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1.发明授权Percutaneous delivery system for treatment of osteonecrosis of the hip and methods of use thereof 有权用于治疗髋关节骨坏死的经皮递送系统及其使用方法公开(公告)号：US08092452B2
公开(公告)日：2012-01-10
申请号：US11751321
申请日：2007-05-21
IPC分类号： A61B17/56
CPC分类号： A61M31/002
摘要： Systems, methods, and carriers for percutaneous delivery of growth factors to treat osteonecrosis in the hip and other locations are disclosed. A rolled carrier comprising a biphasic ceramic rolled by a collagen sponge, and carrying a growth factor, are inserted via a delivery tube or cannula into a pre-formed hole in bone without overstuffing of the carrier or growth factor.
摘要翻译： 公开了用于经皮递送生长因子以治疗髋部和其他位置的骨坏死的系统，方法和载体。 包括由胶原海绵滚动并携带生长因子的双相陶瓷的滚动载体通过输送管或插管插入到骨中的预先形成的孔中，而不会过载载体或生长因子。
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2.发明申请PERCUTANEOUS DELIVERY SYSTEM FOR TREATMENT OF OSTEONECROSIS OF THE HIP AND METHODS OF USE THEREOF 有权用于治疗呕吐的骨质疏松症的PERCUTANEOUS递送系统及其使用方法公开(公告)号：US20080294085A1
公开(公告)日：2008-11-27
申请号：US11751321
申请日：2007-05-21
IPC分类号： A61M31/00
CPC分类号： A61M31/002
摘要： Systems, methods, and carriers for percutaneous delivery of growth factors to treat osteonecrosis in the hip and other locations are disclosed. A rolled carrier comprising a biphasic ceramic rolled by a collagen sponge, and carrying a growth factor, are inserted via a delivery tube or cannula into a pre-formed hole in bone without overstuffing of the carrier or growth factor.
摘要翻译： 公开了用于经皮递送生长因子以治疗髋部和其他位置的骨坏死的系统，方法和载体。 包括由胶原海绵滚动并携带生长因子的双相陶瓷的滚动载体通过输送管或插管插入到骨中的预先形成的孔中，而不会过载载体或生长因子。
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公开(公告)号：US08758793B2
公开(公告)日：2014-06-24
申请号：US11431475
申请日：2006-05-10
IPC分类号： A61F2/00
CPC分类号： A61B17/15 , A61B17/06166 , A61B17/68 , A61B17/72 , A61B50/30 , A61B2017/00464 , A61B2017/564 , A61B2050/005 , A61B2050/006 , A61B2090/061 , A61F2/0095 , A61F2/28 , A61F2002/2817 , A61F2002/2825 , A61F2002/30062 , A61F2002/30115 , A61F2002/30116 , A61F2002/30131 , A61F2002/30138 , A61F2002/30159 , A61F2002/30235 , A61F2002/30237 , A61F2002/30238 , A61F2002/30551 , A61F2002/30593 , A61F2002/30616 , A61F2002/30617 , A61F2002/30677 , A61F2002/30714 , A61F2002/30822 , A61F2002/30827 , A61F2002/30828 , A61F2002/30831 , A61F2002/3096 , A61F2002/4658 , A61F2210/0004 , A61F2230/0006 , A61F2230/0013 , A61F2230/0017 , A61F2230/0028 , A61F2230/0069 , A61F2250/0089 , A61F2250/0097 , A61F2310/00179 , A61F2310/00365 , A61L27/54 , A61L2300/222 , A61L2300/252 , A61L2300/402 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/432 , A61L2300/802
摘要： A therapeutic agent carrier for treating a defect in a bone is disclosed and can include a body that can be configured to approximate a portion of the bone. Further, the therapeutic agent carrier can include a plurality of grooves formed along the body. Each groove can correspond to an incremental length of the body. The therapeutic agent carrier can also include a plurality of dosage stamps along the body and each of the plurality of dosage stamps is adjacent to a corresponding to groove.
