applicant: Soo-Chang Song , Sun-Mi Lee , Chang-Won Kim
Inventor： Soo-Chang Song , Sun-Mi Lee , Chang-Won Kim
IPC: A61K9/14 , A61K31/337 , A61P35/00
CPC classification number: A61K9/0019 , A61K9/0024 , A61K9/06 , A61K47/60 , A61K47/605 , A61L27/18 , A61L27/50 , A61L27/52 , C07F9/065 , C07F9/65815 , C08G65/33306 , C08G65/3356 , C08G79/025 , C08G2650/50 , C08L85/02 , C08L2203/02
Abstract: The present invention relates to a poly(organophosphazene)-bioactive molecule conjugates in which biodegradable and thermosensitive poly(organophosphazene) with a functional group showing the sol-gel phase transition with change of temperature is combined with various bioactive molecules, such as drugs, a preparation method thereof, and a use thereof for delivery of bioactive molecules.
Abstract translation: 本发明涉及一种聚（有机膦腈） - 活性分子共轭物，其中具有显示出随着温度变化的溶胶 - 凝胶相变的官能团的可生物降解和热敏聚（有机膦腈）与各种生物活性分子如药物组合， 其制备方法及其用于递送生物活性分子的用途。
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5.发明申请THERMOSENSITIVE POLYPHOSPHAZENE-BIOACTIVE MOLECULE CONJUGATES, PREPARATION METHOD THEREOF AND USE THEREOF 有权耐热多磷酸生物活性分子共聚物，其制备方法及其用途公开(公告)号：US20090181088A1
公开(公告)日：2009-07-16
申请号：US11568852
申请日：2006-11-03
Applicant: Soo-Chang Song , Sun-Mi Lee , Chang-Won Kim
Inventor： Soo-Chang Song , Sun-Mi Lee , Chang-Won Kim
IPC: A61K9/14 , A61K31/337 , A61P35/00
CPC classification number: A61K9/0019 , A61K9/0024 , A61K9/06 , A61K47/60 , A61K47/605 , A61L27/18 , A61L27/50 , A61L27/52 , C07F9/065 , C07F9/65815 , C08G65/33306 , C08G65/3356 , C08G79/025 , C08G2650/50 , C08L85/02 , C08L2203/02
Abstract: The present invention relates to a poly(organophosphazene)-bioactive molecule conjugates in which biodegradable and thermosensitive poly(organophosphazene) with a functional group showing the sol-gel phase transition with change of temperature is combined with various bioactive molecules, such as drugs, a preparation method thereof, and a use thereof for delivery of bioactive molecules.
Abstract translation: 本发明涉及一种聚（有机膦腈） - 活性分子共轭物，其中具有显示出随着温度变化的溶胶 - 凝胶相变的官能团的可生物降解和热敏聚（有机膦腈）与各种生物活性分子如药物组合， 其制备方法及其用于递送生物活性分子的用途。
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Patent Agency Ranking
公开(公告)号：US08586020B2
公开(公告)日：2013-11-19
申请号：US13173783
申请日：2011-06-30
Applicant: Soo-Chang Song , Thrimoorthy Potta , Mi-Ran Park
Inventor： Soo-Chang Song , Thrimoorthy Potta , Mi-Ran Park
CPC classification number: A61L27/18 , A61L27/52 , A61L27/54 , A61L2300/80 , C08G79/02 , C08G79/025 , C08J3/075 , C08J2385/02 , C08L85/02
Abstract: Provided are a use of chemically-crosslinkable, poly(organophosphazene)s for biomaterials, chemically-crosslinkable poly(organophosphazene)s with a physiologically active substance covalently-bonded thereto, a use thereof for biomaterials, and a process for preparing the same. The chemical crosslinkings can be made by UV irradiation, and/or a crosslinker, and/or an additive, and/or an enzyme, and/or a mixing of at least one polymer.
Abstract translation: 提供了用于生物材料的化学交联的聚（有机膦腈），与共价键合的生理活性物质的化学交联的聚（有机膦腈），其生物材料的用途及其制备方法的用途。 化学交联可以通过UV照射和/或交联剂，/或添加剂和/或酶进行，和/或至少一种聚合物的混合。
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7.发明申请PHOSPHAZENE HYDROGELS WITH CHEMICAL CORSS-LINK, PREPARATION METHOD THEREOF AND USE THEREOF 有权具有化学连接性的PHOSPHAZENE HYDROGELS，其制备方法及其用途公开(公告)号：US20100297155A1
公开(公告)日：2010-11-25
申请号：US12452322
申请日：2008-05-23
Applicant: Soo-Chang Song , Thrimoorthy Potta , Sun-Mi Lee
Inventor： Soo-Chang Song , Thrimoorthy Potta , Sun-Mi Lee
IPC: A61K39/00 , A61K35/00 , A61K35/12 , A61K35/14 , A61K47/30 , C08G79/02 , A61P35/00 , A61K35/44 , A61K35/34 , A61K35/30 , A61K35/32 , A61P37/04
CPC classification number: C08G79/025 , A61K9/06 , A61K47/34 , C08G65/33306 , C08G2650/50 , C08J3/075 , C08J3/246 , C08J3/28 , C08J2385/02 , C08L85/02 , C08L2203/02
Abstract: A phosphazene-based polymer hydrogel with a chemical cross-linkings formed by radiating ultraviolet (UV) and/or mixing with cross-linking agent and/or enzyme, a method of preparing the same, and a hydrogel forming a chemical cross-linking by radiating ultraviolet and/or mixing with a cross-linking agent and/or an enzyme; where the hydrigel shows a sol-gel behavior and has an excellent solidity by containing the phosphazene-based polymer that is capable of cross-linking at a certain concentration, are provided.
