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公开(公告)号：US09034921B2
公开(公告)日：2015-05-19
申请号：US14122836
申请日：2012-06-01
申请人： Soongyu Choi , Kwang Seop Song , Suk Ho Lee , Min Ju Kim , Hee Jeong Seo , Eun-Jung Park , Younggyu Kong , So Ok Park , Hyunku Kang , Myung Eun Jung , Kinam Lee , Hyun Jung Kim , Jun Sung Lee , Min Woo Lee , Mi-Soon Kim , Dong Ho Hong , Misuk Kang
发明人： Soongyu Choi , Kwang Seop Song , Suk Ho Lee , Min Ju Kim , Hee Jeong Seo , Eun-Jung Park , Younggyu Kong , So Ok Park , Hyunku Kang , Myung Eun Jung , Kinam Lee , Hyun Jung Kim , Jun Sung Lee , Min Woo Lee , Mi-Soon Kim , Dong Ho Hong , Misuk Kang
IPC分类号： A61K31/351 , C07D407/04 , C07D309/10 , C07D405/10 , C07D407/10 , C07D407/14 , C07D409/04 , C07D409/10 , C07D411/10 , C07D413/04 , C07D405/14 , C07D413/10
CPC分类号： C07D309/10 , C07D405/10 , C07D405/14 , C07D407/04 , C07D407/10 , C07D407/14 , C07D409/04 , C07D409/10 , C07D409/14 , C07D411/10 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14
摘要： A compound with a diphenylmethane moiety having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney is disclosed. A pharmaceutical composition including the compound as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly diabetes is disclosed. A method for preparing the compound, and a method for preventing or treating metabolic disorders, particularly diabetes, by using the compound is provided.
摘要翻译： 公开了具有对钠依赖性葡萄糖转运蛋白2（SGLT2）具有抑制活性的二苯基甲烷部分的化合物存在于肠和肾中。 公开了包含该化合物作为活性成分的药物组合物，其可用于预防或治疗代谢紊乱，特别是糖尿病。 提供了制备该化合物的方法，以及通过使用该化合物预防或治疗代谢紊乱，特别是糖尿病的方法。
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公开(公告)号：US20140088079A1
公开(公告)日：2014-03-27
申请号：US14122836
申请日：2012-06-01
申请人： Soongyu Choi , Kwang Seop Song , Suk Ho Lee , Min Ju Kim , Hee Jeong Seo , Eun-Jung Park , Younggyu Kong , So Ok Park , Hyunku Kang , Myung Eun Jung , Kinam Lee , Hyun Jung Kim , Jun Sung Lee , Min Woo Lee , Mi-Soon KIM , Dong Ho Hong , Misuk Kang
发明人： Soongyu Choi , Kwang Seop Song , Suk Ho Lee , Min Ju Kim , Hee Jeong Seo , Eun-Jung Park , Younggyu Kong , So Ok Park , Hyunku Kang , Myung Eun Jung , Kinam Lee , Hyun Jung Kim , Jun Sung Lee , Min Woo Lee , Mi-Soon KIM , Dong Ho Hong , Misuk Kang
IPC分类号： C07D309/10 , C07D405/10 , C07D413/04 , C07D409/10 , C07D413/10 , C07D405/14 , C07D407/04 , C07D407/10
CPC分类号： C07D309/10 , C07D405/10 , C07D405/14 , C07D407/04 , C07D407/10 , C07D407/14 , C07D409/04 , C07D409/10 , C07D409/14 , C07D411/10 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14
摘要： The present invention relates to a compound with a diphenylmethane moiety having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney, and a pharmaceutical composition comprising the same as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly diabetes. The present invention also provides a method for preparing the compound, and a method for preventing or treating metabolic disorders, particularly diabetes, by using the compound.
