公开(公告)号：US20130103127A1

公开(公告)日：2013-04-25

申请号：US13640777

申请日：2011-04-08

申请人： Stefan Müller ,  Steffen Ortlib ,  Ingo Dreher

发明人： Stefan Müller ,  Steffen Ortlib ,  Ingo Dreher

IPC分类号： A61F7/00

CPC分类号： A61F7/0085 ,  A61F2007/0064 ,  A61F2007/0087 ,  A61M5/44 ,  A61M19/00 ,  A61M35/003 ,  A61M2202/0225 ,  A61M2202/0283 ,  A61M2202/03 ,  A61M2205/3606 ,  A61M2205/8225 ,  F25D9/00

摘要： A hand-operated cooling device for cryotherapy for treating pain, inflammations, muscle tensions or the like, includes a main body and a receptacle, which can be inserted at least partially into the main body, for the exchangeable accommodation and insertion of a gas pressure vessel. The main body includes a gas outlet actuation arrangement, which can effect, by manual actuation, the outflow of a gas from the gas pressure vessel when the receptacle is inserted, and the receptacle includes a cooling surface, which can be cooled by the outflowing gas and by the gas pressure vessel jacket, wherein the gas can be conducted inside the main body and inside the receptacle by a gas conducting arrangement and can exit at the receptacle adjacent to the cooling surface. Commercially available gas pressure vessels, in particular cream dispensing capsules, can be inserted into the cooling device, so that a simple and cost-effective use of therapeutic OT medical cryotherapy having a pleasant cooling effect is made possible.

摘要翻译： 用于治疗疼痛，炎症，肌肉紧张等的冷冻治疗用手动冷却装置包括主体和容器，其可以至少部分地插入主体中，用于可更换的容纳和插入气体压力 船只。 主体包括气体出口致动装置，其可以通过手动致动而在插座插入时从气体压力容器流出气体，并且容器包括可由流出气体冷却的冷却表面 并且通过气体压力容器护套，其中气体可以通过气体导电装置在主体内部和内部导入，并且可以在靠近冷却表面的容器处离开。 可以将市售的气体压力容器，特别是奶油分配胶囊插入冷却装置，使得可以简单且成本有效地使用具有令人愉快的冷却效果的治疗性OT医疗冷冻疗法。

公开(公告)号：US09398975B2

公开(公告)日：2016-07-26

申请号：US13640777

申请日：2011-04-08

申请人： Stefan Müller ,  Steffen Ortlib ,  Ingo Dreher

发明人： Stefan Müller ,  Steffen Ortlib ,  Ingo Dreher

IPC分类号： A61F7/00 ,  A61M19/00 ,  A61M35/00 ,  F25D9/00 ,  A61M5/44

CPC分类号： A61F7/0085 ,  A61F2007/0064 ,  A61F2007/0087 ,  A61M5/44 ,  A61M19/00 ,  A61M35/003 ,  A61M2202/0225 ,  A61M2202/0283 ,  A61M2202/03 ,  A61M2205/3606 ,  A61M2205/8225 ,  F25D9/00

摘要： A hand-operated cooling device for cryotherapy for treating pain, includes a main body and a receptacle, which can be inserted at least partially into the main body, for the exchangeable accommodation and insertion of a gas pressure vessel. The main body includes a manual gas outlet actuation arrangement, which can effects the outflow of a gas from the gas pressure vessel when the receptacle is inserted. The receptacle includes a cooling surface, which can be cooled by the outflowing gas and by the gas pressure vessel jacket, wherein the gas can be conducted inside the main body and inside the receptacle by a gas conducting arrangement and can exit at the receptacle adjacent to the cooling surface. Commercially available gas pressure vessels, can be inserted into the cooling device, so that a simple and cost-effective use of therapeutic OT medical cryotherapy having a pleasant cooling effect is made possible.

摘要翻译： 用于治疗疼痛的冷冻治疗的手动冷却装置包括主体和容器，其可以至少部分地插入主体中，以用于气体压力容器的可更换的容纳和插入。 主体包括手动气体出口致动装置，其在插入插座时可以实现来自气体压力容器的气体的流出。 容器包括冷却表面，该冷却表面可以通过流出的气体和气体压力容器外套来冷却，其中气体可以通过导气装置在主体内部和内部进入，并且可以在靠近的容器 冷却表面。 可以将市售的气体压力容器插入冷却装置，使得可以简单且成本有效地使用具有令人愉快的冷却效果的治疗性OT医疗冷冻治疗。

