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公开(公告)号:US09403830B2
公开(公告)日:2016-08-02
申请号:US13942988
申请日:2013-07-16
申请人: Asitha Abeywardane , Steven Richard Brunette , Michael Jason Burke , Thomas Martin Kirrane, Jr. , Chuk Chui Man , Daniel Richard Marshall , Anil Kumar Padyana , Hossein Razavi , Robert Sibley , Lana Louise Smith Keenan , Roger John Snow , Ronald John Sorcek , Hidenori Takahashi , Steven John Taylor , Michael Robert Turner , Erick Richard Roush Young , Qiang Zhang , Yunlong Zhang , Renee M. Zindell
发明人: Asitha Abeywardane , Steven Richard Brunette , Michael Jason Burke , Thomas Martin Kirrane, Jr. , Chuk Chui Man , Daniel Richard Marshall , Anil Kumar Padyana , Hossein Razavi , Robert Sibley , Lana Louise Smith Keenan , Roger John Snow , Ronald John Sorcek , Hidenori Takahashi , Steven John Taylor , Michael Robert Turner , Erick Richard Roush Young , Qiang Zhang , Yunlong Zhang , Renee M. Zindell
IPC分类号: C07D487/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D401/12 , C07D417/14 , C07D471/04 , C07D471/20 , C07D491/20 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/549 , A61K31/55 , A61K31/551 , C07D405/12 , C07D497/08 , C07D498/04
CPC分类号: C07D487/04 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/549 , A61K31/55 , A61K31/551 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/20 , C07D491/20 , C07D497/08 , C07D498/04
摘要: The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein A1, A2, L1 and B are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorders. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,其中A1,A2,L1和B如本文所定义。 式(I)化合物可用作白三烯A4水解酶(LTA4H)的抑制剂和治疗LTA4H相关病症。 本发明还涉及包含式(I)化合物的药物组合物,使用这些化合物治疗各种疾病和病症的方法,以及制备这些化合物的方法。
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公开(公告)号:US08946203B2
公开(公告)日:2015-02-03
申请号:US13785034
申请日:2013-03-05
申请人: Asitha Abeywardane , Steven Richard Brunette , Michael J. Burke , Suresh R. Kapadia , Thomas Martin Kirrane , Matthew Russell Netherton , Hossein Razavi , Sonia Rodriguez , Anjan Saha , Robert Sibley , Lana Louise Smith-Keenan , Hidenori Takahashi , Michael Robert Turner , Jiang-Ping Wu , Erick Richard Roush Young , Qiang Zhang , Qing Zhang , Renee M. Zindell
发明人: Asitha Abeywardane , Steven Richard Brunette , Michael J. Burke , Suresh R. Kapadia , Thomas Martin Kirrane , Matthew Russell Netherton , Hossein Razavi , Sonia Rodriguez , Anjan Saha , Robert Sibley , Lana Louise Smith-Keenan , Hidenori Takahashi , Michael Robert Turner , Jiang-Ping Wu , Erick Richard Roush Young , Qiang Zhang , Qing Zhang , Renee M. Zindell
IPC分类号: C07D519/00 , C07D491/04 , C07D487/08 , A61K31/357 , C07D491/052 , C07D405/10 , C07D295/096 , C07D295/155 , C07D513/04 , C07D405/14 , C07D319/20 , C07D405/12 , C07D487/10 , C07D413/10 , C07D417/10 , C07D417/14 , C07D471/10 , C07D487/04
CPC分类号: C07D491/052 , A61K31/357 , C07D295/096 , C07D295/155 , C07D319/20 , C07D405/10 , C07D405/12 , C07D405/14 , C07D413/10 , C07D417/10 , C07D417/14 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/04 , C07D513/04 , C07D519/00
摘要: The present invention relates to compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
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公开(公告)号:US20130196973A1
公开(公告)日:2013-08-01
申请号:US13418377
申请日:2012-03-13
申请人: Asitha Abeywardane , Michael J. Burke , Thomas Martin Kirrane , Matthew Russell Netherton , Anil Kumar Padyana , Lana Louise Smith Keenan , Hidenori Takahashi , Michael Robert Turner , Qiang Zhang , Qing Zhang
发明人: Asitha Abeywardane , Michael J. Burke , Thomas Martin Kirrane , Matthew Russell Netherton , Anil Kumar Padyana , Lana Louise Smith Keenan , Hidenori Takahashi , Michael Robert Turner , Qiang Zhang , Qing Zhang