摘要翻译： 本发明涉及具有对存在于肠和肾中的钠依赖性葡萄糖协同转运蛋白2（SGLT2）具有抑制活性的二苯基甲烷部分的化合物和包含其作为活性成分的药物组合物，其可用于预防 或治疗代谢紊乱，特别是糖尿病。 本发明还提供了一种制备该化合物的方法，以及通过使用该化合物来预防或治疗代谢紊乱，特别是糖尿病的方法。
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3.发明授权Arylpiperazine-containing imidazole 4-carboxamide derivatives and pharmaceutical composition comprising same 有权含有芳基哌嗪的咪唑4-甲酰胺衍生物和包含其的药物组合物公开(公告)号：US08835436B2
公开(公告)日：2014-09-16
申请号：US13383143
申请日：2010-07-09
申请人： Jinhwa Lee , Hee Jeong Seo , Suk Youn Kang , Eun-Jung Park , Min Ju Kim , Suk Ho Lee , Jong Yup Kim , Jeongmin Kim , Myung Eun Jung , Hyun Jung Kim , Mi-soon Kim , Ho Kyun Han , Kwang Woo Ahn , Min Woo Lee , Ki-Nam Lee , Ae Nim Pae , Woo-Kyu Park
发明人： Jinhwa Lee , Hee Jeong Seo , Suk Youn Kang , Eun-Jung Park , Min Ju Kim , Suk Ho Lee , Jong Yup Kim , Jeongmin Kim , Myung Eun Jung , Hyun Jung Kim , Mi-soon Kim , Ho Kyun Han , Kwang Woo Ahn , Min Woo Lee , Ki-Nam Lee , Ae Nim Pae , Woo-Kyu Park
IPC分类号： A61K31/496 , C07D233/88 , C07D401/12 , C07D403/06 , C07D405/04 , C07D417/14
CPC分类号： C07D417/14 , A61K31/496 , C07D233/88 , C07D401/12 , C07D403/06 , C07D405/04
摘要： A novel arylpiperazine-containing imidazole 4-carboxamide derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an active ingredient for preventing or treating a depressive disorder are provided.
摘要翻译： 提供了一种新的含有芳基哌嗪的咪唑-4-甲酰胺衍生物或其药学上可接受的盐，以及包含其作为预防或治疗抑郁障碍的活性成分的药物组合物。
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4.发明申请NOVEL ARYLPIPERAZINE-CONTAINING IMIDAZOLE 4-CARBOXAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING SAME 有权新颖的含有阿维菌素的咪唑烷四羧酰胺衍生物和包含其的药物组合物公开(公告)号：US20120115881A1
公开(公告)日：2012-05-10
申请号：US13383143
申请日：2010-07-09
申请人： Jinhwa Lee , Hee Jeong Seo , Suk Youn Kang , Eun-Jung Park , Min Ju Kim , Suk Ho Lee , Jong yup Kim , Jeongmin Kim , Myung Eun Jung , Hyun Jung Kim , Mi-soon Kim , Ho kyun Han , Kwang Woo Ahn , Min Woo Lee , Ki-Nam Lee , Ae Nim Pae , Woo-Kyu Park
发明人： Jinhwa Lee , Hee Jeong Seo , Suk Youn Kang , Eun-Jung Park , Min Ju Kim , Suk Ho Lee , Jong yup Kim , Jeongmin Kim , Myung Eun Jung , Hyun Jung Kim , Mi-soon Kim , Ho kyun Han , Kwang Woo Ahn , Min Woo Lee , Ki-Nam Lee , Ae Nim Pae , Woo-Kyu Park
IPC分类号： A61K31/497 , A61P25/24 , C07D403/12
CPC分类号： C07D417/14 , A61K31/496 , C07D233/88 , C07D401/12 , C07D403/06 , C07D405/04
摘要： A novel arylpiperazine-containing imidazole 4-carboxamide derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an active ingredient for preventing or treating a depressive disorder are provided.
摘要翻译： 提供了一种新的含有芳基哌嗪的咪唑-4-甲酰胺衍生物或其药学上可接受的盐，以及包含其作为预防或治疗抑郁障碍的活性成分的药物组合物。
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5.发明申请NOVEL C-ARYL GLUCOSIDE SGLT2 INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME 有权新型C-ARYL GLUCOSIDE SGLT2抑制剂和包含其的药物组合物公开(公告)号：US20120101051A1
公开(公告)日：2012-04-26
申请号：US13379301
申请日：2010-06-18
申请人： Jinhwa Lee , Suk Ho Lee , Hee Jeong Seo , Min Ju Kim , Suk Youn Kang , Jeongmin Kim , Sung-Han Lee , Myung Eun Jung , Eun Jung Son , Kwang-Seop Song , Mi-Soon Kim
发明人： Jinhwa Lee , Suk Ho Lee , Hee Jeong Seo , Min Ju Kim , Suk Youn Kang , Jeongmin Kim , Sung-Han Lee , Myung Eun Jung , Eun Jung Son , Kwang-Seop Song , Mi-Soon Kim
IPC分类号： A61K31/706 , A61P3/10 , A61P3/00 , C08B37/00 , A61K31/7056
CPC分类号： C07D417/14 , C07D405/10 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/10
摘要： A novel C-aryl glucoside compound, or a pharmaceutically acceptable salt or a prodrug thereof having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney; and a pharmaceutical composition comprising the same as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly, diabetes, are provided.
