公开(公告)号：US06562821B2

公开(公告)日：2003-05-13

申请号：US10085119

申请日：2002-02-27

申请人： Soumitra S. Ghosh ,  Tomas R. Szabo

发明人： Soumitra S. Ghosh ,  Tomas R. Szabo

IPC分类号： C07C27928

CPC分类号： A61K31/5375 ,  A61K31/155 ,  C07C279/28

摘要： Compounds, compositions and methods treating arthritic disorders such as osteoarthritis or rheumatoid arthritis, and for treating other diseases associated with altered mitochondrial function, such as cancer, psoriasis, stroke, Alzheimer's Disease and diabetes. The compounds of this invention have the following structure (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein R1-5 are as defined herein. The methods of this invention are directed to administering to a warm-blooded animal in need thereof an effective amount of a compound of structure (I), typically in the form of a pharmaceutical composition.

摘要翻译： 治疗关节炎疾病如骨关节炎或类风湿性关节炎的化合物，组合物和方法，以及用于治疗与线粒体功能改变相关的其它疾病，例如癌症，牛皮癣，中风，阿尔茨海默氏病和糖尿病。 本发明的化合物具有以下结构（I）：包括其立体异构体，前药和药学上可接受的盐，其中R1-5如本文所定义。 本发明的方法涉及向有需要的温血动物施用有效量的结构式（I）的化合物，通常为药物组合物的形式。

公开(公告)号：US06900197B2

公开(公告)日：2005-05-31

申请号：US10020867

申请日：2001-12-14

申请人： Tomas R. Szabo ,  Soumitra S. Ghosh ,  Robert E. Davis

发明人： Tomas R. Szabo ,  Soumitra S. Ghosh ,  Robert E. Davis

IPC分类号： A61K31/409 ,  A61K33/24 ,  A61P3/04 ,  C07D487/22 ,  C07F15/06 ,  A61K31/555 ,  A61K31/40 ,  A61K31/415

CPC分类号： C07D487/22

摘要： Cobalt-porphyrin (Co-P) complexes for use as anti-obesity agents, and compositions and methods related thereto. The Co-P complexes exhibit reduced redox activity compared to cobalt mesoporphyrin (Co-MP) and cobalt protoporphyrin (Co-PP), which alleviates the deleterious effects associated with administration of Co-P associated with oxidative stress, particularly in the context of injection site toxicity.

公开(公告)号：US06927218B2

公开(公告)日：2005-08-09

申请号：US10386154

申请日：2003-03-11

申请人： Soumitra S. Ghosh ,  Tomas R. Szabo

发明人： Soumitra S. Ghosh ,  Tomas R. Szabo

IPC分类号： C07D295/12 ,  A61K31/155 ,  A61K31/277 ,  A61K31/5375 ,  A61P3/10 ,  A61P17/06 ,  A61P19/02 ,  A61P21/00 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  A61P27/02 ,  A61P27/16 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07C279/28

CPC分类号： A61K31/5375 ,  A61K31/155 ,  C07C279/28

摘要： Compounds, compositions and methods treating arthritic disorders such as osteoarthritis or rheumatoid arthritis, and for treating other diseases associated with altered mitochondrial function, such as cancer, psoriasis, stroke, Alzheimer's Disease and diabetes. The compounds of this invention have the following structure (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein R1-5 are as defined herein. The methods of this invention are directed to administering to a warm-blooded animal in need thereof an effective amount of a compound of structure (I), typically in the form of a pharmaceutical composition.

公开(公告)号：US07001729B2

公开(公告)日：2006-02-21

申请号：US09811131

申请日：2001-03-14

申请人： Christen M. Anderson ,  Robert E. Davis ,  William Clevenger ,  Sandra Eileen Wiley ,  Scott W. Miller ,  Tomas R. Szabo ,  Soumitra S. Ghosh ,  Walter H. Moos ,  Yazhong Pei

发明人： Christen M. Anderson ,  Robert E. Davis ,  William Clevenger ,  Sandra Eileen Wiley ,  Scott W. Miller ,  Tomas R. Szabo ,  Soumitra S. Ghosh ,  Walter H. Moos ,  Yazhong Pei

IPC分类号： G01N29/00 ,  G01N33/573 ,  C12N11/00

CPC分类号： C07K14/47 ,  C07K2319/00 ,  C07K2319/07 ,  C07K2319/21 ,  C07K2319/23 ,  C12N15/62 ,  C12N2799/021

摘要： Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.

