公开(公告)号：US09526699B2

公开(公告)日：2016-12-27

申请号：US11568851

申请日：2006-11-03

Applicant: Soo-Chang Song ,  Sun-Mi Lee ,  Chang-Won Kim ,  Mi-Ran Park

Inventor： Soo-Chang Song ,  Sun-Mi Lee ,  Chang-Won Kim ,  Mi-Ran Park

IPC: A61K38/00 ,  C08G79/02 ,  A61K9/00 ,  A61K38/02 ,  A61K39/00 ,  A61K48/00 ,  A61K47/30 ,  A61K38/21 ,  A61K38/26 ,  A61K38/18 ,  A61K38/20 ,  A61K38/28 ,  A61K38/23 ,  A61K38/27 ,  A61K39/395 ,  A61K39/29 ,  A61K31/337 ,  A61K31/704 ,  A61K9/06 ,  A61K9/08 ,  A61K47/34 ,  A61K47/48

CPC classification number: A61K9/06 ,  A61K9/0024 ,  A61K9/08 ,  A61K47/34 ,  A61K47/6903 ,  C08G79/025

Abstract: The present invention relates to a biodegradable and thermosensitive poly(organophosphazene) with a functional group, a preparation method thereof, and a use thereof for delivery of bioactive substances. According to the present invention, poly(organophosphazene) is a phosphagen-based polymer showing biodegradability, thermosensitivity, and sol-gel phase transition depending on temperature change, whereby when administered into a living body with bioactive substances such as drugs, the poly(organophosphazene) forms a gel-phase at body temperature to be capable of controlled release of the bioactive substances. Further, the poly(organophosphazene) has functional groups to chemically bind with bioactive substances through an ionic bond, covalent bond, or coordinate covalent bond to be capable of a sustained release of the bioactive substances due to its good binding property. Therefore, the poly(organophosphazene) is useful as a delivery material for bioactive substances.

Abstract translation: 本发明涉及具有官能团的生物可降解和热敏聚（有机膦腈），其制备方法及其用于递送生物活性物质的用途。 根据本发明，聚（有机膦腈）是基于温度变化显示生物降解性，热敏性和溶胶 - 凝胶相变的基于磷酸酯的聚合物，其中当用生物活性物质如药物施用于生物体时，聚（有机膦腈 ）在体温下形成凝胶相以能够控制释放生物活性物质。 此外，聚（有机膦腈）具有通过离子键，共价键或配位共价键与生物活性物质化学结合的官能团，由于其良好的结合性能，能够持续释放生物活性物质。 因此，聚（有机膦腈）可用作生物活性物质的递送材料。

公开(公告)号：US20090022683A1

公开(公告)日：2009-01-22

申请号：US11568851

申请日：2006-11-03

Applicant: Soo-Chang Song ,  Sun-Mi Lee ,  Chang-Won Kim ,  Mi-Ran Park

Inventor： Soo-Chang Song ,  Sun-Mi Lee ,  Chang-Won Kim ,  Mi-Ran Park

IPC: A61K38/00 ,  C08G79/02 ,  A61K9/00 ,  A61K38/02 ,  A61K39/00 ,  A61K48/00 ,  A61K47/30 ,  A61K38/21 ,  A61K38/26 ,  A61K38/18 ,  A61K38/20 ,  A61K38/28 ,  A61K38/22 ,  A61K38/23 ,  A61K38/27 ,  A61K39/395 ,  A61K39/29 ,  A61K31/337 ,  A61K31/704

CPC classification number: A61K9/06 ,  A61K9/0024 ,  A61K9/08 ,  A61K47/34 ,  A61K47/6903 ,  C08G79/025

Abstract: The present invention relates to a biodegradable and thermosensitive poly(organophosphazene) with a functional group, a preparation method thereof, and a use thereof for delivery of bioactive substances. According to the present invention, poly(organophosphazene) is a phosphagen-based polymer showing biodegradability, thermosensitivity, and sol-gel phase transition depending on temperature change, whereby when administered into a living body with bioactive substances such as drugs, the poly(organophosphazene) forms a gel-phase at body temperature to be capable of controlled release of the bioactive substances. Further, the poly(organophosphazene) has functional groups to chemically bind with bioactive substances through an ionic bond, covalent bond, or coordinate covalent bond to be capable of a sustained release of the bioactive substances due to its good binding property. Therefore, the poly(organophosphazene) is useful as a delivery material for bioactive substances.

