公开(公告)号：US20100330568A1

公开(公告)日：2010-12-30

申请号：US12735313

申请日：2009-01-09

申请人： Stefan Meuer ,  Thomas Giese ,  Christian Jacobi ,  Jürgen Römisch ,  Stefan Haag

发明人： Stefan Meuer ,  Thomas Giese ,  Christian Jacobi ,  Jürgen Römisch ,  Stefan Haag

IPC分类号： C12Q1/68 ,  G01N33/68 ,  C12Q1/02

CPC分类号： G01N33/6854 ,  G01N33/5047

摘要： A method of determining a patient's susceptibility for NK cell modulation by immunoglobulins in response to a treatment of a disease or prophylaxis of a disease with immunoglobulins wherein a modulation of natural killer cells caused by said immunoglobulins is determined.

摘要翻译： 确定患者对免疫球蛋白响应于疾病治疗或用免疫球蛋白预防疾病的NK细胞调节的敏感性的方法，其中确定由所述免疫球蛋白引起的天然杀伤细胞的调节。

公开(公告)号：US20150211064A1

公开(公告)日：2015-07-30

申请号：US14114276

申请日：2012-06-06

申请人： Stefan Meuer ,  Thomas Geise ,  Christian Jacobi ,  Stefan Haag ,  Juergen Roemisch

发明人： Stefan Meuer ,  Thomas Geise ,  Christian Jacobi ,  Stefan Haag ,  Juergen Roemisch

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/156

摘要： A method for determining the likelihood of response of an individual, suffering from a disease, towards immunoglobulin therapy has the steps of providing a sample containing B- and T-lymphocytes, natural killer cells, invariant T-cells and monocytes of the individual; genotyping of at least one of the polynucleotides of an ADAMTS9-Intron; a KLHDC8A-Intron or of a flanking region of the CD14 gene, and awarding the value of 1 for the homozygous Single Nucleotide Polymorphism combinations, which suggests that the blood sample stems from a person which will not respond to immunoglobulin treatment, while awarding the value of 0 for SNP not meeting that criteria, which suggests that the blood sample stems from a person which will respond to immunoglobulin treatment.

摘要翻译： 确定患有疾病的个体对免疫球蛋白治疗的反应可能性的方法具有以下步骤：提供含有个体的B和T淋巴细胞，天然杀伤细胞，不变T细胞和单核细胞的样品; 至少一种ADAMTS9-内含子的多核苷酸的基因分型; KLHDC8A-内含子或CD14基因的侧翼区域，并且为纯合的单核苷酸多态性组合赋予1值，这表明血液样品源于不对免疫球蛋白治疗反应的人，同时赋予该值 为0的SNP不符合该标准，这表明血液样本来源于将对免疫球蛋白治疗作出反应的人。

公开(公告)号：US10437602B2

公开(公告)日：2019-10-08

申请号：US13524839

申请日：2012-06-15

申请人： Dan F. Greiner ,  Christian Jacobi ,  Marcel Mitran ,  Timothy J. Slegel

发明人： Dan F. Greiner ,  Christian Jacobi ,  Marcel Mitran ,  Timothy J. Slegel

IPC分类号： G06F9/30 ,  G06F9/38 ,  G06F9/46 ,  G06F9/48

摘要： Program exception conditions cause a transaction to abort and typically result in an interruption in which the operating system obtains control. A program interruption filtering control is provided to selectively present the interrupt. That is, the interrupt from the program exception condition may or may not be presented depending at least on the program interruption filtering control and a transaction class associated with the program exception condition. The program interruption filtering control is provided by a TRANSACTION BEGIN instruction.

公开(公告)号：US09740549B2

公开(公告)日：2017-08-22

申请号：US13524857

申请日：2012-06-15

申请人： Brenton F. Belmar ,  Christian Jacobi ,  Randall W. Philley ,  Timothy J. Slegel

发明人： Brenton F. Belmar ,  Christian Jacobi ,  Randall W. Philley ,  Timothy J. Slegel

IPC分类号： G06F7/00 ,  G06F17/00 ,  G06F11/07 ,  G06F17/30 ,  G06F9/46 ,  G06F13/24

CPC分类号： G06F11/076 ,  G06F9/466 ,  G06F11/0721 ,  G06F13/24 ,  G06F17/30371

摘要： Processing of transactions within a computing environment is facilitated by taking actions to increase the chances of successfully executing a transaction. A counter is maintained that provides a count of how often a transaction has aborted. The counter increments the count each time the transaction is aborted, and it is reset to zero upon successful completion of the transaction or an interruption leading to no more re-executions of the transaction. If the count reaches a threshold value, then an interrupt is presented and transaction execution is unsuccessful. However, before the count reaches the threshold, a number of actions may be taken to increase the chances of successfully executing the transaction. These actions include actions to be performed within the processor executing the transaction, and/or actions to be performed against conflicting processors.