公开(公告)号：US06906175B2

公开(公告)日：2005-06-14

申请号：US09809889

申请日：2001-03-16

申请人： Christen M. Anderson ,  Robert E. Davis ,  William Clevenger ,  Sandra Eileen Wiley ,  Scott W. Miller ,  Tomas R. Szabo ,  Soumitra S. Ghosh ,  Walter H. Moos ,  Yazhong Pei

发明人： Christen M. Anderson ,  Robert E. Davis ,  William Clevenger ,  Sandra Eileen Wiley ,  Scott W. Miller ,  Tomas R. Szabo ,  Soumitra S. Ghosh ,  Walter H. Moos ,  Yazhong Pei

IPC分类号： G01N33/50 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7056 ,  A61K31/7064 ,  A61K45/00 ,  A61P3/00 ,  A61P3/10 ,  A61P17/06 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  A61P27/16 ,  A61P35/00 ,  A61P43/00 ,  C07H15/256 ,  C07H15/26 ,  C07K1/22 ,  C07K14/47 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12N15/62 ,  C12P21/02 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  C07K1/00 ,  C07K14/00

CPC分类号： C07K14/47 ,  C07K2319/00 ,  C07K2319/07 ,  C07K2319/21 ,  C07K2319/23 ,  C12N15/62 ,  C12N2799/021

摘要： Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.

摘要翻译： 提供了用于产生腺嘌呤核苷酸转运蛋白（ANT）多肽和融合蛋白的组合物和方法，包括产生和使用具有调节启动子的重组表达构建体。 还公开了ANT配体以及用于鉴定ANT配体的组合物和方法，结合ANT的试剂和与ANT相互作用的试剂。

公开(公告)号：US06902908B2

公开(公告)日：2005-06-07

申请号：US09811094

申请日：2001-03-14

申请人： Christen M. Anderson ,  Robert E. Davis ,  William Clevenger ,  Sandra Eileen Wiley ,  Scott W. Miller ,  Tomas R. Szabo ,  Soumitra S. Ghosh ,  Walter H. Moos ,  Yazhong Pei

发明人： Christen M. Anderson ,  Robert E. Davis ,  William Clevenger ,  Sandra Eileen Wiley ,  Scott W. Miller ,  Tomas R. Szabo ,  Soumitra S. Ghosh ,  Walter H. Moos ,  Yazhong Pei

IPC分类号： G01N33/50 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7056 ,  A61K31/7064 ,  A61K45/00 ,  A61P3/00 ,  A61P3/10 ,  A61P17/06 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  A61P27/16 ,  A61P35/00 ,  A61P43/00 ,  C07H15/256 ,  C07H15/26 ,  C07K1/22 ,  C07K14/47 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12N15/62 ,  C12P21/02 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  C12N15/00 ,  C07H21/04 ,  C12N15/63

CPC分类号： C07K14/47 ,  C07K2319/00 ,  C07K2319/07 ,  C07K2319/21 ,  C07K2319/23 ,  C12N15/62 ,  C12N2799/021

摘要： Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.

摘要翻译： 提供了用于产生腺嘌呤核苷酸转运蛋白（ANT）多肽和融合蛋白的组合物和方法，包括产生和使用具有调节启动子的重组表达构建体。 还公开了ANT配体以及用于鉴定ANT配体的组合物和方法，结合ANT的试剂和与ANT相互作用的试剂。

公开(公告)号：US06887670B2

公开(公告)日：2005-05-03

申请号：US09811132

申请日：2001-03-14

申请人： Christen M. Anderson ,  Robert E. Davis ,  Tomas R. Szabo ,  Soumitra S. Ghosh ,  Walter H. Moos ,  Yazhong Pei

发明人： Christen M. Anderson ,  Robert E. Davis ,  Tomas R. Szabo ,  Soumitra S. Ghosh ,  Walter H. Moos ,  Yazhong Pei

IPC分类号： G01N33/50 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7056 ,  A61K31/7064 ,  A61K45/00 ,  A61P3/00 ,  A61P3/10 ,  A61P17/06 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  A61P27/16 ,  A61P35/00 ,  A61P43/00 ,  C07H15/256 ,  C07H15/26 ,  C07K1/22 ,  C07K14/47 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12N15/62 ,  C12P21/02 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  C07K1/00 ,  C07K1/14 ,  C07K1/16 ,  C07K17/00

CPC分类号： C07K14/47 ,  C07K2319/00 ,  C07K2319/07 ,  C07K2319/21 ,  C07K2319/23 ,  C12N15/62 ,  C12N2799/021

摘要： Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.