Abstract translation: 本发明涉及具有官能团的生物可降解和热敏聚（有机膦腈），其制备方法及其用于递送生物活性物质的用途。 根据本发明，聚（有机膦腈）是基于温度变化显示生物降解性，热敏性和溶胶 - 凝胶相变的基于磷酸酯的聚合物，其中当用生物活性物质如药物施用于生物体时，聚（有机膦腈 ）在体温下形成凝胶相以能够控制释放生物活性物质。 此外，聚（有机膦腈）具有通过离子键，共价键或配位共价键与生物活性物质化学结合的官能团，由于其良好的结合性能，能够持续释放生物活性物质。 因此，聚（有机膦腈）可用作生物活性物质的递送材料。

公开(公告)号：US08075916B2

公开(公告)日：2011-12-13

申请号：US12122665

申请日：2008-05-17

Applicant: Soo-Chang Song ,  Mi-Ran Park ,  Sun-Mi Lee

Inventor： Soo-Chang Song ,  Mi-Ran Park ,  Sun-Mi Lee

IPC: A61K38/00 ,  A61K9/00 ,  A61K38/02 ,  A61K39/00 ,  C08G79/02

CPC classification number: A61K31/56 ,  A61K9/06 ,  A61K31/7052 ,  A61K47/34 ,  C08G65/33306 ,  C08G79/025 ,  C08G2650/50 ,  C08L2203/02

Abstract: A biodegradable and thermosensitive poly(organophosphazene) with a functional group, a preparation method thereof, and a use thereof for delivery of bioactive substances are provided.

Abstract translation: 提供具有官能团的可生物降解和热敏聚（有机膦腈），其制备方法及其用于递送生物活性物质的用途。

公开(公告)号：US20090181088A1

公开(公告)日：2009-07-16

申请号：US11568852

申请日：2006-11-03

Applicant: Soo-Chang Song ,  Sun-Mi Lee ,  Chang-Won Kim

Inventor： Soo-Chang Song ,  Sun-Mi Lee ,  Chang-Won Kim

IPC: A61K9/14 ,  A61K31/337 ,  A61P35/00

CPC classification number: A61K9/0019 ,  A61K9/0024 ,  A61K9/06 ,  A61K47/60 ,  A61K47/605 ,  A61L27/18 ,  A61L27/50 ,  A61L27/52 ,  C07F9/065 ,  C07F9/65815 ,  C08G65/33306 ,  C08G65/3356 ,  C08G79/025 ,  C08G2650/50 ,  C08L85/02 ,  C08L2203/02

Abstract: The present invention relates to a poly(organophosphazene)-bioactive molecule conjugates in which biodegradable and thermosensitive poly(organophosphazene) with a functional group showing the sol-gel phase transition with change of temperature is combined with various bioactive molecules, such as drugs, a preparation method thereof, and a use thereof for delivery of bioactive molecules.

Abstract translation: 本发明涉及一种聚（有机膦腈） - 活性分子共轭物，其中具有显示出随着温度变化的溶胶 - 凝胶相变的官能团的可生物降解和热敏聚（有机膦腈）与各种生物活性分子如药物组合， 其制备方法及其用于递送生物活性分子的用途。

公开(公告)号：US08287888B2

公开(公告)日：2012-10-16

申请号：US11568852

申请日：2006-11-03

Applicant: Soo-Chang Song ,  Sun-Mi Lee ,  Chang-Won Kim

Inventor： Soo-Chang Song ,  Sun-Mi Lee ,  Chang-Won Kim

IPC: A61K9/14 ,  A61K31/337 ,  A61P35/00

CPC classification number: A61K9/0019 ,  A61K9/0024 ,  A61K9/06 ,  A61K47/60 ,  A61K47/605 ,  A61L27/18 ,  A61L27/50 ,  A61L27/52 ,  C07F9/065 ,  C07F9/65815 ,  C08G65/33306 ,  C08G65/3356 ,  C08G79/025 ,  C08G2650/50 ,  C08L85/02 ,  C08L2203/02

Abstract: The present invention relates to a poly(organophosphazene)-bioactive molecule conjugates in which biodegradable and thermosensitive poly(organophosphazene) with a functional group showing the sol-gel phase transition with change of temperature is combined with various bioactive molecules, such as drugs, a preparation method thereof, and a use thereof for delivery of bioactive molecules.