公开(公告)号：US09710266B2

公开(公告)日：2017-07-18

申请号：US13421451

申请日：2012-03-15

申请人： Jonathan D. Bradbury ,  Michael K. Gschwind ,  Christian Jacobi ,  Eric M. Schwarz ,  Timothy J. Slegel

发明人： Jonathan D. Bradbury ,  Michael K. Gschwind ,  Christian Jacobi ,  Eric M. Schwarz ,  Timothy J. Slegel

IPC分类号： G06F9/38 ,  G06F9/30 ,  G06F9/355

CPC分类号： G06F9/30043 ,  G06F9/3001 ,  G06F9/3004 ,  G06F9/30076 ,  G06F9/355 ,  G06F9/3824 ,  G06F9/3861

摘要： A Load Count to Block Boundary instruction is provided that provides a distance from a specified memory address to a specified memory boundary. The memory boundary is a boundary that is not to be crossed in loading data. The boundary may be specified a number of ways, including, but not limited to, a variable value in the instruction text, a fixed instruction text value encoded in the opcode, or a register based boundary; or it may be dynamically determined.

公开(公告)号：US09459867B2

公开(公告)日：2016-10-04

申请号：US13421456

申请日：2012-03-15

申请人： Jonathan D. Bradbury ,  Michael K. Gschwind ,  Christian Jacobi ,  Eric M. Schwarz ,  Timothy J. Slegel

发明人： Jonathan D. Bradbury ,  Michael K. Gschwind ,  Christian Jacobi ,  Eric M. Schwarz ,  Timothy J. Slegel

IPC分类号： G06F9/30 ,  G06F9/38 ,  G06F9/455

CPC分类号： G06F9/30043 ,  G06F9/30007 ,  G06F9/30036 ,  G06F9/3004 ,  G06F9/30047 ,  G06F9/30098 ,  G06F9/3013 ,  G06F9/30145 ,  G06F9/3824 ,  G06F9/3861 ,  G06F9/45516

摘要： A Load to Block Boundary instruction is provided that loads a variable number of bytes of data into a register while ensuring that a specified memory boundary is not crossed. The boundary may be specified a number of ways, including, but not limited to, a variable value in the instruction text, a fixed instruction text value encoded in the opcode, or a register based boundary.

摘要翻译： 加载到块提供了将可变数量的字节数据加载到寄存器中，同时确保指定的存储器边界未被越过。 边界可以指定多种方式，包括但不限于指令文本中的可变值，编码在操作码中的固定指令文本值或基于寄存器的边界。

公开(公告)号：US09336046B2

公开(公告)日：2016-05-10

申请号：US13524877

申请日：2012-06-15

申请人： Dan F. Greiner ,  Christian Jacobi ,  Timothy J. Slegel

发明人： Dan F. Greiner ,  Christian Jacobi ,  Timothy J. Slegel

IPC分类号： G06F9/46 ,  G06F9/30 ,  G06F9/38

CPC分类号： G06F9/30098 ,  G06F9/3004 ,  G06F9/30087 ,  G06F9/30145 ,  G06F9/3834 ,  G06F9/3842 ,  G06F9/3857 ,  G06F9/3861 ,  G06F9/466

摘要： A transaction executing within a computing environment ends prior to completion; i.e., execution is aborted. Pursuant to aborting execution, a hardware transactional execution CPU mode is exited, and one or more of the following is performed: restoring selected registers; committing nontransactional stores on abort; branching to a transaction abort program status word specified location; setting a condition code and/or abort code; and/or preserving diagnostic information.

