公开(公告)号：US20080307751A1

公开(公告)日：2008-12-18

申请号：US11664620

申请日：2005-09-30

申请人： Stephen D. Newman ,  Trevor O. Glasbey

发明人： Stephen D. Newman ,  Trevor O. Glasbey

IPC分类号： B65B55/02 ,  C11D1/00 ,  A45C11/04

CPC分类号： C11D3/0078 ,  A61L12/04 ,  C11D17/003

摘要： An aqueous contact lens storage solution comprises a viscoelastic rheology modifier; and not more than 0.3% w/v of an alkali metal salt; the solution has a pH of between 6.0 and 8.0 and an osmolality of between 100 and 400 mOsm/kg, and the solution has viscoelastic properties, even if heat sterilized at 121° C. for at least 15 minutes. The viscoelastic rheology modifier may be selected from the following acids or their alkali metal salts: hyaluronic acid, poly (acrylic acid), crosslinked poly (acrylic acid), poly (methacrylic acid), carboxymethyl cellulose, alginic acid and mixtures thereof. The alkali metal salt may be present in an amount of from 0.01% to 0.3% w/v, and be selected from sodium chloride, sodium bicarbonate, sodium dihydrogen phosphate, disodium hydrogen phosphate, trisodium phosphate, sodium tetraborate, sodium citrate, sodium acetate, sodium lactate, potassium chloride, potassium bicarbonate, potassium dihydrogen phosphate, dipotassium hydrogen phosphate, tripotassium phosphate, potassium tetraborate, potassium citrate, potassium acetate, potassium lactate and mixtures thereof. The solution may be an inhomogeneous combination of a gel component and an additional liquid component. If so, the solution has a pH of between 6.0 and 8.0 and an osmolality of between 100 and 400 mOsm/kg when in a homogeneous form.

摘要翻译： 水溶性隐形眼镜储存溶液包含粘弹性流变改性剂; 和不超过0.3％w / v的碱金属盐; 该溶液具有6.0至8.0的渗透压和100至400mOsm / kg的渗透压，并且该溶液具有粘弹性，即使在121℃热灭菌至少15分钟。 粘弹性流变改性剂可以选自以下酸或其碱金属盐：透明质酸，聚（丙烯酸），交联聚（丙烯酸），聚（甲基丙烯酸），羧甲基纤维素，海藻酸及其混合物。 碱金属盐的存在量可以为0.01〜0.3％w / v，选自氯化钠，碳酸氢钠，磷酸二氢钠，磷酸氢二钠，磷酸三钠，四硼酸钠，柠檬酸钠，乙酸钠 ，乳酸钠，氯化钾，碳酸氢钾，磷酸二氢钾，磷酸氢二钾，磷酸三钾，四硼酸钾，柠檬酸钾，乙酸钾，乳酸钾及其混合物。 溶液可以是凝胶组分和另外的液体组分的不均匀组合。 如果是这样，当均匀形式时，溶液的pH值在6.0和8.0之间，重量摩尔渗透压浓度在100和400mOsm / kg之间。

公开(公告)号：US5453467A

公开(公告)日：1995-09-26

申请号：US199285

申请日：1994-04-28

申请人： Clement H. Bamford ,  Kadem G. Al-Lamee ,  Yiannakis Yianni ,  Martin C. Wiles ,  Trevor O. Glasbey

发明人： Clement H. Bamford ,  Kadem G. Al-Lamee ,  Yiannakis Yianni ,  Martin C. Wiles ,  Trevor O. Glasbey

IPC分类号： A61L27/00 ,  A61L33/00 ,  B01D67/00 ,  C07F9/09 ,  C07F9/10 ,  C08F8/40 ,  C08F283/00 ,  C08F291/00 ,  C08G18/28 ,  C08G18/83 ,  C08J7/12 ,  C08J7/16 ,  C08L75/16 ,  G02B1/04 ,  C08F4/52 ,  C08F255/02 ,  C08F259/08 ,  C08F283/04

CPC分类号： B01D67/0093 ,  A61L33/0088 ,  C08F283/00 ,  C08F291/00 ,  C08F8/40 ,  C08G18/288 ,  C08G18/836 ,  C08J7/16 ,  C08L75/16 ,  G02B1/043 ,  B01D2323/38 ,  C08J2381/06

摘要： A graft polymer obtainable by grafting a polymer substrate with a compound of formula (I), in which the groups R are the same or different and each is a straight or branched C.sub.1 -C.sub.4 alkyl group; X is an aryl group or a straight or branched C.sub.1 -C.sub.20 alkylene group, optionally containing one or more carbon-carbon double or triple bonds, ether linkages or aryl groups; the aryl groups being unsubstituted or substituted by one or more C.sub.1-4 alkyl groups; n is from 2 to 4; and A is a reactive group, is useful as a biocompatible material in contact lenses, biomedical devices and blood-containing devices. In a preferred embodiment A is a polymerizable group and the graft polymer is produced by radical initiated polymerization of the compound of formula (I) on the substrate which is initiated by a radical-forming group on the substrate.

摘要翻译： 通过用式（I）化合物接枝聚合物底物而获得的接枝聚合物，其中基团R相同或不同，并且各自为直链或支链C 1 -C 4烷基; X是任选含有一个或多个碳 - 碳双键或三键的芳基或直链或支链C 1 -C 20亚烷基，醚键或芳基; 芳基是未取代的或被一个或多个C 1-4烷基取代; n为2〜4; 并且A是反应性基团，可用作隐形眼镜，生物医学装置和含血装置中的生物相容性材料。 在优选的实施方案中，A是可聚合基团，并且接枝聚合物通过由底物上的自由基形成基团引发的基底上的式（I）化合物的自由基引发聚合制备。