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    Spatially scanned optical reader system and method for using same
    2.
    发明申请
    Spatially scanned optical reader system and method for using same 审中-公开

    公开(公告)号：US20060205058A1

    公开(公告)日：2006-09-14

    申请号：US11437477

    申请日：2006-05-18

    申请人： Anthony Frutos ,  Jacques Gollier ,  Jinlin Peng ,  Garrett Piech ,  Michael Webb

    发明人： Anthony Frutos ,  Jacques Gollier ,  Jinlin Peng ,  Garrett Piech ,  Michael Webb

    IPC分类号： C12M1/34

    CPC分类号： G01N21/253 ,  G01N21/554 ,  G01N21/7743

    摘要： An optical reader system is described herein that uses a scanned optical beam to interrogate a biosensor to determine if a biomolecular binding event occurred on a surface of the biosensor. In one embodiment, the optical reader system includes a light source, a detector and a processor (e.g., computer, DSP). The light source outputs an optical beam which is scanned across a moving biosensor and while this is happening the detector collects the optical beam which is reflected from the biosensor. The computer processes the collected optical beam and records the resulting raw spectral or angle data which is a function of a position (and possibly time) on the biosensor. The processor can then analyze the raw data to create a spatial map of resonant wavelength (peak position) or resonant angle which indicates whether or not a biomolecular binding event occurred on the biosensor. Several other uses of the raw data are also described herein.

    Spatially scanned optical reader system and method for using same
    3.
    发明申请
    Spatially scanned optical reader system and method for using same 失效

    公开(公告)号：US20060141611A1

    公开(公告)日：2006-06-29

    申请号：US11027547

    申请日：2004-12-29

    申请人： Anthony Frutos ,  Jacques Gollier ,  Jinlin Peng ,  Garrett Piech ,  Michael Webb

    发明人： Anthony Frutos ,  Jacques Gollier ,  Jinlin Peng ,  Garrett Piech ,  Michael Webb

    IPC分类号： C12M1/34

    CPC分类号： G01N21/253 ,  G01N21/554 ,  G01N21/7743

    摘要： An optical reader system is described herein that uses a scanned optical beam to interrogate a biosensor to determine if a biomolecular binding event occurred on a surface of the biosensor. In one embodiment, the optical reader system includes a light source, a detector and a processor (e.g., computer, DSP). The light source outputs an optical beam which is scanned across a moving biosensor and while this is happening the detector collects the optical beam which is reflected from the biosensor. The computer processes the collected optical beam and records the resulting raw spectral or angle data which is a function of a position (and possibly time) on the biosensor. The processor can then analyze the raw data to create a spatial map of resonant wavelength (peak position) or resonant angle which indicates whether or not a biomolecular binding event occurred on the biosensor. Several other uses of the raw data are also described herein.

    Optimized method for LID biosensor resonance detection
    6.
    发明申请
    Optimized method for LID biosensor resonance detection 失效
    LID生物传感器共振检测的优化方法

    公开(公告)号：US20070276608A1

    公开(公告)日：2007-11-29

    申请号：US11716425

    申请日：2007-03-09

    申请人： Jacques Gollier ,  Garrett Piech ,  Michael Webb ,  Qi Wu

    发明人： Jacques Gollier ,  Garrett Piech ,  Michael Webb ,  Qi Wu

    IPC分类号： G06F19/00

    CPC分类号： G01J3/28 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/1895 ,  G01J3/2803 ,  G01N21/7743

    摘要： An optical interrogation system is described herein that can interrogate a label-independent-detection (LID) biosensor and monitor a biological event on top of the biosensor without suffering from problematical parasitic reflections and/or problematical pixelation effects. In one embodiment, the optical interrogation system is capable of interrogating a biosensor and using a low pass filter algorithm to digitally remove problematic parasitic reflections contained in the spectrum of an optical resonance which makes it easier to determine whether or not a biological event occurred on the biosensor. In another embodiment, the optical interrogation system is capable of interrogating a biosensor and using an oversampling/smoothing algorithm to reduce oscillations in the estimated location of an optical resonance caused by the problematical pixelation effect which makes it easier to determine whether or not a biological event occurred on the biosensor.

    摘要翻译： 本文描述了一种光询问系统，其可以询问标签无关检测（LID）生物传感器并在生物传感器顶部监测生物事件，而不会遇到有问题的寄生反射和/或有问题的像素化效应。 在一个实施例中，光询问系统能够询问生物传感器并使用低通滤波器算法来数字地去除包含在光学共振的光谱中的有问题的寄生反射，这使得更容易确定生物事件是否发生在 生物传感器 在另一个实施例中，光询问系统能够询问生物传感器并使用过采样/平滑算法来减少由问题像素化效应引起的光学共振的估计位置中的振荡，这使得更容易确定生物事件 发生在生物传感器上。

    Optical interrogation system and method for increasing a read-out speed of a spectrometer
    7.
    发明申请
    Optical interrogation system and method for increasing a read-out speed of a spectrometer 失效
    光学询问系统和增加光谱仪读出速度的方法