摘要翻译： 在计算环境中执行的事务在完成之前结束; 即执行中止。 根据中止执行，退出硬件事务执行CPU模式，执行以下一个或多个操作：恢复所选择的寄存器; 在中止时承诺非事务性商店; 分支到事务中止程序状态字指定位置; 设置条件代码和/或中止代码; 和/或保存诊断信息。

公开(公告)号：US09262320B2

公开(公告)日：2016-02-16

申请号：US13524355

申请日：2012-06-15

申请人： Khary J. Alexander ,  Jonathan T. Hsieh ,  Christian Jacobi ,  Patrick M. West

发明人： Khary J. Alexander ,  Jonathan T. Hsieh ,  Christian Jacobi ,  Patrick M. West

IPC分类号： G06F12/08 ,  G06F9/46 ,  G06F9/30 ,  G06F9/38

CPC分类号： G06F12/08 ,  G06F9/30 ,  G06F9/3004 ,  G06F9/30043 ,  G06F9/30087 ,  G06F9/3013 ,  G06F9/3834 ,  G06F9/3859 ,  G06F9/466 ,  G06F9/467 ,  G06F12/0815 ,  G06F12/084

摘要： Embodiments relate to tracking a transactional execution footprint. An aspect includes receiving a store instruction which includes store data. It is determined if the store instruction is executing within a transaction that effectively delays committing stores to a shared cache until the transaction has completed. The store data is stored to a cache line in a local cache. The cache line is marked as dirty if the transaction is active. The stored data that was marked as dirty in the local cache is invalidated if the transaction has terminated abnormally. The stored data is un-marked if it is determined that the transaction has successfully ended.

摘要翻译： 实施例涉及跟踪事务执行足迹。 一方面包括接收包括存储数据的存储指令。 确定存储指令是否在事务内执行，以有效地将提交存储延迟到共享高速缓存，直到事务完成。 存储数据被存储到本地高速缓存中的高速缓存行。 如果事务处于活动状态，则缓存行被标记为脏。 如果事务异常终止，则在本地缓存中标记为脏的存储数据将无效。 如果确定交易已成功结束，则存储的数据将被取消标记。

公开(公告)号：US20130339675A1

公开(公告)日：2013-12-19

申请号：US13524796

申请日：2012-06-15

申请人： Dan F. Greiner ,  Christian Jacobi ,  Timothy J. Slegel

发明人： Dan F. Greiner ,  Christian Jacobi ,  Timothy J. Slegel

IPC分类号： G06F9/00

CPC分类号： G06F11/1474 ,  G06F9/3861 ,  G06F9/466 ,  G06F9/467 ,  G06F11/3636 ,  G06F11/366 ,  G06F11/3688 ,  G06F13/4068 ,  G06F2201/87

摘要： Task specific diagnostic controls are provided to facilitate the debugging of certain types of abort conditions. The diagnostic controls may be set to cause transactions to be selectively aborted, allowing a transaction to drive its abort handler routine for testing purposes. The controls include, for instance, a transaction diagnostic scope and a transaction diagnostic control. The transaction diagnostic scope indicates when the transaction diagnostic control is to be applied, and the transaction diagnostic control indicates whether transactions are to selectively aborted.

摘要翻译： 提供任务特定的诊断控制，以便于某些类型的中止条件的调试。 可以设置诊断控件以导致事务被选择性地中止，从而允许事务驱动其中止处理程序用于测试目的。 控件包括例如事务诊断范围和事务诊断控件。 事务诊断范围指示何时应用事务诊断控件，并且事务诊断控件指示是否选择性地中止事务。

公开(公告)号：US20130339674A1

公开(公告)日：2013-12-19

申请号：US13524765

申请日：2012-06-15

申请人： Dan F. Greiner ,  Christian Jacobi ,  Timothy J. Slegel

发明人： Dan F. Greiner ,  Christian Jacobi ,  Timothy J. Slegel

IPC分类号： G06F9/30

CPC分类号： G06F9/3861 ,  G06F9/3004 ,  G06F9/30087 ,  G06F9/30098 ,  G06F9/3834 ,  G06F9/466 ,  G06F9/467 ,  G06F9/528

摘要： Restricted instructions are prohibited from execution within a transaction. There are classes of instructions that are restricted regardless of type of transaction: constrained or nonconstrained. There are instructions only restricted in constrained transactions, and there are instructions that are selectively restricted for given transactions based on controls specified on instructions used to initiate the transactions.

摘要翻译： 限制的指令在交易中被禁止执行。 无论事务类型如何，都有限制性的指令类型：受限制的或不受约束的。 只有受限制的交易中才有限制性的指令，并且根据用于启动交易的指令指定的控制指令，有选择地限制给定的交易。