摘要翻译： 公开了一种用于治疗骨缺损的治疗剂载体，并且可以包括可构造为近似骨的一部分的主体。 此外，治疗剂载体可以包括沿着身体形成的多个凹槽。 每个凹槽可以对应于身体的增量长度。 治疗剂载体还可以包括沿着身体的多个剂量标记，并且多个剂量标记中的每一个与对应的凹槽相邻。
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公开(公告)号：US08469964B2
公开(公告)日：2013-06-25
申请号：US11431693
申请日：2006-05-10
CPC分类号： A61B17/15 , A61B17/06166 , A61B17/68 , A61B17/72 , A61B50/30 , A61B2017/00464 , A61B2017/564 , A61B2050/005 , A61B2050/006 , A61B2090/061 , A61F2/0095 , A61F2/28 , A61F2002/2817 , A61F2002/2825 , A61F2002/30062 , A61F2002/30115 , A61F2002/30116 , A61F2002/30131 , A61F2002/30138 , A61F2002/30159 , A61F2002/30235 , A61F2002/30237 , A61F2002/30238 , A61F2002/30551 , A61F2002/30593 , A61F2002/30616 , A61F2002/30617 , A61F2002/30677 , A61F2002/30714 , A61F2002/30822 , A61F2002/30827 , A61F2002/30828 , A61F2002/30831 , A61F2002/3096 , A61F2002/4658 , A61F2210/0004 , A61F2230/0006 , A61F2230/0013 , A61F2230/0017 , A61F2230/0028 , A61F2230/0069 , A61F2250/0089 , A61F2250/0097 , A61F2310/00179 , A61F2310/00365 , A61L27/54 , A61L2300/222 , A61L2300/252 , A61L2300/402 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/432 , A61L2300/802
摘要： A bone cutting template is disclosed and can include a body. A plurality of grooves can be formed along the body and each groove can correspond to an incremental length of the body. The bone cutting template can include a plurality of length stamps along the body. Each of the plurality of length stamps can be adjacent to a corresponding groove.
摘要翻译： 骨切割模板被公开并且可以包括身体。 可以沿着主体形成多个槽，并且每个槽可对应于主体的增量长度。 骨切割模板可以包括沿着身体的多个长度邮票。 多个长度标记中的每一个可以与相应的凹槽相邻。
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公开(公告)号：US08617585B2
公开(公告)日：2013-12-31
申请号：US11388250
申请日：2006-03-23
IPC分类号： A61F2/00
CPC分类号： A61M25/1011 , A61B17/7061 , A61B17/7098 , A61B17/72 , A61B17/7258 , A61B17/8808 , A61M25/007 , A61M25/0108 , A61M2025/1052
摘要： An intramedullary drug delivery device is disclosed and can be inserted within a bone canal of a bone. The intramedullary drug delivery device can include a housing. A drug delivery region can be established along the housing. Also, the drug delivery region can be configured to substantially span a fracture within the bone.
摘要翻译： 公开了一种髓内药物输送装置，并且可以将其插入到骨的骨管内。 髓内药物递送装置可以包括壳体。 可以沿着房屋建立药物递送区域。 而且，药物递送区域可以构造成基本上跨越骨骼内的骨折。
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公开(公告)号：US09357215B2
公开(公告)日：2016-05-31
申请号：US13764831
申请日：2013-02-12
申请人： Michael Boden , Scott D. Boden
发明人： Michael Boden , Scott D. Boden
CPC分类号： H04N19/90 , H04N21/4307 , H04N21/631 , H04N21/6581 , H04N21/8106
摘要： In some embodiments, a request for an audio stream associated with a video output may be received. Upon receiving the request, the requested audio stream may be encoded for transmission over a network and sent to a user device associated with the request.
摘要翻译： 在一些实施例中，可以接收与视频输出相关联的音频流的请求。 在接收到请求时，所请求的音频流可以被编码用于通过网络传输并发送到与该请求相关联的用户设备。
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7.发明申请NOGGIN INHIBITORY COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO 有权用于操作的NOGGIN抑制组合物及其相关方法公开(公告)号：US20130337082A1
公开(公告)日：2013-12-19
申请号：US13980598
申请日：2012-02-23
CPC分类号： A61L27/00 , A61L27/12 , A61L27/227 , A61L27/54 , A61L2300/414 , A61L2300/432 , A61L2430/02
摘要： This disclosure relates to compounds and compositions for forming bone and methods related thereto. In certain embodiments, the disclosure relates to methods of forming bone comprising implanting a bone graft composition comprising a growth factor such as BMP in a subject at a site of desired bone growth or enhancement in combination with a Noggin blocker.