公开(公告)号：US08987011B2

公开(公告)日：2015-03-24

申请号：US13391916

申请日：2010-08-18

申请人： Klaus Köhler ,  Stefan Müller ,  Patrick Waltereit

发明人： Klaus Köhler ,  Stefan Müller ,  Patrick Waltereit

IPC分类号： H01L27/088 ,  H01L29/66 ,  H01L29/778 ,  H01L29/20

CPC分类号： H01L29/66462 ,  H01L29/2003 ,  H01L29/7787

摘要： A method for determining the structure of a transistor having at least one first layer including GaN, one second layer including AlxGa1-xN disposed on the first layer, and one fourth layer including a metal or an alloy disposed on the second layer. The method includes setting the layer thickness of the second layer, setting the aluminum content x of the second layer, producing at least the second layer and the first layer, determining the surface potential of formula (I) and/or the charge carrier density n, and/or the charge carrier motility μ after producing the second layer and the first layer, and selecting the material of the fourth layer as a function of the at least one measurement result.

摘要翻译： 一种用于确定晶体管的结构的方法，所述晶体管具有包括GaN的至少一个第一层，设置在所述第一层上的包括Al x Ga 1-x N的一个第二层以及包括设置在所述第二层上的金属或合金的第四层。 该方法包括设定第二层的层厚度，设定第二层的铝含量x，产生至少第二层和第一层，确定式（I）的表面电位和/或电荷载流子密度n ，和/或产生第二层和第一层之后的电荷载流子运动μ，以及根据至少一个测量结果选择第四层的材料。

公开(公告)号：US20140302172A1

公开(公告)日：2014-10-09

申请号：US14239067

申请日：2012-08-16

申请人： Christoph Schaab ,  Klaus Godl ,  Martin Klammer ,  Andreas Tebbe ,  Stefan Müller

发明人： Christoph Schaab ,  Klaus Godl ,  Martin Klammer ,  Andreas Tebbe ,  Stefan Müller

IPC分类号： C12Q1/68 ,  G01N33/569

CPC分类号： C12Q1/6881 ,  G01N33/56966 ,  G01N33/574 ,  G01N2333/70546

摘要： The present invention relates to a method for predicting the responsiveness of a mammalian tumor cell or cancer cell to an inhibitor of a kinase of the Src family, such as dasatinib, bosutinib, saracatinib or ponatinib. The present invention also provides for a method for predicting the responsiveness of an individual to an inhibitor of a kinase of the Src family, whereby the individual is suspected to suffer from cancer. These methods involve the evaluation of the status of integrin β4, wherein said status is indicative for the responsiveness to the inhibitor. Furthermore, a kit useful for carrying out the methods described herein as well as an oligo- or polynucleotide and/or antibodies capable of detecting the expression level of integrin β4 for predicting the responsiveness to the inhibitor are provided.

摘要翻译： 本发明涉及一种用于预测哺乳动物肿瘤细胞或癌细胞对Src家族的激酶抑制剂（如达沙替尼，波斯库替尼，沙拉单抗或番茄碱）的反应性的方法。 本发明还提供了一种用于预测个体对Src家族的激酶抑制剂的反应性的方法，由此该个体怀疑患有癌症。 这些方法包括评价整联蛋白的状态; 4，其中所述状态指示对抑制剂的反应性。 此外，提供了可用于实施本文所述方法的试剂盒以及能够检测整联蛋白4的表达水平以预测对抑制剂的反应性的寡核苷酸和/或多核苷酸和/或抗体。

公开(公告)号：US20140013750A1

公开(公告)日：2014-01-16

申请号：US13997587

申请日：2011-12-21

申请人： Stefan Müller ,  Konrad Herrmann ,  Anayet Temelci-Andon ,  Harald Köhler

发明人： Stefan Müller ,  Konrad Herrmann ,  Anayet Temelci-Andon ,  Harald Köhler

IPC分类号： F01K25/08 ,  F01K23/12 ,  F01K13/02

CPC分类号： F01K25/08 ,  F01K13/02 ,  F01K23/065 ,  F01K23/101 ,  F01K23/12 ,  F01K25/10 ,  Y02P80/15

摘要： A waste recovery system for a waste-heat source made up of an ORC (Organic-Rankine Cycle) postconnected thereto is described. The waste-heat source is in connection with the heating device of the ORC as well as with an expansion machine for steam expansion in the ORC coupled to a generator. The design and operating behavior of a force-heat coupling system is optimized, a waste-heat recovery system made up of an ORC post-connected to a waste-heat source. The expansion machine for steam expansion in the ORC is therefore started up by the generator which is operating in motor mode, and brought to a minimum starting engine speed able to be specified in a control device.

