摘要:
A process for producing solid dosage forms, in which (i) a plastic mixture of at least one pharmacologically acceptable polymeric binder with a K value of more than 75, at least one pharmaceutical active ingredient and, where appropriate, conventional pharmaceutical additives is prepared and (ii) the plastic mixture is shaped to the required dosage form, with step (i) being carried out under conditions of temperature and shear energy input such that the reduction in molecular weight of the polymeric binder, expressed as the difference in the K value, is less than 15 is described.
摘要:
A process for producing a solid dispersion of an active ingredient which comprises feeding the active ingredient and a matrix-forming agent to an extruder and forming a uniform extrudate, wherein the extruder comprises at least two rotating shafts (2), each of the shafts (2) carrying a plurality of processing elements disposed axially one behind the other, the processing elements defining (i) a feeding and conveying section (A), (ii) at least one mixing section (B), and (iii) a discharging section (E), wherein the processing element(s) defining the mixing section (B) comprise(s) a mixing element (11, 12, 13) that is derived from a screw type element (FIG. 2).
摘要:
A process for producing a solid dispersion of an active ingredient which comprises feeding the active ingredient and a matrix-forming agent to an extruder and forming a uniform extrudate, wherein the extruder comprises at least two rotating shafts (2), each of the shafts (2) carrying a plurality of processing elements disposed axially one behind the other, the processing elements defining (i) a feeding and conveying section (R; A), (ii) at least one reverse-flight section (D), and (iii) a discharging section (E), wherein the processing elements defining the reverse-flight section (R; D) comprise at least one reverse-flight element (14) which is based on a screw-type element having a conveying direction being opposite to the general conveying direction of the extruder.
摘要:
Solid formulation of a crop protection product can be obtained by melt extrusion and shaping of a mixture consisting of: 0.1-80% by wt. of an active ingredient which can be used in crop protection, or of a combination of such active ingredients, 10-80% by wt. of at least one mineral filler, 0-20% by wt. of inorganic or organic additives, and to 100% by wt. of at least one thermoplastic water-insoluble polymer
摘要:
A lined beverage-cooling container is disclosed, the container comprises a carton lined with a watertight liner bag. The walls of the bag are higher than the walls of the carton. Because the bag expands past the walls of the carton, a cavity for holding ice is formed on top of the carton. A method of use such container is also disclosed.
摘要:
Systems and techniques for integrating information for the planning and performance of maintenance activities are described. In one aspect, a method includes receiving a collection of descriptions of maintenance tasks in an enterprise, accessing one or more data stores to receive asset information characterizing assets in the enterprise, process information characterizing assets involved in processes of the enterprise, and process value information characterizing values of the processes to the enterprise, integrating the asset information, the process information, and the process value information to assign costs associated with performance of each of the maintenance tasks, generating a work list including a subset of the collection of maintenance tasks based on the assigned costs, and making the work list available over one or more output devices.
摘要:
An in-space spacecraft servicing system (10) includes a servicing spacecraft (22) and a propellant module (24). The servicing spacecraft includes a client servicing system (136), as well as navigation avionics (108) for independent flight operation and a servicing propellant tank (170). The propellant module moves the servicing module from an upper stage drop off location and releases it in proximity to a client spacecraft (16) for a servicing mission. It has a propellant tank (172) with capacity for multiple missions and is used to refill the servicing spacecraft's propellant tanks between missions. Either or both the servicing spacecraft and the propellant module may have navigation avionics. The servicing spacecraft also has a universal docking adaptor (70) for different client spacecraft, and can convert a client spacecraft from non-cooperative to cooperative.
摘要:
An air outlet device (1) for vehicles, in particular airplanes, comprises a panel (2) with at least one receiving opening, an air outlet (3) arranged in the receiving opening, and a sealing means (6) sealing the air outlet (3) and the panel (2) against each other. At the panel (2) and/or the air outlet (3), a securing means (8) is configured, it serves to mount the air outlet (3) to the panel (2). During the assembly of the air outlet device (1), the securing means (8) holds the air outlet (3) in a defined position in the panel (2) so that curing adhesives can be used as sealing means (6) without any problem.
摘要:
A method and a device (4) for testing an integrated circuit (DUT) uses a stress signal and surface monitoring. A stress signal generator (5) is connected to the integrated circuit (DUT) to apply the stress signal (v(t)) to the integrated circuit. A failure is observed in real time by monitoring the surface (6) of the integrated circuit (DUT) during a monitoring time window (&Dgr;T) by an emission microscope (10) having a controllable shutter (15). The time window has a predetermined relation with respect to the duration of the stress signal.
摘要:
This invention provides an apparatus and method for injecting an additive directly into a polymer melt stream. The method comprises supplying a melt flow of a polymeric host material to a die assembly having a thin-plate assembly and injecting at least one additive into at least one predetermined location in a cross-section of the melt flow of the polymeric host material while the melt flow passes through the die assembly. The method achieves uniform dosing of the one or more additives in the extrusion direction in the polymeric host material without homogeneously mixing the one or more additives and the polymeric host material. The apparatus for directly injecting one or more additives into a polymer melt stream comprises a pumping system, a die assembly having a thin-plate assembly, and a distribution line.