Abstract translation: 具有通过辐射紫外线（UV）和/或与交联剂和/或酶混合形成的化学交联的磷腈基聚合物水凝胶，其制备方法和形成化学交联的水凝胶通过 辐射紫外线和/或与交联剂和/或酶的混合; 其中水凝胶显示出溶胶 - 凝胶行为并且通过含有能够以一定浓度交联的磷腈基聚合物而具有优异的固化性。
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8.发明授权Phosphazene hydrogels with chemical corss-link, preparation method thereof and use thereof 有权具有化学结构的磷腈水凝胶，其制备方法和用途公开(公告)号：US08313771B2
公开(公告)日：2012-11-20
申请号：US12452322
申请日：2008-05-23
Applicant: Soo-Chang Song , Thrimoorthy Potta , Sun-Mi Lee
Inventor： Soo-Chang Song , Thrimoorthy Potta , Sun-Mi Lee
CPC classification number: C08G79/025 , A61K9/06 , A61K47/34 , C08G65/33306 , C08G2650/50 , C08J3/075 , C08J3/246 , C08J3/28 , C08J2385/02 , C08L85/02 , C08L2203/02
Abstract: A phosphazene-based polymer hydrogel with a chemical cross-linkings formed by radiating ultraviolet (UV) and/or mixing with cross-linking agent and/or enzyme, and a method of preparing the same are provided. The hydrogel shows a sol-gel behavior and has an excellent solidity by containing the phosphazene-based polymer that is capable of cross-linking at a certain concentration.
Abstract translation: 提供了具有通过辐射紫外线（UV）和/或与交联剂和/或酶混合形成的化学交联的磷腈基聚合物水凝胶及其制备方法。 水凝胶显示出溶胶 - 凝胶行为，并且通过含有能够以一定浓度进行交联的磷腈基聚合物而具有优异的固体性。
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9.发明授权公开(公告)号：US07259225B2
公开(公告)日：2007-08-21
申请号：US10835378
申请日：2004-04-28
Applicant: Soo-Chang Song , Bae-Houn Lee
Inventor： Soo-Chang Song , Bae-Houn Lee
IPC: C08G63/02
CPC classification number: C08G79/025 , A61K9/0024 , A61K9/06 , A61K47/34
Abstract: Disclosed are polyphosphazenes of Formula 1 showing a sol-gel behavior with a temperature change, a preparation method thereof, and injectable thermosensitive polyphosphazene hydrogels using the same
Abstract translation: 公开了具有温度变化的溶胶 - 凝胶行为的式1的聚磷腈，其制备方法和使用其的可注射的热敏聚磷腈水凝胶
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10.发明授权公开(公告)号：US06417383B1
公开(公告)日：2002-07-09
申请号：US09869761
申请日：2001-07-05
Applicant: Youn Soo Sohn , Soo-Chang Song , Sang Beom Lee
Inventor： Youn Soo Sohn , Soo-Chang Song , Sang Beom Lee
IPC: C07F902
CPC classification number: C07F9/65815
Abstract: The present invention relates to novel cyclotriphosphazene derivatives represented by Formula (1) and a preparation method thereof wherein HNA is an amino acid group selected from glycine group(—NHCH2COO−), aminomalonic acid group(—NHCH(COO−)2), aspartic acid group (—NHCH(CH2COO−)COO−) and glutamic acid group (—NHCH(CH2CH2COO−)COO−), m is a repeating unit of poly(alkoxyethyleneglycol) selected from 2, 7, 12 and 16, and n is an integer representing number of alkyl carbons and selected from 0, 1, and 3.
Abstract translation: 本发明涉及由式（1）表示的新型环三磷腈衍生物及其制备方法，其中HNA是选自甘氨酸基（-NHCH 2 COO-），氨基马来酸（-NHCH（COO-）2）），天冬氨酸 酸基（-NHCH（CH2COO-）COO-）和谷氨酸基（-NHCH（CH2CH2COO-）COO-）），m是选自2,7,12和16的聚（烷氧基乙二醇）的重复单元，n是 代表烷基碳数并且选自0,1和3的整数。
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