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    System for stimulating autonomic targets from pulmonary artery
    6.
    发明授权
    System for stimulating autonomic targets from pulmonary artery 有权
    从肺动脉刺激自主神经系统

    公开(公告)号：US08527064B2

    公开(公告)日：2013-09-03

    申请号：US12327601

    申请日：2008-12-03

    申请人： Yunlong Zhang ,  Haresh G. Sachanandani ,  Dan Li ,  Bin Mi

    发明人： Yunlong Zhang ,  Haresh G. Sachanandani ,  Dan Li ,  Bin Mi

    IPC分类号： A61N1/36

    CPC分类号： A61N1/0587 ,  A61B5/4035 ,  A61B5/6862 ,  A61B5/6876 ,  A61N1/057 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/3627 ,  A61N1/37211 ,  A61N1/37288

    摘要： Various implantable medical device embodiments stimulate an autonomic neural target from within a pulmonary artery, and comprise at least one electrode, a power supply, a neural stimulator connected to the power supply, and an anchor structure. The neural stimulator is configured to generate a neural stimulation signal for delivery to the neural stimulation target through the at least one electrode. The anchor structure is configured to chronically and securely implant the neural stimulator, the power supply and the at least one electrode within the pulmonary artery. The anchor structure, the neural stimulator, the power supply and the at least one electrode are configured to be implanted through a pulmonary valve into the pulmonary artery. In various embodiments, the neural stimulator is configured to be operational to implement a neural stimulation protocol when chronically implanted within the pulmonary artery without a wired connection through the pulmonary valve.

    摘要翻译： 各种可植入医疗装置实施例从肺动脉内刺激自主神经靶标，并且包括至少一个电极，电源，连接到电源的神经刺激器和锚结构。 神经刺激器被配置为产生神经刺激信号，以通过至少一个电极传递到神经刺激靶。 锚结构被配置为长期且牢固地植入神经刺激器，电源和至少一个电极在肺动脉内。 锚结构，神经刺激器，电源和至少一个电极构造成通过肺动脉瓣植入肺动脉。 在各种实施例中，神经刺激器被配置为在长期植入肺动脉内而不通过肺动脉瓣的有线连接的情况下实施神经刺激方案。

    METHODS FOR USING A PULMONARY ARTERY ELECTRODE
    7.
    发明申请
    METHODS FOR USING A PULMONARY ARTERY ELECTRODE 审中-公开
    使用脉动电极的方法

    公开(公告)号：US20130218221A1

    公开(公告)日：2013-08-22

    申请号：US13855570

    申请日：2013-04-02

    申请人： Yongxing Zhang ,  Yunlong Zhang

    发明人： Yongxing Zhang ,  Yunlong Zhang

    IPC分类号： A61N1/365 ,  A61N1/39

    CPC分类号： A61N1/365 ,  A61N1/3605 ,  A61N1/36114 ,  A61N1/3622 ,  A61N1/3624 ,  A61N1/3627 ,  A61N1/368 ,  A61N1/395 ,  A61N1/3956

    摘要： According to some method embodiments, a left pulmonary artery electrode is positioned in a left pulmonary artery, and the left pulmonary artery electrode is used to sense atrial activity, or capture cardiac tissue, or deliver neural stimulation. According to some method embodiments, a right pulmonary artery electrode is positioned in a right pulmonary artery and a left pulmonary artery electrode is positioned in a left pulmonary artery, the right pulmonary artery electrode is used to sense atrial activity, or capture cardiac tissue, or deliver neural stimulation, and the left pulmonary artery electrode is used to sense atrial activity, or capture cardiac tissue, or deliver neural stimulation.

    摘要翻译： 根据一些方法实施例，左肺动脉电极位于左肺动脉中，并且左肺动脉电极用于感测心房活动或捕获心脏组织或递送神经刺激。 根据一些方法实施例，右肺动脉电极位于右肺动脉中，左肺动脉电极位于左肺动脉中，右肺动脉电极用于感测心房活动或捕获心脏组织，或 传递神经刺激，左肺动脉电极用于感测心房活动或捕获心脏组织，或传递神经刺激。

    Intracardiac impedance and its applications
    8.
    发明授权
    Intracardiac impedance and its applications 有权
    心内阻抗及其应用

