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    Bifunctional synthetic molecules
    1.
    发明授权
    Bifunctional synthetic molecules 有权
    双功能合成分子

    公开(公告)号：US08354116B2

    公开(公告)日：2013-01-15

    申请号：US11820172

    申请日：2007-06-18

    申请人： Stephen G. Carter ,  Kanu Patel ,  Zhen Zhu ,  Lixin Qiao

    发明人： Stephen G. Carter ,  Kanu Patel ,  Zhen Zhu ,  Lixin Qiao

    IPC分类号： A61K9/00 ,  A61K8/02

    CPC分类号： C07D213/80 ,  C07C69/612 ,  C07C233/87 ,  C07C2601/14 ,  C07D207/16 ,  C07D217/26 ,  C07D233/06 ,  C07D233/24 ,  C07D233/50 ,  C07D417/04

    摘要： The synthesis and use of bifunctional molecules to improve the topical and transdermal delivery efficiency of various types of therapeutic agents or agents designed to promote the transdermal delivery of those therapeutic agents either into the skin tissue or into the systemic circulation. Three major classes of molecules are covalently joined as bifunctional substances; chemical vasodilators, passive dermal penetration enhancers and therapeutic or diagnostic drugs. Chemical vasodilators may be delivered into the skin to increasing the blood flow in a tissue that has compromised circulation or they may be used as part of a delivery vehicle to promote the delivery of the drug. Passive dermal penetration enhancers are those chemicals that promote the passive penetration of drugs and other chemicals through the stratum corneum and epidermis of the skin tissue. Drugs and diagnostic agents are the third group of chemicals that are candidates for the linkage of molecules.

    摘要翻译： 双功能分子的合成和使用以改善各种类型治疗剂或试剂的局部和透皮递送效率，所述治疗剂或试剂旨在促进将这些治疗剂透皮递送至皮肤组织或进入体循环。 三大类分子共价连接成双功能物质; 化学血管扩张剂，被动皮肤渗透增强剂和治疗或诊断药物。 化学血管扩张剂可以被递送到皮肤中以增加已经损害循环的组织中的血液流动，或者它们可以用作递送载体的一部分以促进药物的递送。 被动皮肤渗透增强剂是促进药物和其他化学物质通过角质层和皮肤组织表皮的被动穿透的化学物质。 药物和诊断剂是作为分子连接的候选物的第三组化学品。

    Bifunctional synthetic molecules
    2.
    发明申请
    Bifunctional synthetic molecules 有权
    双功能合成分子

    公开(公告)号：US20080312296A1

    公开(公告)日：2008-12-18

    申请号：US11820172

    申请日：2007-06-18

    申请人： Stephen G. Carter ,  Kanu Patel ,  Zhen Zhu ,  Lixin Qiao

    发明人： Stephen G. Carter ,  Kanu Patel ,  Zhen Zhu ,  Lixin Qiao

    IPC分类号： A61K31/045 ,  A61K31/19 ,  A61K31/20 ,  A61K31/415 ,  A61K31/44 ,  A61P43/00

    CPC分类号： C07D213/80 ,  C07C69/612 ,  C07C233/87 ,  C07C2601/14 ,  C07D207/16 ,  C07D217/26 ,  C07D233/06 ,  C07D233/24 ,  C07D233/50 ,  C07D417/04

    摘要： The synthesis and use of bifunctional molecules to improve the topical and transdermal delivery efficiency of various types of therapeutic agents or agents designed to promote the transdermal delivery of those therapeutic agents either into the skin tissue or into the systemic circulation. Three major classes of molecules are covalently joined as bifunctional substances; chemical vasodilators, passive dermal penetration enhancers and therapeutic or diagnostic drugs. Chemical vasodilators may be delivered into the skin to increasing the blood flow in a tissue that has compromised circulation or they may be used as part of a delivery vehicle to promote the delivery of the drug. Passive dermal penetration enhancers are those chemicals that promote the passive penetration of drugs and other chemicals through the stratum corneum and epidermis of the skin tissue. Drugs and diagnostic agents are the third group of chemicals that are candidates for the linkage of molecules.

    摘要翻译： 双功能分子的合成和使用以改善各种类型治疗剂或试剂的局部和透皮递送效率，所述治疗剂或试剂旨在促进将这些治疗剂透皮递送至皮肤组织或进入体循环。 三大类分子共价连接成双功能物质; 化学血管扩张剂，被动皮肤渗透增强剂和治疗或诊断药物。 化学血管扩张剂可以被递送到皮肤中以增加已经损害循环的组织中的血液流动，或者它们可以用作递送载体的一部分以促进药物的递送。 被动皮肤渗透增强剂是促进药物和其他化学物质通过角质层和皮肤组织表皮的被动穿透的化学物质。 药物和诊断剂是作为分子连接的候选物的第三组化学品。

    Ibuprofen for Topical Administration
    4.
    发明申请
    Ibuprofen for Topical Administration 有权
    布洛芬用于局部治疗

    公开(公告)号：US20120329875A1

    公开(公告)日：2012-12-27

    申请号：US13604040

    申请日：2012-09-05

    申请人： Stephen G. Carter ,  Zhen Zhu ,  Kanu Patel ,  Diane L. Kozwich

    发明人： Stephen G. Carter ,  Zhen Zhu ,  Kanu Patel ,  Diane L. Kozwich

    IPC分类号： A61K31/192 ,  A61P29/00

    CPC分类号： A61K31/192 ,  A61K9/0014 ,  A61K9/7023 ,  A61K47/16 ,  A61K47/22 ,  A61K47/32

    摘要： Set forth herein is a preparation of ibuprofen (2-(4-isobutylphenyl) propionic acid) in the free acid form that is suitable for topical administration. The topical ibuprofen formulation is prepared by dissolving the free acid form of ibuprofen, or preparing a homogeneous suspension of the free acid form of ibuprofen, in the presence of a pharmaceutically acceptable solvent so as to produce a topical drug formulation compatible with the penetration of 2-(4-isobutylphenyl) propionic acid through the skin tissue. Topical formulations of ibuprofen can be based on a pharmaceutically acceptable solvent such as, e.g., a pyrrolidone solvent or dimethylacetamide.