摘要翻译： 描述了由与后连接的ORC（有机 - 兰金循环）组成的废热源的废物回收系统。 废热源与ORC的加热装置连接，以及用于连接到发电机的ORC中用于蒸汽膨胀的膨胀机。 力 - 热耦合系统的设计和操作行为得到优化，废热回收系统由与废热源后连接的ORC组成。 因此，在ORC中用于蒸汽膨胀的膨胀机由在电动机模式下运行的发电机启动，并使得能够在控制装置中指定的启动发动机转速降至最低。

公开(公告)号：US08557820B2

公开(公告)日：2013-10-15

申请号：US12597930

申请日：2008-04-28

申请人： Martin Vogt ,  Stefan Müller ,  Julie Grumelard ,  Cyrille Deshayes ,  Holger Paul ,  Jürg Haase ,  Thomas Ehlis

发明人： Martin Vogt ,  Stefan Müller ,  Julie Grumelard ,  Cyrille Deshayes ,  Holger Paul ,  Jürg Haase ,  Thomas Ehlis

IPC分类号： A61K31/497 ,  A61K8/00 ,  C07D241/04 ,  C07D295/00 ,  A61Q17/04

CPC分类号： C07D295/192 ,  A61K8/04 ,  A61K8/494 ,  A61K31/495 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/08 ,  A61K2300/00

摘要： Disclosed is the use of an aqueous dispersion comprising (a) a micronized sparingly soluble organic benzophenone derivative of formula (1), selected from the crystal modifications (B) and (C), wherein the crystal modification (B) is characterized by a peak in the X-ray diffraction pattern at a d-spacing of about 7.70; and wherein the crystal modification (C) is characterized by a peak in the X-ray diffraction pattern at a d-spacing of about 7.06; and (b) a dispersing agent selected from anionic, non-ionic and amphoteric surfactants; for protecting the human skin from browning and skin aging. The new crystal modification (C) represents a thermodynamically stable compound of formula (1) at 25° C. This modification is therefore suitable in dispersions comprising micro-fine particles.

摘要翻译： 公开了含有（a）选自晶体改性（B）和（C）的式（1）的微粉化的微溶有机二苯甲酮衍生物的水性分散体的用途，其中所述晶体改性（B）的特征在于峰 在X-射线衍射图中，d-间距约为7.70; 并且其中所述晶体改性（C）的特征在于在约7.06的d间距处的X射线衍射图中的峰; 和（b）选自阴离子，非离子和两性表面活性剂的分散剂; 用于保护人体皮肤免受褐变和皮肤老化。 新的结晶改性（C）在25℃下代表热力学稳定的式（1）化合物。因此，该修饰适用于包含微细颗粒的分散体。

公开(公告)号：US08393556B2

公开(公告)日：2013-03-12

申请号：US12664429

申请日：2008-06-27

申请人： Stefan Müller ,  Bernd Herzog

发明人： Stefan Müller ,  Bernd Herzog

IPC分类号： B02C15/00

CPC分类号： C07D251/24 ,  A61K8/4966 ,  A61K2800/412 ,  A61K2800/413 ,  A61Q17/04 ,  B82Y5/00

摘要： Disclosed is a method of preparing a composition, comprising a micronized insoluble organic UV absorber, which method comprises grinding the insoluble organic UV absorber, in coarse particle form, in a grinding apparatus comprising yttrium-stabilized zirconium oxide grinding beads, in the presence of alkyl polyglucoside having the formula CnH2n+1O(C6H10O5)xH, in which n is an integer ranging from 8 to 16 and x is the mean polymerisation level of the glucoside moiety (C6H10O5) and ranges from 1.4 to 1.6, or an ester thereof and in the presence of an antifoam agent as dispersingagent auxiliary.

摘要翻译： 公开了一种制备组合物的方法，该组合物包含微粉化的不溶性有机UV吸收剂，该方法包括在包含钇稳定的氧化锆研磨珠的研磨装置中，在烷基存在下研磨粗颗粒形式的不溶性有机UV吸收剂 具有式C n H 2n + 10（C 6 H 10 O 5）x H的聚葡萄糖苷，其中n是8至16的整数，x是葡萄糖苷部分（C 6 H 10 O 5）的平均聚合水平，范围为1.4至1.6，或其酯， 消泡剂作为分散助剂的存在。

公开(公告)号：US08097240B2

公开(公告)日：2012-01-17

申请号：US12086648

申请日：2006-12-11

申请人： Stefan Müller ,  Jürg Haase ,  Thomas Ehlis ,  Gilbert Kreyer ,  Jochen Giesinger ,  Martin Vogt