    公开(公告)号：US20070031291A1

    公开(公告)日：2007-02-08

    申请号：US11500048

    申请日：2006-08-07

    申请人： Garrett Piech ,  Michael Webb

    发明人： Garrett Piech ,  Michael Webb

    IPC分类号： G01N21/00

    CPC分类号： G01N21/7743 ,  G01J3/2803

    摘要： A typical use of linear or two dimensional spectrometers is to expose the detector area, and then shift the photo-electric charges out of the device in a serial fashion. If the illuminating signal is spatially narrow relative to the size of the array, this will drive down the percent of the detector that is utilized, as only a relatively small number of pixels are used to detect the beam. The present invention proposes a method which capitalizes on this spatial under-utilization, and alters the clocking scheme to maximize the read-out speed of the pixels containing signal information. This type of clocking scheme raises the optical power saturation level of the spectrometer. Such an improvement in optical power handling is beneficial for spectrometer based detection of resonant waveguide grating biochemical binding, since in such systems the performance is frequently limited by spectrometer saturation.

    摘要翻译： 线性或二维光谱仪的典型用途是暴露检测器区域，然后将光电荷以串联方式移出设备。 如果照明信号相对于阵列的尺寸在空间上窄，则这将驱动所使用的检测器的百分比，因为仅使用相对较少数量的像素来检测光束。 本发明提出了一种利用该空间利用不足的方法，并且改变了时钟方案以使包含信号信息的像素的读出速度最大化。 这种类型的时钟方案提高了光谱仪的光功率饱和水平。 光功率处理的这种改进对于谐振波导光栅生化结合的基于光谱仪的检测是有利的，因为在这样的系统中，性能常常受到光谱仪饱和度的限制。

    Conveyors
    8.
    发明授权
    Conveyors 有权
    输送机

    公开(公告)号：US08813946B2

    公开(公告)日：2014-08-26

    申请号：US13696132

    申请日：2011-05-05

    申请人： Michael Webb

    发明人： Michael Webb

    IPC分类号： B65G47/53

    CPC分类号： B65G47/53 ,  B65B19/00 ,  B65B35/56 ,  B65G17/12 ,  B65G47/08 ,  B65G47/082 ,  B65G2201/0205

    摘要： Elongate packs of circular biscuits are fed at high speed from a wrapping output conveyor to a transverse indexing conveyor. The indexing conveyor has a series of compartments with inclined sides, each compartment receiving a pair of packs end to end. The conveyor indexes each time that it receives a pair of packs, the compartments holding the packs against movement longitudinally of the conveyor. The packs are removed in groups from the indexing conveyor and urged together on a tray of adjustable dimension. Orientation of the packs is maintained, for consistent presentation of printing ABCD.

    摘要翻译： 圆形饼干的长条包装从包装输出输送机高速进料到横向分度输送机。 分度输送机具有一系列具有倾斜侧面的隔间，每个隔间端接到一对包装。 输送机每次接收到一对包装箱时都会指出，这些隔间保持包装不受传送带纵向移动。 这些包装从分度输送机中分组取出，并一起推到可调节尺寸的托盘上。 维护包装的方向，以便一致地显示印刷ABCD。

    Conveyors
    10.
    发明授权
    Conveyors 有权
    输送机

    公开(公告)号：US07654381B2

    公开(公告)日：2010-02-02

    申请号：US12280385

    申请日：2007-02-22

    申请人： Michael Webb

    发明人： Michael Webb

    IPC分类号： B65G47/26 ,  B65G47/34

    CPC分类号： B65G15/58 ,  B65G17/46 ,  B65G47/082 ,  B65G2201/0205 ,  B65G2201/0217

    摘要： An indexing conveyor 1 travels at (90) degrees to a wrapping output conveyor (2), which conveys elongate packs (3) of circular biscuits at high speed with their diameter-ends leading. The indexing conveyor 1 receives the packs (3) and conveys them in an orthogonal direction, with their long-dimensions leading. The indexing conveyor (1) has a regular series of V-section lugs (11), which receive and center the packs (3) and can accommodate a range of diameters of circular packs (3) while maintaining a constant pitch. A pair of lifting bars (12) lifts a group (31) of packs (3) at a time during the dwell period of the index of the (10) conveyor (1). The packs (3) of each group (31) are moved together during the lift so that they are touching, to ensure that a robotic pick-and-place system can pick up the group (31) reliably.

    摘要翻译： 分度输送机1以（90）度行进到包装输出输送机（2），该包装输送输送机（2）以直径端领先的方式高速地传送圆形饼干的细长包装（3）。 分度输送机1接收包装（3）并以正方向传送它们的长尺寸。 分度输送机（1）具有规则的一系列V形截面凸耳（11），它们容纳和定心包装（3）并且可以容纳一定范围的圆形包装（3）的直径，同时保持恒定的间距。 在（10）输送机（1）的索引的停留期间，一对升降杆（12）一次提升组（3）的组（31）。 每个组（31）的组件（3）在提升期间一起移动以使其接触，以确保机器人拾放系统可靠地拾取组（31）。