IPC分类号: C07D319/20 , C07D417/10 , C07D471/10 , C07D417/14 , C07D405/14 , C07D491/056 , C07D487/04 , C07D487/10 , C07D405/10 , C07D487/08
CPC分类号: C07D295/16 , A61K31/397 , A61K31/5377 , C07D295/096 , C07D319/20 , C07D405/10 , C07D405/12 , C07D405/14 , C07D417/10 , C07D417/14 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/056
摘要: The present invention relates to compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
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公开(公告)号:US08551982B2
公开(公告)日:2013-10-08
申请号:US13418377
申请日:2012-03-13
申请人: Asitha Abeywardane , Michael J. Burke , Thomas Martin Kirrane , Matthew Russell Netherton , Anil Kumar Padyana , Lana Louise Smith Keenan , Hidenori Takahashi , Michael Robert Turner , Qiang Zhang , Qing Zhang
发明人: Asitha Abeywardane , Michael J. Burke , Thomas Martin Kirrane , Matthew Russell Netherton , Anil Kumar Padyana , Lana Louise Smith Keenan , Hidenori Takahashi , Michael Robert Turner , Qiang Zhang , Qing Zhang
IPC分类号: A61K31/553 , A61K31/55 , A61K31/551 , A61K31/438 , A61K31/436 , A61K31/453 , A61K31/5377 , A61K31/40 , A61K31/4025 , A61K31/357 , C07D267/08 , C07D225/02 , C07D243/08 , C07D245/02 , C07D221/20 , C07D491/04 , C07D401/02 , C07D413/14 , C07D405/14 , C07D405/02 , C07D319/16
CPC分类号: C07D295/16 , A61K31/397 , A61K31/5377 , C07D295/096 , C07D319/20 , C07D405/10 , C07D405/12 , C07D405/14 , C07D417/10 , C07D417/14 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/056
摘要: The present invention relates to compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
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公开(公告)号:US09150556B2
公开(公告)日:2015-10-06
申请号:US12596152
申请日:2008-05-15
申请人: Asitha Abeywardane , Brian Nicholas Cook , Stephane De Lombaert , Michel Jose Emmanuel , Xin Guo , Ming-Hong Hao , Jin Mi Kim , Ho Yin Lo , Chuk Chui Man , Tina Marie Morwick , Peter Allen Nemoto , Kevin Chungeng Qian , Hidenori Takahashi , Steven John Taylor
发明人: Asitha Abeywardane , Brian Nicholas Cook , Stephane De Lombaert , Michel Jose Emmanuel , Xin Guo , Ming-Hong Hao , Jin Mi Kim , Ho Yin Lo , Chuk Chui Man , Tina Marie Morwick , Peter Allen Nemoto , Kevin Chungeng Qian , Hidenori Takahashi , Steven John Taylor
IPC分类号: C07D235/26 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D417/06 , C07D417/14 , C07D471/04
CPC分类号: C07D409/06 , C07D235/26 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/06 , C07D417/06 , C07D417/14 , C07D471/04
摘要: Disclosed are small molecule inhibitors which are useful in treating various diseases and conditions involving chymase.
摘要翻译: 公开了可用于治疗涉及胃促胰酶的各种疾病和病症的小分子抑制剂。
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公开(公告)号:US20100240702A1
公开(公告)日:2010-09-23
申请号:US12596152
申请日:2008-05-15
申请人: Asitha Abeywardane , Brian Nicholas Cook , Stephane De Lombaert , Michel Jose Emmanuel , Xin Guo , Ming-Hong Hao , Jin Mi Kim , Ho Yin Lo , Chuk Chui Man , Tina Marie Morwick , Peter Allen Nemoto , Kevin Chungeng Qian , Hidenori Takahashi , Steven John Taylor
发明人: Asitha Abeywardane , Brian Nicholas Cook , Stephane De Lombaert , Michel Jose Emmanuel , Xin Guo , Ming-Hong Hao , Jin Mi Kim , Ho Yin Lo , Chuk Chui Man , Tina Marie Morwick , Peter Allen Nemoto , Kevin Chungeng Qian , Hidenori Takahashi , Steven John Taylor
IPC分类号: A61K31/454 , C07D235/26 , C07D211/32 , A61K31/4166 , A61P9/12 , A61P9/10 , A61P13/12
CPC分类号: C07D409/06 , C07D235/26 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/06 , C07D417/06 , C07D417/14 , C07D471/04
摘要: Disclosed are small molecule inhibitors which are useful in treating various diseases and conditions involving chymase.
