摘要:
Embodiments of the invention comprise microfluidic devices, instrumentation interfacing with those devices, processes for fabricating that device, and methods of employing that device to perform PCR amplification. Embodiments of the invention are also compatible with quantitative Polymerase Chain Reaction (“qPCR”) processes. Microfluidic devices in accordance with the invention may contain a plurality of parallel processing channels. Fully independent reactions can take place in each of the plurality of parallel processing channels. The availability of independent processing channels allows a microfluidic device in accordance with the invention to be used in a number of ways. For example, separate samples could be processed in each of the independent processing channels. Alternatively, different loci on a single sample could be processed in multiple processing channels.
摘要:
Analytical systems and methods that use a modular interface structure for providing an interface between a sample substrate and an analytical unit, where the analytical unit typically has a particular interface arrangement for implementing various analytical and control functions. Using a number of variants for each module of the modular interface structure advantageously provides cost effective and efficient ways to perform numerous tests using a particular substrate or class of substrates with a particular analytical and control systems interface arrangement. Improved optical illumination and detection system for simultaneously analyzing reactions or conditions in multiple parallel microchannels are also provided. Increased throughput and improved emissions detection is provided by the present invention by simultaneously illuminating multiple parallel microchannels at a non-normal incidence using an excitation beam including multiple excitation frequencies, and simultaneously detecting emissions from the substances in the microchannels in a direction normal to the substrate using a detection module with multiple detectors.
摘要:
The present invention is an automated microfluidic chip processing apparatus that includes a deck for holding at least one microfluidic chip and capable of being accessed by a liquid handling system, a fluid control system, and a detection system, wherein a chip handling device transports the chip from the deck to the fluid control system and the detection system. The present invention also includes a chip for use with an automated microfluidic chip processing apparatus, and a method for processing a microfluidic chip using such an apparatus.
摘要:
The present invention is generally directed to improved methods, structures and systems for interfacing microfluidic devices with ancillary systems that are used in conjunction with such devices. These systems typically include control and monitoring systems (620) for controlling the performance of the processes carried out within the device, e.g., monitoring and controlling environmental conditions and monitoring results of the processes performed, e.g., detection.
摘要:
A priming unit for a microfluidics device contains a pressurization unit and pressure and temperature detectors as part of a feedback loop that controls the pressure applied by the pressurization unit and the time during which the pressure is applied. This control feature is particularly useful in controlling the exposure time of the microchannels to dyes in the priming liquids since certain dyes tend to adhere to the walls of the channels and produce non-uniform results.
摘要:
The invention provides a system and method for dissolution testing. The system includes multiple dissolution vessels and a dose carrier positioned above the dissolution vessels. The dose carrier holds multiple removable carousels that receive individual doses for dissolution tested. Carousels that receive tablets or sinkers typically have a first configuration, while carousels that receive baskets typically have a second configuration. The two different configurations of carousels are interchangeable on the same dose ring. The system further includes a drive head positioned above the dose carrier, the drive head having a basket arbor and a mixing paddle removably and interchangeably attached. A pipettor integral with the system transfers sample aliquots having volumes in the range of 50 μl to 1 ml from the dissolution vessels to wells of an external receptacle.
摘要:
A priming unit for a microfluidics device contains a pressurization unit and pressure and temperature detectors as part of a feedback loop that controls the pressure applied by the pressurization unit and the time during which the pressure is applied. This control feature is particularly useful in controlling the exposure time of the microchannels to dyes in the priming liquids since certain dyes tend to adhere to the walls of the channels and produce non-uniform results.
摘要:
The invention provides a sanitization tracking and alerting system and method that automatically monitors hand sanitization actions of workers within a facility and reminds them of violations of hand sanitization requirements. The sanitization system may comprise a communications network providing interaction between a central computer with a database and one or more sanitizer dispenser systems, which dispense a sanitizer to the workers upon demand. The sanitizer dispensing system may have a reader for reading an identification device associated with the worker and a motion detector that detects when the worker is in the proximity of the dispensing mechanism. The sanitizer dispenser system may contain logic for determining which one of a number of workers in its vicinity may press a dispensing means, sending that information to the central computer, and activating an audio or visual indicator if the central computer determines that the worker is not sanitized, as determined by the length of time since the last hand sanitization event of the worker or whether or not the worker had done something that would require another hand sanitization action.
摘要:
A container is provided for shipping and storing a pre-wetted and preconditioned microfluidic “sipper” chip. The container contains both dry compartments and wet compartments. A base contains a fluid-filled reservoir configured to house the capillaries. The opening of the reservoir is sealed with an O-ring. The plastic mount of the chip rests on the base in a dry compartment. The upper surface of the chip contains several wells containing fluid. A gasket is provided with plugs configured to be disposed within and seal the wells. Alternatively, the wells are first sealed with a foil film adhered to the well openings with an adhesive and a gasket is disposed between the foil and a cover, which is removably attached to the base. When the cover is closed, the gasket and O-ring seal the wet compartments to prevent leakage and to slow evaporation.
摘要:
A new ultra light weight, spring action, stand system for supporting a golf bag is provided. According to one aspect of the present invention, the stand system includes a top bracket, a pair of legs, a guide, a wire form, and a footplate. The top bracket is configured for coupling to a top portion of a golf bag. The pair of legs may be pivotably coupled to the top bracket. The guide is for coupling to a bottom portion of the golf bag to restrain lateral movement of the wire form, for example. The wire form is slidably coupled through the guide and engages the legs. The actuation of the wire form moves the legs from a retracted position to an extended position. Finally, the footplate is pivotably mounted to the wire form and is positioned to have a contact point with the ground for actuating the wire form that is behind the plane of the legs. According to other aspects of the present invention, the stand system includes one or more of the following: a bi-planar cut away base to facilitate engagement of the spring mechanism, a double clip and crimped wire form to hold the clip in place at a very high tension, oversized feet to provide increased stability and usability in soft soil conditions, a compact retracted leg arrangement that will not poke or prod the golfer as he/she carries the bag, and a novel femur design that prevents the unsightly occurrence of crossed legs.