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公开(公告)号：US20120009098A1
公开(公告)日：2012-01-12
申请号：US13238342
申请日：2011-09-21
申请人： Stephane Mouradian , Josh Molho , Ming Wu , Hayley Wu , Javier A. Farinas
发明人： Stephane Mouradian , Josh Molho , Ming Wu , Hayley Wu , Javier A. Farinas
IPC分类号： B01L3/00
CPC分类号： B01L3/502761 , B01L3/502715 , B01L2200/027 , B01L2300/0681 , B01L2300/0816 , B01L2300/0819
摘要： A microfluidic device with a filter includes a substrate; a flowpath including a well formed in the substrate in fluid communication with a channel formed in the substrate; and a filter disposed across the flowpath and associated with the channel.
摘要翻译： 具有过滤器的微流体装置包括基板; 流路，其包括在所述基板中形成的与形成在所述基板中的通道流体连通的阱; 以及跨过流路设置并与通道相关联的过滤器。
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公开(公告)号：US09034196B2
公开(公告)日：2015-05-19
申请号：US13238342
申请日：2011-09-21
申请人： Stephane Mouradian , Josh Molho , Ming Wu , Hayley Wu , Javier A. Farinas
发明人： Stephane Mouradian , Josh Molho , Ming Wu , Hayley Wu , Javier A. Farinas
CPC分类号： B01L3/502761 , B01L3/502715 , B01L2200/027 , B01L2300/0681 , B01L2300/0816 , B01L2300/0819
摘要： A microfluidic device with a filter includes a substrate; a flowpath including a well formed in the substrate in fluid communication with a channel formed in the substrate; and a filter disposed across the flowpath and associated with the channel.
摘要翻译： 具有过滤器的微流体装置包括：基板; 流路，其包括在所述基板中形成的与形成在所述基板中的通道流体连通的阱; 以及跨过流路设置并与通道相关联的过滤器。
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公开(公告)号：US20080277356A1
公开(公告)日：2008-11-13
申请号：US11745411
申请日：2007-05-07
申请人： Stephane Mouradian , Josh Molho , Ming Wu , Hayley Wu , Javier A. Farinas
发明人： Stephane Mouradian , Josh Molho , Ming Wu , Hayley Wu , Javier A. Farinas
CPC分类号： B01L3/502761 , B01L3/502715 , B01L2200/027 , B01L2300/0681 , B01L2300/0816 , B01L2300/0819
摘要： A microfluidic device with a filter includes a substrate; a flowpath including a well formed in the substrate in fluid communication with a channel formed in the substrate; and a filter disposed across the flowpath.
摘要翻译： 具有过滤器的微流体装置包括基板; 流路，其包括在所述基板中形成的与形成在所述基板中的通道流体连通的阱; 以及设置在流路上的过滤器。
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4.发明授权Method and apparatus for performing peptide digestion on a microfluidic device 有权在微流体装置上进行肽消化的方法和装置公开(公告)号：US09097723B2
公开(公告)日：2015-08-04
申请号：US11397307
申请日：2006-04-03
IPC分类号： C12Q1/37 , G01N33/543 , G01N33/68
CPC分类号： G01N33/6842
摘要： The invention provides methods and apparatuses that allow a protein sample to undergo reduction, alkylation, and digestion in a continuous flow process carried out within a microfluidic device. Methods and apparatuses in accordance with the invention can be employed as part of an automated proteomics analysis carried out in an integrated proteomics system.
摘要翻译： 本发明提供允许蛋白质样品在微流体装置内进行的连续流动过程中进行还原，烷基化和消化的方法和装置。 根据本发明的方法和装置可以用作在综合蛋白质组学系统中进行的自动蛋白质组学分析的一部分。
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5.发明申请Method and apparatus for use in temperature controlled processing of microfluidic samples 审中-公开用于微流体样品的温度控制处理的方法和装置公开(公告)号：US20060246493A1
公开(公告)日：2006-11-02
申请号：US11398489
申请日：2006-04-04
申请人： Morten Jensen , Andrea Chow , Colin Kennedy , Stephane Mouradian
发明人： Morten Jensen , Andrea Chow , Colin Kennedy , Stephane Mouradian
CPC分类号： B01L7/525 , B01L3/5025 , B01L3/5027 , B01L3/502715 , B01L3/502746 , B01L3/50851 , B01L7/5255 , B01L2300/0609 , B01L2300/0816 , B01L2300/0829 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0877 , B01L2300/1822 , B01L2300/1827 , B01L2400/0418 , B01L2400/0487
摘要： Embodiments of the invention comprise microfluidic devices, instrumentation interfacing with those devices, processes for fabricating that device, and methods of employing that device to perform PCR amplification. Embodiments of the invention are also compatible with quantitative Polymerase Chain Reaction (“qPCR”) processes. Microfluidic devices in accordance with the invention may contain a plurality of parallel processing channels. Fully independent reactions can take place in each of the plurality of parallel processing channels. The availability of independent processing channels allows a microfluidic device in accordance with the invention to be used in a number of ways. For example, separate samples could be processed in each of the independent processing channels. Alternatively, different loci on a single sample could be processed in multiple processing channels.
摘要翻译： 本发明的实施方案包括微流体装置，与这些装置接口的装置，用于制造该装置的方法以及使用该装置进行PCR扩增的方法。 本发明的实施方案也与定量聚合酶链式反应（“qPCR”）方法相容。 根据本发明的微流体装置可以包含多个并行处理通道。 在多个并行处理通道的每一个中可以发生完全独立的反应。 独立处理通道的可用性允许按照本发明的微流体装置以多种方式使用。 例如，可以在每个独立处理通道中处理单独的样本。 或者，可以在多个处理通道中处理单个样品上的不同基因座。
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公开(公告)号：US20060246533A1
公开(公告)日：2006-11-02
申请号：US11397307
申请日：2006-04-03
IPC分类号： C12Q1/37 , G01N33/543
CPC分类号： G01N33/6842
摘要： The invention provides methods and apparatuses that allow a protein sample to undergo reduction, alkylation, and digestion in a continuous flow process carried out within a microfluidic device. Methods and apparatuses in accordance with the invention can be employed as part of an automated proteomics analysis carried out in an integrated proteomics system.
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