专利检索 ap:"Chuk Chui Man" 第 1 页

1.

发明授权
Azaquinazolinediones chymase inhibitors 有权
标题翻译：氮杂喹啉酮糖苷酶抑制剂

公开(公告)号：US08501749B2

公开(公告)日：2013-08-06

申请号：US13146765

申请日：2010-01-26

申请人： Xin Guo , Chuk Chui Man , Hidenori Takahashi

发明人： Xin Guo , Chuk Chui Man , Hidenori Takahashi

IPC分类号： C07D471/04 , C07D475/02 , A61K31/519

CPC分类号： C07D475/02 , C07D471/04

摘要： Disclosed are small molecule inhibitors of the formula (I), which are useful in treating various diseases and conditions involving chymase.

摘要翻译： 公开了式（I）的小分子抑制剂，其可用于治疗涉及糜酶的各种疾病和病症。

2.

发明授权
Quinazolinedione chymase inhibitors 有权
标题翻译：喹唑啉二酮胃促胰酶抑制剂

公开(公告)号：US08377949B2

公开(公告)日：2013-02-19

申请号：US12673103

申请日：2008-08-12

申请人： Xin Guo , Ho Yin Lo , Chuk Chui Man , Hidenori Takahashi

发明人： Xin Guo , Ho Yin Lo , Chuk Chui Man , Hidenori Takahashi

IPC分类号： A01N43/54 , A61K31/517 , C07D491/00

CPC分类号： C07D403/06 , C07D417/06

摘要： Disclosed are small molecule inhibitors which are useful in treating various diseases and conditions involving Chymase.

摘要翻译： 公开了可用于治疗涉及糜酶的各种疾病和病症的小分子抑制剂。

3.

发明授权
Benzimidazole inhibitors of leukotriene production 有权
标题翻译：苯并咪唑抑制剂白三烯生产

公开(公告)号：US08420655B2

公开(公告)日：2013-04-16

申请号：US12957766

申请日：2010-12-01

申请人： Zhidong Chen , Ming-Hong Hao , Weimin Liu , Ho-Yin Lo , Pui Leng Loke , Chuk Chui Man , Tina Marie Morwick , Peter Allen Nemoto , Hidenori Takahashi , Heather Tye , Lifen Wu

发明人： Zhidong Chen , Ming-Hong Hao , Weimin Liu , Ho-Yin Lo , Pui Leng Loke , Chuk Chui Man , Tina Marie Morwick , Peter Allen Nemoto , Hidenori Takahashi , Heather Tye , Lifen Wu

IPC分类号： A61K31/506 , C07D403/14

CPC分类号： C07D471/04 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12

摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salt thereof, wherein R1-R7 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1 -R 7如本文所定义。本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

4.

发明授权
Biarylamide inhibitors of leukotriene production 有权
标题翻译：白三烯生产的二芳基酰胺抑制剂

公开(公告)号：US09073895B2

公开(公告)日：2015-07-07

申请号：US13325564

申请日：2011-12-14

申请人： Angela Berry , Zhidong Chen , Stephane De Lombaert , Michel Jose Emmanuel , Pui Leng Loke , Chuk Chui Man , Tina Marie Morwick , Hidenori Takahashi

发明人： Angela Berry , Zhidong Chen , Stephane De Lombaert , Michel Jose Emmanuel , Pui Leng Loke , Chuk Chui Man , Tina Marie Morwick , Hidenori Takahashi

IPC分类号： C07D213/72 , A61K31/345 , C07D405/10 , C07D239/42 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14

CPC分类号： C07D405/10 , C07D239/42 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14

摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, C, R1a, R1b, R2, R3, R4a and R4b are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中A，B，C，R 1a，R 1b，R 2，R 3，R 4a和R 4b如本文所定义。本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

5.

发明申请
INHIBITORS OF LEUKOTRIENE PRODUCTION 有权
标题翻译：白藜芦素生产抑制剂

公开(公告)号：US20140031339A1

公开(公告)日：2014-01-30

申请号：US13942988

申请日：2013-07-16

申请人： Asitha ABEYWARDANE , Steven Richard BRUNETTE , Michael Jason BURKE , Thomas Martin KIRRANE, JR. , Chuk Chui MAN , Daniel Richard MARSHALL , Anil Kumar PADYANA , Hossein RAZAVI , Robert SIBLEY , Lana Louise SMITH KEENAN , Roger John SNOW , Ronald John SORCEK , Hidenori TAKAHASHI , Steven John TAYLOR , Michael Robert TURNER , Erick Richard Roush YOUNG , Qiang ZHANG , Yunlong ZHANG , Renee M. ZINDELL

发明人： Asitha ABEYWARDANE , Steven Richard BRUNETTE , Michael Jason BURKE , Thomas Martin KIRRANE, JR. , Chuk Chui MAN , Daniel Richard MARSHALL , Anil Kumar PADYANA , Hossein RAZAVI , Robert SIBLEY , Lana Louise SMITH KEENAN , Roger John SNOW , Ronald John SORCEK , Hidenori TAKAHASHI , Steven John TAYLOR , Michael Robert TURNER , Erick Richard Roush YOUNG , Qiang ZHANG , Yunlong ZHANG , Renee M. ZINDELL

IPC分类号： C07D401/14 , C07D413/14 , C07D487/04 , C07D498/04 , C07D497/08 , A61K31/5377 , A61K31/55 , A61K31/549 , A61K31/496 , A61K31/4545 , A61K31/454 , C07D405/12 , A61K31/551

CPC分类号： C07D487/04 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/549 , A61K31/55 , A61K31/551 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/20 , C07D491/20 , C07D497/08 , C07D498/04

摘要： The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein A1, A2, L1 and B are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorders. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.

摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中A1，A2，L1和B如本文所定义。式（I）化合物可用作白三烯A4水解酶（LTA4H）的抑制剂和治疗LTA4H相关疾病。本发明还涉及包含式（I）化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，以及制备这些化合物的方法。

6.

发明申请
BIARYLAMIDE INHIBITORS OF LEUKOTRIENE PRODUCTION 有权
标题翻译：白藜芦素生产的氨基酰胺抑制剂

公开(公告)号：US20120322795A1

公开(公告)日：2012-12-20

申请号：US13325564

申请日：2011-12-14

申请人： Angela BERRY , Zhidong CHEN , Stephane DE LOMBAERT , Michel Jose EMMANUEL , Pui Leng LOKE , Chuk Chui MAN , Tina Marie MORWICK , Hidenori TAKAHASHI

发明人： Angela BERRY , Zhidong CHEN , Stephane DE LOMBAERT , Michel Jose EMMANUEL , Pui Leng LOKE , Chuk Chui MAN , Tina Marie MORWICK , Hidenori TAKAHASHI

IPC分类号： A61K31/506 , C07D405/14 , C07D417/14 , C07D413/14 , A61K31/5377 , C07D471/04 , A61K31/519 , C07D239/42 , A61K31/505 , C07D413/12 , C07D417/12 , A61K31/4439 , C07D401/12 , A61K31/501 , A61K31/4709 , A61K31/427 , A61K31/541 , A61K31/444 , C07D403/12 , C07D513/04 , A61P9/00 , A61P9/10 , A61P29/00 , A61P37/08 , A61P11/00 , A61P13/12 , A61P35/00 , C07D405/10

CPC分类号： C07D405/10 , C07D239/42 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14

摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, C, R1a, R1b, R2, R3, R4a and R4b are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中A，B，C，R 1a，R 1b，R 2，R 3，R 4a和R 4b如本文所定义。本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

7.

发明申请
Benzimidazolone Chymase Inhibitors 有权
标题翻译：苯并咪唑酮糜酶抑制剂

公开(公告)号：US20100240702A1

公开(公告)日：2010-09-23

申请号：US12596152

申请日：2008-05-15

申请人： Asitha Abeywardane , Brian Nicholas Cook , Stephane De Lombaert , Michel Jose Emmanuel , Xin Guo , Ming-Hong Hao , Jin Mi Kim , Ho Yin Lo , Chuk Chui Man , Tina Marie Morwick , Peter Allen Nemoto , Kevin Chungeng Qian , Hidenori Takahashi , Steven John Taylor

发明人： Asitha Abeywardane , Brian Nicholas Cook , Stephane De Lombaert , Michel Jose Emmanuel , Xin Guo , Ming-Hong Hao , Jin Mi Kim , Ho Yin Lo , Chuk Chui Man , Tina Marie Morwick , Peter Allen Nemoto , Kevin Chungeng Qian , Hidenori Takahashi , Steven John Taylor

IPC分类号： A61K31/454 , C07D235/26 , C07D211/32 , A61K31/4166 , A61P9/12 , A61P9/10 , A61P13/12

CPC分类号： C07D409/06 , C07D235/26 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/06 , C07D417/06 , C07D417/14 , C07D471/04

摘要： Disclosed are small molecule inhibitors which are useful in treating various diseases and conditions involving chymase.

摘要翻译： 公开了可用于治疗涉及胃促胰酶的各种疾病和病症的小分子抑制剂。

8.

发明申请
Substituted pyrazole compounds useful as soluble epoxide hyrolase inhibitors 审中-公开
标题翻译：用作可溶性环氧化物酶抑制剂的取代的吡唑化合物

公开(公告)号：US20090227588A1

公开(公告)日：2009-09-10

申请号：US12095928

申请日：2006-11-14

申请人： Roman Wolfgang Fleck , Xin Guo , Ho Yin Lo , Chuk Chui Man

发明人： Roman Wolfgang Fleck , Xin Guo , Ho Yin Lo , Chuk Chui Man

IPC分类号： A61K31/5377 , C07D401/14 , A61K31/444 , A61K31/4439 , C07D401/04 , A61P3/10 , A61K31/501 , C07D413/14

CPC分类号： C07D231/12 , C07D231/22 , C07D401/04 , C07D401/14 , C07D405/14 , C07D417/14

摘要： Disclosed are compounds active against soluble epoxide hydrolase (sEH), compositions thereof and methods of using and making same.

摘要翻译： 公开了对可溶性环氧化物水解酶（sEH）有活性的化合物，其组合物和使用和制备其的方法。