摘要翻译： 在肠和肾中存在对钠依赖性葡萄糖共转运体2（SGLT2）具有抑制活性的新型C-芳基葡糖苷化合物或其药学上可接受的盐或前药; 并且提供了包含其作为活性成分的药物组合物，其可用于预防或治疗代谢紊乱，特别是糖尿病。
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6.发明授权C-aryl glucoside SGLT2 inhibitors and pharmaceutical compositions comprising same 有权C-芳基葡糖苷SGLT2抑制剂和包含其的药物组合物公开(公告)号：US08541380B2
公开(公告)日：2013-09-24
申请号：US13379301
申请日：2010-06-18
申请人： Jinhwa Lee , Suk Ho Lee , Hee Jeong Seo , Min Ju Kim , Suk Youn Kang , Jeongmin Kim , Sung-Han Lee , Myung Eun Jung , Eun Jung Son , Kwang-Seop Song , Mi-Soon Kim
发明人： Jinhwa Lee , Suk Ho Lee , Hee Jeong Seo , Min Ju Kim , Suk Youn Kang , Jeongmin Kim , Sung-Han Lee , Myung Eun Jung , Eun Jung Son , Kwang-Seop Song , Mi-Soon Kim
CPC分类号： C07D417/14 , C07D405/10 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/10
摘要： A novel C-aryl glucoside compound, or a pharmaceutically acceptable salt or a prodrug thereof having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney; and a pharmaceutical composition comprising the same as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly, diabetes, are provided.
摘要翻译： 在肠和肾中存在对钠依赖性葡萄糖共转运体2（SGLT2）具有抑制活性的新型C-芳基葡糖苷化合物或其药学上可接受的盐或前药; 并且提供了包含其作为活性成分的药物组合物，其可用于预防或治疗代谢紊乱，特别是糖尿病。
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7.发明授权Thiazole derivatives as SGLT2 inhibitors and pharmaceutical composition comprising same 有权作为SGLT2抑制剂的噻唑衍生物和包含其的药物组合物公开(公告)号：US08586550B2
公开(公告)日：2013-11-19
申请号：US13704081
申请日：2011-06-10
申请人： Jinhwa Lee , Jeongmin Kim , Suk Ho Lee , Junwon Lee , Kwang-Seop Song , Eun-Jung Park , Min Ju Kim , Hee Jeong Seo , Sung-Han Lee , Eun Jung Son , Jong Yup Kim , Suk Youn Kang , Younggyu Kong
发明人： Jinhwa Lee , Jeongmin Kim , Suk Ho Lee , Junwon Lee , Kwang-Seop Song , Eun-Jung Park , Min Ju Kim , Hee Jeong Seo , Sung-Han Lee , Eun Jung Son , Jong Yup Kim , Suk Youn Kang , Younggyu Kong
IPC分类号： A61K31/70 , A61K31/425 , C07H5/04 , C07H5/06 , C07D277/60
CPC分类号： C07H7/04 , C07D309/10 , C07D417/10 , C07D417/14 , C07D493/10 , C07H17/02
摘要： The present invention relates to a novel compound with thiazole ring having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney, and a pharmaceutical composition comprising the same as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly diabetes.
摘要翻译： 本发明涉及一种具有对存在于肠和肾中的钠依赖性葡萄糖协同转运蛋白2（SGLT2）具有抑制活性的噻唑环的新型化合物，以及包含其作为活性成分的药物组合物，其可用于预防 或治疗代谢紊乱，特别是糖尿病。
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8.发明申请Thiazole Derivatives as SGLT2 Inhibitors and Pharmaceutical Composition Comprising Same 有权噻唑衍生物作为SGLT2抑制剂和药物组合物组成公开(公告)号：US20130090298A1
公开(公告)日：2013-04-11
申请号：US13704081
申请日：2011-06-10
申请人： Jinhwa Lee , Jeongmin Kim , Suk Ho Lee , Junwon Lee , Kwang-Seop Song , Eun-Jung Park , Min Ju Kim , Hee Jeong Seo , Sung-Han Lee , Eun Jung Son , Jong Yup Kim , Suk Youn Kang , Younggyu Kong
发明人： Jinhwa Lee , Jeongmin Kim , Suk Ho Lee , Junwon Lee , Kwang-Seop Song , Eun-Jung Park , Min Ju Kim , Hee Jeong Seo , Sung-Han Lee , Eun Jung Son , Jong Yup Kim , Suk Youn Kang , Younggyu Kong
CPC分类号： C07H7/04 , C07D309/10 , C07D417/10 , C07D417/14 , C07D493/10 , C07H17/02
摘要： The present invention relates to a novel compound with thiazole ring having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney, and a pharmaceutical composition comprising the same as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly diabetes.