摘要翻译: 公开了可用于治疗涉及胃促胰酶的各种疾病和病症的小分子抑制剂。
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7.Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof 有权
标题翻译: 糖皮质激素模拟物,其制备方法,药物组合物及其用途公开(公告)号:US08741897B2
公开(公告)日:2014-06-03
申请号:US10947420
申请日:2004-09-22
申请人: Younes Bekkali , Rajashekhar Betageri , Michel J. Emmanuel , Abdelhakim Hammach , Christian Hanke Justus Joachim Harcken , Thomas Martin Kirrane, Jr. , Daniel Kuzmich , Thomas Wai-Ho Lee , Pingrong Liu , Usha R. Patel , John Robert Proudfoot , Hossein Razavi , Doris Riether , Hidenori Takahashi , David S. Thomson , Ji Wang , Renee Zindell
发明人: Younes Bekkali , Rajashekhar Betageri , Michel J. Emmanuel , Abdelhakim Hammach , Christian Hanke Justus Joachim Harcken , Thomas Martin Kirrane, Jr. , Daniel Kuzmich , Thomas Wai-Ho Lee , Pingrong Liu , Usha R. Patel , John Robert Proudfoot , Hossein Razavi , Doris Riether , Hidenori Takahashi , David S. Thomson , Ji Wang , Renee Zindell
IPC分类号: C07D487/04 , A61K31/519 , A61K31/5377 , A61K31/4355 , A61K31/5025 , A61P25/28 , A61P9/00 , A61P35/00 , A61K31/4402 , A61K31/4409 , A61K31/4418 , A61K31/4406 , A61K31/497 , A61K31/506 , A61K31/4184 , A61K31/404 , A61K31/416 , A61K31/47
CPC分类号: C07D213/75 , A61K31/4745 , A61K31/52 , C07D209/08 , C07D209/12 , C07D213/30 , C07D215/14 , C07D231/12 , C07D231/56 , C07D237/20 , C07D239/42 , C07D307/79 , C07D319/06 , C07D319/08 , C07D333/56 , C07D403/10 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04
摘要: Compounds of Formula (IA), (IB), (IC), and (ID) wherein R1, R2, R3, R4, R5, and R6 are as respectively defined herein for Formula (IA), (IB), (IC), and (ID), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译: 式(IA),(IB),(IC)和(ID)的化合物,其中R 1,R 2,R 3,R 4,R 5和R 6如本文中对于式(IA),(IB) ,和(ID),或互变异构体,前药,溶剂合物或其盐; 含有这些化合物的药物组合物,以及调节糖皮质激素受体功能的方法和治疗由糖皮质激素受体功能介导的疾病状态或病症的方法,或其特征在于使用这些化合物的患者的炎症,过敏或增殖过程。
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8.Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and thereof 有权
标题翻译: 糖皮质激素模拟物,其制备方法,药物组合物及其制备方法公开(公告)号:US08212040B2
公开(公告)日:2012-07-03
申请号:US11410408
申请日:2006-04-25
申请人: Younes Bekkali , Rajashehar Betageri , Mario G. Cardozo , Thomas A. Gilmore , Christian Hanke Justus Joachim Harcken , Thomas Martin Kirrane , Daniel Kuzmich , John Robert Proudfoot , Doris Riether , Hidenori Takahashi , David S. Thomson , Ji Wang , Renee M. Zindell , Hossein Razavi
发明人: Younes Bekkali , Rajashehar Betageri , Mario G. Cardozo , Thomas A. Gilmore , Christian Hanke Justus Joachim Harcken , Thomas Martin Kirrane , Daniel Kuzmich , John Robert Proudfoot , Doris Riether , Hidenori Takahashi , David S. Thomson , Ji Wang , Renee M. Zindell , Hossein Razavi
IPC分类号: C07D471/02 , A61K31/44
CPC分类号: C07D209/12 , C07D213/30 , C07D215/14 , C07D217/16 , C07D231/12 , C07D233/64 , C07D235/12 , C07D237/08 , C07D239/26 , C07D241/12 , C07D261/18 , C07D263/32 , C07D263/56 , C07D277/24 , C07D277/64 , C07D307/80 , C07D333/16 , C07D401/06 , C07D405/06 , C07D471/04
摘要: Compounds of Formula (IA) wherein R1, R2, R3, R4 and R5 are as defined herein for Formula (IA), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译: 式(IA)的化合物,其中R 1,R 2,R 3,R 4和R 5如本文对式(IA)所定义,或其互变异构体,前药,溶剂合物或其盐; 含有这些化合物的药物组合物,以及调节糖皮质激素受体功能的方法和治疗由糖皮质激素受体功能介导的疾病状态或病症的方法,或其特征在于使用这些化合物的患者的炎症,过敏或增殖过程。
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公开(公告)号:US08501749B2
公开(公告)日:2013-08-06
申请号:US13146765
申请日:2010-01-26
申请人: Xin Guo , Chuk Chui Man , Hidenori Takahashi
发明人: Xin Guo , Chuk Chui Man , Hidenori Takahashi
IPC分类号: C07D471/04 , C07D475/02 , A61K31/519
CPC分类号: C07D475/02 , C07D471/04
摘要: Disclosed are small molecule inhibitors of the formula (I), which are useful in treating various diseases and conditions involving chymase.
摘要翻译: 公开了式(I)的小分子抑制剂,其可用于治疗涉及糜酶的各种疾病和病症。
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公开(公告)号:US08377949B2
公开(公告)日:2013-02-19
申请号:US12673103
申请日:2008-08-12
申请人: Xin Guo , Ho Yin Lo , Chuk Chui Man , Hidenori Takahashi
发明人: Xin Guo , Ho Yin Lo , Chuk Chui Man , Hidenori Takahashi
IPC分类号: A01N43/54 , A61K31/517 , C07D491/00
CPC分类号: C07D403/06 , C07D417/06
摘要: Disclosed are small molecule inhibitors which are useful in treating various diseases and conditions involving Chymase.
摘要翻译: 公开了可用于治疗涉及糜酶的各种疾病和病症的小分子抑制剂。
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