摘要翻译： 本公开涉及用于形成骨的化合物和组合物及其相关方法。 在某些实施方案中，本公开内容涉及形成骨的方法，包括在Noggin阻断剂组合的期望骨生长或增强的部位，在受试者中植入包含生长因子如BMP的骨移植组合物。
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公开(公告)号：US08293232B2
公开(公告)日：2012-10-23
申请号：US13353632
申请日：2012-01-19
CPC分类号： A61K9/0024 , A61K9/0085 , A61K38/177 , A61K38/1774 , A61K38/18 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/1866 , A61K38/1875 , A61K38/19 , A61K38/30 , A61K47/42 , A61L27/24 , A61L27/54 , A61L27/56 , A61L2300/414
摘要： A carrier matrix may be delivered to a target position within a patient in a minimally invasive manner by first cutting a collagen sponge sheet into a plurality of relatively small pieces. These pieces are sized so that, when wet, they are capable of flowing through a cannula and/or reduced-diameter syringe tip. The pieces are placed into a syringe and wetted, say with a morphogenic solution, and optionally mixed with a bulking material, which is similarly sized to fit through the cannula. The thoroughly mixed and wetted product forms a viscous aggregate which may then be injected into the patient at the target site.
摘要翻译： 通过首先将胶原海绵片切割成多个相对小的片，可以以微创方式将载体基质递送到患者体内的目标位置。 这些件的尺寸使得在潮湿时它们能够流过套管和/或减小直径的针头。 将片放置在注射器中并用形态发生溶液润湿，并且可选地与填充材料混合，膨胀材料的尺寸类似于穿过套管。 充分混合和润湿的产品形成粘性聚集体，然后可以在目标部位将其注入患者体内。
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公开(公告)号：US08268008B2
公开(公告)日：2012-09-18
申请号：US11489262
申请日：2006-07-19
申请人： Randal R. Betz , Scott D. Boden , Christine Clark , Nanette Forsyth , John W. Morris , Kathy Traianedes
发明人： Randal R. Betz , Scott D. Boden , Christine Clark , Nanette Forsyth , John W. Morris , Kathy Traianedes
IPC分类号： A61F2/28
CPC分类号： A61F2/28 , A61F2/4455 , A61F2/4644 , A61F2002/2817 , A61F2002/2835 , A61F2002/30059 , A61F2002/30075 , A61F2002/30153 , A61F2002/30329 , A61F2002/30593 , A61F2002/30677 , A61F2002/30805 , A61F2002/30957 , A61F2002/30975 , A61F2002/4649 , A61F2210/0061 , A61F2220/0025 , A61F2230/0019 , A61F2310/00293 , A61F2310/00329 , A61F2310/00365 , A61L27/3608 , A61L27/365 , A61L27/3658 , A61L27/38 , A61L31/005 , A61L2430/02
摘要： An osteoimplant is made up of a coherent aggregate of elongate bone particles.
摘要翻译： 骨植入物由细长骨颗粒的相干骨料组成。
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公开(公告)号：US20110092953A1
公开(公告)日：2011-04-21
申请号：US12977310
申请日：2010-12-23
申请人： Neil Beals , Jeffrey L. Scifert , Scott D. Boden
发明人： Neil Beals , Jeffrey L. Scifert , Scott D. Boden
CPC分类号： A61K9/0024 , A61K9/0085 , A61K38/177 , A61K38/1774 , A61K38/18 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/1866 , A61K38/1875 , A61K38/19 , A61K38/30 , A61K47/42 , A61L27/24 , A61L27/54 , A61L27/56 , A61L2300/414
摘要： A carrier matrix may be delivered to a target position within a patient in a minimally invasive manner by first cutting a collagen sponge sheet into a plurality of relatively small pieces. These pieces are sized so that, when wet, they are capable of flowing through a cannula and/or reduced-diameter syringe tip. The pieces are placed into a syringe and wetted, say with a morphogenic solution, and optionally mixed with a bulking material, which is similarly sized to fit through the cannula. The thoroughly mixed and wetted product forms a viscous aggregate which may then be injected into the patient at the target site.
摘要翻译： 通过首先将胶原海绵片切割成多个相对小的片，可以以微创方式将载体基质递送到患者体内的目标位置。 这些件的尺寸使得在潮湿时它们能够流过套管和/或减小直径的针头。 将片放置在注射器中并用形态发生溶液润湿，并且可选地与填充材料混合，膨胀材料的尺寸类似于穿过套管。 充分混合和润湿的产品形成粘性聚集体，然后可以在目标部位将其注入患者体内。
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