发明人： Stefan Müller ,  Jürg Haase ,  Thomas Ehlis ,  Gilbert Kreyer ,  Jochen Giesinger ,  Martin Vogt

IPC分类号： A61Q17/04 ,  C07D241/04

CPC分类号： C07D295/192 ,  A61K8/411 ,  A61K8/42 ,  A61K8/49 ,  A61K8/494 ,  A61K2800/43 ,  A61Q17/04

摘要： Disclosed is the use of an aqueous dispersion comprising (a) a micronized sparingly soluble organic compound which has a UV-Vis spectrum with a maximum from 380 to 420 nm; and (b) an anionic dispersing agent for protecting the human skin from browning and skin aging.

摘要翻译： 公开了包含（a）微波化的微溶有机化合物的水分散体的使用，其具有最大值为380至420nm的UV-Vis光谱; 和（b）用于保护人体皮肤免于褐变和皮肤老化的阴离子分散剂。

公开(公告)号：US07999128B2

公开(公告)日：2011-08-16

申请号：US12223686

申请日：2007-02-06

申请人： Jürg Haase ,  Stefan Müller ,  Thomas Ehlis

发明人： Jürg Haase ,  Stefan Müller ,  Thomas Ehlis

IPC分类号： C07F7/04

CPC分类号： A61Q17/04 ,  A61K8/585 ,  C07F7/0838

摘要： Disclosed are hydroxyphenylbenzophenone derivatives of formula (1), wherein R1 and R2 independently from each other are hydrogen; C1-C20alkenyl; C3-C10cycloalkyl; or R1 and R2 together with the linking nitrogen atom form a 5- 6-membered heterocyclic ring; R3, R4 and R5 independently from each other are C1-C4alkyl; C1-C4alkoxy; or a radical of formula (1a) R6 is C1-C6alkyl; and A is a straight-chain or branched C3-C6alkylene, which is optionally interrupted by one or more *—O—*, or *—O—(CO)—* groups; and m is 0; or a number from 1 to 5. The compounds are useful as cosmetic UV filters with outstanding solubility properties in cosmetic oils.

摘要翻译： 公开了式（1）的羟基苯基二苯甲酮衍生物，其中R 1和R 2彼此独立地是氢; C1-C20烯基; C 3 -C 10环烷基; 或R 1和R 2与连接氮原子一起形成5-6元杂环; R 3，R 4和R 5彼此独立地为C 1 -C 4烷基; C1-C4烷氧基; 或式（1a）的基团，R 6为C 1 -C 6烷基; 并且A是直链或支链C 3 -C 6亚烷基，其任选地被一个或多个* -O- *或* -O-（CO）*基团间隔; m为0; 或1至5的数字。该化合物可用作化妆品油中具有优异溶解性的化妆品UV滤光片。

公开(公告)号：US20100307009A1

公开(公告)日：2010-12-09

申请号：US12735095

申请日：2008-12-12

申请人： Heinrich Schwer ,  Stefan Müller ,  Gerhard Kienzler

发明人： Heinrich Schwer ,  Stefan Müller ,  Gerhard Kienzler

IPC分类号： B26B19/02 ,  H02K33/02

CPC分类号： H02K33/04 ,  B26B19/282

摘要： A drive unit for a hair cutting machine comprises a driving motor that includes a substantially U-shaped stator which has a first leg, a second leg, and at least one additional leg located between the first leg and the second leg, at least one field coil which can be disposed on the at least one additional leg, and an armature. Lateral air gap sections are formed between the first and second leg and the armature while central air gap sections are formed between the additional leg and the armature. The central air gap sections and the lateral air gap sections extend at an angle from a longitudinal axis. A first nose, which faces away from the additional leg, is arranged at the end of the first leg, while a notch, which faces the additional leg and corresponds to the first nose, is arranged on the second leg.

摘要翻译： 用于头发切割机的驱动单元包括驱动马达，该驱动马达包括基本上为U形的定子，该定子具有第一腿部，第二腿部以及位于第一腿部和第二腿部之间的至少一个附加支腿，至少一个场 线圈，其可以设置在至少一个附加腿上，以及电枢。 横向间隙部分形成在第一和第二腿部与电枢之间，而中央气隙部分形成在附加腿部和衔铁之间。 中心气隙部分和横向气隙部分从纵向轴线以一定角度延伸。 面向附加腿部的第一鼻子布置在第一腿部的末端，而面向附加腿部并对应于第一鼻部的凹口布置在第二腿部上。