Abstract translation: 本发明涉及一种聚（有机膦腈） - 活性分子共轭物，其中具有显示出随着温度变化的溶胶 - 凝胶相变的官能团的可生物降解和热敏聚（有机膦腈）与各种生物活性分子如药物组合， 其制备方法及其用于递送生物活性分子的用途。

公开(公告)号：US08313771B2

公开(公告)日：2012-11-20

申请号：US12452322

申请日：2008-05-23

Applicant: Soo-Chang Song ,  Thrimoorthy Potta ,  Sun-Mi Lee

Inventor： Soo-Chang Song ,  Thrimoorthy Potta ,  Sun-Mi Lee

IPC: A61K9/14 ,  A61K47/48 ,  C08G69/26 ,  C08G79/02 ,  C08G73/00

CPC classification number: C08G79/025 ,  A61K9/06 ,  A61K47/34 ,  C08G65/33306 ,  C08G2650/50 ,  C08J3/075 ,  C08J3/246 ,  C08J3/28 ,  C08J2385/02 ,  C08L85/02 ,  C08L2203/02

Abstract: A phosphazene-based polymer hydrogel with a chemical cross-linkings formed by radiating ultraviolet (UV) and/or mixing with cross-linking agent and/or enzyme, and a method of preparing the same are provided. The hydrogel shows a sol-gel behavior and has an excellent solidity by containing the phosphazene-based polymer that is capable of cross-linking at a certain concentration.

Abstract translation: 提供了具有通过辐射紫外线（UV）和/或与交联剂和/或酶混合形成的化学交联的磷腈基聚合物水凝胶及其制备方法。 水凝胶显示出溶胶 - 凝胶行为，并且通过含有能够以一定浓度进行交联的磷腈基聚合物而具有优异的固体性。

公开(公告)号：US20100297155A1

公开(公告)日：2010-11-25

申请号：US12452322

申请日：2008-05-23

Applicant: Soo-Chang Song ,  Thrimoorthy Potta ,  Sun-Mi Lee

Inventor： Soo-Chang Song ,  Thrimoorthy Potta ,  Sun-Mi Lee

IPC: A61K39/00 ,  A61K35/00 ,  A61K35/12 ,  A61K35/14 ,  A61K47/30 ,  C08G79/02 ,  A61P35/00 ,  A61K35/44 ,  A61K35/34 ,  A61K35/30 ,  A61K35/32 ,  A61P37/04

CPC classification number: C08G79/025 ,  A61K9/06 ,  A61K47/34 ,  C08G65/33306 ,  C08G2650/50 ,  C08J3/075 ,  C08J3/246 ,  C08J3/28 ,  C08J2385/02 ,  C08L85/02 ,  C08L2203/02

Abstract: A phosphazene-based polymer hydrogel with a chemical cross-linkings formed by radiating ultraviolet (UV) and/or mixing with cross-linking agent and/or enzyme, a method of preparing the same, and a hydrogel forming a chemical cross-linking by radiating ultraviolet and/or mixing with a cross-linking agent and/or an enzyme; where the hydrigel shows a sol-gel behavior and has an excellent solidity by containing the phosphazene-based polymer that is capable of cross-linking at a certain concentration, are provided.

Abstract translation: 具有通过辐射紫外线（UV）和/或与交联剂和/或酶混合形成的化学交联的磷腈基聚合物水凝胶，其制备方法和形成化学交联的水凝胶通过 辐射紫外线和/或与交联剂和/或酶的混合; 其中水凝胶显示出溶胶 - 凝胶行为并且通过含有能够以一定浓度交联的磷腈基聚合物而具有优异的固化性。