    摘要翻译： 本文所述是适用于局部给药的游离酸形式的布洛芬（2-（4-异丁基苯基）丙酸）的制剂。 通过在游离酸形式的布洛芬溶解游离酸形式的布洛芬或在药学上可接受的溶剂的存在下制备游离酸形式的均匀悬浮液来制备局部布洛芬制剂，以产生与渗透2相兼容的局部药物制剂 - （4-异丁基苯基）丙酸通过皮肤组织。 布洛芬的局部制剂可以基于药学上可接受的溶剂，例如吡咯烷酮溶剂或二甲基乙酰胺。

    Ibuprofen for topical administration
    5.
    发明授权
    Ibuprofen for topical administration 有权
    布洛芬用于局部给药

    公开(公告)号：US09561174B2

    公开(公告)日：2017-02-07

    申请号：US13604040

    申请日：2012-09-05

    申请人： Stephen G. Carter ,  Zhen Zhu ,  Kanu Patel ,  Diane Kozwich

    发明人： Stephen G. Carter ,  Zhen Zhu ,  Kanu Patel ,  Diane Kozwich

    IPC分类号： A61K31/192 ,  A61K47/32 ,  A61P29/00 ,  A61K9/00 ,  A61K9/70

    CPC分类号： A61K31/192 ,  A61K9/0014 ,  A61K9/7023 ,  A61K47/16 ,  A61K47/22 ,  A61K47/32

    摘要： Set forth herein is a preparation of ibuprofen (2-(4-isobutylphenyl) propionic acid) in the free acid form that is suitable for topical administration. The topical ibuprofen formulation is prepared by dissolving the free acid form of ibuprofen, or preparing a homogeneous suspension of the free acid form of ibuprofen, in the presence of a pharmaceutically acceptable solvent so as to produce a topical drug formulation compatible with the penetration of 2-(4-isobutylphenyl) propionic acid through the skin tissue. Topical formulations of ibuprofen can be based on a pharmaceutically acceptable solvent such as, e.g., a pyrrolidone solvent or dimethylacetamide.

    摘要翻译： 本文所述是适用于局部给药的游离酸形式的布洛芬（2-（4-异丁基苯基）丙酸）的制剂。 通过在游离酸形式的布洛芬溶解游离酸形式的布洛芬或在药学上可接受的溶剂的存在下制备游离酸形式的均匀悬浮液来制备局部布洛芬制剂，以产生与渗透2相兼容的局部药物制剂 - （4-异丁基苯基）丙酸通过皮肤组织。 布洛芬的局部制剂可以基于药学上可接受的溶剂，例如吡咯烷酮溶剂或二甲基乙酰胺。

    Ibuprofen for Topical Administration
    8.
    发明申请
    Ibuprofen for Topical Administration 审中-公开
    布洛芬用于局部治疗

    公开(公告)号：US20100137443A1

    公开(公告)日：2010-06-03

    申请号：US12557470

    申请日：2009-09-10

    申请人： Stephen G. Carter ,  Zhen Zhu ,  Kanu Patel ,  Diane L. Kozwich

    发明人： Stephen G. Carter ,  Zhen Zhu ,  Kanu Patel ,  Diane L. Kozwich

    IPC分类号： A61K31/192 ,  A61P29/00

    CPC分类号： A61K31/192 ,  A61K9/0014 ,  A61K9/7023 ,  A61K47/16 ,  A61K47/22 ,  A61K47/32

    摘要： Set forth herein is a preparation of ibuprofen (2-(4-isobutylphenyl)propionic acid) in the free acid form that is suitable for topical administration. The topical ibuprofen formulation is prepared by dissolving the free acid form of ibuprofen, or preparing a homogeneous suspension of the free acid form of ibuprofen, in the presence of a pharmaceutically acceptable solvent so as to produce a topical drug formulation compatible with the penetration of 2-(4-isobutylphenyl) propionic acid through the skin tissue. Topical formulations of ibuprofen can be based on a pharmaceutically acceptable solvent such as, e.g., a pyrrolidone solvent or dimethylacetamide.

    摘要翻译： 本文所述是适用于局部给药的游离酸形式的布洛芬（2-（4-异丁基苯基）丙酸）的制剂。 通过在游离酸形式的布洛芬溶解游离酸形式的布洛芬或在药学上可接受的溶剂的存在下制备游离酸形式的均匀悬浮液来制备局部布洛芬制剂，以产生与渗透2相兼容的局部药物制剂 - （4-异丁基苯基）丙酸通过皮肤组织。 布洛芬的局部制剂可以基于药学上可接受的溶剂，例如吡咯烷酮溶剂或二甲基乙酰胺。