摘要翻译： 本发明涉及一种具有对存在于肠和肾中的钠依赖性葡萄糖协同转运蛋白2（SGLT2）具有抑制活性的噻唑环的新型化合物，以及包含其作为活性成分的药物组合物，其可用于预防 或治疗代谢紊乱，特别是糖尿病。
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9.发明授权Arylpiperazine-containing pyrrole 3-carboxamide derivatives for treating depressive disorders 有权含有芳基哌嗪的吡咯3-甲酰胺衍生物用于治疗抑郁障碍公开(公告)号：US08895558B2
公开(公告)日：2014-11-25
申请号：US13121551
申请日：2009-09-23
申请人： Jinhwa Lee , Suk Youn Kang , Eun-Jung Park , Kwang-Seop Song , Min Ju Kim , Hee Jeong Seo , Suk Ho Lee , Jeongmin Kim , Ae Nim Pae , Woo-Kyu Park
发明人： Jinhwa Lee , Suk Youn Kang , Eun-Jung Park , Kwang-Seop Song , Min Ju Kim , Hee Jeong Seo , Suk Ho Lee , Jeongmin Kim , Ae Nim Pae , Woo-Kyu Park
IPC分类号： C07D207/34 , C07D401/12 , C07D401/04 , C07D405/04 , C07D417/12 , A61K31/496 , A61K31/498 , C07D405/12 , C07D207/50 , C07D207/36 , C07D401/14
CPC分类号： C07D207/34 , C07D207/36 , C07D207/50 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D417/12
摘要： The present invention relates to novel arylpiperazine-containing pyrrole 3-carboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof which is useful for preventing or treating depressive disorders. The present invention also provides a method for preparing the arylpiperazine-containing pyrrole 3-carboxamide derivatives or the pharmaceutically acceptable salt thereof, a pharmaceutical composition containing same, and a method for preventing or treating depressive disorders.
摘要翻译： 本发明涉及可用于预防或治疗抑郁障碍的式（I）的新型含芳基哌嗪的吡咯-3-甲酰胺衍生物或其药学上可接受的盐。 本发明还提供了制备含芳基哌嗪的吡咯3-甲酰胺衍生物或其药学上可接受的盐的方法，含有它的药物组合物，以及预防或治疗抑郁障碍的方法。
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10.发明申请ARYLPIPERAZINE-CONTAINING PYRROLE 3-CARBOXAMIDE DERIVATIVES FOR TREATING DEPRESSIVE DISORDERS 有权含有ARYLPIPERAZINE的PYRROLE 3-羧酰胺衍生物用于治疗恶心疾病公开(公告)号：US20110178091A1
公开(公告)日：2011-07-21
申请号：US13121551
申请日：2009-09-23
申请人： Jinhwa Lee , Suk Youn Kang , Eun-Jung Park , Kwang-Seop Song , Min Ju Kim , Hee Jeong Seo , Suk Ho Lee , Jeongmin Kim , Ae Nim Pae , Woo-Kyu Park
发明人： Jinhwa Lee , Suk Youn Kang , Eun-Jung Park , Kwang-Seop Song , Min Ju Kim , Hee Jeong Seo , Suk Ho Lee , Jeongmin Kim , Ae Nim Pae , Woo-Kyu Park
IPC分类号： A61K31/498 , C07D403/12 , A61K31/496 , C07D401/14 , A61P25/24
CPC分类号： C07D207/34 , C07D207/36 , C07D207/50 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D417/12
摘要： The present invention relates to novel arylpiperazine-containing pyrrole 3-carboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof which is useful for preventing or treating depressive disorders. The present invention also provides a method for preparing the arylpiperazine-containing pyrrole 3-carboxamide derivatives or the pharmaceutically acceptable salt thereof, a pharmaceutical composition containing same, and a method for preventing or treating depressive disorders.
摘要翻译： 本发明涉及可用于预防或治疗抑郁障碍的式（I）的新型含芳基哌嗪的吡咯-3-甲酰胺衍生物或其药学上可接受的盐。 本发明还提供了制备含芳基哌嗪的吡咯3-甲酰胺衍生物或其药学上可接受的盐的方法，含有它的药物组合物，以及预防或治疗抑郁障碍的方法。
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