    公开(公告)号：US08494618B2

    公开(公告)日：2013-07-23

    申请号：US11208922

    申请日：2005-08-22

    申请人： Yunlong Zhang ,  James O. Gilkerson ,  Yongxing Zhang ,  Boyce Moon

    发明人： Yunlong Zhang ,  James O. Gilkerson ,  Yongxing Zhang ,  Boyce Moon

    IPC分类号： A61B5/04 ,  A61N1/00

    CPC分类号： A61N1/3962 ,  A61N1/3621 ,  A61N1/36521 ,  A61N1/3925

    摘要： A system to measure intracardiac impedance includes implantable electrodes and a medical device. The electrodes sense electrical signals of a heart of a subject. The medical device includes a cardiac signal sensing circuit coupled to the implantable electrodes, an impedance measurement circuit coupled to the same or different implantable electrodes, and a controller circuit coupled to the cardiac signal sensing circuit and the impedance measurement circuit. The cardiac signal sensing circuit provides a sensed cardiac signal. The impedance measurement circuit senses intracardiac impedance between the electrodes to obtain an intracardiac impedance signal. The controller circuit determines cardiac cycles of the subject using the sensed cardiac signal, and detects tachyarrhythmia using cardiac-cycle to cardiac-cycle changes in a plurality of intracardiac impedance parameters obtained from the intracardiac impedance signal.

    摘要翻译： 测量心内阻抗的系统包括可植入电极和医疗装置。 电极感测受试者心脏的电信号。 医疗装置包括耦合到可植入电极的心脏信号感测电路，耦合到相同或不同可植入电极的阻抗测量电路，以及耦合到心脏信号感测电路和阻抗测量电路的控制器电路。 心脏信号感测电路提供感测的心脏信号。 阻抗测量电路感测电极之间的心内阻抗，以获得心内阻抗信号。 控制器电路使用感测到的心脏信号来确定受试者的心脏周期，并且使用从心脏内阻抗信号获得的多个心内阻抗参数中的心脏周期与心脏周期变化来检测快速性心律失常。

    Cardiac force sensor and methods of use
    9.
    发明授权
    Cardiac force sensor and methods of use 有权
    心脏力传感器及使用方法

    公开(公告)号：US08417355B2

    公开(公告)日：2013-04-09

    申请号：US12940172

    申请日：2010-11-05

    申请人： Yongxing Zhang ,  Yunlong Zhang ,  Xuan Wei

    发明人： Yongxing Zhang ,  Yunlong Zhang ,  Xuan Wei

    IPC分类号： A61N1/05

    CPC分类号： A61B5/224 ,  A61B5/0464 ,  A61B5/11 ,  A61B5/6846 ,  A61B5/686 ,  A61B5/6869 ,  A61N1/3627

    摘要： A method and apparatus permit sensing one or more forces exerted by one or more portions of a heart. A force transducer and displacement sensor are disclosed. A movement of one or more portions of a heart can be translated into one or more signals indicative of force. These signals can be used to provide information such as to diagnose or treat one or more conditions.

    摘要翻译： 一种方法和装置允许感测由心脏的一个或多个部分施加的一个或多个力。 公开了一种力传感器和位移传感器。 心脏的一个或多个部分的运动可以被转换为指示力的一个或多个信号。 这些信号可用于提供诸如诊断或治疗一种或多种病症的信息。

    Methods for using a pulmonary artery electrode
    10.
    发明授权
    Methods for using a pulmonary artery electrode 有权
    肺动脉电极的使用方法

    公开(公告)号：US08417354B2

    公开(公告)日：2013-04-09

    申请号：US12779177

    申请日：2010-05-13

    申请人： Yongxing Zhang ,  Yunlong Zhang

    发明人： Yongxing Zhang ,  Yunlong Zhang

    IPC分类号： A61N1/368

    CPC分类号： A61N1/365 ,  A61N1/3605 ,  A61N1/36114 ,  A61N1/3622 ,  A61N1/3624 ,  A61N1/3627 ,  A61N1/368 ,  A61N1/395 ,  A61N1/3956

    摘要： According to some method embodiments, a left pulmonary artery electrode is positioned in a left pulmonary artery, and the left pulmonary artery electrode is used to sense atrial activity, or capture cardiac tissue, or deliver neural stimulation. According to some method embodiments, a right pulmonary artery electrode is positioned in a right pulmonary artery and a left pulmonary artery electrode is positioned in a left pulmonary artery, the right pulmonary artery electrode is used to sense atrial activity, or capture cardiac tissue, or deliver neural stimulation, and the left pulmonary artery electrode is used to sense atrial activity, or capture cardiac tissue, or deliver neural stimulation.

    摘要翻译： 根据一些方法实施例，左肺动脉电极位于左肺动脉中，并且左肺动脉电极用于感测心房活动或捕获心脏组织或递送神经刺激。 根据一些方法实施例，右肺动脉电极位于右肺动脉中，左肺动脉电极位于左肺动脉中，右肺动脉电极用于感测心房活动或捕获心脏组织，或 传递神经刺激，左肺动脉电极用于感测心房活动或捕获心脏组织，或传递神经刺激。