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    Substrate index modification for increasing the sensitivity of grating-coupled waveguides
    1.
    发明申请
    Substrate index modification for increasing the sensitivity of grating-coupled waveguides 失效
    用于增加光栅耦合波导的灵敏度的基板索引修改

    公开(公告)号：US20050025421A1

    公开(公告)日：2005-02-03

    申请号：US10632276

    申请日：2003-08-01

    申请人： Stephen Caracci ,  Mircea Despa ,  Eric Mozdy ,  Mark Salik

    发明人： Stephen Caracci ,  Mircea Despa ,  Eric Mozdy ,  Mark Salik

    IPC分类号： G01N21/77 ,  G02B6/34

    CPC分类号： G01N21/7743

    摘要： A grating-coupled waveguide (GCW) and a method are described herein that can be used to detect the presence of a biological substance (e.g., cell, drug, chemical compound) in a sensing region of the GCW. The GCW includes a substrate, a diffraction grating and a waveguide film that has a higher index of refraction than the substrate which has an index of refraction ≦1.5. The relatively low-index substrate effectively increases the sensitivity of the GCW by causing the waveguide mode to shift towards a biological substance located in a sensing region above the waveguide film, thereby increasing the field strength of the mode's evanescent tail in this region. In one embodiment, an array of the GCWs are incorporated within the wells of a microplate.

    摘要翻译： 本文描述了可用于检测GCW感测区域中生物物质（例如细胞，药物，化合物）的存在的光栅耦合波导（GCW）和方法。 GCW包括具有比折射率<= 1.5的衬底更高的折射率的衬底，衍射光栅和波导膜。 相对低折射率的衬底通过使波导模式朝向位于波导膜上方的感测区域中的生物物质移动，从而有效地增加了GCW的灵敏度，从而增加了该区域中模式的渐逝尾部的场强。 在一个实施方案中，将GCW的阵列并入微板的孔内。

    Arrayed sensor measurement system and method
    2.
    发明申请
    Arrayed sensor measurement system and method 失效
    阵列传感器测量系统及方法

    公开(公告)号：US20050099622A1

    公开(公告)日：2005-05-12

    申请号：US11019439

    申请日：2004-12-21

    申请人： Stephen Caracci ,  Norman Fontaine ,  Eric Mozdy ,  Po Yuen

    发明人： Stephen Caracci ,  Norman Fontaine ,  Eric Mozdy ,  Po Yuen

    IPC分类号： G01N21/25 ,  G02B27/10 ,  G01J3/50

    CPC分类号： G01N21/253 ,  G01N2201/04 ,  G01N2201/10 ,  G02B27/1086

    摘要： Optical interrogation systems and methods are described herein that are capable of measuring the angles (or changes in the angles) at which light reflects, transmits, scatters, or is emitted from an array of sensors or specimens that are distributed over a large area 2-dimensional array. In one embodiment of the present invention, the optical interrogation system has a far-field diffraction measurement configuration so it can simultaneously receive the light from sensors in all or a sub-section of a sensor array at a detector. In another embodiment of the present invention, the optical interrogation system incorporates an anamorphic optical receive system that enables parallel detection of angular responses from the sensors in the 2D array. In yet another embodiment of the present invention, the optical interrogation system incorporates an angular measurement system which measures the change in angular tilt of the sensor plane when the sensor array is moved or removed and then replaced in the measurement system. Several other embodiments of optical interrogation systems and methods are also described herein. A significant advantage of the present invention is that the system has no critical moving or scanning parts, which are frequently the source of measurement sensitivity limitations.

    摘要翻译： 本文描述了光学询问系统和方法，其能够测量光从其分布在大面积上的传感器或样本阵列2反射，透射，散射或发射的角度（或角度变化） 维数组。 在本发明的一个实施例中，光学询问系统具有远场衍射测量配置，因此它可以在检测器处同时从传感器阵列的全部或子部分接收来自传感器的光。 在本发明的另一实施例中，光学询问系统包括变形光学接收系统，其能够并行地检测来自2D阵列中的传感器的角度响应。 在本发明的另一个实施例中，光学询问系统包括角度测量系统，该系统测量当传感器阵列移动或移除并随后在测量系统中被更换时传感器平面的角度倾斜度的变化。 本文还描述了光询问系统和方法的其他几个实施例。 本发明的显着优点是该系统没有关键的移动或扫描部件，其经常是测量灵敏度限制的来源。

    Label-free high throughput biomolecular screening system and method
    3.
    发明申请
    Label-free high throughput biomolecular screening system and method 审中-公开
    无标记的高通量生物分子筛选系统和方法

    公开(公告)号：US20070020689A1

    公开(公告)日：2007-01-25

    申请号：US11489173

    申请日：2006-07-19

    申请人： Stephen Caracci ,  Volker Eckelt ,  Anthony Frutos ,  Mark Krol ,  Thomas Moore ,  David Pastel ,  Gordon Shedd

    发明人： Stephen Caracci ,  Volker Eckelt ,  Anthony Frutos ,  Mark Krol ,  Thomas Moore ,  David Pastel ,  Gordon Shedd

    IPC分类号： C40B30/06 ,  G01N33/53 ,  G06F19/00 ,  C12M1/34

    CPC分类号： G01N35/028 ,  G01N2035/00158 ,  G01N2035/00356 ,  G01N2035/0097

    摘要： A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a chemical compound (drug candidate) with a biomolecule (therapeutic target) can be detected using assay volumes and concentrations that are compatible with the current practices of HTS in the pharmaceutical industry. The screening system also enables the detection of bio-chemical interactions that occurr in the wells of a microplate which incorporates biosensors and surface chemistry to immobilize the therapeutic target at the surface of the biosensors. The screening system also includes fluid handling and plate handling devices to help perform automated HTS assays.

    摘要翻译： 本文描述了一种筛选系统和方法，其提供用于实现无标记高通量筛选（HTS）以帮助发现新药物的独特且实用的解决方案。 在一个实施方案中，筛选系统使得能够进行直接结合测定，其中化学化合物（药物候选物）与生物分子（治疗靶标）的生物分子相互作用可以使用与当前实践相兼容的测定体积和浓度来检测 HTS在制药行业。 筛选系统还能够检测在微板的孔中发生的生物化学相互作用，其结合生物传感器和表面化学以将治疗靶固定在生物传感器的表面。 筛选系统还包括流体处理和板处理装置，以帮助执行自动HTS测定。